HK1171761A1 - α- β- α- α-羥基， β-甲基- α-孕烷- -酮 加奈索酮 的製備方法 - Google Patents
α- β- α- α-羥基， β-甲基- α-孕烷- -酮 加奈索酮 的製備方法Info
- Publication number
- HK1171761A1 HK1171761A1 HK12112640.5A HK12112640A HK1171761A1 HK 1171761 A1 HK1171761 A1 HK 1171761A1 HK 12112640 A HK12112640 A HK 12112640A HK 1171761 A1 HK1171761 A1 HK 1171761A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ganaxolone
- pregnan
- hydroxy
- methyl
- making
- Prior art date
Links
- PGTVWKLGGCQMBR-FLBATMFCSA-N Ganaxolone Chemical compound C([C@@H]1CC2)[C@](C)(O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 PGTVWKLGGCQMBR-FLBATMFCSA-N 0.000 title 1
- 229950006567 ganaxolone Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23355309P | 2009-08-13 | 2009-08-13 | |
| PCT/US2010/045176 WO2011019821A2 (en) | 2009-08-13 | 2010-08-11 | METHOD FOR MAKING 3α-HYDROXY, 3β- METHYL-5α-PREGNAN-20-ONE (GANAXOLONE) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1171761A1 true HK1171761A1 (zh) | 2013-04-05 |
Family
ID=43586809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12112640.5A HK1171761A1 (zh) | 2009-08-13 | 2012-12-07 | α- β- α- α-羥基， β-甲基- α-孕烷- -酮 加奈索酮 的製備方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8362286B2 (zh) |
| EP (1) | EP2464653B1 (zh) |
| JP (1) | JP5745517B2 (zh) |
| KR (1) | KR101778603B1 (zh) |
| CN (1) | CN102549007B (zh) |
| AU (1) | AU2010282570B2 (zh) |
| BR (1) | BR112012003085B1 (zh) |
| CA (1) | CA2769820C (zh) |
| EA (1) | EA024269B1 (zh) |
| ES (1) | ES2524724T3 (zh) |
| HK (1) | HK1171761A1 (zh) |
| IL (1) | IL217857A (zh) |
| MX (1) | MX2012001728A (zh) |
| NZ (1) | NZ597940A (zh) |
| WO (1) | WO2011019821A2 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008006888A (es) | 2005-11-28 | 2008-09-30 | Marinus Pharmaceuticals | Formulas y metodos para la manufactura y uso de la ganaxolona. |
| US9629853B2 (en) | 2014-05-21 | 2017-04-25 | Wisconsin Alumni Research Foundation | Uses of ganaxolone |
| CZ2015130A3 (cs) * | 2015-02-25 | 2016-03-30 | Vysoká škola chemicko - technologická v Praze | (3α,5β,20S)-3-Nitrooxy-pregnan-20-karboxylová kyselina |
| EA036155B1 (ru) | 2015-10-16 | 2020-10-06 | Маринус Фармасьютикалс, Инк. | Инъекционные составы нейростероида, содержащие наночастицы |
| CN106279326A (zh) * | 2016-08-09 | 2017-01-04 | 南京臣功制药股份有限公司 | 一种醋酸甲羟孕酮胶囊的有关物质及其分析检测方法 |
| CN106366149B (zh) * | 2016-08-09 | 2018-01-23 | 南京臣功制药股份有限公司 | 一种醋酸甲羟孕酮分散片的有关物质及其分析检测方法 |
| EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
| US10391105B2 (en) | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
| IT201800009683A1 (it) * | 2018-10-22 | 2020-04-22 | Ind Chimica Srl | Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone) |
| US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
| MX2022001553A (es) | 2019-08-05 | 2022-04-18 | Marinus Pharmaceuticals Inc | Ganaxolona para su uso en el tratamiento del estado epileptico. |
| CN114828889A (zh) | 2019-12-06 | 2022-07-29 | 马瑞纳斯制药公司 | 用于治疗结节性硬化症的加奈索酮 |
| IT202000021316A1 (it) * | 2020-09-09 | 2022-03-09 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI (3α,5α)-3-IDROSSI-3-METIL-PREGNAN-20-ONE (GANAXOLONE) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953429A (en) * | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
| US5319115A (en) | 1987-08-25 | 1994-06-07 | Cocensys Inc. | Method for making 3α-hydroxy, 3β-substituted-pregnanes |
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| AU698834B2 (en) * | 1993-05-24 | 1998-11-12 | Purdue Pharma Ltd. | Methods and compositions for inducing sleep |
| FR2720747B1 (fr) * | 1994-06-02 | 1996-07-12 | Roussel Uclaf | Nouveau procédé de préparation d'un stéroïde 16béta-méthyl et nouveaux intermédiaires. |
| GEP20002033B (en) * | 1994-11-23 | 2000-04-10 | Cocensys Inc Us | Androstane and Pregnane Series Compounds for Allosteric Modulation of GABA Receptor |
| WO2006010085A1 (en) * | 2004-07-09 | 2006-01-26 | Roxro Pharma, Inc. | Use of neurosteroids to treat neuropathic pain |
| MX2008006888A (es) * | 2005-11-28 | 2008-09-30 | Marinus Pharmaceuticals | Formulas y metodos para la manufactura y uso de la ganaxolona. |
-
2010
- 2010-08-11 EP EP10808696.8A patent/EP2464653B1/en active Active
- 2010-08-11 JP JP2012524841A patent/JP5745517B2/ja active Active
- 2010-08-11 KR KR1020127006429A patent/KR101778603B1/ko active IP Right Grant
- 2010-08-11 MX MX2012001728A patent/MX2012001728A/es active IP Right Grant
- 2010-08-11 CN CN201080035660.3A patent/CN102549007B/zh active Active
- 2010-08-11 CA CA2769820A patent/CA2769820C/en active Active
- 2010-08-11 WO PCT/US2010/045176 patent/WO2011019821A2/en active Application Filing
- 2010-08-11 BR BR112012003085-0A patent/BR112012003085B1/pt active IP Right Grant
- 2010-08-11 AU AU2010282570A patent/AU2010282570B2/en active Active
- 2010-08-11 NZ NZ597940A patent/NZ597940A/xx unknown
- 2010-08-11 US US12/854,226 patent/US8362286B2/en active Active
- 2010-08-11 EA EA201270241A patent/EA024269B1/ru active IP Right Revival
- 2010-08-11 ES ES10808696.8T patent/ES2524724T3/es active Active
-
2012
- 2012-01-31 IL IL217857A patent/IL217857A/en active IP Right Grant
- 2012-12-07 HK HK12112640.5A patent/HK1171761A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL217857A0 (en) | 2012-03-29 |
| US20110040112A1 (en) | 2011-02-17 |
| CN102549007B (zh) | 2015-03-18 |
| AU2010282570A1 (en) | 2012-02-23 |
| JP5745517B2 (ja) | 2015-07-08 |
| EA024269B1 (ru) | 2016-09-30 |
| ES2524724T3 (es) | 2014-12-11 |
| WO2011019821A2 (en) | 2011-02-17 |
| KR101778603B1 (ko) | 2017-09-14 |
| BR112012003085A2 (pt) | 2020-12-01 |
| KR20120084715A (ko) | 2012-07-30 |
| NZ597940A (en) | 2013-03-28 |
| CA2769820A1 (en) | 2011-02-17 |
| CN102549007A (zh) | 2012-07-04 |
| JP2013501803A (ja) | 2013-01-17 |
| EP2464653A2 (en) | 2012-06-20 |
| CA2769820C (en) | 2017-06-27 |
| EA201270241A1 (ru) | 2013-09-30 |
| US8362286B2 (en) | 2013-01-29 |
| BR112012003085B1 (pt) | 2021-06-01 |
| MX2012001728A (es) | 2012-06-01 |
| WO2011019821A3 (en) | 2011-06-16 |
| AU2010282570B2 (en) | 2014-04-24 |
| EP2464653B1 (en) | 2014-10-22 |
| IL217857A (en) | 2016-03-31 |
| EP2464653A4 (en) | 2013-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1171761A1 (zh) | α- β- α- α-羥基， β-甲基- α-孕烷- -酮 加奈索酮 的製備方法 | |
| EP2500548A4 (en) | PROCESS FOR PRODUCING BLADE | |
| EP2463313A4 (en) | METHOD FOR MANUFACTURING COPOLYMER | |
| GB0911905D0 (en) | Method | |
| GB0902476D0 (en) | Method | |
| GB0910707D0 (en) | Method | |
| EP2405384B8 (en) | Method for manufacturing card | |
| EP2474560A4 (en) | METHOD OF PREPARING AN 11 SUGAR SIALYLOLIGOSACCHARIDE PEPTIDE | |
| GB0913525D0 (en) | Method | |
| PL2432877T3 (pl) | Metoda otrzymywania (+) -zizaenu | |
| EP2476710A4 (en) | PROCESS FOR PREPARING POLYBUTADIENE | |
| IL217656A (en) | Method for producing 1,1,3-trichloro-1-propane | |
| GB0901444D0 (en) | Method | |
| IL214287A0 (en) | Method for producing 2-aminobiphenylene | |
| GB0905367D0 (en) | Method | |
| GB0903316D0 (en) | Method | |
| GB0908770D0 (en) | Method | |
| ZA201203155B (en) | Method for isolating methylglycinenitrile-n,n-diacetonitrile | |
| IL214362A0 (en) | Method for producing hydroxymethyl diphenyloxiranes and corresponding 1-azolylmethyl-1,2-diphenyloxiranes | |
| GB0821302D0 (en) | Method for making an alloy | |
| PL2484005T3 (pl) | Sposób eksploatacji maszyny prądu stałego | |
| EP2306603A4 (en) | METHOD FOR PRODUCING A CONNECTION BAR | |
| EP2500333A4 (en) | PROCESS FOR PRODUCTION OF BETA-SIALON PHOSPHORUS | |
| GB0902034D0 (en) | Method | |
| GB0900560D0 (en) | Method |