HK1168101A1 - Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4- yl)amino]nicotinic acid - Google Patents

Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4- yl)amino]nicotinic acid

Info

Publication number
HK1168101A1
HK1168101A1 HK12108881.1A HK12108881A HK1168101A1 HK 1168101 A1 HK1168101 A1 HK 1168101A1 HK 12108881 A HK12108881 A HK 12108881A HK 1168101 A1 HK1168101 A1 HK 1168101A1
Authority
HK
Hong Kong
Prior art keywords
difluoro
biphenyl
methoxy
amino
manufacturing
Prior art date
Application number
HK12108881.1A
Other languages
English (en)
Inventor
Bernardini Maria Carmen Boix
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of HK1168101A1 publication Critical patent/HK1168101A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/803Processes of preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK12108881.1A 2009-10-16 2012-09-12 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4- yl)amino]nicotinic acid HK1168101A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382212A EP2314577A1 (en) 2009-10-16 2009-10-16 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
PCT/EP2010/006283 WO2011045059A1 (en) 2009-10-16 2010-10-14 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid

Publications (1)

Publication Number Publication Date
HK1168101A1 true HK1168101A1 (en) 2012-12-21

Family

ID=41402565

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12108881.1A HK1168101A1 (en) 2009-10-16 2012-09-12 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4- yl)amino]nicotinic acid

Country Status (32)

Country Link
US (1) US8598363B2 (zh)
EP (2) EP2314577A1 (zh)
JP (1) JP5809630B2 (zh)
KR (1) KR101699999B1 (zh)
CN (2) CN103936668A (zh)
AU (1) AU2010306098B2 (zh)
BR (1) BR112012008464B1 (zh)
CA (1) CA2776328C (zh)
CL (1) CL2012000739A1 (zh)
CO (1) CO6430508A2 (zh)
CR (1) CR20120185A (zh)
CY (1) CY1115161T1 (zh)
DK (1) DK2488497T3 (zh)
EA (1) EA022805B1 (zh)
ES (1) ES2467165T3 (zh)
HK (1) HK1168101A1 (zh)
HR (1) HRP20140523T1 (zh)
IL (1) IL218446A (zh)
IN (1) IN2012DN01938A (zh)
ME (1) ME01812B (zh)
MX (1) MX2012004033A (zh)
MY (1) MY160308A (zh)
NZ (1) NZ598429A (zh)
PE (1) PE20121173A1 (zh)
PL (1) PL2488497T3 (zh)
PT (1) PT2488497E (zh)
RS (1) RS53319B (zh)
SI (1) SI2488497T1 (zh)
SM (1) SMT201400064B (zh)
UA (1) UA107811C2 (zh)
WO (1) WO2011045059A1 (zh)
ZA (1) ZA201201563B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) * 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) * 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
JP7343373B2 (ja) * 2019-12-02 2023-09-12 花王株式会社 香料組成物

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SI9620081B (en) 1995-06-21 2001-06-30 Asta Medica Ag Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
AP2002002387A0 (en) 1999-06-10 2002-03-31 Warner Lambert Co Method of inhibiting amyloid aggregation and imaging amyloid deposits.
SI1381356T1 (sl) 2001-04-05 2008-12-31 Aventis Pharma Inc Uporaba (Z)-2-ciano-3-hidroksi-but-2-enojska kislina-(4'-trifluorometilfenil)-amida za zdravljenje multiple skleroze
PE20030120A1 (es) 2001-06-19 2003-02-12 Merck & Co Inc Sal amina de un antagonista de receptor de integrin
DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
MXPA04000224A (es) 2001-07-10 2005-07-25 4Sc Ag Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos.
US7258118B2 (en) 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
DE10202940A1 (de) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
WO2003068752A1 (en) * 2002-02-13 2003-08-21 Glaxo Group Limited Benzenesulfonamide derivatives as antipsychotic agents
JP4287752B2 (ja) * 2002-04-13 2009-07-01 ハンリム ファーマシューティカル カンパニー リミテッド アムロジピンニコチネート及びその製造方法
AR042206A1 (es) * 2002-11-26 2005-06-15 Novartis Ag Acidos fenilaceticos y derivados
EP1581478A1 (en) 2002-12-23 2005-10-05 4Sc Ag Dhodh-inhibitors and method for their identification
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SE0400234D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New compounds, methods for their preparation and use thereof
AU2005257862A1 (en) 2004-05-21 2006-01-05 The Uab Research Foundation Compositions and methods relating to pyrimidine synthesis inhibitors
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RU2007118691A (ru) 2004-10-19 2008-11-27 Авентис Фармасьютикалз Инк. (Us) Применение 4-трифторметилфениламида (z)-2-циано-3-гидрокси-бут-2-еновой кислоты для лечения воспалительных заболеваний кишечника
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
CN1696100B (zh) * 2005-06-01 2010-11-24 黑龙江福和华星制药集团股份有限公司 痤疮治疗药阿达帕林的新型简捷合成方法
ES2319596B1 (es) * 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
AU2008213147A1 (en) 2007-02-06 2008-08-14 Chelsea Therapeutics, Inc. New compounds, methods for their preparation and use thereof
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2210615A1 (en) 2009-01-21 2010-07-28 Almirall, S.A. Combinations comprising methotrexate and DHODH inhibitors
EP2228367A1 (en) 2009-03-13 2010-09-15 Almirall, S.A. Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
EP2230232A1 (en) 2009-03-13 2010-09-22 Almirall, S.A. Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors

Also Published As

Publication number Publication date
EP2488497B1 (en) 2014-03-12
SI2488497T1 (sl) 2014-08-29
PE20121173A1 (es) 2012-08-30
ZA201201563B (en) 2012-11-28
AU2010306098A1 (en) 2012-03-15
ME01812B (me) 2014-09-20
DK2488497T3 (da) 2014-06-10
CR20120185A (es) 2012-06-11
CN102574800B (zh) 2014-09-17
IN2012DN01938A (zh) 2015-08-21
IL218446A0 (en) 2012-04-30
UA107811C2 (en) 2015-02-25
CA2776328A1 (en) 2011-04-21
EP2314577A1 (en) 2011-04-27
KR20120087131A (ko) 2012-08-06
PT2488497E (pt) 2014-05-28
CY1115161T1 (el) 2016-12-14
CN102574800A (zh) 2012-07-11
JP2013507407A (ja) 2013-03-04
EA201200594A1 (ru) 2012-11-30
BR112012008464A2 (pt) 2015-09-22
WO2011045059A1 (en) 2011-04-21
CL2012000739A1 (es) 2012-10-12
BR112012008464B1 (pt) 2021-08-24
US8598363B2 (en) 2013-12-03
CN103936668A (zh) 2014-07-23
SMT201400064B (it) 2014-07-07
MX2012004033A (es) 2012-05-08
ES2467165T3 (es) 2014-06-12
IL218446A (en) 2014-08-31
RS53319B (en) 2014-10-31
US20120245359A1 (en) 2012-09-27
EA022805B1 (ru) 2016-03-31
EP2488497A1 (en) 2012-08-22
NZ598429A (en) 2014-02-28
AU2010306098B2 (en) 2015-10-15
CA2776328C (en) 2017-08-08
PL2488497T3 (pl) 2014-07-31
CO6430508A2 (es) 2012-04-30
KR101699999B1 (ko) 2017-01-26
HRP20140523T1 (hr) 2014-07-04
JP5809630B2 (ja) 2015-11-11
MY160308A (en) 2017-02-28

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