HK1167999A1 - 酸性神經酰胺酶的向溶酶體抑制劑 - Google Patents

酸性神經酰胺酶的向溶酶體抑制劑

Info

Publication number
HK1167999A1
HK1167999A1 HK12108760.7A HK12108760A HK1167999A1 HK 1167999 A1 HK1167999 A1 HK 1167999A1 HK 12108760 A HK12108760 A HK 12108760A HK 1167999 A1 HK1167999 A1 HK 1167999A1
Authority
HK
Hong Kong
Prior art keywords
lysosomotropic
inhibitors
acid ceramidase
ceramidase
acid
Prior art date
Application number
HK12108760.7A
Other languages
English (en)
Inventor
．別拉夫斯基
柏愛萍
．肖爾茨
．哈努恩
．諾里斯
柳湘
Original Assignee
南卡羅來納醫科大學研究發展基金會
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南卡羅來納醫科大學研究發展基金會 filed Critical 南卡羅來納醫科大學研究發展基金會
Publication of HK1167999A1 publication Critical patent/HK1167999A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK12108760.7A 2008-11-06 2012-09-07 酸性神經酰胺酶的向溶酶體抑制劑 HK1167999A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11185208P 2008-11-06 2008-11-06
PCT/US2009/063586 WO2010054223A1 (en) 2008-11-06 2009-11-06 Lysosomotropic inhibitors of acid ceramidase

Publications (1)

Publication Number Publication Date
HK1167999A1 true HK1167999A1 (zh) 2012-12-21

Family

ID=42153265

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12108760.7A HK1167999A1 (zh) 2008-11-06 2012-09-07 酸性神經酰胺酶的向溶酶體抑制劑

Country Status (10)

Country Link
US (1) US8697379B2 (zh)
EP (1) EP2348839B1 (zh)
JP (1) JP5721631B2 (zh)
CN (1) CN102368905B (zh)
AU (1) AU2009313400A1 (zh)
BR (1) BRPI0921278A2 (zh)
CA (1) CA2742866C (zh)
HK (1) HK1167999A1 (zh)
RU (1) RU2011117722A (zh)
WO (1) WO2010054223A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006050265A2 (en) * 2004-10-29 2006-05-11 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
WO2006050264A1 (en) 2004-10-29 2006-05-11 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
WO2010054223A1 (en) 2008-11-06 2010-05-14 Musc Foundation For Research Development Lysosomotropic inhibitors of acid ceramidase
AU2009332952A1 (en) * 2008-12-30 2011-07-21 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase
ES2791760T3 (es) 2011-09-07 2020-11-05 Sinai School Medicine Ceramidasa y diferenciación celular
ITMI20120923A1 (it) 2012-05-28 2013-11-29 Fond Istituto Italiano Di Tec Nologia 45 Inibitori della ceramidasi acida e loro usi come medicamenti
ITMI20120921A1 (it) 2012-05-28 2013-11-29 Fond Istituto Italiano Di Tec Nologia 45 Inibitori della ceramidasi acida e loro usi come medicamenti
WO2013181530A1 (en) * 2012-06-01 2013-12-05 Icahn School Of Medicine At Mount Sinai Ceramide levels in the treatment and prevention of infections
EP2968479B1 (en) 2013-03-14 2019-07-17 Icahn School of Medicine at Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
WO2015119393A1 (ko) * 2014-02-04 2015-08-13 (주)네오팜 발모촉진용 또는 탈모방지용 조성물
KR20150091983A (ko) * 2014-02-04 2015-08-12 (주)네오팜 발모촉진용 또는 탈모방지용 조성물
WO2015173168A1 (en) 2014-05-12 2015-11-19 Fondazione Istituto Italiano Di Tecnologia Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
WO2015173169A1 (en) 2014-05-12 2015-11-19 Fondazione Istituto Italiano Di Tecnologia Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
WO2018200931A1 (en) * 2017-04-28 2018-11-01 University Of Virginia Patent Foundation Compositions and methods for treating cancer
CN110598636B (zh) * 2019-09-09 2023-01-17 哈尔滨工业大学 一种基于特征迁移的舰船目标识别方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2515465A (en) 1946-03-22 1950-07-18 Merck & Co Inc Preparation of 2-alkyl-4-isopropylidene-5(4)-oxazolones
GB630712A (en) 1946-03-22 1949-10-19 Merck & Co Inc Process of preparing intermediates useful in the preparation of penicill amine
GB844431A (en) * 1957-12-07 1960-08-10 Boehringer & Soehne Gmbh Injectable aqueous solutions of chloramphenicol
US3466292A (en) 1966-05-13 1969-09-09 Upjohn Co Diazatricyclododecanediones and diazatricyclododecadiendiones
GB1307539A (en) * 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
US4016287A (en) 1972-07-17 1977-04-05 Boehringer Ingelheim Gmbh Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof
DE2408813A1 (de) 1974-02-23 1975-09-04 Agfa Gevaert Ag N-carbamoyloxypyridiniumsalze und verfahren zur herstellung derselben
US4481203A (en) 1977-04-05 1984-11-06 Taiho Pharmaceutical Company, Limited Composition containing 1-(n-hexylcarbamoyl)-5-fluorouracil and uracil
DE2817494A1 (de) 1977-05-03 1978-11-09 Continental Pharma Aminoalkohol-derivat
US4151198A (en) 1978-06-02 1979-04-24 American Cyanamid Company Resolution of N-acyl-DL (+)-phenylalanines
US4283541A (en) 1980-05-27 1981-08-11 Usv Pharmaceutical Corporation Pyridylacyl-hydroxamates
US4544670A (en) 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4937232A (en) 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
EP0310545A3 (de) 1987-09-02 1989-07-26 Ciba-Geigy Ag Cyanoguanidine als Härter für Epoxidharze
US5262568A (en) 1990-03-02 1993-11-16 State Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
US5679350A (en) 1992-05-28 1997-10-21 The University Of Toledo Method of delivery of a medicament to a cancer cell using a pathway of plasminogen activator material
US5369030A (en) 1992-09-11 1994-11-29 Duke University Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
WO1995006037A1 (en) * 1993-08-27 1995-03-02 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
WO1997010817A1 (en) 1995-09-20 1997-03-27 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US5830916A (en) 1996-05-23 1998-11-03 Duke University Inhibitor of ceramidase
DE19621038A1 (de) 1996-05-24 1997-11-27 Boehringer Ingelheim Kg Aminoguanidine, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
US6649362B2 (en) 1997-09-08 2003-11-18 Medvet Science Pty. Ltd. Screening method for an agent having an effect on a sphingosine kinase signaling pathway
AU765809B2 (en) 1998-02-12 2003-10-02 Emory University Sphingolipid derivatives and their methods of use
EP1127075A2 (en) 1998-11-06 2001-08-29 MUSC Foundation For Research Development A method of treating tumors using fas-induced apoptosis
WO2001079152A1 (en) 2000-04-19 2001-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
US6756504B2 (en) 2000-04-19 2004-06-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
US6696081B2 (en) 2000-06-09 2004-02-24 Duke University Carbohydrate based lipid compositions and supramolecular structures comprising same
CN1744919A (zh) 2000-09-11 2006-03-08 南卡罗莱纳医科大学研究发展基金会 使用凋亡的选择性诱导来治疗肿瘤的方法和组合物
WO2003005965A2 (en) 2001-07-11 2003-01-23 Musc Foundation For Research Development Modulators of ceramidase and methods of use based thereon
JP2004210733A (ja) * 2003-01-07 2004-07-29 Kyowa Hakko Kogyo Co Ltd アリールスルファマート誘導体
MXPA05005664A (es) * 2003-01-27 2005-07-27 Pfizer Prod Inc Derivados de isotiazol.
CA2516250A1 (en) 2003-02-19 2004-09-02 Endacea, Inc. A1 adenosine receptor antagonists
EP1707211A4 (en) * 2003-11-28 2009-08-05 Takara Bio Inc Ceramidase INHIBITORS
KR100822530B1 (ko) 2004-03-05 2008-04-16 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 및 ｐ2ｘ2/3 길항물질로서의 다이아미노피리미딘
JP2005336174A (ja) * 2004-04-27 2005-12-08 Santen Pharmaceut Co Ltd 変形性関節症治療剤
WO2006050264A1 (en) 2004-10-29 2006-05-11 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
WO2006050265A2 (en) 2004-10-29 2006-05-11 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
JP2006298807A (ja) * 2005-04-19 2006-11-02 Lead Chemical Co Ltd 新規化合物及びその用途
BRPI0611966B1 (pt) 2005-06-17 2022-05-03 Apogee Biotechnology Corporation Composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica os compreendendo
WO2007117400A2 (en) * 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyridines as modulators of the histamine h4 receptor
CN101600686A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 氯霉素、甲砜霉素及其类似物的水溶性前药
WO2010054223A1 (en) 2008-11-06 2010-05-14 Musc Foundation For Research Development Lysosomotropic inhibitors of acid ceramidase
AU2009332952A1 (en) 2008-12-30 2011-07-21 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase

Also Published As

Publication number Publication date
JP2012508249A (ja) 2012-04-05
CA2742866C (en) 2017-10-24
WO2010054223A1 (en) 2010-05-14
CN102368905B (zh) 2015-04-01
CA2742866A1 (en) 2010-05-14
BRPI0921278A2 (pt) 2015-08-25
EP2348839A1 (en) 2011-08-03
US20110251197A1 (en) 2011-10-13
RU2011117722A (ru) 2012-12-20
AU2009313400A1 (en) 2010-05-14
EP2348839B1 (en) 2017-04-05
CN102368905A (zh) 2012-03-07
JP5721631B2 (ja) 2015-05-20
US8697379B2 (en) 2014-04-15
EP2348839A4 (en) 2012-04-04

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Effective date: 20201104