HK1167404A1 - 用作 受體調節劑的苯並硫雜二氮雜䓬衍生物 - Google Patents

用作 受體調節劑的苯並硫雜二氮雜䓬衍生物

Info

Publication number
HK1167404A1
HK1167404A1 HK12108187.2A HK12108187A HK1167404A1 HK 1167404 A1 HK1167404 A1 HK 1167404A1 HK 12108187 A HK12108187 A HK 12108187A HK 1167404 A1 HK1167404 A1 HK 1167404A1
Authority
HK
Hong Kong
Prior art keywords
ampa
nmda
receptor modulators
derivatives used
benzothiadiazepine derivatives
Prior art date
Application number
HK12108187.2A
Other languages
English (en)
Inventor
Alexis Cordi
Patrice Desos
Pierre Lestage
Laurence Danober
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1167404A1 publication Critical patent/HK1167404A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK12108187.2A 2009-03-20 2012-08-21 用作 受體調節劑的苯並硫雜二氮雜䓬衍生物 HK1167404A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901300A FR2943342B1 (fr) 2009-03-20 2009-03-20 Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR2010/000227 WO2010106249A1 (fr) 2009-03-20 2010-03-18 Derives de benzothiadiazepines en tant que modulateures des recepteurs ampa et nmda

Publications (1)

Publication Number Publication Date
HK1167404A1 true HK1167404A1 (zh) 2012-11-30

Family

ID=40863576

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12108187.2A HK1167404A1 (zh) 2009-03-20 2012-08-21 用作 受體調節劑的苯並硫雜二氮雜䓬衍生物

Country Status (45)

Country Link
US (1) US8236790B2 (zh)
EP (1) EP2246339B1 (zh)
JP (1) JP5437473B2 (zh)
KR (1) KR101431504B1 (zh)
CN (1) CN102361860B (zh)
AP (1) AP3050A (zh)
AR (1) AR075892A1 (zh)
AT (1) ATE513822T1 (zh)
AU (1) AU2010200815B2 (zh)
BR (1) BRPI1009200A2 (zh)
CA (1) CA2696705C (zh)
CL (1) CL2011002287A1 (zh)
CO (1) CO6361956A2 (zh)
CR (1) CR20110484A (zh)
CU (1) CU24030B1 (zh)
CY (1) CY1111807T1 (zh)
DK (1) DK2246339T3 (zh)
EA (1) EA020259B1 (zh)
EC (1) ECSP11011340A (zh)
ES (1) ES2368691T3 (zh)
FR (1) FR2943342B1 (zh)
GE (1) GEP20135862B (zh)
HK (1) HK1167404A1 (zh)
HN (1) HN2011002458A (zh)
HR (1) HRP20110626T1 (zh)
IL (1) IL215016A (zh)
JO (1) JO2780B1 (zh)
MA (1) MA33131B1 (zh)
MX (1) MX2011009638A (zh)
MY (1) MY154001A (zh)
NI (1) NI201100169A (zh)
NZ (1) NZ595082A (zh)
PE (1) PE20120113A1 (zh)
PL (1) PL2246339T3 (zh)
PT (1) PT2246339E (zh)
RS (1) RS51919B (zh)
SA (1) SA110310217B1 (zh)
SG (1) SG174274A1 (zh)
SI (1) SI2246339T1 (zh)
TN (1) TN2011000469A1 (zh)
TW (1) TWI388326B (zh)
UA (1) UA100477C2 (zh)
UY (1) UY32475A (zh)
WO (1) WO2010106249A1 (zh)
ZA (1) ZA201001905B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8952034B2 (en) * 2009-07-27 2015-02-10 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
AU2011272787B2 (en) 2010-07-02 2015-06-18 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
US9150591B2 (en) 2010-08-10 2015-10-06 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
NZ716420A (en) 2011-05-10 2017-05-26 Gilead Sciences Inc Fused heterocyclic compounds as sodium channel modulators
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (zh) 2011-07-01 2018-04-28
AU2015224425B2 (en) * 2011-07-01 2017-02-09 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
EP2813508B1 (en) 2012-02-08 2018-01-31 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505411A (ja) * 1992-04-15 1995-06-15 ローン−プーラン・ロレ・ソシエテ・アノニム ３，４−ジヒドロ−１ｈ−１，２，４−ベンゾチアジアジン−１，１−ジオキシド−２−カルボン酸誘導体，それらの製造およびそれらを含有する医学的生成物
EP1054877A1 (en) * 1998-02-11 2000-11-29 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
PL342843A1 (en) * 1998-02-18 2001-07-16 Neurosearch As Novel compounds and their use as positive ampa receptor modulators
US6156746A (en) * 1998-08-25 2000-12-05 Bristol-Myers Squibb Company 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) * 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
DE10300973A1 (de) * 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2877338B1 (fr) * 2004-11-03 2007-01-26 Servier Lab Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NI201100169A (es) 2012-01-11
HRP20110626T1 (hr) 2011-10-31
MX2011009638A (es) 2011-09-28
CO6361956A2 (es) 2012-01-20
ZA201001905B (en) 2010-11-24
CU20110169A7 (es) 2012-02-15
MA33131B1 (fr) 2012-03-01
PT2246339E (pt) 2011-08-01
RS51919B (en) 2012-02-29
CR20110484A (es) 2011-10-24
PL2246339T3 (pl) 2011-11-30
NZ595082A (en) 2013-12-20
US8236790B2 (en) 2012-08-07
SI2246339T1 (sl) 2011-09-30
UY32475A (es) 2010-09-30
UA100477C2 (uk) 2012-12-25
CA2696705C (fr) 2013-02-12
HN2011002458A (es) 2014-05-19
EP2246339A1 (fr) 2010-11-03
TWI388326B (zh) 2013-03-11
PE20120113A1 (es) 2012-02-24
CL2011002287A1 (es) 2012-02-03
GEP20135862B (en) 2013-06-25
WO2010106249A1 (fr) 2010-09-23
KR20110128209A (ko) 2011-11-28
EP2246339B1 (fr) 2011-06-22
US20100240635A1 (en) 2010-09-23
AP2011005935A0 (en) 2011-10-31
IL215016A (en) 2013-08-29
TW201036615A (en) 2010-10-16
AP3050A (en) 2014-11-30
CN102361860A (zh) 2012-02-22
FR2943342A1 (fr) 2010-09-24
ATE513822T1 (de) 2011-07-15
BRPI1009200A2 (pt) 2017-06-13
MY154001A (en) 2015-04-30
CN102361860B (zh) 2014-09-10
SG174274A1 (en) 2011-10-28
FR2943342B1 (fr) 2011-03-04
CY1111807T1 (el) 2015-10-07
JP2012520858A (ja) 2012-09-10
EA201101334A1 (ru) 2012-04-30
AU2010200815B2 (en) 2015-05-07
EA020259B1 (ru) 2014-09-30
TN2011000469A1 (fr) 2013-03-27
ECSP11011340A (es) 2011-10-31
SA110310217B1 (ar) 2013-06-15
CU24030B1 (es) 2014-10-02
ES2368691T3 (es) 2011-11-21
IL215016A0 (en) 2011-11-30
KR101431504B1 (ko) 2014-08-20
DK2246339T3 (da) 2011-10-10
AR075892A1 (es) 2011-05-04
AU2010200815A1 (en) 2010-10-07
CA2696705A1 (fr) 2010-09-20
JP5437473B2 (ja) 2014-03-12
JO2780B1 (en) 2014-03-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190317