HK1158312A1 - 基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制 - Google Patents

基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制

Info

Publication number
HK1158312A1
HK1158312A1 HK11112579.1A HK11112579A HK1158312A1 HK 1158312 A1 HK1158312 A1 HK 1158312A1 HK 11112579 A HK11112579 A HK 11112579A HK 1158312 A1 HK1158312 A1 HK 1158312A1
Authority
HK
Hong Kong
Prior art keywords
nucleic acid
sample preparation
acid sample
highly simplified
based nucleic
Prior art date
Application number
HK11112579.1A
Other languages
English (en)
Inventor
.凱瑞 羅伯特.
Original Assignee
洛斯阿拉莫斯國家安全有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 洛斯阿拉莫斯國家安全有限責任公司 filed Critical 洛斯阿拉莫斯國家安全有限責任公司
Publication of HK1158312A1 publication Critical patent/HK1158312A1/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • G01N33/54387Immunochromatographic test strips
    • G01N33/54388Immunochromatographic test strips based on lateral flow
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/405Concentrating samples by adsorption or absorption

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK11112579.1A 2008-05-05 2011-11-21 基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制 HK1158312A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12664508P 2008-05-05 2008-05-05
PCT/US2009/002809 WO2009137059A1 (en) 2008-05-05 2009-05-05 Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control

Publications (1)

Publication Number Publication Date
HK1158312A1 true HK1158312A1 (zh) 2012-07-13

Family

ID=41264882

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11112579.1A HK1158312A1 (zh) 2008-05-05 2011-11-21 基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制

Country Status (7)

Country Link
US (2) US9207236B2 (zh)
EP (2) EP3067694A1 (zh)
JP (2) JP2011522521A (zh)
CN (1) CN102084238B (zh)
CA (1) CA2723536C (zh)
HK (1) HK1158312A1 (zh)
WO (1) WO2009137059A1 (zh)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008105814A2 (en) 2006-08-22 2008-09-04 Los Alamos National Security, Llc Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
EP3067694A1 (en) 2008-05-05 2016-09-14 Los Alamos National Security, LLC Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9500645B2 (en) * 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
WO2013134742A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
WO2011087813A2 (en) * 2009-12-22 2011-07-21 University Of Washington Capillarity-based devices for performing chemical processes and associated systems and methods
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
US9423398B2 (en) * 2011-02-08 2016-08-23 The Board Of Regents For Oklahoma State University Apparatus and method for biologic sample rapid collection and recovery device, and convenient storage
CA2830533C (en) 2011-03-22 2020-02-18 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
KR101508670B1 (ko) 2011-04-20 2015-04-07 메사 테크 인터내셔널, 인코포레이티드 핵산 검출 및 동정을 위한 통합 장치
WO2012178187A1 (en) 2011-06-23 2012-12-27 Paul Yager Reagent patterning in capillarity-based analyzers and associated systems and methods
US20140295415A1 (en) * 2011-11-04 2014-10-02 Diagnostics For All, Inc. Low cost, disposable molecular diagnostic devices
US9874556B2 (en) * 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
WO2014081460A1 (en) * 2012-11-20 2014-05-30 Kisner Mark Chemical sequencing and control to expand and enhance detection capabilities utilizing a colorimetric test
EP2948249A1 (en) 2013-01-22 2015-12-02 University of Washington through its Center for Commercialization Sequential delivery of fluid volumes and associated devices, systems and methods
US10031100B2 (en) * 2013-03-13 2018-07-24 Robert Bosch Gmbh Generation of pH/temperature/ionic gradients on a lateral flow platform with multiple parallel lanes for modulating protein interactions
US20150167065A1 (en) * 2013-12-13 2015-06-18 General Electric Company Isothermal amplification of nucleic acids within a porous matrix
SG11201607582RA (en) 2014-03-07 2016-10-28 Univ California Devices for integrating analyte extraction, concentration and detection
US10195610B2 (en) 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
WO2015168342A1 (en) 2014-04-29 2015-11-05 Accudx Corporation A novel affinity matrix and devices for isolation and purification of rna and dna for point of care molecular devices
US9593368B2 (en) 2014-07-01 2017-03-14 General Electric Company Methods for amplifying nucleic acids on substrates
US10472620B2 (en) * 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
US10870845B2 (en) 2014-07-01 2020-12-22 Global Life Sciences Solutions Operations UK Ltd Methods for capturing nucleic acids
CN106796231A (zh) 2014-10-07 2017-05-31 3M创新有限公司 使用色谱分离富集来检测分析物的方法
US10634672B2 (en) 2014-10-07 2020-04-28 3M Innovative Properties Company Method of detecting a microorganism using chromatographic enrichment
CN107002147B (zh) * 2014-12-11 2022-01-28 环球生命科学解决方案运营英国有限公司 用于俘获核酸的方法
WO2016106111A1 (en) * 2014-12-23 2016-06-30 Ge Healthcare Uk Limited Methods and reagents for reverse-transcription polymerase chain reaction
CA2972587A1 (en) 2014-12-31 2016-07-07 Click Diagnostics, Inc. Devices and methods for molecular diagnostic testing
AU2016253147B2 (en) 2015-04-24 2021-07-22 Mesa Biotech, Inc. Fluidic test cassette
US20180148774A1 (en) * 2015-05-16 2018-05-31 Godx, Inc Point of need testing device and methods of use thereof
CA3002020C (en) 2015-09-04 2024-02-27 The Regents Of The University Of California Methods and devices for analyte collection, extraction, concentration, and detection for clinical applications
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US10656151B2 (en) * 2016-01-29 2020-05-19 Ortho-Clinical Diagnostics, Inc. Air capillary vent for a lateral flow assay device
US10596566B2 (en) * 2016-04-15 2020-03-24 Mauk et al. Capillary-action microfluidic device for point-of-care diagnostics
US10987674B2 (en) 2016-04-22 2021-04-27 Visby Medical, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
CN116083539A (zh) * 2016-06-09 2023-05-09 加利福尼亚大学董事会 纯化和扩增核酸的方法
WO2018005710A1 (en) 2016-06-29 2018-01-04 Click Diagnostics, Inc. Devices and methods for the detection of molecules using a flow cell
WO2018039139A1 (en) 2016-08-22 2018-03-01 The Regents Of The University Of California Hydrogel platform for aqueous two-phase concentration of a target to enhance its detection
DE102017200183A1 (de) * 2017-01-09 2018-07-12 Robert Bosch Gmbh Nucleinsäurebasierter Lateral Flow-Assay für schnelle Fleischspeziesbestimmung
US11209427B2 (en) 2017-03-27 2021-12-28 The Regents Of The University Of California Semi-quantitative lateral-flow immunoassay for the detection of CSF leaks
JP7239568B2 (ja) 2017-11-09 2023-03-14 ビスビュー メディカル,インコーポレイテッド 携帯型分子診断デバイスおよび標的ウイルスの検出方法
US11746372B2 (en) 2017-12-01 2023-09-05 Godx, Inc. Rapid nucleic acids separation and sample preparation via hollow-centered silica microsphere
KR102037411B1 (ko) * 2018-02-09 2019-10-28 광주과학기술원 측방 유동 분리 기반의 dna 추출 디바이스
CN109187448B (zh) * 2018-07-25 2021-08-13 西安交通大学 一种多目标物碟式侧流试纸芯片及其激光切割制备方法、使用方法、应用和检测装置
GB201819417D0 (en) * 2018-11-29 2019-01-16 Quantumdx Group Ltd Vacuum-assisted drying of filters in microfluidic systems
EP3990660A1 (en) * 2019-06-25 2022-05-04 The Board Of Trustees Of The University Of Illinois Methods and devices for identifying pathogens and antibodies and treatment device therefore
WO2021138544A1 (en) 2020-01-03 2021-07-08 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
CA3176545A1 (en) 2020-04-22 2021-10-28 President And Fellows Of Harvard College Isothermal methods, compositions, kits, and systems for detecting nucleic acids
WO2021231607A1 (en) * 2020-05-12 2021-11-18 Godx, Inc. Point of need diagnostic device and methods of use thereof
WO2022075981A1 (en) * 2020-10-07 2022-04-14 Hewlett-Packard Development Company, L.P. Fluid-wicking membranes

Family Cites Families (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3667607A (en) * 1970-11-27 1972-06-06 Baker Chem Co J T Chromatographic material
US4235601A (en) * 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4960691A (en) * 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
IE69047B1 (en) * 1989-03-23 1996-08-07 Gary Harold Gregory Hen Thorpe Liquid transfer devices
US5541099A (en) * 1989-08-10 1996-07-30 Life Technologies, Inc. Cloning and expression of T5 DNA polymerase reduced in 3'-to-5' exonuclease activity
US5225163A (en) 1989-08-18 1993-07-06 Angenics, Inc. Reaction apparatus employing gravitational flow
EP0455905B1 (en) 1990-05-11 1998-06-17 Microprobe Corporation Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
US6007999A (en) * 1991-07-31 1999-12-28 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
GB9123922D0 (en) 1991-11-11 1992-01-02 Bunce Roger A Liquid transfer devices
JP2832117B2 (ja) * 1991-11-29 1998-12-02 キヤノン株式会社 サンプル測定デバイス及びサンプル測定システム
WO1993014217A1 (en) * 1992-01-10 1993-07-22 Life Technologies, Inc. Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules
US6555349B1 (en) * 1993-01-22 2003-04-29 Cornell Research Foundation, Inc. Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase
US5432065A (en) 1993-03-30 1995-07-11 United States Biochemical Corporation Cycle sequencing with non-thermostable DNA polymerases
GB9307319D0 (en) * 1993-04-07 1993-06-02 British Tech Group Liquid transfer devices
JPH0775600A (ja) * 1993-09-08 1995-03-20 Toyobo Co Ltd 標的核酸の検出法
AU687535B2 (en) 1994-03-16 1998-02-26 Gen-Probe Incorporated Isothermal strand displacement nucleic acid amplification
US6037127A (en) * 1994-03-31 2000-03-14 E. I. Du Pont De Nemours And Company Method for detection of non-denatured nucleic acid fragments
GB9416002D0 (en) * 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
GB9502112D0 (en) * 1995-02-03 1995-03-22 British Biocell Int Assay device and method
US20040110167A1 (en) * 1995-07-13 2004-06-10 Gerdes John C. Lateral flow system for nucleic acid detection
US5989813A (en) 1995-07-13 1999-11-23 Molecular Innovations, Inc. Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6750031B1 (en) 1996-01-11 2004-06-15 The United States Of America As Represented By The Secretary Of The Navy Displacement assay on a porous membrane
EP0880598A4 (en) * 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US5741647A (en) 1996-02-16 1998-04-21 Tam; Joseph Wing On Flow through nucleic acid hybridisation uses thereof and a device thereof
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
WO1998022625A1 (en) 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6190612B1 (en) 1998-01-21 2001-02-20 Bayer Corporation Oxygen sensing membranes and methods of making same
DK1696236T3 (da) 1998-03-30 2014-08-18 Orasure Technologies Inc Opsamlingsindretning til analyse af mundvæsker
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
GB9821526D0 (en) * 1998-10-02 1998-11-25 Genosis Inc Capture assay
US6261779B1 (en) * 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
AU1821700A (en) 1998-11-18 2000-06-05 Orchid Biosciences, Inc. One-step nucleic acid dipstick device with movable membrane
WO2000031538A1 (en) * 1998-11-23 2000-06-02 Praxsys Biosystems, Inc. Improved lateral flow assays
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6300069B1 (en) 1999-05-03 2001-10-09 Qiagen Gmbh Generation and amplification of nucleic acids from ribonucleic acids
US6743399B1 (en) 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
US6471916B1 (en) * 1999-11-09 2002-10-29 Packard Instrument Company Apparatus and method for calibration of a microarray scanning system
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6468749B1 (en) * 2000-03-30 2002-10-22 Quark Biotech, Inc. Sequence-dependent gene sorting techniques
GB0016813D0 (en) 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (4)
GB0016814D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (3)
EP1362122A2 (en) * 2000-09-12 2003-11-19 TransGenetics Incorporated Microarrayed organization of transcription factor target genes
CA2424941A1 (en) * 2000-10-10 2002-04-18 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
WO2002052265A1 (fr) 2000-12-26 2002-07-04 Matsushita Electric Industrial Co., Ltd. Procede d'analyse de liaison specifique et dispositif d'analyse de liaison specifique correspondant
IL153504A0 (en) * 2001-03-09 2003-07-06 Nugen Technologies Inc Methods and compositions for amplification of rna sequences
CA2439074A1 (en) * 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
EP1384022A4 (en) * 2001-04-06 2004-08-04 California Inst Of Techn AMPLIFICATION OF NUCLEIC ACID USING MICROFLUIDIC DEVICES
WO2002090961A2 (en) 2001-05-03 2002-11-14 Immunetics, Inc. Systems and methods for detection of analytes in biological fluids
DE50214200D1 (de) * 2001-06-05 2010-03-25 Curevac Gmbh Stabilisierte Tumorantigen-mRNA mit erhöhtem G/C-Gehalt
US20030044862A1 (en) 2001-06-22 2003-03-06 The Board Of Trustees Of The Leland Stanford Jr. University Diagnostic marker for tumor hypoxia and prognosis
EP1416276B1 (en) 2001-08-09 2007-03-07 Matsushita Electric Industrial Co., Ltd. Biosensors and measurement method
US6916541B2 (en) 2001-09-07 2005-07-12 Penn State Research Foundation Modified substrates for the attachment of biomolecules
KR100488281B1 (ko) 2001-09-15 2005-05-10 아람 바이오시스템 주식회사 열 대류를 이용한 염기서열 증폭 방법 및 장치
WO2003046508A2 (en) * 2001-11-09 2003-06-05 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
CA2469464A1 (en) * 2001-12-07 2003-06-19 Dyax Corporation Method and apparatus for washing magnetically responsive particles
EP1468116A2 (en) * 2002-01-16 2004-10-20 Dynal Biotech ASA Method for isolating nucleic acids and protein from a single sample
US7772383B2 (en) 2002-01-25 2010-08-10 The Trustees Of Princeton University Chemical PCR: Compositions for enhancing polynucleotide amplification reactions
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
JP2005532827A (ja) * 2002-07-12 2005-11-04 ブリティッシュ・バイオセル・インターナショナル・リミテッド 側方フローアッセイ用のデバイスおよびその方法
US20050239358A1 (en) 2002-07-23 2005-10-27 Microban Products Company Antimicrobial melamine resin and products made therefrom
US20040064435A1 (en) 2002-07-26 2004-04-01 Ahmad-Maher Moubayed Clinical assessment and diagnostic tool for use with peristaltic pump
US20040018577A1 (en) 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US7662594B2 (en) * 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
CA2498764C (en) * 2002-09-20 2015-11-10 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
JP2006520190A (ja) * 2003-01-21 2006-09-07 マイクロニクス, インコーポレイテッド 流体の微小流体的な操作、増幅、および分析(例えば、細菌アッセイおよびアンチグロブリン試験)のための方法およびシステム
TWI333545B (en) * 2003-04-02 2010-11-21 Cholestech Corp Adhered membranes retaining porosity and biological activity
FR2856046B1 (fr) 2003-06-16 2005-07-29 Biomerieux Sa Microvanne fluidique a ouverture par commande electrique
US7722817B2 (en) 2003-08-28 2010-05-25 Epocal Inc. Lateral flow diagnostic devices with instrument controlled fluidics
WO2005084534A1 (en) * 2003-09-03 2005-09-15 Life Patch International, Inc. Personal diagnostic devices and related methods
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
WO2005026665A2 (en) 2003-09-15 2005-03-24 Diagnoswiss S.A. Microfluidic flow monitoring device
JP2005110621A (ja) 2003-10-10 2005-04-28 Aisin Seiki Co Ltd 核酸増幅方法及び核酸増幅用試薬キット
CA2545653C (en) * 2003-11-21 2014-07-08 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
JP4250523B2 (ja) * 2003-12-25 2009-04-08 株式会社東芝 マイクロリアクタ、分析システム、分析方法、反応システム、反応方法、分離システム、分離方法
CA2561343C (en) * 2004-03-30 2013-01-22 Whatman, Inc. Lateral flow assay on a single hydrophilic monolithic matrix made of a network of fibres
WO2006071247A2 (en) * 2004-03-30 2006-07-06 California Institute Of Technology Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots
US20050227275A1 (en) 2004-04-07 2005-10-13 Access Bio, Inc. Nucleic acid detection system
US8173078B2 (en) 2004-04-28 2012-05-08 Industrial Technology Research Institute Gravity-driven micropump
US7273590B2 (en) 2004-04-29 2007-09-25 Industrial Technology Research Institute gravity-driven apparatus and method for control of microfluidic devices
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
JP2007538236A (ja) * 2004-05-21 2007-12-27 アトノミックス アクティーゼルスカブ ヒドロゲルを含む表面弾性波センサ
SE527036C2 (sv) * 2004-06-02 2005-12-13 Aamic Ab Analysanordning med reglerat flöde och motsvarande förfarande
CN101091113A (zh) 2004-11-30 2007-12-19 环球科技(新西兰)有限公司 样本分析方法及设备
US20060127886A1 (en) * 2004-12-15 2006-06-15 Kaylor Rosann M Sample-efficient lateral flow immunoassay
US9101927B2 (en) 2005-01-31 2015-08-11 Realbio Technologies Ltd. Multistep reaction lateral flow capillary device
US7396689B2 (en) 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US20060240569A1 (en) * 2005-04-20 2006-10-26 Becton, Dickinson And Company Semi-quantitative immunochromatographic device
US7439079B2 (en) 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
WO2006122311A2 (en) * 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Microfluidic chip
JP5033791B2 (ja) * 2005-05-23 2012-09-26 ファディア・アクチボラグ 二段階側流分析法および装置
US20070015166A1 (en) * 2005-07-14 2007-01-18 Nilsen Thor W Lateral flow methods and devices for detection of nucleic acid binding proteins
US20070054301A1 (en) 2005-09-06 2007-03-08 Gen-Probe Incorporated Methods, compositions and kits for isothermal amplification of nucleic acids
JP2007071711A (ja) * 2005-09-07 2007-03-22 Fujifilm Corp 分析チップ
CN101400993A (zh) 2005-11-10 2009-04-01 阿普尔拉股份有限公司 包括多孔聚合物电极的微流体系统
CN101360819A (zh) 2006-01-20 2009-02-04 凸版印刷株式会社 反应容器及dna的扩增反应方法
US7537917B2 (en) 2006-03-31 2009-05-26 Collins Michael J Microwave assisted PCR amplification of DNA
EP2041573B1 (en) 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
WO2008105814A2 (en) 2006-08-22 2008-09-04 Los Alamos National Security, Llc Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
JP2008148690A (ja) * 2006-11-22 2008-07-03 Fujifilm Corp マイクロチップを用いた核酸増幅方法およびマイクロチップ、それを用いた核酸増幅システム
EP1972938B1 (de) * 2007-03-19 2014-05-14 Ivoclar Vivadent Teststreifen für die Bestimmung des Kariesrisikos
US8105783B2 (en) * 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8455190B2 (en) 2007-08-01 2013-06-04 Dana-Farber Cancer Institute, Inc. Enrichment of a target sequence
TW200909338A (en) 2007-08-23 2009-03-01 Ind Tech Res Inst Autonomous microfluidic apparatus
US9409166B2 (en) 2007-12-10 2016-08-09 The Trustees Of The University Of Pennsylvania Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications
DE102007062441A1 (de) 2007-12-20 2009-06-25 Aj Innuscreen Gmbh Mobiles Schnelltestsystem für die Nukleinsäureanalytik
EP2252890B1 (en) * 2008-02-22 2014-07-02 Orion Diagnostica Oy Method and device for detection of carbohydrates
AU2009222181B2 (en) 2008-02-29 2014-12-04 Northwestern University Barriers for facilitating biological reactions
EP3067694A1 (en) 2008-05-05 2016-09-14 Los Alamos National Security, LLC Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control
WO2009137509A2 (en) 2008-05-05 2009-11-12 Great Lakes Orthodontics Ltd. Method of designing custom articulator inserts using four-dimensional data
EP2406394B1 (en) 2009-03-12 2014-01-08 Brandeis University Reagents and methods for pcr
US8084272B2 (en) * 2009-03-25 2011-12-27 Abbott Point Of Care Inc. Amelioration of heterophile antibody immunosensor interference
FR2945097B1 (fr) 2009-04-30 2011-06-03 Commissariat Energie Atomique Vanne microfluidique a usage unique.
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
WO2011087813A2 (en) 2009-12-22 2011-07-21 University Of Washington Capillarity-based devices for performing chemical processes and associated systems and methods
NZ721912A (en) 2010-03-09 2018-01-26 Netbio Inc Unitary biochip providing sample-in to results-out processing and methods of manufacture

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US20110117540A1 (en) 2011-05-19
WO2009137059A1 (en) 2009-11-12
CN102084238B (zh) 2016-06-01
EP2279403A1 (en) 2011-02-02
US9207236B2 (en) 2015-12-08
EP3067694A1 (en) 2016-09-14
US9944922B2 (en) 2018-04-17
US20160083716A1 (en) 2016-03-24
CA2723536A1 (en) 2009-11-12
CN102084238A (zh) 2011-06-01
EP2279403B1 (en) 2016-03-16
JP2015108637A (ja) 2015-06-11
CA2723536C (en) 2017-06-13
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EP2279403A4 (en) 2011-11-23
JP6026570B2 (ja) 2016-11-16

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