HK1142065A1 - 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h- phthalazin-1-one 4-[3-(4---1-)-4--]-2h--1- - Google Patents

4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h- phthalazin-1-one 4-[3-(4---1-)-4--]-2h--1-

Info

Publication number
HK1142065A1
HK1142065A1 HK10108450.4A HK10108450A HK1142065A1 HK 1142065 A1 HK1142065 A1 HK 1142065A1 HK 10108450 A HK10108450 A HK 10108450A HK 1142065 A1 HK1142065 A1 HK 1142065A1
Authority
HK
Hong Kong
Prior art keywords
phthalazin
cyclopropanecarbonyl
piperazine
fluoro
carbonyl
Prior art date
Application number
HK10108450.4A
Other languages
English (en)
Chinese (zh)
Inventor
Kathryn Anne Quigley
Ezra John Still
Leonard Jesse Chyall
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of HK1142065A1 publication Critical patent/HK1142065A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK10108450.4A 2007-10-17 2010-09-07 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h- phthalazin-1-one 4-[3-(4---1-)-4--]-2h--1- HK1142065A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98050807P 2007-10-17 2007-10-17
PCT/GB2008/003510 WO2009050469A1 (en) 2007-10-17 2008-10-17 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl] -2h-phthalaz in-1-one

Publications (1)

Publication Number Publication Date
HK1142065A1 true HK1142065A1 (en) 2010-11-26

Family

ID=40227654

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10108450.4A HK1142065A1 (en) 2007-10-17 2010-09-07 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h- phthalazin-1-one 4-[3-(4---1-)-4--]-2h--1-

Country Status (13)

Country Link
US (1) US8183369B2 (xx)
EP (1) EP2212296B1 (xx)
JP (1) JP5593229B2 (xx)
KR (1) KR101598231B1 (xx)
CN (1) CN101821242B (xx)
AU (1) AU2008313467B2 (xx)
BR (1) BRPI0817537B1 (xx)
CA (1) CA2702429A1 (xx)
ES (1) ES2530695T3 (xx)
HK (1) HK1142065A1 (xx)
MX (1) MX2010004028A (xx)
RU (1) RU2487868C2 (xx)
WO (1) WO2009050469A1 (xx)

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CN105753789B (zh) * 2015-04-17 2018-09-25 苏州晶云药物科技有限公司 奥拉帕尼与尿素的共晶及其制备方法
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CN106699672B (zh) * 2015-11-16 2019-10-29 上海博邦医药科技有限公司 一种奥拉帕尼无定型物及其制备方法
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CN111278433A (zh) 2017-09-26 2020-06-12 特沙诺有限公司 尼拉帕尼制剂
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US10703728B1 (en) * 2019-06-18 2020-07-07 Scinopharm Taiwan, Ltd. Crystalline form of olaparib and a process for preparing the same
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WO2022058785A1 (en) 2020-09-16 2022-03-24 Nuformix Technologies Limited Olaparib oxalic acid cocrystals and their pharmaceutical use
CN114249695A (zh) * 2020-09-21 2022-03-29 齐鲁制药有限公司 一种奥拉帕利的新晶型、制备方法及用途
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
EP4015375B1 (en) 2020-12-21 2023-03-01 LEONARDO S.p.A. Indicator for an aircraft capable of hovering and method for assisting performing a manoeuvre for the aforesaid aircraft
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Also Published As

Publication number Publication date
US20100286157A1 (en) 2010-11-11
RU2487868C2 (ru) 2013-07-20
AU2008313467A1 (en) 2009-04-23
JP2011500655A (ja) 2011-01-06
RU2010111570A (ru) 2011-11-27
AU2008313467B2 (en) 2013-08-29
US8183369B2 (en) 2012-05-22
MX2010004028A (es) 2010-04-30
WO2009050469A1 (en) 2009-04-23
KR20100087153A (ko) 2010-08-03
JP5593229B2 (ja) 2014-09-17
BRPI0817537B1 (pt) 2022-04-05
KR101598231B1 (ko) 2016-02-26
CA2702429A1 (en) 2009-04-23
BRPI0817537A2 (pt) 2015-03-31
EP2212296B1 (en) 2014-12-03
ES2530695T3 (es) 2015-03-04
CN101821242B (zh) 2013-07-24
CN101821242A (zh) 2010-09-01
EP2212296A1 (en) 2010-08-04

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