HK1122018A1 - Aminodiazepines as toll-like receptor modulators - Google Patents
Aminodiazepines as toll-like receptor modulatorsInfo
- Publication number
- HK1122018A1 HK1122018A1 HK08113232.3A HK08113232A HK1122018A1 HK 1122018 A1 HK1122018 A1 HK 1122018A1 HK 08113232 A HK08113232 A HK 08113232A HK 1122018 A1 HK1122018 A1 HK 1122018A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- toll
- aminodiazepines
- receptor modulators
- compositions
- methods
- Prior art date
Links
- IRTBTAFDVGMKON-UHFFFAOYSA-N 1H-diazepin-3-amine Chemical class NC1=NNC=CC=C1 IRTBTAFDVGMKON-UHFFFAOYSA-N 0.000 title 1
- 102000002689 Toll-like receptor Human genes 0.000 title 1
- 108020000411 Toll-like receptor Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 102100033110 Toll-like receptor 8 Human genes 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000005784 autoimmunity Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70966705P | 2005-08-19 | 2005-08-19 | |
PCT/US2006/032099 WO2007040840A2 (en) | 2005-08-19 | 2006-08-17 | Aminodiazepines as toll-like receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1122018A1 true HK1122018A1 (en) | 2009-05-08 |
Family
ID=37890540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08113232.3A HK1122018A1 (en) | 2005-08-19 | 2008-12-04 | Aminodiazepines as toll-like receptor modulators |
Country Status (10)
Country | Link |
---|---|
US (2) | US8163738B2 (lt) |
EP (1) | EP1928845B1 (lt) |
JP (1) | JP5246865B2 (lt) |
CN (1) | CN101287716A (lt) |
DK (1) | DK1928845T3 (lt) |
HK (1) | HK1122018A1 (lt) |
HR (1) | HRP20130942T1 (lt) |
SI (1) | SI1928845T1 (lt) |
TW (1) | TWI382019B (lt) |
WO (1) | WO2007040840A2 (lt) |
Families Citing this family (148)
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TWI404537B (zh) * | 2005-08-19 | 2013-08-11 | Array Biopharma Inc | 作為類鐸受體(toll-like receptor)調節劑之8-經取代苯并氮雜呯 |
TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯 |
DK2313111T3 (da) | 2008-08-01 | 2013-12-02 | Ventirx Pharmaceuticals Inc | Toll-lignende receptoragonistformuleringer og anvendelse deraf |
CA2742863C (en) | 2008-11-06 | 2017-05-09 | Ventirx Pharmaceuticals, Inc. | Methods of synthesis of benzazepine derivatives |
ES2620629T3 (es) * | 2009-08-18 | 2017-06-29 | Ventirx Pharmaceuticals, Inc. | Benzoazepinas sustituidas como moduladores del receptor tipo Toll |
WO2011022509A2 (en) | 2009-08-18 | 2011-02-24 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
CA2772916C (en) | 2009-09-02 | 2019-01-15 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
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JP5246865B2 (ja) | 2013-07-24 |
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WO2007040840A2 (en) | 2007-04-12 |
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