HK1115181A1 - Devices and method for programmable microscale manipulation of fluids - Google Patents

Devices and method for programmable microscale manipulation of fluids

Info

Publication number
HK1115181A1
HK1115181A1 HK08111000A HK08111000A HK1115181A1 HK 1115181 A1 HK1115181 A1 HK 1115181A1 HK 08111000 A HK08111000 A HK 08111000A HK 08111000 A HK08111000 A HK 08111000A HK 1115181 A1 HK1115181 A1 HK 1115181A1
Authority
HK
Hong Kong
Prior art keywords
directed
present
fluids
devices
material layer
Prior art date
Application number
HK08111000A
Other languages
English (en)
Inventor
Piero Zucchelli
Bart Van Der Vyver
Original Assignee
Noble Venture Finance Ii S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noble Venture Finance Ii S A filed Critical Noble Venture Finance Ii S A
Publication of HK1115181A1 publication Critical patent/HK1115181A1/xx

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003—Valves for single use only
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F16K99/004—Operating means specially adapted for microvalves operated by temperature variations using radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/058—Microfluidics not provided for in B81B2201/051 - B81B2201/054
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
    • B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
    • B81C2201/019—Bonding or gluing multiple substrate layers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/2886—Laser cutting, e.g. tissue catapult
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/1624—Destructible or deformable element controlled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/1624—Destructible or deformable element controlled
    • Y10T137/1632—Destructible element
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
HK08111000A 2002-12-04 2008-10-02 Devices and method for programmable microscale manipulation of fluids HK1115181A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43079202P 2002-12-04 2002-12-04

Publications (1)

Publication Number Publication Date
HK1115181A1 true HK1115181A1 (en) 2008-11-21

Family

ID=32469532

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08111000A HK1115181A1 (en) 2002-12-04 2008-10-02 Devices and method for programmable microscale manipulation of fluids

Country Status (10)

Country Link
US (1) US7152616B2 (xx)
EP (2) EP1567796B1 (xx)
JP (1) JP2006508790A (xx)
CN (3) CN101158447B (xx)
AT (1) ATE397177T1 (xx)
AU (1) AU2003293399A1 (xx)
CA (1) CA2508475C (xx)
DE (1) DE60321376D1 (xx)
HK (1) HK1115181A1 (xx)
WO (1) WO2004050242A2 (xx)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7032608B2 (en) * 2004-09-01 2006-04-25 Harris Corporation Microfluidic check-valve embedded in LCP
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US20060093528A1 (en) * 2004-10-18 2006-05-04 Applera Corporation Device including a dissolvable structure for flow control
US7822276B2 (en) * 2005-02-17 2010-10-26 Iris International, Inc. Method and apparatus for analyzing body fluids
WO2006093978A2 (en) * 2005-03-02 2006-09-08 The Regents Of The University Of California Flow switching on a multi-structured microfluidic cd (compact disc) using coriolis force
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
JP2008542743A (ja) * 2005-06-03 2008-11-27 スピンエックス インコーポレイテッド 流体のプログラム可能な微小スケール操作のための計量計
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7390377B1 (en) * 2005-09-22 2008-06-24 Sandia Corporation Bonding thermoplastic polymers
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US7998433B2 (en) * 2006-04-04 2011-08-16 Samsung Electronics Co., Ltd. Valve unit and apparatus having the same
US8092385B2 (en) 2006-05-23 2012-01-10 Intellidx, Inc. Fluid access interface
FR2901489A1 (fr) 2006-05-29 2007-11-30 Debiotech Sa Dispositif microfluidique avec materiau de volume variable
KR100763924B1 (ko) * 2006-08-16 2007-10-05 삼성전자주식회사 밸브 유닛, 이를 구비한 반응 장치 및, 채널에 밸브를형성하는 방법
US8464760B2 (en) 2006-08-16 2013-06-18 Samsung Electronic Co., Ltd. Valve unit, reaction apparatus with the same, and method of forming valve in channel
KR100851980B1 (ko) * 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
EP1916524A1 (de) * 2006-09-27 2008-04-30 Roche Diagnostics GmbH Rotierbares Testelement
KR100846501B1 (ko) 2006-11-09 2008-07-17 삼성전자주식회사 밸브 유닛 및 이를 구비한 유체 처리 장치
US7857141B2 (en) * 2006-12-11 2010-12-28 Samsung Electronics Co., Ltd. Apparatus and method for separating components
US8307988B2 (en) * 2006-12-11 2012-11-13 Samsung Electronics Co., Ltd. Apparatus and method for separating components
KR100818290B1 (ko) * 2006-12-11 2008-03-31 삼성전자주식회사 성분 분리 장치 및 성분 분리 방법
TW200844420A (en) * 2006-12-22 2008-11-16 3M Innovative Properties Co Enhanced sample processing devices, systems and methods
KR101596189B1 (ko) 2006-12-22 2016-02-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 미세유체 시스템을 위한 열 전달 방법 및 구조체
WO2008081530A1 (ja) * 2006-12-28 2008-07-10 Fujikin Incorporated エントランス絞り溝付微小流量制御装置の設計方法、
KR101258434B1 (ko) * 2007-05-03 2013-05-02 삼성전자주식회사 미세유동 시스템 및,이의 제조방법
KR20080107212A (ko) * 2007-06-05 2008-12-10 삼성전자주식회사 유체 컨테이너를 구비한 미세유동 장치
KR101391736B1 (ko) 2007-08-07 2014-05-07 삼성전자주식회사 미세유동 밸브, 상기 미세유동 밸브의 제조 방법 및 상기미세유동 밸브를 포함하는 미세유동 장치
JP2009069011A (ja) * 2007-09-13 2009-04-02 Sony Corp 反応制御装置及び反応制御方法
EP2214801A4 (en) * 2007-11-22 2016-12-21 Samsung Electronics Co Ltd THIN FILM VALVE DEVICE AND ITS CONTROL APPARATUS
WO2009112030A1 (en) * 2008-03-12 2009-09-17 Fluimedix Aps Controlled liquid handling
US9121055B2 (en) * 2008-04-24 2015-09-01 3M Innovative Properties Company Analysis of nucleic acid amplification curves using wavelet transformation
WO2009150549A2 (en) * 2008-06-13 2009-12-17 Spinx, Inc. Microfluidic devices and methods for proteins crystallization and in situ x-ray diffraction
US9879360B2 (en) * 2008-06-20 2018-01-30 International Business Machines Corporation Microfluidic selection of library elements
JP2010071675A (ja) * 2008-09-16 2010-04-02 Yuichi Uchiumi 微小化学システム及び微小化学システム装置
US8151482B2 (en) * 2008-11-25 2012-04-10 William H Moss Two-stage static dryer for converting organic waste to solid fuel
US9057568B2 (en) * 2008-12-16 2015-06-16 California Institute Of Technology Temperature control devices and methods
GB2467298A (en) * 2009-01-23 2010-07-28 Univ Dublin City Multilayer microfluidic device
GB2468111A (en) * 2009-02-23 2010-08-25 Univ Dublin City Multilayer Fluidic Device
US8753290B2 (en) 2009-03-27 2014-06-17 Intellectual Inspiration, Llc Fluid transfer system and method
US8230744B2 (en) 2009-05-06 2012-07-31 Cequr Sa Low-dead volume microfluidic circuit and methods
US20100282766A1 (en) * 2009-05-06 2010-11-11 Heiko Arndt Low-Dead Volume Microfluidic Component and Method
WO2011026315A1 (en) * 2009-09-02 2011-03-10 The Hong Kong University Of Science And Technology Method of producing spatially variable pretilt angles across a liquid crystal cell
KR101532314B1 (ko) * 2009-10-27 2015-06-29 삼성전자주식회사 미세 유체 소자의 품질 관리 방법 및 품질 관리 장치
WO2011051821A2 (en) 2009-10-30 2011-05-05 Spinx, Inc. Siphoning as a washing method and apparatus for heterogenenous assays
US8980550B2 (en) 2009-12-15 2015-03-17 California Institute Of Technology Methods for measuring samples using consumer electronic devices and systems
CN106018858B (zh) * 2010-03-31 2018-08-14 艾博特健康公司 生物流体样本分析系统和分析生物流体样本的方法
JP2012098272A (ja) * 2010-08-23 2012-05-24 Nsk Ltd 標的物質濃度測定装置および標的物質濃度測定方法
CN101949377A (zh) * 2010-09-17 2011-01-19 大连理工大学 一种薄膜式仿生微流控液体驱动泵
US9821306B2 (en) 2010-11-23 2017-11-21 Andrew Alliance S.A. Devices and methods for programmable manipulation of pipettes
US9233369B2 (en) 2010-12-23 2016-01-12 California Institute Of Technology Fluidic devices and fabrication methods for microfluidics
US8968585B2 (en) 2010-12-23 2015-03-03 California Institute Of Technology Methods of fabrication of cartridges for biological analysis
US9856448B2 (en) 2011-03-04 2018-01-02 The Board Of Trustees Of The Leland Stanford Junior Univesity Devices and methods for long-term intracellular access
US8808516B2 (en) * 2011-03-04 2014-08-19 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for long-term intracellular access
PT3270141T (pt) 2011-03-08 2020-08-28 Univ Laval Dispositivo centrípeto fluídico
US9266725B2 (en) 2011-04-27 2016-02-23 The Board Of Trustees Of The Leland Stanford Junior University Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space
EP2709760B1 (en) 2011-05-18 2019-06-05 DiaSorin S.p.A. Systems and methods for valving on a sample processing device
CN103547370A (zh) 2011-05-18 2014-01-29 3M创新有限公司 用于样品处理装置上体积计量的系统和方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
ES2870874T3 (es) 2011-05-18 2021-10-27 Diasorin S P A Sistemas y métodos para detectar la presencia de un volumen seleccionado de material en un dispositivo de procesamiento de muestra
JP5974429B2 (ja) 2011-07-20 2016-08-23 ソニー株式会社 複合材料構造物及びその製造方法
US9442108B2 (en) 2011-08-30 2016-09-13 National Research Council Of Canada Centrifugally-enhanced capture method and device
US9518291B2 (en) 2011-12-23 2016-12-13 California Institute Of Technology Devices and methods for biological sample-to-answer and analysis
US8883088B2 (en) 2011-12-23 2014-11-11 California Institute Of Technology Sample preparation devices and systems
US9090890B2 (en) 2011-12-23 2015-07-28 California Institute Of Technology Devices and methods for biological sample preparation
US9090891B2 (en) 2011-12-23 2015-07-28 California Institute Of Technology Pen-shaped device for biological sample preparation and analysis
US8873055B2 (en) 2012-08-03 2014-10-28 California Institute Of Technology Optical technique for chemical and biochemical analysis
KR101815031B1 (ko) 2012-09-28 2018-01-08 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코 기능성 디바이스 및 기능성 디바이스의 제조 방법
US9284520B2 (en) 2012-11-05 2016-03-15 California Institute Of Technology Instruments for biological sample preparation devices
WO2014071259A1 (en) * 2012-11-05 2014-05-08 California Institute Of Technology Methods of fabrication of cartridges for biological analysis
US10065186B2 (en) * 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
EP2972219B1 (en) * 2013-03-15 2022-01-19 Abbott Laboratories Automated reagent manager of a diagnostic analyzer system
JP6098315B2 (ja) * 2013-04-15 2017-03-22 株式会社島津製作所 光または放射線測定用容器並びに測定システム
US9675944B2 (en) * 2013-07-19 2017-06-13 Saint-Gobain Performance Plastics Corporation Reciprocating fluid agitator
CN103399419A (zh) * 2013-08-07 2013-11-20 苏州扬清芯片科技有限公司 一种温控型滤光器件
CN103394382A (zh) * 2013-08-07 2013-11-20 苏州扬清芯片科技有限公司 一种具有滤光特性的微流控芯片
CN103387683A (zh) * 2013-08-07 2013-11-13 苏州扬清芯片科技有限公司 一种感温性聚二甲基硅氧烷薄膜的制备方法
CN103389171A (zh) * 2013-08-07 2013-11-13 苏州扬清芯片科技有限公司 一种具有感温特性的微流控芯片
CA2941823C (en) 2014-03-07 2023-01-17 National Research Council Of Canada Centrifugal microfluidic chip control
JP6600861B2 (ja) * 2015-04-08 2019-11-06 株式会社パートナーファーム 固相反応チップ及びこれを用いた測定方法
WO2017066485A1 (en) * 2015-10-13 2017-04-20 Landers James P Devices and methods for extraction, separation and thermocycling
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
WO2017214541A1 (en) 2016-06-09 2017-12-14 The Board Of Trustees Of The Leland Stanford Junior University Nanostraw well insert devices for improved cell transfection and viability
EP3474993A4 (en) * 2016-06-27 2019-12-18 Abaxis, Inc. DEVICES WITH MODIFIED LINES
CN107583675B (zh) * 2016-07-06 2023-04-14 广州好芝生物科技有限公司 一种流控机构及含有该机构的系统
EP3512802B1 (en) 2016-09-13 2021-07-21 The Board of Trustees of the Leland Stanford Junior University Methods of non-destructive nanostraw intracellular sampling for longitudinal cell monitoring
GB201622024D0 (en) * 2016-11-14 2017-02-08 Inventage Lab Inc Apparatus and method for large scale production of monodisperse, microsheric and biodegradable polymer-based drug delivery
RU170307U1 (ru) * 2016-12-05 2017-04-20 Общество с ограниченной ответственностью "Химпродукт" Устройство для приготовления раствора коагулянта путем циркуляции раствора с помощью насоса
WO2018112786A1 (zh) * 2016-12-21 2018-06-28 无锡源清天木生物科技有限公司 一种用于微流控制的液体流量控制装置和微流控制方法
CN107051598B (zh) * 2017-03-20 2019-12-06 上海交通大学 Pcr微流控芯片和其制备与使用方法以及pcr设备
JP7104140B2 (ja) 2017-07-19 2022-07-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 非接着細胞内に生物学的に重要なカーゴを送達する為のナノストローを用いる器具及び方法
CN107524919B (zh) * 2017-08-16 2019-09-17 朱伟明 管道流体流速增速方法及管道流体输送系统
CN108671971A (zh) * 2018-05-11 2018-10-19 北京科技大学 一种循环肿瘤细胞及团簇阴性分离的微流控装置和方法
WO2019240959A1 (en) * 2018-06-16 2019-12-19 Sandstone Diagnostics, Inc. Device and method of imaging fluidic samples
KR102599483B1 (ko) * 2018-08-24 2023-11-08 조에티스 서비시즈 엘엘씨 마이크로 유체 회전자 디바이스
JP2022504858A (ja) 2018-10-16 2022-01-13 クリプトス バイオテクノロジーズ，インコーポレイテッド 生化学反応容器の温度監視のための方法およびシステム
CN111330655A (zh) * 2018-12-18 2020-06-26 深圳先进技术研究院 用于脂质化合物检测的微流控芯片和脂质化合物的检测方法
CN111889027A (zh) * 2019-05-05 2020-11-06 微纳芯 (苏州)科技有限公司 一种滴落试剂制备小球的方法及设备
CN110705007B (zh) * 2019-08-16 2021-03-26 北京航空航天大学 一种等离子体涡旋发生器的效率评估方法
US11761888B2 (en) * 2020-01-09 2023-09-19 Government Of The United States Of America, As Represented By The Secretary Of Commerce Infrared thermal desorber and performing infrared thermal desorption
CN111378578A (zh) * 2020-03-23 2020-07-07 广州再生医学与健康广东省实验室 一种细胞培养用的气体限流器
CN112324929A (zh) * 2020-10-09 2021-02-05 东南大学 一种光圈式微流控流量调节器
CN112275336B (zh) * 2020-10-20 2021-11-19 大连理工大学 一种多通道集成微流控芯片及其高通量制备单分散凝胶微球的方法
CN113009167B (zh) * 2021-02-23 2022-06-24 山东美毅生物技术有限公司 一种可实现液体精准控制吸入排出的显微操作装置
WO2022191830A1 (en) * 2021-03-10 2022-09-15 Hewlett-Packard Development Company, L.P. Destructible microfluidic valves
EP4124385A1 (en) * 2021-07-26 2023-02-01 Helaxy Inc. Assembly and method for combined nucleic acid purification and amplification
CN113952993B (zh) * 2021-11-23 2022-09-20 中北大学 集成微混合器与Tesla阀的多级惯性微流控血样处理芯片
CN114370711B (zh) * 2021-12-29 2023-01-20 华北电力大学 一种相变材料层辅助的特斯拉阀型流道光伏光热组件
CN115518698A (zh) * 2022-08-22 2022-12-27 深圳市卓润生物科技有限公司 微流控芯片
CN115899339B (zh) * 2023-03-10 2023-05-26 成都凯天电子股份有限公司 一种反拱型光纤爆破片

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736432A (en) 1971-03-22 1973-05-29 Varian Associates Bacterial colony counting method and apparatus
US4248346A (en) 1979-01-29 1981-02-03 Fluoroware, Inc. Shipping container for semiconductor substrate wafers
US4276048A (en) 1979-06-14 1981-06-30 Dynatech Ag Miniature reaction container and a method and apparatus for introducing micro volumes of liquid to such a container
US5278048A (en) 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
EP0417305A4 (en) 1989-03-07 1992-04-22 Idemitsu Petrochemical Co. Ltd. Analyzer of liquid sample and analyzing method of liquid sample using said analyzer
JPH02269938A (ja) 1989-04-11 1990-11-05 Idemitsu Petrochem Co Ltd 分析装置
JP2754747B2 (ja) 1989-06-19 1998-05-20 ソニー株式会社 基板収納容器
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
DE59105165D1 (de) 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
EP0497077B1 (de) 1991-01-28 1996-07-17 Ciba-Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
US5583838A (en) * 1992-03-12 1996-12-10 Mitsubishi Denki Kabushiki Kaisha Recording apparatus having data recording rate phase-synchronized to recording time data recorded on a recording medium
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
IL108497A0 (en) 1993-02-01 1994-05-30 Seq Ltd Methods and apparatus for dna sequencing
US5441951A (en) 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US6309601B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
JP3403233B2 (ja) 1994-01-20 2003-05-06 テルモ株式会社 バルーンカテーテル
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5789251A (en) 1994-06-16 1998-08-04 Astle; Thomas W. Multi-well bioassay tray with evaporation protection and method of use
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
WO1996015576A1 (en) 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Liquid distribution system
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US6048734A (en) * 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
WO1997021090A1 (en) * 1995-12-05 1997-06-12 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
FR2744803B1 (fr) * 1996-02-12 1998-03-13 Bio Merieux Procede et dispositif de traitement d'une carte d'analyse
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
EP0909385B1 (en) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
WO1998028623A1 (en) 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US5911737A (en) 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
AP9901660A0 (en) 1997-02-28 1999-09-30 Burstein Lab Inc Laboratory in a disk.
AU727083B2 (en) 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
DE19721104A1 (de) 1997-05-20 1998-11-26 Sympatec Gmbh Verfahren und Vorrichtung zur Probenahme aus dispersen Stoffströmen
AU7591998A (en) 1997-05-23 1998-12-11 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5851346A (en) 1997-05-29 1998-12-22 Beckman Instruments, Inc. Apparatus for sealing containers
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5959291A (en) 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6803019B1 (en) 1997-10-15 2004-10-12 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6857449B1 (en) 1998-01-20 2005-02-22 Caliper Life Sciences, Inc. Multi-layer microfluidic devices
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6131410A (en) 1998-03-16 2000-10-17 The Regents Of The University Of California Vacuum fusion bonding of glass plates
US6123798A (en) 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
GB9809943D0 (en) 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6274089B1 (en) 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6039804A (en) 1998-09-09 2000-03-21 Emerald Biostructures, Inc. Crystallization tray
US6231721B1 (en) 1998-10-09 2001-05-15 Weyerhaeuser Company Compressible wood pulp product
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6062261A (en) 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
DE19858443A1 (de) * 1998-12-17 2000-07-06 Inst Mikrotechnik Mainz Gmbh Verfahren zum Abgeben eines Fluids, fluidisches Bauteil sowie Vorrichtung zur Handhabung solcher Bauteile
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6334301B1 (en) 1999-02-25 2002-01-01 Vacco Industries, Inc. Assembly of etched sheets forming a fluidic module
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
IL147302A0 (en) 1999-06-28 2002-08-14 California Inst Of Techn Microfabricated elastomeric valve and pump systems
SE9902474D0 (sv) 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
US6340589B1 (en) 1999-07-23 2002-01-22 Mj Research, Inc. Thin-well microplate and methods of making same
SE9903011D0 (sv) 1999-08-26 1999-08-26 Aamic Ab Sätt att framställa en plastprodukt och ett härför utnyttjat plastproduktformande arrangemang
WO2001017797A1 (en) 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US6521451B2 (en) 1999-12-09 2003-02-18 California Institute Of Technology Sealed culture chamber
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
AU2610201A (en) 2000-01-06 2001-07-16 Caliper Technologies Corporation Ultra high throughput sampling and analysis systems and methods
EP1259324A2 (en) * 2000-02-18 2002-11-27 Aclara BioSciences, Inc. Multiple-site reaction device and method
JP4927287B2 (ja) 2000-03-31 2012-05-09 マイクロニックス、インコーポレーテッド タンパク質の結晶化のマイクロ流動体装置
CA2344887A1 (en) 2000-04-21 2001-10-21 George T. Detitta Method for growing crystals
WO2001087487A2 (en) 2000-05-15 2001-11-22 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
EP1284819A2 (en) 2000-05-15 2003-02-26 Tecan Trading AG Microfluidics devices and methods for high throughput screening
WO2001087768A2 (en) * 2000-05-15 2001-11-22 Tecan Trading Ag Use of vapor-deposited conformal coatings in microfluidic structures
US20020015959A1 (en) 2000-06-23 2002-02-07 Bardell Ronald L. Fluid mixing in microfluidic structures
US6885982B2 (en) 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
US6829753B2 (en) 2000-06-27 2004-12-07 Fluidigm Corporation Microfluidic design automation method and system
US6615856B2 (en) 2000-08-04 2003-09-09 Biomicro Systems, Inc. Remote valving for microfluidic flow control
USD463031S1 (en) 2000-10-11 2002-09-17 Aclara Biosciences, Inc. Microvolume sample plate
US6681788B2 (en) 2001-01-29 2004-01-27 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications

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EP1567796A2 (en) 2005-08-31
CN101158447B (zh) 2012-12-26
CN101158447A (zh) 2008-04-09
JP2006508790A (ja) 2006-03-16
AU2003293399A1 (en) 2004-06-23
CA2508475C (en) 2011-08-30
ATE397177T1 (de) 2008-06-15
EP2096341A1 (en) 2009-09-02
CN1745264A (zh) 2006-03-08
CA2508475A1 (en) 2004-06-17
EP1567796A4 (en) 2006-06-28
WO2004050242A3 (en) 2004-08-05
DE60321376D1 (de) 2008-07-10
AU2003293399A8 (en) 2004-06-23
EP1567796B1 (en) 2008-05-28
WO2004050242A2 (en) 2004-06-17
CN101158695A (zh) 2008-04-09
US7152616B2 (en) 2006-12-26
CN100380034C (zh) 2008-04-09
US20050109396A1 (en) 2005-05-26

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