HK1102597A1 - 1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors - Google Patents

1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors

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Publication number
HK1102597A1
HK1102597A1 HK07110898.5A HK07110898A HK1102597A1 HK 1102597 A1 HK1102597 A1 HK 1102597A1 HK 07110898 A HK07110898 A HK 07110898A HK 1102597 A1 HK1102597 A1 HK 1102597A1
Authority
HK
Hong Kong
Prior art keywords
ethynediyl
ptp
inhibitors
bis
benzene derivatives
Prior art date
Application number
HK07110898.5A
Other languages
English (en)
Inventor
Dominique Swinnen
Catherine Jorand-Lebrun
Patrick Gerber
Jerome Gonzalez
Agnes Bombrun
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of HK1102597A1 publication Critical patent/HK1102597A1/xx

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HK07110898.5A 2004-04-07 2007-10-09 1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors HK1102597A1 (en)

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US56628004P 2004-04-29 2004-04-29
PCT/EP2005/051426 WO2005097773A1 (fr) 2004-04-07 2005-03-29 Derives de 1,1'-(1,2-ethynediyle)bis-benzene inhibiteurs de ptp 1-b

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EP1904048B1 (fr) 2005-07-15 2011-11-23 Merck Serono SA Inhibiteurs glepp-1 dans le traitement de troubles autoimmunes et/ou inflammatoires
HUE047422T2 (hu) 2005-12-23 2020-04-28 Ariad Pharma Inc Biciklusos heteroaril vegyületek
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KR20090010186A (ko) * 2006-04-13 2009-01-29 주식회사 뉴로테크 살리실산 유도체 화합물 및 이를 포함하는 약학 조성물
JP5273038B2 (ja) 2006-05-08 2013-08-28 アリアド・ファーマシューティカルズ・インコーポレイテッド 単環式ヘテロアリール化合物
JP5273037B2 (ja) 2006-05-08 2013-08-28 アリアド・ファーマシューティカルズ・インコーポレイテッド アセチレン性ヘテロアリール化合物
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WO2009120783A1 (fr) * 2008-03-25 2009-10-01 The Johns Hopkins University Inhibiteurs à haute affinité de protéase ns3/4a du virus de l'hépatite c
AU2009314631B2 (en) 2008-11-12 2014-07-31 Takeda Pharmaceutical Company Limited Pyrazinopyrazines and derivatives as kinase inhibitors
EP2358658A4 (fr) * 2008-11-20 2012-11-14 Reddys Lab Ltd Dr Préparation de rasagiline et de ses sels
WO2013029555A1 (fr) * 2011-09-01 2013-03-07 天津医科大学附属肿瘤医院 Dérivés de lavendustine a, leur procédé de préparation et leur utilisation
CA3167093A1 (fr) 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Forme cristalline c du monochlorhydrate de benzamide a fonction 3-(imidazo[1,2-b]pyridazine-3-ylethynyl)-4-methyle-n-{4-[(4-methylpiperazine-1-yl)methyle)3(trifluoromethyle)phenyle}
CA2945263A1 (fr) 2014-04-09 2015-10-15 Christopher Rudd Utilisation d'inhibiteurs ou d'activateurs de gsk -3 qui modulent l'expression de pd -1 ou de t-bet pour moduler l'immunite due aux lymphocytes t
WO2016001452A1 (fr) 2014-07-04 2016-01-07 Universität Zürich Composés, destinés plus particulièrement à être utilisés dans le traitement d'une maladie ou d'une pathologie pour laquelle un inhibiteur du bromodomaine est indiqué
EP3588064B1 (fr) * 2017-02-23 2022-09-07 IHI Corporation Sonde de détection de radicaux oh, dispositif de mesure de radicaux oh et procédé de mesure de radicaux oh
EP3840740A4 (fr) * 2018-08-20 2022-10-05 Maggie's Pearl, LLC Méthodes pour traiter des troubles congénitaux de la glycosylation
EP4215607A1 (fr) 2020-09-18 2023-07-26 IUCF-HYU (Industry-University Cooperation Foundation Hanyang University) Protéine de fusion ptpsigma-fc et composition pharmaceutique la comprenant

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US20090029903A1 (en) 2009-01-29
CN1997638B (zh) 2011-07-06
EA200601869A1 (ru) 2007-04-27
IL178425A0 (en) 2007-02-11
JP5043645B2 (ja) 2012-10-10
BRPI0508790A (pt) 2007-09-04
UA85405C2 (ru) 2009-01-26
US7947851B2 (en) 2011-05-24
AU2005231980A1 (en) 2005-10-20
CA2560648A1 (fr) 2005-10-20
JP2007532514A (ja) 2007-11-15
IL178425A (en) 2012-02-29
CN1997638A (zh) 2007-07-11
NO20065122L (no) 2006-11-07
WO2005097773A1 (fr) 2005-10-20
AR048465A1 (es) 2006-04-26
AU2005231980B2 (en) 2011-09-08
MXPA06011678A (es) 2007-01-23
EP1756081A1 (fr) 2007-02-28
EA011930B1 (ru) 2009-06-30
CA2560648C (fr) 2013-01-22
KR101194968B1 (ko) 2012-10-25
KR20070008675A (ko) 2007-01-17

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