HK1098077A1 - Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin - Google Patents

Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin

Info

Publication number
HK1098077A1
HK1098077A1 HK07105811.9A HK07105811A HK1098077A1 HK 1098077 A1 HK1098077 A1 HK 1098077A1 HK 07105811 A HK07105811 A HK 07105811A HK 1098077 A1 HK1098077 A1 HK 1098077A1
Authority
HK
Hong Kong
Prior art keywords
integrin
treating
beta
alpha
compositions
Prior art date
Application number
HK07105811.9A
Other languages
English (en)
Inventor
Dean Sheppard
Amha Atakilit
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of HK1098077A1 publication Critical patent/HK1098077A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK07105811.9A 2004-04-02 2007-05-31 Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin HK1098077A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55917504P 2004-04-02 2004-04-02
PCT/US2005/011222 WO2005094391A2 (en) 2004-04-02 2005-03-30 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH αVβ5 INTEGRIN

Publications (1)

Publication Number Publication Date
HK1098077A1 true HK1098077A1 (en) 2007-07-13

Family

ID=35064346

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07105811.9A HK1098077A1 (en) 2004-04-02 2007-05-31 Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin

Country Status (15)

Country Link
US (2) US20050226865A1 (xx)
EP (2) EP1734996B1 (xx)
JP (2) JP5223072B2 (xx)
CN (1) CN1964740A (xx)
AU (1) AU2005229015C1 (xx)
CA (1) CA2562038C (xx)
CY (1) CY1114497T1 (xx)
DK (1) DK1734996T3 (xx)
ES (2) ES2671522T3 (xx)
HK (1) HK1098077A1 (xx)
HR (1) HRP20130782T1 (xx)
PL (1) PL1734996T3 (xx)
PT (1) PT1734996E (xx)
RS (1) RS52918B (xx)
WO (1) WO2005094391A2 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101752515B1 (ko) * 2009-07-24 2017-06-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ａｖｂ５ 인테그린과 결부된 질환의 치료 및 예방을 위한 방법 및 조성물
WO2013181666A2 (en) * 2012-06-01 2013-12-05 Isis Pharmaceuticals, Inc. Antisense compounds targeting genes associated with fibronectin
WO2014144616A2 (en) * 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 5 antibodies and uses thereof
MX2015011670A (es) * 2013-03-15 2016-03-31 Biogen Ma Inc Tratamiento y prevencion de lesion renal aguda usando anticuerpos anti-alfa v beta 5.
WO2015009948A1 (en) * 2013-07-19 2015-01-22 Regents Of The University Of California Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
US20170362324A1 (en) * 2014-09-12 2017-12-21 Biogen Ma Inc. Humanized anti-alpha v beta 5 antibodies and uses thereof
US11339221B2 (en) 2017-11-01 2022-05-24 Tufts Medical Center, Inc. Bispecific antibody constructs and methods of use

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37889A (en) * 1863-03-10 Mode of
US19206A (en) * 1858-01-26 Hydrant
US171271A (en) * 1875-12-21 Improvement in bob-sleds
US139398A (en) * 1873-05-27 Improvement in lamp-extinguishers
US10023A (en) * 1853-09-20 Machine fob sawing sticks eob broom-handles
US72500A (en) * 1867-12-24 Improvement in bleaceisg and scouring hemp, flax, aid other fibres
US18192A (en) * 1857-09-15 And samuel m
US19037A (en) * 1858-01-05 Washing-machine
US19035A (en) * 1858-01-05 mallary
US181440A (en) * 1876-08-22 Improvement in steam-boiler furnaces
US77321A (en) * 1868-04-28 Amos bank
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
AU606320B2 (en) 1985-11-01 1991-02-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5231114A (en) 1990-06-22 1993-07-27 Wakunaga Seiyaku Kabushiki Kaisha Polysulfides compounds and lipid peroxidation inhibitor containing the polysulfide compounds as active ingredient
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5527679A (en) 1991-05-01 1996-06-18 Dana Farber Cancer Institute β5 protein and DNA encoding the same
DE4142366A1 (de) * 1991-07-15 1993-06-24 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4123341A1 (de) * 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
US6291196B1 (en) * 1992-01-31 2001-09-18 Research Corporation Technologies, Inc. Melanoma and prostate cancer specific antibodies for immunodetection and immunotherapy
CA2131389A1 (en) 1992-03-02 1993-09-16 John M. Maraganore Thrombin receptor antagonists
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US6210671B1 (en) 1992-12-01 2001-04-03 Protein Design Labs, Inc. Humanized antibodies reactive with L-selectin
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5780426A (en) 1995-06-07 1998-07-14 Ixsys, Incorporated Fivemer cyclic peptide inhibitors of diseases involving αv β3
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
CZ40998A3 (cs) * 1995-08-14 1998-09-16 The Scripps Research Institute Použití antagonisty anb5 pro výrobu prostředků, schopných inhibovat angiogenezi v tkáních
US7053041B1 (en) * 1996-05-31 2006-05-30 The Scripps Research Institute Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
WO1997040830A1 (en) 1996-05-01 1997-11-06 Eli Lilly And Company Therapeutic treatment for vegf related diseases
DE69737631T3 (de) 1996-08-12 2011-08-18 Mitsubishi Tanabe Pharma Corp. MEDIKAMENTE ENTHALTEND Rho-KINASE INHIBITOREN
UA60311C2 (uk) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
CO4920232A1 (es) * 1997-01-08 2000-05-29 Smithkline Beecham Corp Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin
TW589189B (en) 1997-08-04 2004-06-01 Scras Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
KR100586202B1 (ko) * 1997-08-08 2006-06-07 더 리전트 오브 더 유니버시티 오브 캘리포니아 ανβ6 길항제로의 급성 폐 상해 및 섬유증의 치료방법
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
GB9827152D0 (en) 1998-07-03 1999-02-03 Devgen Nv Characterisation of gene function using double stranded rna inhibition
DE19842415A1 (de) * 1998-09-16 2000-03-23 Merck Patent Gmbh Pharmazeutische Zubereitung
AU764211C (en) 1998-12-01 2006-03-30 Abbvie Biotherapeutics Inc. Humanized antibodies to gamma-interferon
AU2215900A (en) 1998-12-30 2000-07-31 Edema Clearance, Inc. Gene therapy for pulmonary edema using adenovirus vectors encoding na,k-atpase
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US6399581B1 (en) 1999-05-11 2002-06-04 Harbor Branch Oceanographic Institution, Inc. Compound possessing potent thrombin receptor antagonist activity
DE60021521T4 (de) 1999-09-29 2006-09-21 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamide zur behandlung von integrin vermittelten störungen
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
GB2356198A (en) 1999-10-29 2001-05-16 Merck & Co Inc Isoxazole thrombin receptor antagonists
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
JP4787447B2 (ja) 2000-01-20 2011-10-05 メルク・シャープ・エンド・ドーム・コーポレイション αｖインテグリン受容体拮抗薬
EP1254116A4 (en) 2000-01-24 2003-04-23 Merck & Co Inc ALPHA V INTEGRIN RECEPTOR ANTAGONISTS
US6403612B2 (en) 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
US6515023B2 (en) 2000-01-31 2003-02-04 Merck & Co., Inc. Thrombin receptor antagonists
ATE464892T1 (de) 2000-02-03 2010-05-15 Eisai R&D Man Co Ltd Inhibitoren der integrinexpression
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
US6970452B2 (en) 2000-03-13 2005-11-29 Curitell Communications Inc. Common subscriber managing apparatus and method based on functional modeling of a common subscriber server for use in an ALL-IP network and method therefor
AU2001259078A1 (en) 2000-04-18 2001-10-30 Edema Clearance, Inc. Gene theraphy for pulmonary edema using adenovirus vectors encoding a beta2adrenergic receptor gene
US6900232B2 (en) 2000-06-15 2005-05-31 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists
US7288390B2 (en) * 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
DE10041423A1 (de) 2000-08-23 2002-03-07 Merck Patent Gmbh Biphenylderivate
US20020072500A1 (en) 2000-09-27 2002-06-13 Thomas Rogers Hydroxy acid integrin antagonists
ES2259047T3 (es) 2000-10-24 2006-09-16 MERCK & CO., INC. Antagonista de receptor de integrina de la dibenzoxazepina.
JP2004532616A (ja) 2000-12-28 2004-10-28 ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド 二本鎖ｒｎａ仲介遺伝子抑制
EP1393075A4 (en) 2001-04-04 2006-06-14 Allergan Inc METHODS OF SCREENING AND USE OF ANGIOGENESIS INHIBITORS
JP2004529918A (ja) 2001-04-09 2004-09-30 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物
US20040019206A1 (en) 2001-09-27 2004-01-29 Peter Ruminiski Lactone integrin antagonists
DK1539739T3 (da) * 2002-08-16 2011-03-07 Janssen Pharmaceutica Nv Piperidinylforbindelser, der selektivt binder integriner
US20040266755A1 (en) 2003-05-29 2004-12-30 Schering Aktiengesellschaft Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine
TWI552751B (zh) 2011-06-20 2016-10-11 Ｈ 朗德貝克公司 投予４－（（１ｒ，３ｓ）－６－氯－３－苯基－二氫茚－１－基）－１，２，２－三甲基－哌及其鹽用於治療精神分裂症的方法

Also Published As

Publication number Publication date
PL1734996T3 (pl) 2013-09-30
AU2005229015B2 (en) 2012-08-30
EP1734996A2 (en) 2006-12-27
CA2562038C (en) 2017-04-25
US20090280118A1 (en) 2009-11-12
AU2005229015C1 (en) 2013-01-17
JP2007531733A (ja) 2007-11-08
US20050226865A1 (en) 2005-10-13
EP2394662A2 (en) 2011-12-14
RS52918B (en) 2014-02-28
EP1734996A4 (en) 2008-09-10
JP5223072B2 (ja) 2013-06-26
PT1734996E (pt) 2013-07-18
JP5681149B2 (ja) 2015-03-04
CN1964740A (zh) 2007-05-16
ES2671522T3 (es) 2018-06-06
WO2005094391A2 (en) 2005-10-13
JP2013028611A (ja) 2013-02-07
EP2394662B1 (en) 2018-03-21
US7815908B2 (en) 2010-10-19
HRP20130782T1 (xx) 2013-09-30
ES2411965T3 (es) 2013-07-09
EP2394662A3 (en) 2012-02-22
EP1734996B1 (en) 2013-05-22
AU2005229015A1 (en) 2005-10-13
WO2005094391A3 (en) 2005-12-01
CA2562038A1 (en) 2005-10-13
DK1734996T3 (da) 2013-06-10
CY1114497T1 (el) 2016-10-05

Similar Documents

Publication Publication Date Title
HK1098077A1 (en) Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin
CY2020003I1 (el) Anti-il-12 αντισωματα, συνθεσεις, μεθοδοι και χρησεις για την θεραπευτικη αγωγη της παθολογιας του crohn
BR0314052A (pt) Imidazolpiridinas e métodos para sua fabricação e uso
ATE499088T1 (de) Glp-1-fc fusionsprotein-formulierung
ATE476990T1 (de) Cd20-bindende polypeptidzusammensetzungen
ATE536188T1 (de) Fcgammariib-spezifische antikörper und verfahren zur verwendung davon
BRPI0516437A (pt) utilização de uma quantidade eficaz de pelo menos um microorganismo, processo de tratamento cosmético, composição cosmética e/ou dermatológica e composição para absorção oral
DK1385864T3 (da) Anti-VEGF-2-antistoffer
IL178474A0 (en) Monoclonal antibodies to hepatocyte growth factor and pharmaceutical compositions containing the same
IL181473A (en) Antibodies @ people @ against @@@ beta @@ preparations that include them and use them
MXPA05007466A (es) Metodos para el tratamiento de enfermedades pulmonares.
BRPI0502382A (pt) processo para a preparação de artigos moldados de poliuretano
WO2005121778A3 (en) Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases
DE60232660D1 (de) Humane dr4-antikörper und deren anwendungen
EP1978034A4 (en) ANTI-PERIOSTINE ANTIBODIES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PERIOSTIN-RELATED DISEASE CONTAINING THE ANTIBODY
DE60042066D1 (de) Chimärische dr4 antikörper und ihre verwendung
UY28101A1 (es) Ureas substituidas y carbamatos útiles para el tratamiento de la enfermedad de alzheimer
EP1558766A4 (en) USE OF A33 ANTIGENES AND JAM IT
DK1411962T3 (da) Terapi for pancreacancer med monoklonalt stof
HK1154904A1 (zh) 天然 抗體及其抑制劑
ATE314861T1 (de) Verwendung von antikörper gegen mag zur behandlung ischämischer schlaganfälle
BRPI0417993A (pt) anticorpo anti-cd52 para tratamento da diabetes
AU2003293803A1 (en) 17.beta- (alpha-hydroxy) -esters of androstanes as intermediates for the preparation for the preparation of 17.beta.-fluorinated-androstane esters
IL165300A (en) Composition comprising antibodies for the prophylaxis of respiratory infections
DE60337030D1 (de) Anti-idiotypische antikörper gegen faktor-viii-hemmer und deren verwendungen

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190328