DE60232660D1 - Humane dr4-antikörper und deren anwendungen - Google Patents
Humane dr4-antikörper und deren anwendungenInfo
- Publication number
- DE60232660D1 DE60232660D1 DE60232660T DE60232660T DE60232660D1 DE 60232660 D1 DE60232660 D1 DE 60232660D1 DE 60232660 T DE60232660 T DE 60232660T DE 60232660 T DE60232660 T DE 60232660T DE 60232660 D1 DE60232660 D1 DE 60232660D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- human
- applications
- kits
- diagnosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30322001P | 2001-07-03 | 2001-07-03 | |
PCT/US2002/020712 WO2003066661A2 (en) | 2001-07-03 | 2002-06-29 | Human dr4 antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60232660D1 true DE60232660D1 (de) | 2009-07-30 |
Family
ID=27734188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60232660T Expired - Lifetime DE60232660D1 (de) | 2001-07-03 | 2002-06-29 | Humane dr4-antikörper und deren anwendungen |
Country Status (14)
Country | Link |
---|---|
US (2) | US7252994B2 (de) |
EP (2) | EP2192130A1 (de) |
JP (1) | JP4509570B2 (de) |
AT (1) | ATE433996T1 (de) |
AU (2) | AU2002366430B2 (de) |
CA (1) | CA2451680C (de) |
CY (1) | CY1110505T1 (de) |
DE (1) | DE60232660D1 (de) |
DK (1) | DK1409544T3 (de) |
ES (1) | ES2328234T3 (de) |
HK (1) | HK1065323A1 (de) |
IL (1) | IL159527A0 (de) |
PT (1) | PT1409544E (de) |
WO (1) | WO2003066661A2 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7476383B2 (en) * | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US7361341B2 (en) * | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
WO2003054216A2 (en) * | 2001-12-20 | 2003-07-03 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
ES2239886B1 (es) * | 2003-11-05 | 2006-12-16 | Universidad De Barcelona | Metodo y aparato para la determinacion de la viabilidad celular. |
AU2012200602B2 (en) * | 2004-08-06 | 2012-11-08 | Genentech, Inc. | Assays and methods using biomarkers |
DK1774037T3 (da) | 2004-08-06 | 2011-08-15 | Genentech Inc | Analyser og fremgangsmåder, der anvender biomarkører |
ZA200701614B (en) | 2004-08-06 | 2008-10-29 | Genentech Inc | Assays and methods using biomarkers |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
WO2007022157A2 (en) | 2005-08-16 | 2007-02-22 | Genentech, Inc. | Apoptosis sensitivity to ap02l/trail by testing for 'galnac-t14 expression in cells/tissues |
JP2007063225A (ja) * | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
EP1945244B1 (de) * | 2005-10-16 | 2016-05-04 | Yeda Research And Development Co., Ltd. | Verwendung von caspase-8 in pharmazeutischen zusammensetzungen und diagnoseverfahren für entzündliche hauterkrankungen, störungen oder zustände |
JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
EP2001875A2 (de) | 2006-03-08 | 2008-12-17 | Takeda San Diego, Inc. | Glucokinase-aktivatoren |
ATE522518T1 (de) | 2006-05-31 | 2011-09-15 | Takeda San Diego Inc | Indazol- und isoindolderivate als glucokinaseaktivierende stoffe |
US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
US8173645B2 (en) * | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
CA2802349A1 (en) * | 2010-06-16 | 2011-12-22 | The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services | Anti-dr4 agonist antibodies |
JP6184965B2 (ja) | 2011-10-28 | 2017-08-23 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | ポリペプチド構築物およびその使用 |
EP2684896A1 (de) | 2012-07-09 | 2014-01-15 | International-Drug-Development-Biotech | Antikörper gegen die DR5-Familie, bispezifische oder multivalente Antikörper gegen die DR5-Familie und Verfahren zu deren Verwendung |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
AU2013388126B2 (en) | 2013-04-29 | 2019-03-07 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2b |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
EP3212216A4 (de) | 2014-10-29 | 2018-04-18 | Teva Pharmaceuticals Australia Pty Ltd | Varianten von interferon alpha2b |
KR20180069066A (ko) * | 2015-10-30 | 2018-06-22 | 갤럭시 바이오테크, 엘엘씨 | 사멸 수용체 4 및 사멸 수용체 5에 결합하는 매우 강력한 항체 |
MX2018006333A (es) | 2015-12-01 | 2018-08-01 | Genmab Bv | Anticuerpos anti-receptor de muerte 5 (dr5) y metodos de uso de los mismos. |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8905669D0 (en) * | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
AU1368292A (en) | 1991-03-11 | 1992-10-06 | Sheila Drover | Murine monoclonal antibodies recognizing polymorphic determinants of hla |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
DE674004T1 (de) | 1994-02-04 | 1996-09-19 | Bio Merieux | MSRV1 Virus und ansteckender und/oder krankheitserregender MSRV2, die mit Multipler Sklerose verbunden sind, ihre nukleären Bestandteile und Verwendungen. |
IL122408A0 (en) | 1995-06-29 | 1998-06-15 | Immunex Corp | Dna encoding a trail polypeptide and its preparation |
US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
DK0939804T4 (da) | 1996-10-25 | 2011-07-18 | Human Genome Sciences Inc | Neutrokin-alpha |
EP2003203A1 (de) | 1996-12-23 | 2008-12-17 | Immunex Corporation | Ligand für den Rezeptorauslöser von NF-kappa b, wobei der Ligand Mitglied der TNF-Überfamilie ist |
US6433147B1 (en) | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
EP1862548A1 (de) | 1997-01-28 | 2007-12-05 | Human Genome Sciences, Inc. | Death-Domain-enthaltender Rezeptor 4 (DR4: Death receptor 4), Mitglied der TNF-Rezeptor-Superfamilie und Bindung an Trail (APO2-L) |
US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
CA2644454A1 (en) | 1997-03-17 | 1998-09-24 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
EP1007562A4 (de) | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | Tomornekrosefaktorrezeptor verwandte proteine tango-63d und tango-63e |
ID23855A (id) | 1997-04-16 | 2000-05-25 | Amgen Inc | Protein pengikat osteoprotegerin dan reseptor |
EP0981618B2 (de) | 1997-05-15 | 2011-08-24 | Genentech, Inc. | Anti-apo-2 antikörper |
AU8400398A (en) | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
WO1999004001A1 (en) | 1997-07-21 | 1999-01-28 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-5 |
EP1019502A2 (de) | 1997-08-06 | 2000-07-19 | Regeneron Pharmaceuticals, Inc. | Humane waisenrezeptor ntr-1 |
JP2001514888A (ja) | 1997-08-15 | 2001-09-18 | アイドゥン ファーマシューティカルズ, インコーポレイテッド | Trailレセプター、これをコードする核酸、およびその使用方法 |
WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
AU2093499A (en) | 1997-12-30 | 1999-07-19 | Chiron Corporation | Members of tnf and tnfr families |
US20040180049A1 (en) * | 1998-01-26 | 2004-09-16 | Genentech, Inc. | DR4 antibodies and uses thereof |
EP1053256B9 (de) * | 1998-01-26 | 2012-01-18 | Genentech, Inc. | Antikörper gegen "death receptor 4" (dr4) und deren verwendungen |
US20040120947A1 (en) * | 1998-01-26 | 2004-06-24 | Genentech, Inc. | DR4 antibodies and uses thereof |
AU4561199A (en) | 1998-06-12 | 1999-12-30 | Genentech Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
US6252050B1 (en) * | 1998-06-12 | 2001-06-26 | Genentech, Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
PT1181319E (pt) | 1999-05-28 | 2009-07-14 | Genentech Inc | Anticorpos quiméricos contra dr4 e suas utilizações |
US7291714B1 (en) * | 1999-06-30 | 2007-11-06 | Millennium Pharmaceuticals, Inc. | Glycoprotein VI and uses thereof |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
KR100932577B1 (ko) * | 2001-05-18 | 2009-12-17 | 기린 홀딩스 가부시키가이샤 | 항 trail-r 항체 |
MXPA03010747A (es) | 2001-05-25 | 2004-03-02 | Human Genome Sciences Inc | Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral. |
ES2357225T3 (es) | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
MXPA04004184A (es) | 2001-11-01 | 2005-01-25 | Uab Research Foundation | Combinaciones de anticuerpos selectivos para un receptor de ligando que induce apoptosis relacionada al factor de necrosis tumoral y otros agentes terapeuticos. |
WO2003042367A2 (en) | 2001-11-14 | 2003-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
-
2002
- 2002-06-29 EP EP09004361A patent/EP2192130A1/de not_active Withdrawn
- 2002-06-29 AT AT02805988T patent/ATE433996T1/de active
- 2002-06-29 AU AU2002366430A patent/AU2002366430B2/en not_active Expired
- 2002-06-29 PT PT02805988T patent/PT1409544E/pt unknown
- 2002-06-29 CA CA2451680A patent/CA2451680C/en not_active Expired - Lifetime
- 2002-06-29 WO PCT/US2002/020712 patent/WO2003066661A2/en active Search and Examination
- 2002-06-29 EP EP02805988A patent/EP1409544B1/de not_active Expired - Lifetime
- 2002-06-29 JP JP2003566032A patent/JP4509570B2/ja not_active Expired - Lifetime
- 2002-06-29 US US10/480,730 patent/US7252994B2/en not_active Expired - Lifetime
- 2002-06-29 ES ES02805988T patent/ES2328234T3/es not_active Expired - Lifetime
- 2002-06-29 DK DK02805988T patent/DK1409544T3/da active
- 2002-06-29 IL IL15952702A patent/IL159527A0/xx active IP Right Grant
- 2002-06-29 DE DE60232660T patent/DE60232660D1/de not_active Expired - Lifetime
-
2004
- 2004-10-14 HK HK04107906.4A patent/HK1065323A1/xx not_active IP Right Cessation
-
2007
- 2007-06-28 US US11/819,575 patent/US7744881B2/en active Active
-
2008
- 2008-12-18 AU AU2008260311A patent/AU2008260311A1/en not_active Abandoned
-
2009
- 2009-08-19 CY CY20091100882T patent/CY1110505T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1409544B1 (de) | 2009-06-17 |
WO2003066661A3 (en) | 2003-11-27 |
CA2451680C (en) | 2011-04-19 |
JP4509570B2 (ja) | 2010-07-21 |
US7252994B2 (en) | 2007-08-07 |
CA2451680A1 (en) | 2003-08-14 |
JP2005517021A (ja) | 2005-06-09 |
AU2008260311A1 (en) | 2009-01-15 |
ATE433996T1 (de) | 2009-07-15 |
AU2002366430A1 (en) | 2003-09-02 |
US20080233646A1 (en) | 2008-09-25 |
EP2192130A1 (de) | 2010-06-02 |
DK1409544T3 (da) | 2009-10-26 |
PT1409544E (pt) | 2009-09-16 |
ES2328234T3 (es) | 2009-11-11 |
EP1409544A2 (de) | 2004-04-21 |
EP1409544A4 (de) | 2005-11-09 |
AU2002366430B2 (en) | 2008-09-18 |
US7744881B2 (en) | 2010-06-29 |
WO2003066661A2 (en) | 2003-08-14 |
IL159527A0 (en) | 2004-06-01 |
HK1065323A1 (en) | 2005-02-18 |
US20040147725A1 (en) | 2004-07-29 |
CY1110505T1 (el) | 2015-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |