DE60337030D1 - Anti-idiotypische antikörper gegen faktor-viii-hemmer und deren verwendungen - Google Patents
Anti-idiotypische antikörper gegen faktor-viii-hemmer und deren verwendungenInfo
- Publication number
- DE60337030D1 DE60337030D1 DE60337030T DE60337030T DE60337030D1 DE 60337030 D1 DE60337030 D1 DE 60337030D1 DE 60337030 T DE60337030 T DE 60337030T DE 60337030 T DE60337030 T DE 60337030T DE 60337030 D1 DE60337030 D1 DE 60337030D1
- Authority
- DE
- Germany
- Prior art keywords
- factor viii
- idiotypic antibodies
- antibodies
- inhibitory
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940124135 Factor VIII inhibitor Drugs 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 108010054218 Factor VIII Proteins 0.000 abstract 3
- 102000001690 Factor VIII Human genes 0.000 abstract 3
- 229960000301 factor viii Drugs 0.000 abstract 3
- 102000002110 C2 domains Human genes 0.000 abstract 2
- 108050009459 C2 domains Proteins 0.000 abstract 2
- 102100026735 Coagulation factor VIII Human genes 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000010172 mouse model Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02447150A EP1388544A1 (de) | 2002-07-31 | 2002-07-31 | Anti-Idiotypische Antikörper gegen Factor VIII-Inhibitor und Verwendungen davon |
| PCT/EP2003/008365 WO2004014955A1 (en) | 2002-07-31 | 2003-07-28 | Anti-idiotypic antibodies against factor viii inhibitor and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60337030D1 true DE60337030D1 (de) | 2011-06-16 |
Family
ID=30129275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60337030T Expired - Lifetime DE60337030D1 (de) | 2002-07-31 | 2003-07-28 | Anti-idiotypische antikörper gegen faktor-viii-hemmer und deren verwendungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7582296B2 (de) |
| EP (2) | EP1388544A1 (de) |
| JP (1) | JP2006515565A (de) |
| AT (1) | ATE508140T1 (de) |
| AU (1) | AU2003260335B2 (de) |
| CA (1) | CA2494698C (de) |
| DE (1) | DE60337030D1 (de) |
| DK (1) | DK1581560T3 (de) |
| ES (1) | ES2366280T3 (de) |
| PT (1) | PT1581560E (de) |
| WO (1) | WO2004014955A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004010050A1 (de) * | 2004-03-02 | 2005-09-22 | Bayer Healthcare Ag | Spezifische monoklonale und polyklonale Antikörper für Repinotan und dessen ringoffene Form |
| FR2889534B1 (fr) * | 2005-08-04 | 2012-11-02 | Lab Francais Du Fractionnement | Anticorps anti-idiotypique neutralisant l'activite inhibitrice d'un anticorps inhibiteur du facteur viii |
| FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| FR2897868B1 (fr) * | 2006-02-24 | 2012-08-31 | Lab Francais Du Fractionnement | Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii. |
| CN101883793A (zh) * | 2007-08-23 | 2010-11-10 | Lfb生物科技公司 | 中和针对因子ⅷ的c1结构域的抑制性抗体的抑制活性的抗独特型抗体 |
| GB201216002D0 (en) * | 2012-09-07 | 2012-10-24 | Deutsches Rheuma Forschungszentrum Berlin Drfz | Compositions adn methods |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6210671B1 (en) * | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
| IT1277827B1 (it) * | 1995-03-01 | 1997-11-12 | Ministero Uni Ricerca Scient E | Anticorpo monoclonale chimerico murino/umano o un suo frammento specifico per il recettore egf (egf-r) |
| DE69624436T2 (de) * | 1995-04-08 | 2003-08-28 | Lg Chemical Ltd | Humaner 4-1bb spezifischer humaner antikörper und diesen produzierende zellinie |
| AU690474B2 (en) * | 1995-09-11 | 1998-04-23 | Kyowa Hakko Kirin Co., Ltd. | Antibody againts alpha-chain of human interleukin 5 receptor |
| JP3683278B2 (ja) * | 1995-12-20 | 2005-08-17 | ザ ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション | マウスモノクローナル抗イディオタイプ抗体１１ｄ１０およびその使用方法 |
| WO1999058680A2 (en) * | 1998-05-08 | 1999-11-18 | Stichting Sanquin Bloedvoorziening | Method for diagnosis and treatment of haemophilia a patients with an inhibitor |
| DK1194528T3 (da) | 1999-07-14 | 2007-07-09 | D Collen Res Foundation Vzw | Monoklonalt antistof mod faktor VII, hvilket antistof selv ved forekomst i molært overskud kun delvist inaktiverer faktor VII, samt fremgangsmåde til produktion af et sådant antistof |
| EP1197755A1 (de) * | 2000-10-11 | 2002-04-17 | Pepscan Systems B.V. | Bestimmung von Protein-Bindungsstellen |
-
2002
- 2002-07-31 EP EP02447150A patent/EP1388544A1/de not_active Withdrawn
-
2003
- 2003-07-28 AT AT03784106T patent/ATE508140T1/de active
- 2003-07-28 DK DK03784106.1T patent/DK1581560T3/da active
- 2003-07-28 WO PCT/EP2003/008365 patent/WO2004014955A1/en active Application Filing
- 2003-07-28 AU AU2003260335A patent/AU2003260335B2/en not_active Ceased
- 2003-07-28 CA CA2494698A patent/CA2494698C/en not_active Expired - Fee Related
- 2003-07-28 JP JP2004526816A patent/JP2006515565A/ja active Pending
- 2003-07-28 PT PT03784106T patent/PT1581560E/pt unknown
- 2003-07-28 DE DE60337030T patent/DE60337030D1/de not_active Expired - Lifetime
- 2003-07-28 ES ES03784106T patent/ES2366280T3/es not_active Expired - Lifetime
- 2003-07-28 EP EP03784106A patent/EP1581560B1/de not_active Expired - Lifetime
- 2003-07-28 US US10/523,444 patent/US7582296B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2494698A1 (en) | 2004-02-19 |
| ATE508140T1 (de) | 2011-05-15 |
| ES2366280T3 (es) | 2011-10-18 |
| CA2494698C (en) | 2011-03-15 |
| WO2004014955A1 (en) | 2004-02-19 |
| EP1388544A1 (de) | 2004-02-11 |
| DK1581560T3 (da) | 2011-08-22 |
| US7582296B2 (en) | 2009-09-01 |
| AU2003260335B2 (en) | 2009-01-08 |
| PT1581560E (pt) | 2011-08-17 |
| AU2003260335A1 (en) | 2004-02-25 |
| JP2006515565A (ja) | 2006-06-01 |
| WO2004014955A9 (en) | 2005-03-24 |
| US20060239998A1 (en) | 2006-10-26 |
| EP1581560B1 (de) | 2011-05-04 |
| EP1581560A1 (de) | 2005-10-05 |
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