HK1097550A1 - Antiviral nucleoside analogues as inhibitors of retroviral reverse transcriptase and dna polymerase - Google Patents

Antiviral nucleoside analogues as inhibitors of retroviral reverse transcriptase and dna polymerase

Info

Publication number
HK1097550A1
HK1097550A1 HK07103270.8A HK07103270A HK1097550A1 HK 1097550 A1 HK1097550 A1 HK 1097550A1 HK 07103270 A HK07103270 A HK 07103270A HK 1097550 A1 HK1097550 A1 HK 1097550A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
dna polymerase
reverse transcriptase
nucleoside analogues
antiviral nucleoside
Prior art date
Application number
HK07103270.8A
Other languages
English (en)
Inventor
Xiao-Xiong Zhou
Nils-Gunnar Johansson
Horst Waehling
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9702957A external-priority patent/SE9702957D0/xx
Priority claimed from SE9704147A external-priority patent/SE9704147D0/xx
Priority claimed from SE9800452A external-priority patent/SE9800452D0/xx
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of HK1097550A1 publication Critical patent/HK1097550A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK07103270.8A 1997-08-15 2007-03-27 Antiviral nucleoside analogues as inhibitors of retroviral reverse transcriptase and dna polymerase HK1097550A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702957A SE9702957D0 (sv) 1997-08-15 1997-08-15 Antivirals
SE9704147A SE9704147D0 (sv) 1997-11-12 1997-11-12 Nucleosides
SE9800452A SE9800452D0 (sv) 1998-02-13 1998-02-13 Antivirals

Publications (1)

Publication Number Publication Date
HK1097550A1 true HK1097550A1 (en) 2007-06-29

Family

ID=27355886

Family Applications (2)

Application Number Title Priority Date Filing Date
HK01103586A HK1032968A1 (en) 1997-08-15 2001-05-23 Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
HK07103270.8A HK1097550A1 (en) 1997-08-15 2007-03-27 Antiviral nucleoside analogues as inhibitors of retroviral reverse transcriptase and dna polymerase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK01103586A HK1032968A1 (en) 1997-08-15 2001-05-23 Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)

Country Status (24)

Country Link
EP (2) EP1123935B1 (xx)
JP (1) JP3844654B2 (xx)
KR (1) KR100529272B1 (xx)
CN (2) CN1286845C (xx)
AT (2) ATE200900T1 (xx)
AU (1) AU728892B2 (xx)
CA (1) CA2298704C (xx)
CZ (1) CZ300757B6 (xx)
DE (3) DE69800753T4 (xx)
DK (1) DK0988304T3 (xx)
ES (2) ES2239637T3 (xx)
GR (1) GR3036004T3 (xx)
HK (2) HK1032968A1 (xx)
HU (1) HU228060B1 (xx)
IL (2) IL134503A0 (xx)
MY (1) MY116269A (xx)
NZ (1) NZ502837A (xx)
PL (1) PL338643A1 (xx)
PT (1) PT988304E (xx)
SG (1) SG96604A1 (xx)
SI (1) SI0988304T1 (xx)
TR (2) TR200000398T2 (xx)
TW (1) TW580500B (xx)
WO (1) WO1999009031A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) * 1909-10-07 2002-10-01 Medivir Ab Prodrugs
FR2794752A1 (fr) * 1999-06-11 2000-12-15 Laphal Sa Lab Nouveaux composes derives de nucleosides, leurs procedes de preparation, et les compositions pharmaceutiques en renfermant
FR2796384A1 (fr) * 1999-07-12 2001-01-19 Laphal Sa Lab Nouveaux esters derives de nucleosides, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
MY141789A (en) 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
AUPS037002A0 (en) * 2002-02-07 2002-02-28 Melbourne Health Viral variants and uses therefor
WO2004087169A1 (en) * 2003-03-27 2004-10-14 Boehringer Ingelheim International Gmbh Antiviral combination of nevirapine and a further antiretroviral compound
EP1610781A1 (en) 2003-03-27 2006-01-04 Boehringer Ingelheim International GmbH Antiviral combination of tipranavir and a further antiretroviral compound
WO2004087140A1 (en) * 2003-03-27 2004-10-14 Boehringer Ingelheim International Gmbh Antiviral combination of a dipyridodiazepinone and a further antiretroviral compound
GB0400290D0 (en) 2004-01-08 2004-02-11 Medivir Ab dUTPase inhibitors
GB0513835D0 (en) 2005-07-07 2005-08-10 Medivir Ab HIV inhibitors
WO2012115578A1 (en) * 2011-02-21 2012-08-30 Medivir Ab Synthesis of flg
ES2930848T3 (es) * 2015-09-23 2022-12-22 Xwpharma Ltd Profármacos de ácido gamma-hidroxibutírico, composiciones y usos de los mismos
JP2023500794A (ja) * 2019-10-17 2023-01-11 エーアイ‐バイオファーマ 抗ウイルス薬および肝臓標的薬
CN114686188B (zh) * 2020-12-31 2023-05-02 中石化石油工程技术服务有限公司 一种核苷磷脂钻井液润滑剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
CA1321994C (en) * 1987-10-28 1993-09-07 Reid Von Borstel Acylated uridine and cytidine and uses thereof
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
AU663309C (en) * 1991-02-08 2002-08-08 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DE4311801A1 (de) * 1993-04-09 1994-10-13 Hoechst Ag Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
WO1997027194A1 (en) * 1996-01-26 1997-07-31 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
WO1998021223A1 (en) * 1996-11-12 1998-05-22 Medivir Ab Nucleosides

Also Published As

Publication number Publication date
PL338643A1 (en) 2000-11-06
DE69800753D1 (de) 2001-06-07
HK1032968A1 (en) 2001-08-10
TR200000398T2 (tr) 2000-07-21
IL134503A0 (en) 2001-04-30
CA2298704A1 (en) 1999-02-25
EP1123935A2 (en) 2001-08-16
TR200002273T2 (tr) 2002-06-21
JP2001515079A (ja) 2001-09-18
GR3036004T3 (en) 2001-09-28
HUP0100087A3 (en) 2003-01-28
CN1286845C (zh) 2006-11-29
AU728892B2 (en) 2001-01-18
ES2158689T3 (es) 2001-09-01
DK0988304T3 (da) 2001-08-20
CA2298704C (en) 2006-07-11
KR100529272B1 (ko) 2005-11-17
ATE293112T1 (de) 2005-04-15
CZ2000449A3 (cs) 2000-08-16
KR20010022873A (ko) 2001-03-26
DE69800753T2 (de) 2001-10-25
HUP0100087A1 (hu) 2002-01-28
EP1123935B1 (en) 2005-04-13
PT988304E (pt) 2001-10-31
DE69829784D1 (de) 2005-05-19
JP3844654B2 (ja) 2006-11-15
NZ502837A (en) 2001-01-26
EP0988304B1 (en) 2001-05-02
ES2239637T3 (es) 2005-10-01
MY116269A (en) 2003-12-31
CN1275983A (zh) 2000-12-06
SG96604A1 (en) 2003-06-16
SI0988304T1 (en) 2001-08-31
IL134503A (en) 2010-06-30
EP0988304A1 (en) 2000-03-29
CN1500800A (zh) 2004-06-02
HU228060B1 (en) 2012-09-28
CZ300757B6 (cs) 2009-08-05
AU8754898A (en) 1999-03-08
WO1999009031A1 (en) 1999-02-25
DE69829784T2 (de) 2006-02-16
EP1123935A3 (en) 2001-09-05
TW580500B (en) 2004-03-21
DE69800753T4 (de) 2002-02-21
ATE200900T1 (de) 2001-05-15
CN1130362C (zh) 2003-12-10

Similar Documents

Publication Publication Date Title
HK1097550A1 (en) Antiviral nucleoside analogues as inhibitors of retroviral reverse transcriptase and dna polymerase
DE69801802D1 (de) Substituierte propargylethoxyamido-nukleoside
JP2002503673A5 (xx)
KR890003761A (ko) 치료학적 아시클릭 뉴클레오시드
KR880003974A (ko) 디아민의 선택적 아미딘화 방법
IE801342L (en) Peptides
DK0663922T3 (da) Nukleotider mærket med infrarødt farvestof og deres anvendelse til nukleinsyredetektion
EA200000838A1 (ru) Пролекарства
FI970648A (fi) Menetelmä nukleiinihappojen jakelemiseksi
AR024364A1 (es) Una composicion cosmetica para el adelgazamiento a base l-arginina, de un analogo de l-arginina, o de uno de sus derivados, que se administra por viatopica
DK0864584T3 (da) Lipopeptider fra Actinoplanes sp. med farmakologisk virkning, fremgangsmåde til deres fremstilling samt deres anvendelse
WO1996031531A3 (en) Fluorescent peptides
LV10446A (lv) Jauni tetrazola atvasinajumi to iegusanas panemiens un farmaceitiskas kompozicijas uz to bazes
ES2164869T3 (es) Conjugados lipidos especificos de nucleosidos-difosfato y su uso como medicamentos.
ES2186127T3 (es) Sintesis de derivados de nucleosidos aciclicos.
EP0331756A4 (en) Agents for prophylaxis and treatment of thrombopenia
Laduree et al. Synthesis of novel C-5 substituted d4T analogues bearing linker arms as potential anti-HIV agents
BRPI0007593B8 (pt) processo para preparar uma aza-macrolida com 4"(r)-nh2"

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140814