HK1095133A1 - Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them - Google Patents
Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing themInfo
- Publication number
- HK1095133A1 HK1095133A1 HK07102213.0A HK07102213A HK1095133A1 HK 1095133 A1 HK1095133 A1 HK 1095133A1 HK 07102213 A HK07102213 A HK 07102213A HK 1095133 A1 HK1095133 A1 HK 1095133A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tricyclic derivatives
- preparations
- pharmaceutically acceptable
- pharmaceutical compositions
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/22—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20030041547 | 2003-06-25 | ||
PCT/KR2004/001518 WO2004113281A1 (en) | 2003-06-25 | 2004-06-23 | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1095133A1 true HK1095133A1 (en) | 2007-04-27 |
Family
ID=36091400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07102213.0A HK1095133A1 (en) | 2003-06-25 | 2007-02-27 | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them |
Country Status (14)
Country | Link |
---|---|
US (1) | US20070179143A1 (zh) |
EP (1) | EP1646608B1 (zh) |
JP (1) | JP4430071B2 (zh) |
KR (1) | KR100667464B1 (zh) |
CN (1) | CN100393698C (zh) |
AT (1) | ATE500216T1 (zh) |
AU (1) | AU2004249639B2 (zh) |
CA (1) | CA2531543C (zh) |
DE (1) | DE602004031621D1 (zh) |
DK (1) | DK1646608T3 (zh) |
ES (1) | ES2358801T3 (zh) |
HK (1) | HK1095133A1 (zh) |
RU (1) | RU2326864C2 (zh) |
WO (1) | WO2004113281A1 (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7622612B2 (en) | 2001-05-28 | 2009-11-24 | Chemtech Research Incorporation | Tricyclic derivatives and their use |
US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
SG179300A1 (en) | 2006-02-21 | 2012-04-27 | Toyama Chemical Co Ltd | Process for production of 3-[5-[4-cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-oxo-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionate ester and intermediate for the process |
KR101077609B1 (ko) | 2009-07-08 | 2011-10-27 | 제일약품주식회사 | 트리사이클릭 유도체의 제조방법 |
PL2470499T3 (pl) * | 2009-08-26 | 2019-11-29 | Alberta Health Services | Nowe pochodne kolchicyny, sposoby i ich zastosowania |
US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
KR101130754B1 (ko) * | 2010-06-25 | 2012-03-28 | 제일약품주식회사 | 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물 |
US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
JP6019126B2 (ja) | 2011-10-07 | 2016-11-02 | エピセントアーレックス・インコーポレイテッドEpicentRx, Inc. | 有機ニトロチオエーテル化合物およびその医療用途 |
KR101494280B1 (ko) * | 2012-12-28 | 2015-02-23 | 한국화학연구원 | 콜치신 유도체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물 |
JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
CN104649943B (zh) * | 2015-01-28 | 2016-10-05 | 中国科学院上海高等研究院 | 秋水仙碱衍生物及其制备方法和应用 |
US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
KR20190040931A (ko) | 2016-01-11 | 2019-04-19 | 에피센트알엑스, 인코포레이티드 | 2-브로모-1-(3,3-디니트로아제티딘-1-일)에타논의 정맥내 투여를 위한 조성물 및 방법 |
US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
WO2017207385A1 (de) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
JP7004677B2 (ja) | 2016-06-01 | 2022-01-21 | バイエル・アニマル・ヘルス・ゲーエムベーハー | 動物におけるアレルギー性および/または炎症性疾患の治療および予防に有用な置換インダゾール |
WO2018060174A1 (de) | 2016-09-29 | 2018-04-05 | Bayer Pharma Aktiengesellschaft | Substituierte benzimidazole, pharmazeutische präparate diese enthaltend, sowie deren verwendung zur herstellung von arzneimitteln |
EP3526195A4 (en) | 2016-10-14 | 2020-05-20 | EpicentRx, Inc. | SULFOXYALKYL ORGANONITRO AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN MEDICINE |
US10538503B2 (en) * | 2016-10-26 | 2020-01-21 | Ishihara Sangyo Kaisha, Ltd. | Method for producing 3-methyl-2-thiophenecarboxylic acid |
BR112020000196A2 (pt) | 2017-07-07 | 2020-07-07 | Epicentrx, Inc. | composições para administração parenteral de agentes terapêuticos |
US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4533675A (en) | 1984-04-17 | 1985-08-06 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates of colchicine for treatment of gout |
IT1276996B1 (it) * | 1995-06-27 | 1997-11-04 | Indena Spa | Derivati della colchicina, loro uso e formulazioni che li contengono |
IT1291550B1 (it) | 1997-04-11 | 1999-01-11 | Indena Spa | Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante |
KR100600158B1 (ko) * | 2001-05-28 | 2006-07-12 | 주식회사 씨트리 | 신규한 알카로이드 유도체 및 이를 함유하는 약제학적조성물 |
-
2004
- 2004-06-23 EP EP04773996A patent/EP1646608B1/en not_active Expired - Lifetime
- 2004-06-23 AU AU2004249639A patent/AU2004249639B2/en not_active Ceased
- 2004-06-23 CN CNB2004800212673A patent/CN100393698C/zh not_active Expired - Lifetime
- 2004-06-23 KR KR1020040047277A patent/KR100667464B1/ko active IP Right Grant
- 2004-06-23 AT AT04773996T patent/ATE500216T1/de active
- 2004-06-23 DE DE602004031621T patent/DE602004031621D1/de not_active Expired - Lifetime
- 2004-06-23 JP JP2006515341A patent/JP4430071B2/ja not_active Expired - Lifetime
- 2004-06-23 CA CA2531543A patent/CA2531543C/en not_active Expired - Fee Related
- 2004-06-23 DK DK04773996.6T patent/DK1646608T3/da active
- 2004-06-23 WO PCT/KR2004/001518 patent/WO2004113281A1/en active Application Filing
- 2004-06-23 ES ES04773996T patent/ES2358801T3/es not_active Expired - Lifetime
- 2004-06-23 US US10/562,615 patent/US20070179143A1/en not_active Abandoned
- 2004-06-23 RU RU2006101987/04A patent/RU2326864C2/ru not_active IP Right Cessation
-
2007
- 2007-02-27 HK HK07102213.0A patent/HK1095133A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1646608A4 (en) | 2006-11-22 |
KR20050001383A (ko) | 2005-01-06 |
KR100667464B1 (ko) | 2007-01-10 |
EP1646608A1 (en) | 2006-04-19 |
EP1646608B1 (en) | 2011-03-02 |
CA2531543C (en) | 2010-10-12 |
CN100393698C (zh) | 2008-06-11 |
DE602004031621D1 (de) | 2011-04-14 |
ES2358801T3 (es) | 2011-05-13 |
JP4430071B2 (ja) | 2010-03-10 |
AU2004249639B2 (en) | 2008-07-17 |
JP2007520422A (ja) | 2007-07-26 |
RU2326864C2 (ru) | 2008-06-20 |
DK1646608T3 (da) | 2011-06-14 |
CN1826316A (zh) | 2006-08-30 |
ATE500216T1 (de) | 2011-03-15 |
AU2004249639A1 (en) | 2004-12-29 |
RU2006101987A (ru) | 2006-07-10 |
US20070179143A1 (en) | 2007-08-02 |
WO2004113281A1 (en) | 2004-12-29 |
CA2531543A1 (en) | 2004-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1095133A1 (en) | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them | |
TNSN04213A1 (en) | High drug load tablet | |
WO2007008752A3 (en) | Sustained release pharmaceutical compositions for highly water soluble drugs | |
HK1097189A1 (en) | Cannabinoid receptor ligands | |
MXPA05008368A (es) | 1,2,4-triazinas inhibidoras del virus de inmunodeficiencia humana. | |
IL185063A0 (en) | Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers | |
GEP20043250B (en) | Use of Indolyl-3-Glyoxylic Acid Derivatives as Anti-tumor Means and Pharmaceutical Compositions Containing the Same | |
HUP0300798A3 (en) | Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them | |
SG147450A1 (en) | Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof | |
SE0302192D0 (sv) | Novel compounds | |
TW200639156A (en) | New compounds | |
WO2001078783A3 (en) | Compositions comprising natural agents for treatment of cancer | |
TW200630343A (en) | 2-Alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof | |
WO2006113495A3 (en) | Dicarboxylic acid ester derivatives of ginsenoside, pharmaceutical preparations containing the same, and preparation thereof | |
MY138923A (en) | Combination chemotherapy | |
WO2005016264A3 (en) | Diamine derivatives of quinone and uses thereof | |
WO2009045053A3 (en) | A cancer sensitizer comprising chlorogenic acid | |
ATE482922T1 (de) | Aloe-emodinderivate und deren verwendung in der behandlung von neoplasien | |
HK1167388A1 (en) | Anticancer compound and pharmaceutical composition containing the same | |
MX2010003594A (es) | Formas cristalinas de sal sodica de dmxaa. | |
TNSN06003A1 (en) | Saquinavir mesylate oral dosage form | |
IL163608A (en) | Sulfonanilides are conserved in their amino / amino acids and derivatives, their process, their pharmaceutical preparations, and their conjugated antibodies and their use in the preparation of drugs for the treatment of culture disorders | |
DE60206940D1 (de) | Pektin und ascorbinsäure enthaltende zusammensetzungen | |
GB2430365B (en) | High-purity texaphyrin metal complexes | |
WO2005032492A3 (en) | Site and rate selective prodrug formulations of d609 with antioxidant and anticancer activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170623 |