HK1089232A1 - Use of a midregional proadrenomedullin partial peptide in biological fluids in the production of immological diagnostic agents - Google Patents
Use of a midregional proadrenomedullin partial peptide in biological fluids in the production of immological diagnostic agentsInfo
- Publication number
- HK1089232A1 HK1089232A1 HK06109469.7A HK06109469A HK1089232A1 HK 1089232 A1 HK1089232 A1 HK 1089232A1 HK 06109469 A HK06109469 A HK 06109469A HK 1089232 A1 HK1089232 A1 HK 1089232A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- biological fluids
- partial peptide
- immological
- production
- diagnostic agents
- Prior art date
Links
- 239000013060 biological fluid Substances 0.000 title abstract 2
- 102000034567 proadrenomedullin Human genes 0.000 title abstract 2
- 108010012004 proadrenomedullin Proteins 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 102000004379 Adrenomedullin Human genes 0.000 abstract 1
- 101800004616 Adrenomedullin Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108010049361 preproadrenomedullin Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10316583A DE10316583A1 (de) | 2003-04-10 | 2003-04-10 | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| PCT/EP2004/000806 WO2004090546A1 (de) | 2003-04-10 | 2004-01-29 | Bestimmung eines midregionalen proadrenomedullin-teilpeptids in biologischen flüssigkeiten zu diagnostischen zwecken sowie immunoassays für die durchführung einer solchen bestimmung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1089232A1 true HK1089232A1 (en) | 2006-11-24 |
Family
ID=33038995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK06109469.7A HK1089232A1 (en) | 2003-04-10 | 2006-08-25 | Use of a midregional proadrenomedullin partial peptide in biological fluids in the production of immological diagnostic agents |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9885709B2 (xx) |
| EP (1) | EP1488209B1 (xx) |
| JP (2) | JP4602321B2 (xx) |
| CN (1) | CN1759319B (xx) |
| AT (1) | ATE312342T1 (xx) |
| DE (2) | DE10316583A1 (xx) |
| ES (1) | ES2250959T3 (xx) |
| HK (1) | HK1089232A1 (xx) |
| MX (1) | MXPA05010827A (xx) |
| WO (1) | WO2004090546A1 (xx) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| JP2007523844A (ja) * | 2003-04-25 | 2007-08-23 | ジェノバ・リミテッド | 心臓血管障害において減少する分泌ポリペプチド種 |
| DE102005036094A1 (de) * | 2005-08-01 | 2007-02-08 | B.R.A.H.M.S Ag | In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| JP4976412B2 (ja) * | 2005-12-01 | 2012-07-18 | ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー | エンドセリン、エンドセリンアゴニスト及びアドレノメジュリンアンタゴニストによる危篤患者の診断及び治療のための方法 |
| CA2633291A1 (en) * | 2005-12-15 | 2007-07-12 | Becton Dickinson And Company | Diagnosis of sepsis |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| EP4357783A2 (en) | 2006-04-04 | 2024-04-24 | Novilux, LLC | Highly sensitive system and methods for analysis of troponin |
| DE102006027818A1 (de) * | 2006-06-16 | 2007-12-20 | B.R.A.H.M.S. Aktiengesellschaft | In vitro Multiparameter-Bestimmungsverfahren zur Diagnose und Frühdiagnose von neurodegenerativen Erkrankungen |
| DE102006034142A1 (de) | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur Steuerung der Therapie von Patienten mit Herzinsuffizienz anhand der vitro Bestimmung von Schwellenwerten von vasoaktiven Peptiden |
| DE102006052916A1 (de) * | 2006-11-08 | 2008-05-15 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung von Diabetes mellitus mittels MR-proADM |
| US9012151B2 (en) * | 2006-11-09 | 2015-04-21 | B.R.A.H.M.S. Gmbh | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin |
| DE102006060112A1 (de) * | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102007009751A1 (de) | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| ATE533061T1 (de) * | 2007-08-03 | 2011-11-15 | Brahms Gmbh | Verfahren zur diagnose bakterieller infektionen |
| ES2552816T3 (es) * | 2008-02-01 | 2015-12-02 | B.R.A.H.M.S Gmbh | Procedimiento para identificar pacientes con trastornos cognitivos leves que necesitan terapia y tratamiento de pacientes de este tipo |
| DE102008007218A1 (de) | 2008-02-01 | 2009-08-06 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Indentifizierung von therapiebedürftigen Patienten und zur präventiven Behandlung derartiger Patienten mit leichten kognitiven Störungen |
| EP2108958A1 (en) | 2008-04-09 | 2009-10-14 | B.R.A.H.M.S. Aktiengesellschaft | Pro-Endothelin-1 for the prediction of impaired peak oxygen consumption |
| CN107085114B (zh) * | 2008-10-07 | 2021-05-25 | B.R.A.H.M.S有限公司 | 用于预测初次不利事件的生物标志物 |
| CN102317790B (zh) * | 2008-11-11 | 2014-12-10 | B.R.A.H.M.S有限公司 | Adm在制备用于评估心力衰竭和/或呼吸短促的制剂中的应用 |
| AU2010259022B2 (en) | 2009-06-08 | 2016-05-12 | Singulex, Inc. | Highly sensitive biomarker panels |
| CN102482343A (zh) | 2009-06-16 | 2012-05-30 | B.R.A.H.M.S有限公司 | 过氧化物氧还蛋白4的诊断应用 |
| WO2011157446A1 (en) * | 2010-06-18 | 2011-12-22 | B.R.A.H.M.S Gmbh | Biomarkers for the prediction of incident cancer |
| EP2541252A1 (en) | 2011-06-30 | 2013-01-02 | B.R.A.H.M.S GmbH | Method of obtaining a binder to prepro-vasopressin or fragments thereof |
| US9402900B2 (en) * | 2011-11-16 | 2016-08-02 | Adrenomed Ag | Methods of modulating adrenomedullin by administering an anti-adrenomedullin (ADM) antibody |
| AU2012338731B2 (en) | 2011-11-16 | 2017-07-06 | Adrenomed Ag | Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
| US11067586B2 (en) | 2011-11-16 | 2021-07-20 | Sphingotec Gmbh | Adrenomedullin assays and methods for determining mature adrenomedullin |
| ES2494191T3 (es) * | 2011-11-16 | 2014-09-15 | Adrenomed Ag | Anticuerpo anti-adrenomedulina (ADM) o fragmento de anticuerpo anti-ADM o andamiaje proteico sin Ig anti-ADM para su utilización en tratamientos |
| EP2780371B1 (en) | 2011-11-16 | 2018-10-24 | AdrenoMed AG | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
| MY174877A (en) | 2011-11-16 | 2020-05-20 | Adrenomed Ag | Anti-adrenomedullin (adm) antibpdy or anti-adm antibody fragment of anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic of acute disease or acute condition |
| AU2012338730B2 (en) | 2011-11-16 | 2017-07-06 | Adrenomed Ag | Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition |
| EP2657707A1 (en) * | 2012-04-26 | 2013-10-30 | B.R.A.H.M.S GmbH | Biomakers for the diagnosis, prognosis, assessment and therapy stratification syncope |
| US10598674B2 (en) * | 2013-03-20 | 2020-03-24 | Sphingotec Gmbh | Adrenomedullin to guide therapy of blood pressure decline |
| CN107250799B (zh) | 2015-02-10 | 2019-09-10 | B.R.A.H.M.S 有限公司 | 作为生物标志物的游离组蛋白 |
| JP6944449B2 (ja) * | 2015-11-27 | 2021-10-06 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 対象の細胞外液量状態のマーカーとしてのＭＲ−ｐｒｏＡＤＭ |
| AU2017375049A1 (en) | 2016-12-16 | 2019-06-13 | Adrenomed Ag | Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
| EP3339324A1 (en) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
| EP3438668A1 (en) | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnosis and risk stratification of fungal infections |
| JP7291688B2 (ja) * | 2017-09-13 | 2023-06-15 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 重篤患者における腎置換療法のための指標としてのアドレノメズリン前駆体 |
| CN111094987B (zh) * | 2017-09-13 | 2023-10-31 | B.R.A.H.M.S有限公司 | 作为异常血小板水平的标志物的肾上腺髓质素原 |
| CN111065927B (zh) * | 2017-09-13 | 2023-10-17 | B.R.A.H.M.S有限公司 | 作为危重患者的治疗监测标记物的pro-adm |
| JP2021500548A (ja) * | 2017-10-18 | 2021-01-07 | アドレノメト アクチェンゲゼルシャフト | 抗アドレノメデュリン（ａｄｍ）結合剤での処置下での治療モニタリング |
| EP3502706A1 (en) | 2017-12-20 | 2019-06-26 | B.R.A.H.M.S GmbH | Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin |
| EP3608673A1 (en) * | 2018-08-08 | 2020-02-12 | B.R.A.H.M.S GmbH | Pro-adm for prognosing the risk of a medical condition requiring hospitalization in patients with symptoms of infectious disease |
| CN109613247A (zh) * | 2018-12-22 | 2019-04-12 | 郑州安图生物工程股份有限公司 | 用于检测组织多肽特异性抗原的试剂盒 |
| JP7407516B2 (ja) * | 2019-03-26 | 2024-01-04 | 森永乳業株式会社 | 抗原ペプチド検出方法 |
| EP3715851A1 (en) | 2019-03-29 | 2020-09-30 | B.R.A.H.M.S GmbH | Prescription of remote patient management based on biomarkers |
| CA3124744A1 (en) | 2019-03-29 | 2020-10-08 | B.R.A.H.M.S Gmbh | Prescription of remote patient management based on biomarkers |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
| GB9211686D0 (en) * | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| DE4227454C1 (de) | 1992-08-19 | 1994-02-03 | Henning Berlin Gmbh | Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens |
| JP2774769B2 (ja) | 1993-04-26 | 1998-07-09 | 賢治 寒川 | アドレノメデュリン |
| NO319913B1 (no) * | 1994-12-09 | 2005-10-03 | Shionogi & Co | Fremgangsmate til sandwichimmunoassay for N-peptid |
| FR2735238B1 (fr) * | 1995-06-09 | 1997-09-05 | Cis Bio Int | Utilisation d'un complexe phycobiliproteine-peptide de liaison en tant que traceur fluorescent |
| US6440421B1 (en) * | 1996-04-18 | 2002-08-27 | Auchkland Uniservices Limited | Treatment of bone disorders with adrenomedullin or adrenomedullin agonists |
| DE19847690A1 (de) * | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
| US6849714B1 (en) * | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6887470B1 (en) * | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| CA2373680C (en) * | 1999-05-17 | 2008-07-29 | Conjuchem Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| JP2001011097A (ja) * | 1999-06-29 | 2001-01-16 | Fujirebio Inc | ヒトα１−６フコース転移酵素を認識する抗体、該抗体を用いた免疫測定方法及び試薬 |
| US6579851B2 (en) * | 2000-03-14 | 2003-06-17 | Amylin Pharmaceuticals, Inc. | Effects of glucagon-like peptide-1 (7-36) on antro-pyloro-duodenal motility |
| DE10035706C2 (de) * | 2000-07-21 | 2002-11-07 | Brahms Ag | Verfahren zur selektiven Bestimmung von blockierenden Autoantikörpern gegen den TSH-Rezeptor |
| EP1379872A2 (en) * | 2001-02-28 | 2004-01-14 | McGILL UNIVERSITY | Use of metabolic phenotyping in individualized treatment with amonafide |
| US6884575B2 (en) * | 2001-03-30 | 2005-04-26 | Protemix Corporation Limited | Phosphoprotein target for insulin and its antagonists |
| JP2002306164A (ja) * | 2001-04-10 | 2002-10-22 | National Institute Of Infectious Diseases | エボラウイルスを認識するモノクローナル抗体 |
| US7361473B2 (en) * | 2001-05-04 | 2008-04-22 | Biosite, Incorporated | Diagnostic markers of acute coronary syndrome and methods of use thereof |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| JP2007523844A (ja) * | 2003-04-25 | 2007-08-23 | ジェノバ・リミテッド | 心臓血管障害において減少する分泌ポリペプチド種 |
| DE102005036094A1 (de) * | 2005-08-01 | 2007-02-08 | B.R.A.H.M.S Ag | In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen |
| DE102006027818A1 (de) * | 2006-06-16 | 2007-12-20 | B.R.A.H.M.S. Aktiengesellschaft | In vitro Multiparameter-Bestimmungsverfahren zur Diagnose und Frühdiagnose von neurodegenerativen Erkrankungen |
| DE102006034142A1 (de) * | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur Steuerung der Therapie von Patienten mit Herzinsuffizienz anhand der vitro Bestimmung von Schwellenwerten von vasoaktiven Peptiden |
| US9012151B2 (en) * | 2006-11-09 | 2015-04-21 | B.R.A.H.M.S. Gmbh | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin |
| EP2131200A1 (en) * | 2008-06-04 | 2009-12-09 | BRAHMS Aktiengesellschaft | A marker for graft failure and mortality |
| EP2180322A1 (en) * | 2008-10-22 | 2010-04-28 | BRAHMS Aktiengesellschaft | Prognostic biomarkers for the progression of primary chronic kidney disease |
| WO2010046136A1 (en) * | 2008-10-24 | 2010-04-29 | B.R.A.H.M.S. Ag | Prognosis and risk assessment in stroke patients by determining the level of marker peptides |
| ES2772930T3 (es) * | 2008-10-31 | 2020-07-08 | Brahms Gmbh | Prohormona arginina vasopresina como biomarcador predictivo para la diabetes |
| EP2427764B1 (en) * | 2009-05-05 | 2017-07-26 | B.R.A.H.M.S GmbH | Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction |
| EP2438447B1 (en) * | 2009-06-05 | 2015-02-18 | B.R.A.H.M.S GmbH | Detection of bacterial infections in subjects suffering from dyspnea. |
-
2003
- 2003-04-10 DE DE10316583A patent/DE10316583A1/de not_active Withdrawn
-
2004
- 2004-01-29 US US10/551,298 patent/US9885709B2/en active Active
- 2004-01-29 MX MXPA05010827A patent/MXPA05010827A/es active IP Right Grant
- 2004-01-29 CN CN2004800063452A patent/CN1759319B/zh not_active Expired - Lifetime
- 2004-01-29 AT AT04700013T patent/ATE312342T1/de active
- 2004-01-29 ES ES04700013T patent/ES2250959T3/es not_active Expired - Lifetime
- 2004-01-29 EP EP04700013A patent/EP1488209B1/de not_active Expired - Lifetime
- 2004-01-29 JP JP2006504400A patent/JP4602321B2/ja not_active Expired - Lifetime
- 2004-01-29 WO PCT/EP2004/000806 patent/WO2004090546A1/de active IP Right Grant
- 2004-01-29 DE DE502004000166T patent/DE502004000166D1/de not_active Expired - Lifetime
-
2006
- 2006-08-25 HK HK06109469.7A patent/HK1089232A1/xx not_active IP Right Cessation
-
2010
- 2010-06-02 JP JP2010127350A patent/JP5021791B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-07 US US14/324,620 patent/US9541549B2/en not_active Expired - Lifetime
-
2018
- 2018-01-12 US US15/869,691 patent/US20180143190A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006523302A (ja) | 2006-10-12 |
| US20070212742A1 (en) | 2007-09-13 |
| EP1488209A1 (de) | 2004-12-22 |
| ES2250959T3 (es) | 2006-04-16 |
| JP4602321B2 (ja) | 2010-12-22 |
| DE10316583A1 (de) | 2004-10-28 |
| CN1759319B (zh) | 2011-08-10 |
| US20140322822A1 (en) | 2014-10-30 |
| US20180143190A1 (en) | 2018-05-24 |
| CN1759319A (zh) | 2006-04-12 |
| DE502004000166D1 (de) | 2006-01-12 |
| JP5021791B2 (ja) | 2012-09-12 |
| US9541549B2 (en) | 2017-01-10 |
| WO2004090546A1 (de) | 2004-10-21 |
| JP2010210644A (ja) | 2010-09-24 |
| ATE312342T1 (de) | 2005-12-15 |
| EP1488209B1 (de) | 2005-12-07 |
| MXPA05010827A (es) | 2006-03-09 |
| US9885709B2 (en) | 2018-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1089232A1 (en) | Use of a midregional proadrenomedullin partial peptide in biological fluids in the production of immological diagnostic agents | |
| HK1099807A1 (en) | Method for detecting the formation of endothelins for medical diagnosis, and antibodies and kits for carrying out one such method | |
| FI3718564T3 (fi) | Uusia anti-IL 13 -vasta-aineita ja niiden käyttöjä | |
| CA2497418A1 (en) | A method for diagnosing cancer by detecting gpc3 | |
| ES2346550T3 (es) | Determinacion de probnp felino o canino. | |
| MX337991B (es) | Metodo para detectar cancer. | |
| HK1078096A1 (en) | Assay and reagents for quantifying hbnp | |
| EP1625163B8 (en) | Method of detecting probnp with a monoclonal antibody binding to the amino acids 38-43 | |
| EP1571160A4 (en) | KIT FOR THE STUDY OF HUMAN LOW MOLECULAR WEIGHT CD14 AND ANTIBODIES | |
| EP1708745A4 (en) | ANTIBODIES FOR ONCOGEN STRAINS OF HPV AND METHODS OF USE | |
| ATE335763T1 (de) | Sandwich-immunoassay zur bestimmung von proanp- teilpeptiden | |
| WO2003016907A1 (fr) | Reactif de dosage pour antigene de la laminine 5 dans un echantillon biologique et procede de dosage | |
| WO2003027149A1 (fr) | Anticorps et utilisation de ce dernier | |
| WO2001075449A1 (fr) | Technique d'investigation du cancer par epreuve biologique d'un autoanticorps contre mdm2 et reactif | |
| CA2366523A1 (en) | Method for analyzing the amount of intraabdominal adipose tissue | |
| BRPI0408067A (pt) | disgnóstico de autismo | |
| WO2009044561A1 (ja) | 抗ｐｒｏＮＴ／ＮＭＮモノクローナル抗体 | |
| ATE481644T1 (de) | Prognose des verlaufs einer krebserkrankung | |
| EP1636587A4 (en) | DIAGNOSTIC KIT FOR LIVER CIRRHOSIS COMPRISING A SPECIFIC ANTIBODY OF A HUMAN PROTO-ONCOGEN PROTEIN | |
| AU3118300A (en) | Cartilage resorption assays | |
| SE9804069D0 (sv) | Test kit and method of diagnosing acute pancreatitis | |
| CA2588614A1 (en) | Method for analyzing the amount of intraabdominal adipose tissue | |
| Hušek et al. | Tracking a new biomarker of bone resorption | |
| JP2003315330A (ja) | 測定試薬 | |
| UA51131A (uk) | Спосіб діагностики аутоімунних захворювань печінки |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE | Patent expired |
Effective date: 20240128 |