HK1086573A1 - Quinazoline derivatives for treatment of cancer - Google Patents

Quinazoline derivatives for treatment of cancer

Info

Publication number
HK1086573A1
HK1086573A1 HK06106582A HK06106582A HK1086573A1 HK 1086573 A1 HK1086573 A1 HK 1086573A1 HK 06106582 A HK06106582 A HK 06106582A HK 06106582 A HK06106582 A HK 06106582A HK 1086573 A1 HK1086573 A1 HK 1086573A1
Authority
HK
Hong Kong
Prior art keywords
cancer
treatment
quinazoline derivatives
quinazoline
derivatives
Prior art date
Application number
HK06106582A
Other languages
English (en)
Inventor
Heron Nicola Murdoch
Pasquet Georges Rene
Mortlock Andrew Austen
Jung Frederic Henri
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1086573A1 publication Critical patent/HK1086573A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK06106582A 2003-04-16 2006-06-08 Quinazoline derivatives for treatment of cancer HK1086573A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03290951 2003-04-16
PCT/GB2004/001614 WO2004094410A1 (en) 2003-04-16 2004-04-14 Chemical compounds

Publications (1)

Publication Number Publication Date
HK1086573A1 true HK1086573A1 (en) 2006-09-22

Family

ID=33305809

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06106582A HK1086573A1 (en) 2003-04-16 2006-06-08 Quinazoline derivatives for treatment of cancer

Country Status (23)

Country Link
US (1) US7691867B2 (ko)
EP (1) EP1613619B1 (ko)
JP (1) JP4709139B2 (ko)
KR (1) KR20060003351A (ko)
CN (1) CN1809557B (ko)
AR (1) AR043875A1 (ko)
AT (1) ATE390422T1 (ko)
AU (1) AU2004232527A1 (ko)
BR (1) BRPI0409427A (ko)
CA (1) CA2522079A1 (ko)
CL (1) CL2004000797A1 (ko)
CO (1) CO5640037A2 (ko)
DE (1) DE602004012725T2 (ko)
ES (1) ES2301981T3 (ko)
HK (1) HK1086573A1 (ko)
IS (1) IS8125A (ko)
MX (1) MXPA05011076A (ko)
NO (1) NO20054842L (ko)
RU (1) RU2005135337A (ko)
TW (1) TW200510392A (ko)
UY (1) UY28271A1 (ko)
WO (1) WO2004094410A1 (ko)
ZA (1) ZA200508372B (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162541A0 (en) * 2001-12-24 2005-11-20 Astrazeneca Ab Substituted quinazoline derivatives as inhibitors of aurora kinases
ES2290529T3 (es) * 2002-12-24 2008-02-16 Astrazeneca Ab Derivados de fosfonooxiquinazolina y su uso farmaceutico.
ES2308182T3 (es) * 2003-06-02 2008-12-01 Astrazeneca Ab Derivadosde (3-((quinazolin-4-il)amino)-1h-pirazol-1-il)acetamida y compuestos relacionados como inhibidores de quinasas aurora para el tratamiento de enfermedades proliferativas tales como el cancer.
DK1746999T3 (da) 2004-05-06 2012-01-23 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amider
CN101072758B (zh) 2004-10-12 2013-07-31 阿斯利康(瑞典)有限公司 喹唑啉衍生物
JP2008515961A (ja) * 2004-10-12 2008-05-15 アストラゼネカ アクチボラグ 癌に対する使用のためのキナゾリン誘導体
WO2006040522A1 (en) * 2004-10-12 2006-04-20 Astrazeneca Ab Quinoline derivatives
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP1819698B1 (en) 2004-11-17 2011-02-23 Rexahn Pharmaceuticals, Inc. 1-[(6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
GB0510963D0 (en) * 2005-05-28 2005-07-06 Astrazeneca Ab Chemical compounds
WO2006129064A1 (en) * 2005-05-28 2006-12-07 Astrazeneca Ab Quinazolines and their use as aurora kinase inhibitors
EP1931639A2 (en) * 2005-09-22 2008-06-18 Astra Zeneca AB Process
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
GB0601215D0 (en) * 2006-01-21 2006-03-01 Astrazeneca Ab Chemical compounds
JP2009528335A (ja) * 2006-03-02 2009-08-06 アストラゼネカ アクチボラグ キナゾリン誘導体
UY30183A1 (es) 2006-03-02 2007-10-31 Astrazeneca Ab Derivados de quinolina
WO2007113565A1 (en) * 2006-04-06 2007-10-11 Astrazeneca Ab Naphthyridine derivatives as anti-cancer agents
GB0609617D0 (en) 2006-05-16 2006-06-21 Astrazeneca Ab Process & intermediate
US20100120717A1 (en) 2006-10-09 2010-05-13 Brown Jason W Kinase inhibitors
FR2908409B1 (fr) 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
TWI577671B (zh) * 2011-11-14 2017-04-11 Sunshine Lake Pharma Co Ltd Aminoquinazoline derivatives and salts thereof and methods of use thereof
CN103012428A (zh) 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
CN104098551B (zh) * 2013-04-03 2019-03-22 广东东阳光药业有限公司 作为欧若拉激酶抑制剂的取代喹唑啉类衍生物
CN103382158B (zh) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 一种2-环戊基氨基乙醇的制备方法
BR112016005317A2 (pt) 2013-09-19 2017-09-12 Centre Nat Rech Scient derivados de quinazolina e seu uso como inibidores de dna metiltransferase

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
TW321649B (ko) * 1994-11-12 1997-12-01 Zeneca Ltd
AU7340096A (en) * 1995-11-07 1997-05-29 Kirin Beer Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
RU2002110461A (ru) * 1999-09-21 2004-03-10 Астразенека Аб (Se) Производные хиназолина и их применение в качестве фармацевтических веществ
GB9922171D0 (en) * 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
PL360439A1 (en) 2000-06-28 2004-09-06 Astrazeneca Ab Substituted quinazoline derivatives and their use as inhibitors
IL162541A0 (en) 2001-12-24 2005-11-20 Astrazeneca Ab Substituted quinazoline derivatives as inhibitors of aurora kinases
AU2003257666A1 (en) * 2002-08-23 2004-03-11 Kirin Beer Kabushiki Kaisha COMPOUND HAVING TGFss INHIBITORY ACTIVITY AND MEDICINAL COMPOSITION CONTAINING THE SAME
CA2508921A1 (en) * 2002-12-24 2004-07-15 Astrazeneca Ab Quinazoline compounds
ES2290529T3 (es) * 2002-12-24 2008-02-16 Astrazeneca Ab Derivados de fosfonooxiquinazolina y su uso farmaceutico.
US20060058325A1 (en) 2002-12-24 2006-03-16 Astrazeneca Ab Therapeutic quniazoline derivatives
ES2308182T3 (es) * 2003-06-02 2008-12-01 Astrazeneca Ab Derivadosde (3-((quinazolin-4-il)amino)-1h-pirazol-1-il)acetamida y compuestos relacionados como inhibidores de quinasas aurora para el tratamiento de enfermedades proliferativas tales como el cancer.
TW200505452A (en) * 2003-06-17 2005-02-16 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
EP1613619B1 (en) 2008-03-26
NO20054842L (no) 2005-11-08
US20060270692A1 (en) 2006-11-30
ATE390422T1 (de) 2008-04-15
MXPA05011076A (es) 2006-01-24
CO5640037A2 (es) 2006-05-31
DE602004012725D1 (de) 2008-05-08
US7691867B2 (en) 2010-04-06
JP4709139B2 (ja) 2011-06-22
IS8125A (is) 2005-11-11
WO2004094410A1 (en) 2004-11-04
CN1809557A (zh) 2006-07-26
ZA200508372B (en) 2007-04-25
CA2522079A1 (en) 2004-11-04
ES2301981T3 (es) 2008-07-01
EP1613619A1 (en) 2006-01-11
CN1809557B (zh) 2012-07-04
JP2006523660A (ja) 2006-10-19
UY28271A1 (es) 2004-11-30
KR20060003351A (ko) 2006-01-10
DE602004012725T2 (de) 2009-04-16
RU2005135337A (ru) 2006-06-10
BRPI0409427A (pt) 2006-04-18
AR043875A1 (es) 2005-08-17
TW200510392A (en) 2005-03-16
CL2004000797A1 (es) 2005-05-27
AU2004232527A1 (en) 2004-11-04

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130414