HK1079980B - Composition for chemoembolotherapy of solid tumors - Google Patents

Composition for chemoembolotherapy of solid tumors Download PDF

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Publication number
HK1079980B
HK1079980B HK05112166.8A HK05112166A HK1079980B HK 1079980 B HK1079980 B HK 1079980B HK 05112166 A HK05112166 A HK 05112166A HK 1079980 B HK1079980 B HK 1079980B
Authority
HK
Hong Kong
Prior art keywords
composition according
particles
microspheres
water
polymer
Prior art date
Application number
HK05112166.8A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1079980A1 (en
Inventor
Andrew Lennard Lewis
Peter William Straford
Simon William Leppard
Brenda Hall
Maria Victoria Gonzalez Fajardo
Pedro Garcia
Original Assignee
Biocompatibles Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0305322A external-priority patent/GB0305322D0/en
Application filed by Biocompatibles Uk Limited filed Critical Biocompatibles Uk Limited
Publication of HK1079980A1 publication Critical patent/HK1079980A1/en
Publication of HK1079980B publication Critical patent/HK1079980B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/14—Organic medium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/48—Isomerisation; Cyclisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
HK05112166.8A 2003-02-12 2004-02-12 Composition for chemoembolotherapy of solid tumors HK1079980B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03250868 2003-02-12
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation
GB0305322.0 2003-03-07
PCT/GB2004/000548 WO2004071495A1 (en) 2003-02-12 2004-02-12 Composition for chemoembolotherapy of solid tumors

Publications (2)

Publication Number Publication Date
HK1079980A1 HK1079980A1 (en) 2006-04-21
HK1079980B true HK1079980B (en) 2008-11-14

Family

ID=32870779

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05112166.8A HK1079980B (en) 2003-02-12 2004-02-12 Composition for chemoembolotherapy of solid tumors

Country Status (9)

Country Link
EP (1) EP1592405B1 (cg-RX-API-DMAC7.html)
JP (2) JP4895802B2 (cg-RX-API-DMAC7.html)
KR (1) KR101157260B1 (cg-RX-API-DMAC7.html)
CN (4) CN102895662B (cg-RX-API-DMAC7.html)
AT (1) ATE396708T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004014101D1 (cg-RX-API-DMAC7.html)
ES (1) ES2308149T3 (cg-RX-API-DMAC7.html)
HK (1) HK1079980B (cg-RX-API-DMAC7.html)
WO (1) WO2004071495A1 (cg-RX-API-DMAC7.html)

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EP1820495B1 (en) 2000-03-24 2017-03-01 Biosphere Medical, Inc. Microspheres for active embolization
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
ES2361919T3 (es) * 2004-09-07 2011-06-24 Biocompatibles Uk Limited Suministro de fármaco a partir de agentes embólicos.
BRPI0608766A8 (pt) 2005-05-09 2018-04-17 Biosphere Medical Sa microsfera substancialmente esférica, composição, e, métodos para administração de medicamento e para embolização ativa em um mamífero
US20080305176A1 (en) * 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US9107833B2 (en) 2006-06-22 2015-08-18 Biocompatibles Uk Limited Rehydratable pharmaceutical product
EP1985286A1 (en) 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
US8940334B2 (en) 2007-05-11 2015-01-27 Nerviano Medical Sciences S.R.L. Pharmaceutical composition of an anthracycline
ES2706023T3 (es) * 2007-08-16 2019-03-27 Biocompatibles Uk Ltd Administración de combinaciones de fármacos
CN105999297A (zh) 2008-12-02 2016-10-12 生物相容英国有限公司 胰腺肿瘤治疗
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
US20150224221A1 (en) 2012-08-31 2015-08-13 Chung-Ang University Industry-Academic Cooperation Foundation Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound
CA2906574C (en) 2013-03-15 2021-08-31 Matthew R. Dreher Imageable embolic microsphere
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
CN107530157B (zh) 2015-03-02 2020-11-10 阿克瑞特医学治疗有限公司 用于改变悬浮液并将悬浮液输送到个体的具有侧开口的导管
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
CN115137870B (zh) 2016-03-14 2024-05-10 生物相容性英国公司 包含颗粒的乳液
PL3451942T3 (pl) 2016-05-04 2021-07-26 Accurate Medical Therapeutics Ltd. Głowica mikrocewnika embolizacyjnego mająca wzór szczelinowy
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
WO2019014408A1 (en) * 2017-07-13 2019-01-17 Boston Scientific Scimed, Inc. EMBOLIC MICROSPHERES
EP3703583B1 (en) 2017-11-02 2025-10-15 Accurate Medical Therapeutics Ltd. Embolization catheter with integral filter
EP3814387A2 (en) 2018-06-29 2021-05-05 Biocompatibles UK Limited Radiopaque polymers
CN113727699A (zh) 2019-03-22 2021-11-30 生物相容英国有限公司 栓塞微球和方法
US12433600B2 (en) 2019-05-23 2025-10-07 Argon Medical Devices, Inc. Embolization catheter for reflux free delivery of microspheres
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
TW202140057A (zh) * 2020-02-25 2021-11-01 美商希皮恩製藥公司 環孢素類似物於治療癌症之用途
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
AU2022422129B2 (en) 2021-12-23 2025-10-23 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them

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US4978713A (en) * 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom
JP3041627B2 (ja) * 1989-04-13 2000-05-15 武田薬品工業株式会社 アントラサイクリン系抗生物質の安定組成物
JPH06329542A (ja) * 1993-05-21 1994-11-29 Kibun Food Chemifa Co Ltd 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物
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AU8877098A (en) * 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
ATE373682T1 (de) * 2000-03-13 2007-10-15 Biocure Inc Embolische zusammensetzungen
AU2001292092A1 (en) * 2000-10-06 2002-04-15 Biocompatibles Uk Limited Zwitterionic polymers
US20060165804A1 (en) * 2002-09-25 2006-07-27 Lewis Andrew L Polymer compositions for administration to animals

Also Published As

Publication number Publication date
JP2011178784A (ja) 2011-09-15
CN103393605A (zh) 2013-11-20
CN106267325A (zh) 2017-01-04
EP1592405A1 (en) 2005-11-09
WO2004071495A1 (en) 2004-08-26
CN106267325B (zh) 2019-09-24
DE602004014101D1 (de) 2008-07-10
ES2308149T3 (es) 2008-12-01
JP2006515358A (ja) 2006-05-25
CN102895662B (zh) 2017-09-12
CN102895662A (zh) 2013-01-30
KR20050103224A (ko) 2005-10-27
CN103393605B (zh) 2018-05-29
CN103908704A (zh) 2014-07-09
JP4895802B2 (ja) 2012-03-14
EP1592405B1 (en) 2008-05-28
HK1079980A1 (en) 2006-04-21
CN103908704B (zh) 2017-09-01
KR101157260B1 (ko) 2012-06-15
JP5616251B2 (ja) 2014-10-29
ATE396708T1 (de) 2008-06-15

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Effective date: 20230217