HK1071313A1 - Preventing and/or treating cardiovascular disease and/or associated heart failure - Google Patents

Preventing and/or treating cardiovascular disease and/or associated heart failure

Info

Publication number
HK1071313A1
HK1071313A1 HK05104473.3A HK05104473A HK1071313A1 HK 1071313 A1 HK1071313 A1 HK 1071313A1 HK 05104473 A HK05104473 A HK 05104473A HK 1071313 A1 HK1071313 A1 HK 1071313A1
Authority
HK
Hong Kong
Prior art keywords
preventing
patient
heart failure
cardiovascular disease
treating cardiovascular
Prior art date
Application number
HK05104473.3A
Other languages
English (en)
Inventor
Garth James Smith Cooper
John Richard Baker
Original Assignee
Philera New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philera New Zealand Ltd filed Critical Philera New Zealand Ltd
Publication of HK1071313A1 publication Critical patent/HK1071313A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/30—Copper compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
HK05104473.3A 2002-03-08 2005-05-28 Preventing and/or treating cardiovascular disease and/or associated heart failure HK1071313A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ51772102 2002-03-08
NZ51772502 2002-03-11
US36438202P 2002-03-12 2002-03-12
PCT/NZ2003/000042 WO2003077901A1 (en) 2002-03-08 2003-03-10 Preventing and/or treating cardiovascular disease and/or associated heart failure

Publications (1)

Publication Number Publication Date
HK1071313A1 true HK1071313A1 (en) 2005-07-15

Family

ID=28046135

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05104473.3A HK1071313A1 (en) 2002-03-08 2005-05-28 Preventing and/or treating cardiovascular disease and/or associated heart failure

Country Status (11)

Country Link
US (4) US6951890B2 (xx)
EP (2) EP1487431B1 (xx)
JP (1) JP4860906B2 (xx)
CN (1) CN1649577A (xx)
AT (1) ATE555782T1 (xx)
AU (1) AU2003225442B2 (xx)
CA (1) CA2478997C (xx)
DK (2) DK1487431T3 (xx)
ES (1) ES2386782T3 (xx)
HK (1) HK1071313A1 (xx)
WO (1) WO2003077901A1 (xx)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018392A1 (en) 1998-09-25 2000-04-06 Glycox Corporation Limited Fructosamine oxidase: antagonists and inhibitors
JP2005504060A (ja) * 2001-08-24 2005-02-10 メイン・メデイカル・センター・リサーチ・インステイテユート 銅依存性の非伝統的前炎症性サイトカイン輸送およびそれに関連する方法、組成物およびキット
US20040038861A1 (en) * 2001-11-26 2004-02-26 Cooper Garth J. S. Methods and compositions for normalizing lipid levels in mammalian tissues
AU2003225442B2 (en) * 2002-03-08 2010-02-04 Philera New Zealand Limited Preventing and/or treating cardiovascular disease and/or associated heart failure
US20070248689A1 (en) * 2002-05-24 2007-10-25 Regents Of The University Of Michigan Copper lowering treatment of inflammatory and fibrotic diseases
CA2490541A1 (en) * 2002-05-24 2003-12-04 The Regents Of The University Of Michigan Copper lowering treatment of inflammatory and fibrotic diseases
US20040142393A1 (en) * 2002-08-01 2004-07-22 Cooper Garth James Smith Methods of use of compounds with preptin function
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
CA3011023A1 (en) * 2002-08-20 2004-03-04 Philera New Zealand Limited Composition comprising triethylenetramine salts for treating tissue damage
EP1694317A4 (en) * 2003-12-19 2010-05-12 Protemix Corp Ltd COPPER ANTAGONIST COMPOUNDS
CN101247793B (zh) 2003-12-29 2013-04-10 哈佛大学校长及研究员协会 治疗或预防肥胖和胰岛素抗性病症的组合物
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US7563460B2 (en) * 2004-02-26 2009-07-21 Med Five, Inc. Enteric coated oral pharmaceutical to erode kidney stones
US20060211752A1 (en) * 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
CA2875095C (en) 2004-07-19 2019-09-03 Philera New Zealand Limited Synthesis of triethylenetetramines
HU227588B1 (hu) * 2004-12-03 2011-09-28 Sinnex Mueszaki Fejlesztoe Es Tanacsado Kft Többszörösen telítetlen zsírsavak észtereit tartalmazó vírusellenes és immunstimuláns gyógyászati készítmény
WO2006104398A1 (en) * 2005-03-26 2006-10-05 Protemix Corporation Limited Copper antagonist compositions
WO2006104402A1 (en) * 2005-03-26 2006-10-05 Protemix Corporation Limited Copper antagonist compositions
US7687082B2 (en) * 2005-04-07 2010-03-30 Astrum Therapeutics Pty. Ltd. Complementary compositions to reduce blood glucose levels and treat diabetes
EP1877801A4 (en) * 2005-04-25 2009-03-18 Protemix Corp Ltd ANALYSIS AND THERAPY OF COPPER REGULATION
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
AU2006312407A1 (en) * 2005-11-09 2007-05-18 Philera New Zealand Limited Treatment of mitochondria-related diseases and improvement of age-related metabolic deficits
EP1993607A4 (en) * 2006-01-10 2012-03-28 Pipex Inc PHARMACEUTICAL COMPOSITIONS AND METHODS FOR OBTAINING AND MAINTAINING A TARGETABLE, STABLE COPPER RATE AND PREVENTING AND TREATING CENTRAL NERVOUS SYSTEM DISEASES RELATED TO SERIAL COPPER RATE
KR100821649B1 (ko) 2006-01-24 2008-04-11 서울시립대학교 산학협력단 클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제
DE602007006641D1 (de) * 2006-02-21 2010-07-01 Astrum Therapeutics Pty Ltd Zusammensetzungen zur verringerung des blutglukosespiegels und zur behandlung von diabetes
WO2007116243A2 (en) * 2006-04-10 2007-10-18 Mintails Limited Method for treating fibromyalgia and related conditions
CA2654020A1 (en) * 2006-06-01 2007-12-13 Burton E. Sobel Methods for inhibiting cardiac pai-1
KR100816798B1 (ko) * 2006-09-08 2008-03-25 (주)팜스웰 의약용 트리에틸렌테트라민 이염산염의 제조방법
WO2008111956A2 (en) * 2007-03-09 2008-09-18 Symcopeia Company Fatty acid oxidation inhibitors treating hyperglycemia and related disorders
US20100311092A1 (en) * 2007-11-30 2010-12-09 Kurland Irwin J Metabolic fuel switching biomarker
WO2010020959A1 (en) * 2008-08-21 2010-02-25 University Of Cape Town Resveratrol-containing composition for treating heart failure
US20100234906A1 (en) * 2009-03-16 2010-09-16 Pacesetter, Inc. System and method for controlling rate-adaptive pacing based on a cardiac force-frequency relation detected by an implantable medical device
JP5896375B2 (ja) 2011-09-09 2016-03-30 池田食研株式会社 改変型グルコース脱水素酵素遺伝子
WO2014145705A2 (en) 2013-03-15 2014-09-18 Battelle Memorial Institute Progression analytics system
WO2014152207A1 (en) 2013-03-15 2014-09-25 Mylan Laboratories, Inc. Hot melt granulation formulations of poorly water-soluble active agents
CZ307108B6 (cs) * 2013-09-06 2018-01-17 Vysoké Učení Technické V Brně Multifunkční poloprovozní jednotka pro snižování polutantů z odpadního plynu
EP2845640B1 (en) 2013-09-06 2018-10-24 Vysoké Ucení Technické V Brne Multifunction operation unit for reducing pollutant concentration in a waste gas
MX2017008959A (es) * 2015-01-07 2018-05-17 Nottingham Univ Hospitals Nhs Trust Biomarcadores relacionados con la funcion del riñon y metodos que involucran su uso.
WO2017049529A1 (en) * 2015-09-24 2017-03-30 Innolife Co., Ltd. A pharmaceutical composition comprising a copper chelating tetramine and the use thereof
US11865162B2 (en) 2016-07-01 2024-01-09 Marshall University Research Corporation Compositions and methods for treatment of uremic cardiomyopathy
CN107811997A (zh) * 2017-11-10 2018-03-20 大连医科大学附属第医院 蛋白酶体抑制剂白藜芦醇在预防和治疗心血管疾病中的应用
MA51919A1 (fr) 2018-05-04 2021-11-30 Orphalan Forme cristalline du tetrachlorhydrate de triethylenetetramine et utilisation pharmaceutique correspondante
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
EP3947433A4 (en) * 2019-04-02 2022-11-23 The Regents of The University of Michigan USE OF SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR LEVELS IN THE MANAGEMENT OF PATIENTS WITH CARDIOVASCULAR DISEASES
AU2020294694A1 (en) * 2019-06-17 2022-02-03 Philera New Zealand Ltd. Combination treatments for central nervous system disorders
CN112138024A (zh) * 2019-06-26 2020-12-29 里弗斯Pah有限责任公司 治疗严重形式的肺动脉高压的方法
CN110464717B (zh) * 2019-09-23 2022-02-18 张建国 一种2,4-二羟基苯甲酸在制备降低血糖的药物的应用
GB2612210A (en) * 2020-06-24 2023-04-26 Reverspah Llc Method of treating severe forms of pulmonary hypertension
CN115998955A (zh) * 2022-12-09 2023-04-25 首都医科大学附属北京安贞医院 一种静脉桥的醛铬复合交联方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3791988A (en) * 1972-03-23 1974-02-12 Hoffmann La Roche Diagnostic test for glucose
PL105793B1 (pl) 1977-11-24 1979-10-31 Sposob otrzymywania soli kwasow dwukarboksylowych i poliamin
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4323558A (en) * 1979-09-10 1982-04-06 Nelson Research & Development Co. Topical trien containing pharmaceutical compositions and methods of use
US4371374A (en) 1980-11-17 1983-02-01 The Rockefeller University Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine
JPS57144215A (en) * 1981-03-02 1982-09-06 Nippon Nousan Kogyo Kk Composition for improving lipometabolism
DE3217071A1 (de) 1982-05-06 1983-11-10 Rüdiger Dr. 6365 Rosbach Gröning Arzneimittel fuer die perorale applikation mit verbesserter biologischer verfuegbarkeit der wirkstoffe
US4665192A (en) 1984-03-19 1987-05-12 The Rockefeller University 2-(2-furoyl)-4(5)-2(furanyl)-1H-imidazole
US4758583A (en) * 1984-03-19 1988-07-19 The Rockefeller University Method and agents for inhibiting protein aging
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
EP0302065B1 (en) 1986-03-21 1994-08-10 Eurasiam Laboratories, Inc. Pharmaceutical compositions
CH667590A5 (it) 1986-07-24 1988-10-31 Inpharzam Int Sa Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. .
CH666814A5 (it) 1986-07-24 1988-08-31 Inpharzam Int Sa Composizione farmaceutica idrosolubile contenente n-acetil-cisteina.
US4866090A (en) * 1988-01-07 1989-09-12 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
EP0331014A3 (de) 1988-03-02 1991-10-23 THERA - Patent Verwaltungs-GmbH Verwendung von ACE-Inhibitoren für die Diabetesprophylaxe
JPH01294631A (ja) * 1988-05-19 1989-11-28 Sanwa Kagaku Kenkyusho Co Ltd 糖尿性疾患治療予防剤及び飲食、し好物
US5077313A (en) * 1988-11-25 1991-12-31 Gert Lubec Process for inhibiting pathological collagen cross-linking in diabetes patients
CA2026686A1 (en) 1989-10-30 1991-05-01 Werner Tschollar Method for preventing onset of type ii diabetes employing an ace inhibitor
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
EP0615458B1 (en) * 1991-12-06 1997-08-06 North Shore University Hospital Research Corporation Method of reducing medical device related infections
US5246970A (en) * 1991-12-16 1993-09-21 Washington University Method of inhibiting nitric oxide formation
JP3157622B2 (ja) 1992-06-05 2001-04-16 株式会社ミツカングループ本社 フルクトシルアミンデグリカーゼ、その製造法及び該酵素を用いたアマドリ化合物の定量方法
JPH06298738A (ja) * 1993-04-15 1994-10-25 Yamanouchi Pharmaceut Co Ltd ５−アミノピラゾール誘導体
JPH07118148A (ja) 1993-10-26 1995-05-09 Tsumura & Co 肝癌予防剤
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
WO1995017900A1 (en) 1993-12-30 1995-07-06 Arcturus Pharmaceutical Corporation Methods for the treatment of the central nervous system or eye involving pathogenic oxidation pathways
US5854271A (en) * 1994-05-02 1998-12-29 Cytos Pharmaceuticals, L.L.C. Effective method for the amelioration and prevention of tissue and cellular damage
WO1996012483A1 (en) 1994-10-25 1996-05-02 Washington University Method of inhibiting nitric oxide formation
AU716005B2 (en) * 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
JP3988838B2 (ja) * 1996-05-29 2007-10-10 日本製粉株式会社 化粧料
US5906996A (en) * 1996-08-21 1999-05-25 Murphy; Michael A. Tetramine treatment of neurological disorders
CA2284170C (en) 1997-03-11 2008-12-02 The General Hospital Corporation Identification of agents for use in the treatment of alzheimer's disease
JPH10324629A (ja) * 1997-03-28 1998-12-08 Otsuka Pharmaceut Co Ltd Ａｇｅ生成阻害組成物
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US6576672B1 (en) * 1998-08-21 2003-06-10 Michael A. Murphy Polyamine treatment of neurological disorders
US20030013772A1 (en) * 2000-02-23 2003-01-16 Murphy Michael A. Composition, synthesis and therapeutic applications of polyamines
US20050085555A1 (en) * 1997-08-21 2005-04-21 Murphy Michael A. Composition, synthesis and therapeutic applications of polyamines
US5980914A (en) * 1997-08-22 1999-11-09 P.N. Gerolymatos S.A. Clioquinol for the treatment of Parkinson's disease
US6821954B2 (en) * 1997-09-18 2004-11-23 Auckland Uniservices Limited Compounds and uses thereof in treating bone disorders
US5972985A (en) * 1997-11-03 1999-10-26 Cytos Pharmaceuticals, Llc Histidine containing nutriceutical compositions
WO1999039712A1 (en) 1998-02-04 1999-08-12 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
US6323218B1 (en) 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
US6147070A (en) * 1998-06-05 2000-11-14 Facchini; Francesco Methods and compositions for controlling iron stores to treat and cure disease states
EP1234585A3 (en) 1998-09-04 2004-01-21 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
WO2000018392A1 (en) * 1998-09-25 2000-04-06 Glycox Corporation Limited Fructosamine oxidase: antagonists and inhibitors
AU772616B2 (en) * 1998-09-25 2004-05-06 Protemix Corporation Limited Fructosamine oxidase assay: methods and materials
JP2000204037A (ja) 1999-01-12 2000-07-25 Tsumura & Co 筋萎縮性側索硬化症治療薬
US6309380B1 (en) * 1999-01-27 2001-10-30 Marian L. Larson Drug delivery via conformal film
US20030166561A1 (en) * 1999-06-18 2003-09-04 Cooper Garth J. S. Peptide
US20030050434A1 (en) * 1999-06-18 2003-03-13 Cooper Garth J.S. Peptide
AU759203B2 (en) 1999-06-18 2003-04-10 Protemix Discovery Limited Peptide having preptin functionality
WO2001085892A1 (en) * 2000-05-11 2001-11-15 The Procter & Gamble Company Highly concentrated fabric softener compositions and articles containing such compositions
US7754765B2 (en) * 2000-12-01 2010-07-13 Radical Vision Therapeutics Inc Copper chelators for treating ocular inflammation
DE60132494T2 (de) * 2000-12-01 2008-12-24 Radical Vision Therapeutics Inc. Kupferchelatbildner zur behandlung von augenentzündungen
NZ528509A (en) 2001-03-30 2005-09-30 Protemix Discovery Ltd Phosphoprotein target for insulin and its antagonists
WO2003002732A1 (en) 2001-06-27 2003-01-09 Biovitrum Ab Citrate lyase poly peptides
WO2003007686A2 (en) * 2001-07-19 2003-01-30 Dmi Biosciences, Inc. Use of copper chelators to inhibit the inactivation of protein c
US20040038861A1 (en) * 2001-11-26 2004-02-26 Cooper Garth J. S. Methods and compositions for normalizing lipid levels in mammalian tissues
AU2002356469A1 (en) 2001-11-26 2003-06-10 Protemix Corp Ltd Methods of compositions for normalizing lipid levels in mammalian tissues
AU2003207441A1 (en) 2002-01-03 2003-07-24 Duke University Methods of modulating localization and physiological function of ip3 receptors
CN1886423A (zh) * 2002-01-18 2006-12-27 普罗特米克斯公司 脂联素的糖基同工型及其用途
WO2003062404A1 (en) * 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
EP1565172A2 (en) 2002-01-29 2005-08-24 Protemix Corporation Limited Suppression of cytotoxic protein conformers
EP1487874A4 (en) 2002-03-01 2007-08-29 Protemix Discovery Ltd FALP PROTEINS
WO2003075910A1 (en) * 2002-03-08 2003-09-18 Protemix Corporation Limited Preventing and/or treating vascular disease, cardiomyopathy and/or associated heart failure
AU2003225442B2 (en) * 2002-03-08 2010-02-04 Philera New Zealand Limited Preventing and/or treating cardiovascular disease and/or associated heart failure
CA2480987C (en) 2002-04-03 2011-06-14 Puleva Biotech, S.A. Natural products and derivatives thereof for protection against neurodegenerative diseases
WO2003093311A1 (en) 2002-04-29 2003-11-13 Protemix Corporation Limited Proteins with deglycating activities and methods of using same
CA2490541A1 (en) 2002-05-24 2003-12-04 The Regents Of The University Of Michigan Copper lowering treatment of inflammatory and fibrotic diseases
JP2003343552A (ja) * 2002-05-27 2003-12-03 Koyo Seiko Co Ltd 円錐ころ軸受
GEP20074270B (en) * 2002-07-23 2007-12-25 Univ Michigan Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
US7189865B2 (en) * 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
US20040142393A1 (en) * 2002-08-01 2004-07-22 Cooper Garth James Smith Methods of use of compounds with preptin function
AU2003281842A1 (en) 2002-08-01 2004-02-23 Auckland Uniservices Limited Preptin methods of use
JP2006500341A (ja) 2002-08-01 2006-01-05 プロテミックス コーポレイション リミティド プレプチン機能を有する化合物の使用方法
CA3011023A1 (en) 2002-08-20 2004-03-04 Philera New Zealand Limited Composition comprising triethylenetramine salts for treating tissue damage
AU2003214725A1 (en) 2002-08-20 2004-03-11 Protemix Corporation Limited Preventing and/or treating cardiovascular disease and/or associated heart failure
WO2004056861A2 (en) 2002-12-23 2004-07-08 Protemix Corporation Limited Glycoisoforms of adiponectin and uses thereof
US20050031651A1 (en) * 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US20070185072A1 (en) 2003-03-21 2007-08-09 Christophe Boldron Nitrogeneous polycyclic derivatives useful as chelators of metal ions and their applications
CN1791408A (zh) 2003-04-03 2006-06-21 普拉纳生物技术有限公司 神经系统疾病的治疗
KR20060015588A (ko) * 2003-05-07 2006-02-17 디엠아이 바이오사이언시스, 인크 구강 케어 방법 및 제품
US7176239B2 (en) * 2003-07-11 2007-02-13 Suming Wang Methods and compositions for treatment of Ataxia-telangeictasia
CN1898260A (zh) 2003-10-28 2007-01-17 普罗特米克斯发现有限公司 具有抗肥胖活性的肽及其它相关应用
EP1694317A4 (en) 2003-12-19 2010-05-12 Protemix Corp Ltd COPPER ANTAGONIST COMPOUNDS
CA2875095C (en) 2004-07-19 2019-09-03 Philera New Zealand Limited Synthesis of triethylenetetramines
WO2006068516A1 (en) 2004-12-20 2006-06-29 Protemix Corporation Limited Implantable medical devices coated with or containing copper chelating compounds

Also Published As

Publication number Publication date
JP2005533003A (ja) 2005-11-04
US8563538B2 (en) 2013-10-22
EP2500018A1 (en) 2012-09-19
EP2500018B1 (en) 2017-07-19
US8987244B2 (en) 2015-03-24
US6951890B2 (en) 2005-10-04
CN1649577A (zh) 2005-08-03
CA2478997A1 (en) 2003-09-25
WO2003077901A1 (en) 2003-09-25
US20140113969A1 (en) 2014-04-24
JP4860906B2 (ja) 2012-01-25
US20060009534A1 (en) 2006-01-12
ES2386782T3 (es) 2012-08-30
AU2003225442B2 (en) 2010-02-04
US8034799B2 (en) 2011-10-11
ATE555782T1 (de) 2012-05-15
EP1487431A4 (en) 2006-10-25
AU2003225442A1 (en) 2003-09-29
CA2478997C (en) 2013-12-17
DK2500018T3 (en) 2017-10-02
US20110212188A1 (en) 2011-09-01
US20030203973A1 (en) 2003-10-30
EP1487431A1 (en) 2004-12-22
DK1487431T3 (da) 2012-08-20
EP1487431B1 (en) 2012-05-02

Similar Documents

Publication Publication Date Title
HK1071313A1 (en) Preventing and/or treating cardiovascular disease and/or associated heart failure
CA2400801A1 (en) Treatment of congestive heart failure by pretreated autologous blood
WO2005030291A3 (en) Method and apparatus for treatment of thrombosed hemodialysis access grafts
ATE355852T1 (de) Verwendung von botulinum toxin zur behandlung von herz- und kreislaufskrankheiten
ATE370765T1 (de) Zugangsleitung zur linken herrzkammer zur stimulierung bei herzversagen
EP1588736A3 (en) Microperfusive electrical stimulation
WO2003026480A3 (en) Methods and apparatus employing ionizing radiation for treatment of cardiac arrhythmia
DE69633195D1 (de) Injektierbare oder implantierbare biomaterialien zum füllen oder abdecken von hohlräumen und lumen eines körpers
CO5611156A2 (es) Metodos de tratamiento de enfermedad vascular
PT955880E (pt) Metodo e aparelho para tratamento de arritmias cardiacas sem alvo discreto
BR0212252A (pt) Métodos para reduzir a hipertensão e a insuficiência cardìaca em um mamìfero
WO2002000210A3 (en) Use of agents capable of reducing uric acid levels for the treatment of cardiovascular disease
WO2001032088A3 (en) Method and apparatus for demand injury in stimulating angiogenesis
DE60335202D1 (en) Chaperonin-10-immunosuppression
WO2002071955A3 (en) Method and apparatus for treatment of atrial fibrillation
WO2000006185A3 (en) Methods of using lanreotide, a somatostatin analogue
WO2003028524A3 (en) Preparation of working fluid for use in cryotherapies
PL335046A1 (en) Method of and agent for treating arteriosclerosis and vascular lesions by preventing proliferation of smooth muscle vascular fibres
PL354961A1 (en) Prevention and treatment of diseases associated with blood coagulation
AU2003283227A8 (en) Method and means for the treatment of vascular and cardiac diseases
AU6648200A (en) Method and composition for preventing or treating adverse physiological effects associated with cardiac disease
WO2006007710A3 (en) Acute inflammatory condition treatment
WO2002062204A3 (en) Methods for diagnosing and treating heart disease
WO2002085376A3 (en) A method for decreasing superoxide anion production and for the treatment of diseases associated with oxidative stress
WO2004037120A3 (en) Implantable medical devices using zinc

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210310