HK1057219A1 - 8.beta-.hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene - Google Patents

8.beta-.hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene

Info

Publication number
HK1057219A1
HK1057219A1 HK04100140.5A HK04100140A HK1057219A1 HK 1057219 A1 HK1057219 A1 HK 1057219A1 HK 04100140 A HK04100140 A HK 04100140A HK 1057219 A1 HK1057219 A1 HK 1057219A1
Authority
HK
Hong Kong
Prior art keywords
sup
compounds
estratriene
action
8beta
Prior art date
Application number
HK04100140.5A
Other languages
English (en)
Inventor
Olaf Peters
Alexander Hillisch
Ina Thieme
Walter Elger
Christa Hegele-Hartung
Uwe Kollenkirchen
Karl-Heinrich Fritzemeier
Vladimir Patchev
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10019167A external-priority patent/DE10019167A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of HK1057219A1 publication Critical patent/HK1057219A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK04100140.5A 2000-04-12 2004-01-09 8.beta-.hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene HK1057219A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10019167A DE10019167A1 (de) 2000-04-12 2000-04-12 Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P 2000-05-26 2000-05-26
PCT/EP2001/004290 WO2001077139A1 (fr) 2000-04-12 2001-04-12 Estratrienes a substitution 8.beta-hydrocarbyle utilises comme oestrogenes a action selective

Publications (1)

Publication Number Publication Date
HK1057219A1 true HK1057219A1 (en) 2004-03-19

Family

ID=26005365

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04100140.5A HK1057219A1 (en) 2000-04-12 2004-01-09 8.beta-.hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene

Country Status (26)

Country Link
US (3) US20040029847A1 (fr)
EP (2) EP1272505B1 (fr)
JP (2) JP3828423B2 (fr)
CN (1) CN100453549C (fr)
AT (2) ATE302790T1 (fr)
AU (3) AU2001273945A1 (fr)
BG (1) BG107173A (fr)
BR (1) BR0109983A (fr)
CA (1) CA2406177C (fr)
CZ (1) CZ20023382A3 (fr)
DE (1) DE50112561D1 (fr)
DK (2) DK1272505T3 (fr)
EA (1) EA006299B1 (fr)
EE (1) EE200200589A (fr)
ES (2) ES2287127T3 (fr)
HK (1) HK1057219A1 (fr)
HR (1) HRP20020892B1 (fr)
HU (1) HUP0300335A2 (fr)
IL (2) IL152248A0 (fr)
MX (1) MXPA02010066A (fr)
NO (2) NO325337B1 (fr)
NZ (1) NZ543724A (fr)
PL (1) PL207488B1 (fr)
PT (1) PT1272504E (fr)
SK (1) SK14632002A3 (fr)
WO (2) WO2001077139A1 (fr)

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DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10039199A1 (de) * 2000-08-10 2002-02-21 Schering Ag Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
DE10151363A1 (de) * 2001-10-17 2003-05-08 Schering Ag Somatotrope Therapie
DE10226326A1 (de) * 2002-06-11 2004-01-15 Schering Ag 9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
ES2315455T3 (es) * 2003-03-27 2009-04-01 Pantarhei Bioscience B.V. Uso de estrogenos para el tratamiento de infertilidad en maniferos machos.
DE10318896A1 (de) * 2003-04-22 2004-11-25 Schering Ag 8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene
PL1689410T3 (pl) * 2003-11-26 2008-10-31 Bayer Schering Pharma Ag Sposób zapobiegania i leczenia nadciśnieniowych chorób serca za pomocą selektywnych estrogenów: 8ß-winylo-estra-1,3,5(10)-trien-3,17ß-diolu i 17ß-fluoro-9a-winylo-estra-1,3,5(10)-trien-3,16a-diolu
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057224A1 (de) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057225A1 (de) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP2014672A1 (fr) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Estratriènes 8 bêta substitués servant d'oestrogènes sélectivement actifs
US20110097405A1 (en) * 2008-02-13 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Estradiol-containing drug delivery system
KR20100117603A (ko) * 2008-02-13 2010-11-03 바이엘 쉐링 파마 악티엔게젤샤프트 안정화 효과를 갖는 약물 전달 시스템
EP2143432A1 (fr) 2008-07-11 2010-01-13 Bayer Schering Pharma AG Dérivés d'estratriènes 9-alpha en tant que ligands sélectifs ER-beta pour la prévention et le traitement du cancer intestinal
JP2012509286A (ja) * 2008-11-21 2012-04-19 バイエル ファーマ アクチエンゲゼルシャフト 薬物送達システム
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US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
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US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
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IL152248A0 (en) 2003-05-29
WO2001077138A1 (fr) 2001-10-18
NO20024908L (no) 2002-11-13
CA2406177C (fr) 2010-06-22
DK1272505T3 (da) 2005-11-07
CN100453549C (zh) 2009-01-21
US20030176405A1 (en) 2003-09-18
AU5834101A (en) 2001-10-23
BG107173A (bg) 2003-05-30
NO20024907L (no) 2002-12-05
PL358667A1 (en) 2004-08-09
SK14632002A3 (sk) 2003-03-04
HRP20020892B1 (en) 2011-08-31
JP3828423B2 (ja) 2006-10-04
CZ20023382A3 (cs) 2003-02-12
DE50112561D1 (de) 2007-07-12
CA2406177A1 (fr) 2001-10-18
NO20024907D0 (no) 2002-10-11
MXPA02010066A (es) 2003-06-04
IL152248A (en) 2008-06-05
HRP20020892A2 (en) 2005-02-28
PT1272504E (pt) 2007-08-29
NZ543724A (en) 2007-07-27
ATE302790T1 (de) 2005-09-15
JP2003530403A (ja) 2003-10-14
PL207488B1 (pl) 2010-12-31
JP2008280355A (ja) 2008-11-20
US20040029847A1 (en) 2004-02-12
ES2287127T3 (es) 2007-12-16
EE200200589A (et) 2004-04-15
EP1272504A1 (fr) 2003-01-08
EA006299B1 (ru) 2005-10-27
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BR0109983A (pt) 2003-02-25
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US7378404B2 (en) 2008-05-27
CN1433424A (zh) 2003-07-30
EP1272505B1 (fr) 2005-08-24
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