HK1042472B - 作爲有效的香草類受體激動劑和鎮痛藥的含有樹脂毒素藥效基團的香草類類似物，其組合物以及應用 - Google Patents

作爲有效的香草類受體激動劑和鎮痛藥的含有樹脂毒素藥效基團的香草類類似物，其組合物以及應用

Info

Publication number
HK1042472B
HK1042472B HK02104276.5A HK02104276A HK1042472B HK 1042472 B HK1042472 B HK 1042472B HK 02104276 A HK02104276 A HK 02104276A HK 1042472 B HK1042472 B HK 1042472B
Authority
HK
Hong Kong
Prior art keywords
vanilloid
receptor agonists
analgesics
compositions
potent
Prior art date
Application number
HK02104276.5A
Other languages
English (en)
Other versions
HK1042472A1 (en
Inventor
李智雨
吴禹澤
朴永鎬
徐永鉅
朴亨根
金熙斗
Original Assignee
Medifron Dbt Co Ltd
Pacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medifron Dbt Co Ltd, Pacific Corp filed Critical Medifron Dbt Co Ltd
Publication of HK1042472A1 publication Critical patent/HK1042472A1/xx
Publication of HK1042472B publication Critical patent/HK1042472B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK02104276.5A 1999-02-22 2002-06-05 作爲有效的香草類受體激動劑和鎮痛藥的含有樹脂毒素藥效基團的香草類類似物，其組合物以及應用 HK1042472B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19990005751 1999-02-22
PCT/KR2000/000137 WO2000050387A1 (en) 1999-02-22 2000-02-21 Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

Publications (2)

Publication Number Publication Date
HK1042472A1 HK1042472A1 (en) 2002-08-16
HK1042472B true HK1042472B (zh) 2005-12-09

Family

ID=36578904

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02104276.5A HK1042472B (zh) 1999-02-22 2002-06-05 作爲有效的香草類受體激動劑和鎮痛藥的含有樹脂毒素藥效基團的香草類類似物，其組合物以及應用

Country Status (12)

Country Link
US (1) US6476076B1 (zh)
EP (1) EP1154989B1 (zh)
JP (1) JP3727851B2 (zh)
CN (1) CN1210254C (zh)
AT (1) ATE312812T1 (zh)
AU (1) AU763824B2 (zh)
CA (1) CA2363531C (zh)
DE (1) DE60024785T2 (zh)
ES (1) ES2253208T3 (zh)
HK (1) HK1042472B (zh)
MX (1) MXPA01008403A (zh)
WO (1) WO2000050387A1 (zh)

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JP3501775B2 (ja) * 2000-05-31 2004-03-02 ファイザー株式会社 ヒトバニロイド受容体様タンパク質
IL153884A0 (en) * 2000-07-20 2003-07-31 Neurogen Corp Capsaicin receptor ligands
US20030153596A1 (en) 2000-08-21 2003-08-14 Suh Young Ger Novel thiourea derivatives and the pharmaceutical compositions containing the same
WO2002016318A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
US20040146590A1 (en) 2001-03-22 2004-07-29 Iadarola Michael J Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin
CA2442049C (en) * 2001-03-22 2010-06-01 Michael J. Iadarola Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist
CA2455754A1 (en) * 2001-07-31 2003-02-20 Bayer Healthcare Ag Amine derivatives
MY138086A (en) 2001-09-13 2009-04-30 Smithkline Beecham Plc Novel urea derivative as vanilloid receptor-1 antagonist
US6872748B2 (en) * 2001-09-27 2005-03-29 Digital Biotech Co., Ltd. Simplified resiniferatoxin analogues as vanilloid receptor agonist showing excellent analgesic activity and the pharmaceutical compositions containing the same
JPWO2003029199A1 (ja) * 2001-09-28 2005-01-13 武田薬品工業株式会社 ベンゼン誘導体、その製造法および用途
AU2002358700A1 (en) * 2001-12-26 2003-07-15 Bayer Aktiengesellschaft Urea derivatives as vr1- antagonists
MXPA04006882A (es) * 2002-01-17 2004-12-06 Neurogen Corp Analogos substituidos de quinazolin-4-ilamina como moduladores de receptores de capsaicina.
ES2319886T3 (es) * 2002-02-20 2009-05-14 Abbott Laboratories Compuestos azabiciclicos condensados que inhiben el sutipo 1 del receptor valinoide (vr1).
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2003095420A1 (en) * 2002-05-08 2003-11-20 Bayer Healthcare Ag Hydroxy tetrahydro-naphthalenylurea derivatives
DE10224107A1 (de) * 2002-05-29 2003-12-11 Gruenenthal Gmbh Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
ES2291725T3 (es) 2002-12-06 2008-03-01 Xention Limited Derivados de tetrahidro-naftaleno.
JP4440113B2 (ja) * 2002-12-09 2010-03-24 バイエル・ヘルスケア・アクチェンゲゼルシャフト バニロイド受容体アンタゴニストとしてのテトラヒドロ−ナフタレン誘導体
EP1438942A1 (en) * 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
EP1594836B1 (en) 2003-02-12 2007-09-19 Bayer HealthCare AG Hydroxy-tetrahydro-naphthalenylurea derivatives
US20040202735A1 (en) * 2003-04-08 2004-10-14 Moore Bob M. Method and kit for controlling bleeding
EP2907503A1 (en) 2003-04-10 2015-08-19 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
KR100707123B1 (ko) * 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물
ES2321719T3 (es) 2003-10-01 2009-06-10 Xention Limited Derivados de tetrahidro-naftaleno y urea.
JP4935073B2 (ja) 2003-10-14 2012-05-23 味の素株式会社 エーテル誘導体
CA2545100A1 (en) * 2003-11-08 2005-05-19 Bayer Healthcare Ag Bicyclic amide, carbamate or urea derivatives as vanilloid receptor modulators
JP2007523888A (ja) 2003-11-08 2007-08-23 バイエル・ヘルスケア・アクチェンゲゼルシャフト テトラヒドロ−キノリニル尿素誘導体
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
JP5159604B2 (ja) * 2005-03-19 2013-03-06 アモーレパシフィック コーポレイション バニロイド受容体拮抗薬としての新規な化合物、その異性体又はその薬剤学的に許容される塩、及びこれを含む医薬組成物
EP1946132B1 (en) * 2005-11-04 2010-04-14 Nxp B.V. Integrated circuit test method and test apparatus
TW200824687A (en) 2006-08-25 2008-06-16 Abbott Lab Compounds that inhibit TRPV1 and uses thereof
EP2134678A2 (en) 2006-12-20 2009-12-23 Abbott Laboratories N-(5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
CA2719018A1 (en) 2008-03-20 2009-09-24 Abbott Laboratories Methods for making central nervous system agents that are trpv1 antagonists
WO2010119877A1 (ja) * 2009-04-13 2010-10-21 味の素株式会社 アミジン誘導体の製造方法
US20120027693A1 (en) 2010-07-27 2012-02-02 Bean Bruce P Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
JP2014504184A (ja) 2010-12-01 2014-02-20 スパイナル・モデュレーション・インコーポレイテッド 神経構造への薬剤の直接送達
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
EP3570861A4 (en) 2017-01-23 2020-11-18 Flex Pharma, Inc. COMPOSITIONS AND PROCEDURES EFFECTING SPORTING PERFORMANCE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021450A (en) * 1989-05-30 1991-06-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof
US5431914A (en) * 1992-04-17 1995-07-11 Adekunle; Michael Method of treating an internal condition by external application of capsaicin without the need for systemic absorption

Also Published As

Publication number Publication date
WO2000050387A1 (en) 2000-08-31
CN1342138A (zh) 2002-03-27
CN1210254C (zh) 2005-07-13
JP2002537373A (ja) 2002-11-05
EP1154989B1 (en) 2005-12-14
EP1154989A1 (en) 2001-11-21
ES2253208T3 (es) 2006-06-01
HK1042472A1 (en) 2002-08-16
JP3727851B2 (ja) 2005-12-21
DE60024785T2 (de) 2006-09-14
MXPA01008403A (es) 2003-06-06
US6476076B1 (en) 2002-11-05
AU2697600A (en) 2000-09-14
DE60024785D1 (de) 2006-01-19
ATE312812T1 (de) 2005-12-15
CA2363531C (en) 2007-07-31
AU763824B2 (en) 2003-07-31
CA2363531A1 (en) 2000-08-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130221