HK1041691B - 新的2-(n-氰基亞氨基)噻唑烷-4-酮衍生物 - Google Patents
新的2-(n-氰基亞氨基)噻唑烷-4-酮衍生物Info
- Publication number
- HK1041691B HK1041691B HK02102951.1A HK02102951A HK1041691B HK 1041691 B HK1041691 B HK 1041691B HK 02102951 A HK02102951 A HK 02102951A HK 1041691 B HK1041691 B HK 1041691B
- Authority
- HK
- Hong Kong
- Prior art keywords
- group
- alkyl group
- atom
- hydrogen atom
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1999/006352 WO2001036402A1 (fr) | 1998-07-14 | 1999-11-12 | Nouveaux derives de 2-(n-cyano-imino)thiazolidin-4-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1041691A1 HK1041691A1 (en) | 2002-07-19 |
| HK1041691B true HK1041691B (zh) | 2004-12-24 |
Family
ID=14237278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02102951.1A HK1041691B (zh) | 1999-11-12 | 2002-04-19 | 新的2-(n-氰基亞氨基)噻唑烷-4-酮衍生物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6380229B1 (zh) |
| EP (1) | EP1142885B1 (zh) |
| JP (1) | JP4285723B2 (zh) |
| KR (1) | KR100608416B1 (zh) |
| CN (1) | CN1159305C (zh) |
| AT (1) | ATE345332T1 (zh) |
| AU (1) | AU767923C (zh) |
| CA (1) | CA2355243C (zh) |
| DE (1) | DE69934027T2 (zh) |
| DK (1) | DK1142885T3 (zh) |
| ES (1) | ES2276547T3 (zh) |
| HK (1) | HK1041691B (zh) |
| IL (1) | IL144229A (zh) |
| PT (1) | PT1142885E (zh) |
| WO (1) | WO2001036402A1 (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2383347A1 (en) | 1999-08-31 | 2001-03-08 | Maxia Pharmaceuticals, Inc. | Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes |
| JP2001199888A (ja) * | 2000-01-24 | 2001-07-24 | Fujimoto Brothers:Kk | 糖尿病治療剤 |
| IL157740A0 (en) | 2001-03-07 | 2004-03-28 | Incyte San Diego Inc | Heterocyclic derivatives and pharmaceutical compositions containing the same |
| US7265139B2 (en) | 2001-03-08 | 2007-09-04 | Incyte San Diego Inc. | RXR activating molecules |
| JP2004530690A (ja) | 2001-05-16 | 2004-10-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症性薬剤として有用なジアリールウレア誘導体 |
| AU2002352706A1 (en) | 2001-11-15 | 2003-06-10 | Maxia Pharmaceuticals, Inc. | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
| AR037714A1 (es) * | 2001-12-06 | 2004-12-01 | Maxia Pharmaceuticals Inc | Derivados de tiazolidinona y oxazolidinona 2-sustituidos para la inhibicion de fosfatasas y el tratamiento de cancer |
| US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| SI1689726T1 (sl) | 2003-11-21 | 2011-01-31 | Actelion Pharmaceuticals Ltd | Derivati 5-(benz-(z)-iliden)-tiazolidin-4-ona kot imunosupresivna sredstva |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| CN101541772B (zh) * | 2006-11-23 | 2013-04-17 | 埃科特莱茵药品有限公司 | 一种制备2-亚氨基-四氢噻唑-4-酮衍生物的新方法 |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| CN103450077B (zh) * | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
| JP6322630B2 (ja) | 2012-08-17 | 2018-05-09 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | （２Ｚ，５Ｚ）−５−（３−クロロ−４−（（Ｒ）−２，３−ジヒドロキシプロポキシ）ベンジリデン）−２−（プロピルイミノ）−３−（ｏ−トリル）チアゾリジン−４−オンの製造方法及び前記方法において使用される中間体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07165371A (ja) | 1993-10-06 | 1995-06-27 | Japan Tobacco Inc | テープ巻き付け方法および装置 |
| JPH0892249A (ja) * | 1994-07-20 | 1996-04-09 | Sankyo Co Ltd | スルホンアミド誘導体 |
| JP3871354B2 (ja) * | 1994-07-29 | 2007-01-24 | 株式会社フジモト・コーポレーション | 新規な２−（ｎ−シアノイミノ）チアゾリジン−４−オン誘導体 |
| JPH08157461A (ja) * | 1994-12-07 | 1996-06-18 | Sankyo Co Ltd | スルホン誘導体 |
| JPH09165371A (ja) | 1995-10-09 | 1997-06-24 | Sankyo Co Ltd | 複素環化合物を含有する医薬 |
| ATE231136T1 (de) * | 1996-04-09 | 2003-02-15 | Reddys Lab Ltd Dr | Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven eigenschaften, verfahren zu deren herstellung und pharmazeutischen zusammenstellungen, die sie enthalten |
| JP2000026438A (ja) * | 1998-07-14 | 2000-01-25 | Fujimoto Brothers:Kk | 新規な２−（ｎ−シアノイミノ）チアゾリジン−４− オン誘導体 |
-
1999
- 1999-11-12 ES ES99974189T patent/ES2276547T3/es not_active Expired - Lifetime
- 1999-11-12 KR KR1020017008765A patent/KR100608416B1/ko not_active IP Right Cessation
- 1999-11-12 EP EP99974189A patent/EP1142885B1/en not_active Expired - Lifetime
- 1999-11-12 CA CA002355243A patent/CA2355243C/en not_active Expired - Fee Related
- 1999-11-12 WO PCT/JP1999/006352 patent/WO2001036402A1/ja active IP Right Grant
- 1999-11-12 US US09/889,103 patent/US6380229B1/en not_active Expired - Lifetime
- 1999-11-12 DK DK99974189T patent/DK1142885T3/da active
- 1999-11-12 CN CNB998154482A patent/CN1159305C/zh not_active Expired - Fee Related
- 1999-11-12 AT AT99974189T patent/ATE345332T1/de active
- 1999-11-12 IL IL144229A patent/IL144229A/en not_active IP Right Cessation
- 1999-11-12 JP JP2001538891A patent/JP4285723B2/ja not_active Expired - Fee Related
- 1999-11-12 PT PT99974189T patent/PT1142885E/pt unknown
- 1999-11-12 DE DE69934027T patent/DE69934027T2/de not_active Expired - Lifetime
- 1999-11-12 AU AU11801/00A patent/AU767923C/en not_active Ceased
-
2002
- 2002-04-19 HK HK02102951.1A patent/HK1041691B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2355243A1 (en) | 2001-05-25 |
| CN1333762A (zh) | 2002-01-30 |
| KR100608416B1 (ko) | 2006-08-02 |
| JP4285723B2 (ja) | 2009-06-24 |
| ATE345332T1 (de) | 2006-12-15 |
| AU1180100A (en) | 2001-05-30 |
| EP1142885A1 (en) | 2001-10-10 |
| HK1041691A1 (en) | 2002-07-19 |
| AU767923C (en) | 2005-03-24 |
| DE69934027D1 (de) | 2006-12-28 |
| IL144229A0 (en) | 2002-05-23 |
| DE69934027T2 (de) | 2007-06-21 |
| WO2001036402A1 (fr) | 2001-05-25 |
| EP1142885A4 (en) | 2003-01-29 |
| EP1142885B1 (en) | 2006-11-15 |
| IL144229A (en) | 2006-10-05 |
| ES2276547T3 (es) | 2007-06-16 |
| DK1142885T3 (da) | 2007-02-26 |
| PT1142885E (pt) | 2007-02-28 |
| KR20010108089A (ko) | 2001-12-07 |
| AU767923B2 (en) | 2003-11-27 |
| CN1159305C (zh) | 2004-07-28 |
| CA2355243C (en) | 2009-01-27 |
| US6380229B1 (en) | 2002-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20141112 |