HK1041482B - 作為細胞毒性抗腫瘤劑的萘並噻吩和二氫苯並噻吩的衍生物 - Google Patents

作為細胞毒性抗腫瘤劑的萘並噻吩和二氫苯並噻吩的衍生物

Info

Publication number
HK1041482B
HK1041482B HK02102913.8A HK02102913A HK1041482B HK 1041482 B HK1041482 B HK 1041482B HK 02102913 A HK02102913 A HK 02102913A HK 1041482 B HK1041482 B HK 1041482B
Authority
HK
Hong Kong
Prior art keywords
dihydrobenzo
naphtho
antitumor agents
thiophene derivatives
cytotoxic antitumor
Prior art date
Application number
HK02102913.8A
Other languages
English (en)
Other versions
HK1041482A1 (en
Inventor
Lee Kuo-Hsiung
Kuo Sheng-Chu
Original Assignee
北卡羅來納-查佩爾山大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北卡羅來納-查佩爾山大學 filed Critical 北卡羅來納-查佩爾山大學
Publication of HK1041482A1 publication Critical patent/HK1041482A1/xx
Publication of HK1041482B publication Critical patent/HK1041482B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK02102913.8A 1998-06-05 2002-04-17 作為細胞毒性抗腫瘤劑的萘並噻吩和二氫苯並噻吩的衍生物 HK1041482B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/092,929 US6174913B1 (en) 1998-06-05 1998-06-05 Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
PCT/US1999/012647 WO1999062909A2 (en) 1998-06-05 1999-06-04 Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents

Publications (2)

Publication Number Publication Date
HK1041482A1 HK1041482A1 (en) 2002-07-12
HK1041482B true HK1041482B (zh) 2005-03-11

Family

ID=22235827

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102913.8A HK1041482B (zh) 1998-06-05 2002-04-17 作為細胞毒性抗腫瘤劑的萘並噻吩和二氫苯並噻吩的衍生物

Country Status (9)

Country Link
US (2) US6174913B1 (zh)
EP (1) EP1093456B1 (zh)
JP (1) JP2002517397A (zh)
CN (1) CN1150197C (zh)
AU (1) AU4548899A (zh)
DE (1) DE69913697T2 (zh)
HK (1) HK1041482B (zh)
TW (1) TWI238165B (zh)
WO (1) WO1999062909A2 (zh)

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AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US20060142271A1 (en) * 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
TWI366459B (en) * 2004-09-28 2012-06-21 Ind Tech Res Inst Novel hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
HUE027443T2 (en) * 2007-09-10 2016-10-28 Boston Biomedical Inc A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors
BR112012023660B8 (pt) 2010-03-19 2021-05-25 Boston Biomedical Inc usos de uma quantidade terapeuticamente eficaz de um composto, ou de um sal, solvato, hidrato ou pró-fármaco farmaceuticamente aceitável do mesmo para o tratamento de câncer
JP6069787B2 (ja) * 2012-03-08 2017-02-01 学校法人早稲田大学 ベンゾジチオフェンキノンポリマー、電荷貯蔵材料、電極活物質、電極、及び電池
SG11201508358RA (en) 2013-04-09 2015-11-27 Boston Biomedical Inc 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
CN109867647A (zh) * 2014-02-07 2019-06-11 北京强新生物科技有限公司 3-取代的羰基萘并[2,3-b]呋喃衍生物或其药学上可接受的盐
JPWO2015151490A1 (ja) * 2014-03-31 2017-04-13 ボストン バイオメディカル， インコーポレイテッド 新規な三環性キノン誘導体
CN107501279B (zh) * 2016-09-20 2018-11-23 东莞市真兴贝特医药技术有限公司 呋喃并喹啉二酮类化合物及其医药用途
WO2018102427A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
CA3062656A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
KR102518835B1 (ko) 2017-10-26 2023-04-05 엘지디스플레이 주식회사 유기 화합물, 이를 포함하는 발광다이오드 및 발광장치
EP3762391A4 (en) * 2018-03-08 2022-08-03 ExxonMobil Technology and Engineering Company SPIROCENTRIC COMPOUNDS AND POLYMERS THEREOF
CN110183463B (zh) * 2019-05-29 2022-05-06 中国科学院重庆绿色智能技术研究院 一种小分子电子给体材料及其制备与应用

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US4419354A (en) * 1982-06-03 1983-12-06 American Cyanamid Company 9,10-Bis(aminoalkoxy)anthracenes
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HU195800B (en) 1983-10-13 1988-07-28 Sandoz Ltd Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them
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US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
JPH1165141A (ja) * 1997-08-11 1999-03-05 Canon Inc 電子写真感光体、該電子写真感光体を有するプロセスカ−トリッジ及び電子写真装置
JPH1195465A (ja) * 1997-09-16 1999-04-09 Konica Corp 電子写真感光体

Also Published As

Publication number Publication date
WO1999062909A3 (en) 2000-03-02
CN1322206A (zh) 2001-11-14
EP1093456B1 (en) 2003-12-17
WO1999062909A2 (en) 1999-12-09
US6174913B1 (en) 2001-01-16
TWI238165B (en) 2005-08-21
JP2002517397A (ja) 2002-06-18
AU4548899A (en) 1999-12-20
DE69913697D1 (de) 2004-01-29
HK1041482A1 (en) 2002-07-12
DE69913697T2 (de) 2004-08-19
US6337346B1 (en) 2002-01-08
WO1999062909A9 (en) 2000-04-27
CN1150197C (zh) 2004-05-19
EP1093456A2 (en) 2001-04-25

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080604