HK1037617A1 - Process for the preparation of imidazodiazepine intermediates - Google Patents

Process for the preparation of imidazodiazepine intermediates

Info

Publication number
HK1037617A1
HK1037617A1 HK01108224A HK01108224A HK1037617A1 HK 1037617 A1 HK1037617 A1 HK 1037617A1 HK 01108224 A HK01108224 A HK 01108224A HK 01108224 A HK01108224 A HK 01108224A HK 1037617 A1 HK1037617 A1 HK 1037617A1
Authority
HK
Hong Kong
Prior art keywords
imidazodiazepine
intermediates
preparation
compound
formula
Prior art date
Application number
HK01108224A
Other languages
English (en)
Inventor
Madhup K Dhaon
Parvis Labib
Deborah A Davis
Grant L Esser
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of HK1037617A1 publication Critical patent/HK1037617A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK01108224A 1999-06-30 2001-11-21 Process for the preparation of imidazodiazepine intermediates HK1037617A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/343,317 US20010014738A1 (en) 1999-06-30 1999-06-30 Process for the preparation of imidazodiazepine intermediates
PCT/US2000/016476 WO2001000625A1 (en) 1999-06-30 2000-06-15 Process for the preparation of imidazodiazepine intermediates

Publications (1)

Publication Number Publication Date
HK1037617A1 true HK1037617A1 (en) 2002-02-15

Family

ID=23345595

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01108224A HK1037617A1 (en) 1999-06-30 2001-11-21 Process for the preparation of imidazodiazepine intermediates

Country Status (15)

Country Link
US (1) US20010014738A1 (pt)
EP (2) EP1105392B1 (pt)
JP (1) JP2003503410A (pt)
KR (1) KR20010079706A (pt)
CN (1) CN1315953A (pt)
AT (1) ATE223414T1 (pt)
AU (1) AU5874600A (pt)
CA (1) CA2341524A1 (pt)
DE (1) DE60000402T2 (pt)
DK (1) DK1105392T3 (pt)
ES (1) ES2185599T3 (pt)
HK (1) HK1037617A1 (pt)
IL (1) IL141394A0 (pt)
PT (1) PT1105392E (pt)
WO (1) WO2001000625A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211350D0 (en) 2002-05-16 2002-06-26 Rolls Royce Plc A gas turbine engine
IL156606A (en) 2003-06-23 2011-07-31 Aviad Kipnis Digital certificates
IT1399764B1 (it) * 2010-05-04 2013-05-03 F S I Fabbrica Italiana Sint Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.
CN103086986B (zh) * 2011-11-01 2015-11-04 上海医药工业研究院 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用
CN103319486B (zh) * 2012-03-22 2017-10-10 徐州市心血管病研究所 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法
CN106032381A (zh) * 2015-03-16 2016-10-19 王志训 一种咪达唑仑衍生物的工业制造方法
CN106032380A (zh) * 2015-03-16 2016-10-19 王志训 一种咪达唑仑的工业制造方法
WO2018035246A1 (en) 2016-08-16 2018-02-22 Uwm Research Foundation, Inc. Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440685A (en) * 1974-09-11 1984-04-03 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
US4307237A (en) * 1974-09-11 1981-12-22 Hoffmann-La Roche Inc. Imidazoles
US4335042A (en) * 1980-04-21 1982-06-15 Hoffmann-La Roche Inc. Process to produce imidazobenzodiazepine intermediates

Also Published As

Publication number Publication date
ATE223414T1 (de) 2002-09-15
ES2185599T3 (es) 2003-05-01
DE60000402T2 (de) 2003-05-22
CN1315953A (zh) 2001-10-03
CA2341524A1 (en) 2001-01-04
JP2003503410A (ja) 2003-01-28
DE60000402D1 (de) 2002-10-10
KR20010079706A (ko) 2001-08-22
PT1105392E (pt) 2002-12-31
EP1105392A1 (en) 2001-06-13
AU5874600A (en) 2001-01-31
WO2001000625A1 (en) 2001-01-04
EP1199308A3 (en) 2002-05-02
EP1105392B1 (en) 2002-09-04
EP1199308A2 (en) 2002-04-24
DK1105392T3 (da) 2002-12-30
IL141394A0 (en) 2002-03-10
US20010014738A1 (en) 2001-08-16

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070615