HK1036985A1 - Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
HK1036985A1
HK1036985A1 HK01107929A HK01107929A HK1036985A1 HK 1036985 A1 HK1036985 A1 HK 1036985A1 HK 01107929 A HK01107929 A HK 01107929A HK 01107929 A HK01107929 A HK 01107929A HK 1036985 A1 HK1036985 A1 HK 1036985A1
Authority
HK
Hong Kong
Prior art keywords
preparation
same
pharmaceutical compositions
compositions containing
artemisinin derivatives
Prior art date
Application number
HK01107929A
Other languages
English (en)
Inventor
Ying Li
Feng Shan
Jin Ming Wu
Guangshao Wu
Jian Ding
Jianxian Han
Atassi Ghanem
Renard Pierre
Original Assignee
Shanghai Inst Materia Medica
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Inst Materia Medica, Servier Lab filed Critical Shanghai Inst Materia Medica
Publication of HK1036985A1 publication Critical patent/HK1036985A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK01107929A 1998-06-17 2001-11-12 Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same HK1036985A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN98114788A CN1084333C (zh) 1998-06-17 1998-06-17 新的青蒿素化合物,其制备方法以及含有它们的药物组合物
PCT/FR1999/001359 WO1999065914A1 (fr) 1998-06-17 1999-06-09 Derives de l'artemisinine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
HK1036985A1 true HK1036985A1 (en) 2002-01-25

Family

ID=5224325

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01107929A HK1036985A1 (en) 1998-06-17 2001-11-12 Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same

Country Status (14)

Country Link
US (1) US6307068B1 (no)
EP (1) EP1086107A1 (no)
JP (1) JP2002518398A (no)
CN (2) CN1084333C (no)
AU (1) AU748798B2 (no)
BR (1) BR9911274A (no)
CA (1) CA2342990A1 (no)
HK (1) HK1036985A1 (no)
HU (1) HUP0102599A3 (no)
NO (1) NO20006257L (no)
NZ (1) NZ508388A (no)
PL (1) PL344984A1 (no)
WO (1) WO1999065914A1 (no)
ZA (1) ZA200007070B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129215D0 (en) * 2001-12-06 2002-01-23 Ufc Ltd Trioxane derivatives
CA2469224A1 (en) * 2001-12-06 2003-06-12 Ufc Limited Trioxane derivatives
US20050070595A1 (en) * 2001-12-06 2005-03-31 O'neil Paul Michael Trioxane derivatives as antimalaria or anticancer compounds
RU2325156C2 (ru) * 2002-06-06 2008-05-27 Юниверсити Оф Вашингтон Ковалентные конъюгаты между родственными артемизинину эндопероксидами и железосодержащими белками и способы применения
ES2377002T3 (es) * 2002-06-06 2012-03-21 University Of Washington Conjugados covalentes entre los endoperóxidos relacionados con la artemisinina y las proteínas transportadoras de hierro y procedimientos de utilización
US6677463B1 (en) * 2002-12-10 2004-01-13 Council Of Scientific And Industrial Research Single pot conversion of artemisinin to artesunic acid
CN1327842C (zh) * 2003-02-12 2007-07-25 沈恒 一种新型的抗肿瘤药物复方制备方法
WO2006002105A1 (en) 2004-06-21 2006-01-05 University Of Mississippi Anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities
CN1814601A (zh) * 2005-02-04 2006-08-09 中国科学院上海药物研究所 具有免疫抑制作用的青蒿素衍生物及药物组合物
FR2899586B1 (fr) 2006-04-11 2008-06-20 Sanofi Aventis Sa Dimeres de derives d'artemisinine, leur preparation et leur application en therapeutique
ITMI20071915A1 (it) * 2007-10-04 2009-04-05 Lachifarma Srl Lab Chimico Far Derivati dell'artemisinina per il trattamento del melanoma
GB0720967D0 (en) * 2007-10-25 2007-12-05 Protophama Ltd Anti-material pharmaceutical composition
GB2469791B (en) * 2009-04-23 2011-12-14 Londonpharma Ltd Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
CN103570738B (zh) * 2012-08-07 2016-04-13 中国科学院上海生命科学研究院 新型青蒿素衍生物及其制法和应用
EP3450549B1 (en) 2012-10-29 2020-09-30 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
CN117695222B (zh) * 2024-02-06 2024-04-26 山东百奥生物医药有限公司 一种用于改善皮肤问题的青蒿素壬二酸酯-聚乙二醇二胺胶束及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916204A (en) * 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
CN1049435A (zh) * 1990-08-16 1991-02-20 中国对外贸易运输总公司 电传线路自动转换开关
US5219880A (en) * 1991-03-29 1993-06-15 Dermatologic Research Corporation Treatment of viral tumors and hemorrhoids with artemisinin and derivatives
CN1038416C (zh) * 1992-12-04 1998-05-20 中国科学院上海药物研究所 新型青蒿素衍生物及其制备方法
CN1049435C (zh) * 1994-11-09 2000-02-16 中国科学院上海药物研究所 含苯基和杂环基的青蒿素衍生物及其制备方法
US5578637A (en) * 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US5677468A (en) 1995-06-29 1997-10-14 Hauser, Inc. Artemisinin dimer compounds having anticancer activity

Also Published As

Publication number Publication date
CN1305482A (zh) 2001-07-25
NZ508388A (en) 2003-07-25
ZA200007070B (en) 2001-10-18
PL344984A1 (en) 2001-11-19
AU748798B2 (en) 2002-06-13
JP2002518398A (ja) 2002-06-25
NO20006257L (no) 2001-02-19
US6307068B1 (en) 2001-10-23
EP1086107A1 (fr) 2001-03-28
WO1999065914A1 (fr) 1999-12-23
BR9911274A (pt) 2001-10-23
CA2342990A1 (fr) 1999-12-23
CN1084333C (zh) 2002-05-08
CN1239097A (zh) 1999-12-22
NO20006257D0 (no) 2000-12-08
AU4047499A (en) 2000-01-05
HUP0102599A2 (hu) 2001-11-28
HUP0102599A3 (en) 2003-03-28
CN1111162C (zh) 2003-06-11

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070609