HK1033829A1 - Polymorphic clopidogrel hydrogenesulphate form - Google Patents

Polymorphic clopidogrel hydrogenesulphate form

Info

Publication number
HK1033829A1
HK1033829A1 HK01104337A HK01104337A HK1033829A1 HK 1033829 A1 HK1033829 A1 HK 1033829A1 HK 01104337 A HK01104337 A HK 01104337A HK 01104337 A HK01104337 A HK 01104337A HK 1033829 A1 HK1033829 A1 HK 1033829A1
Authority
HK
Hong Kong
Prior art keywords
clopidogrel hydrogenesulphate
polymorphic
polymorphic clopidogrel
hydrogenesulphate
hydrogenesulphate form
Prior art date
Application number
HK01104337A
Other languages
English (en)
Inventor
Andre Bousquet
Bertrand Castro
Jean Saint-Germain
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9527349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1033829(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HK1033829A1 publication Critical patent/HK1033829A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
HK01104337A 1998-06-15 2001-06-21 Polymorphic clopidogrel hydrogenesulphate form HK1033829A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9807464A FR2779726B1 (fr) 1998-06-15 1998-06-15 Forme polymorphe de l'hydrogenosulfate de clopidogrel
PCT/FR1999/001371 WO1999065915A1 (fr) 1998-06-15 1999-06-10 Forme polymorphe de l'hydrogenosulfate de clopidogrel

Publications (1)

Publication Number Publication Date
HK1033829A1 true HK1033829A1 (en) 2001-09-28

Family

ID=9527349

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01104337A HK1033829A1 (en) 1998-06-15 2001-06-21 Polymorphic clopidogrel hydrogenesulphate form

Country Status (44)

Country Link
US (2) US6429210B1 (es)
EP (1) EP1087976B1 (es)
JP (1) JP3641584B2 (es)
KR (1) KR100511238B1 (es)
CN (1) CN1128805C (es)
AP (1) AP1344A (es)
AR (1) AR014854A1 (es)
AT (1) ATE222256T1 (es)
AU (1) AU752170B2 (es)
BG (1) BG64508B1 (es)
BR (1) BR9911219A (es)
CA (1) CA2334870C (es)
CO (1) CO5040084A1 (es)
CZ (1) CZ299654B6 (es)
DE (1) DE69902536T2 (es)
DK (1) DK1087976T3 (es)
DZ (1) DZ2817A1 (es)
EA (1) EA002386B1 (es)
EE (1) EE03972B1 (es)
EG (1) EG24015A (es)
ES (1) ES2181439T3 (es)
FR (1) FR2779726B1 (es)
HK (1) HK1033829A1 (es)
HR (1) HRP20000863B1 (es)
HU (1) HU225871B1 (es)
ID (1) ID28264A (es)
IL (2) IL139790A0 (es)
IS (1) IS2469B (es)
ME (1) ME00686B (es)
MY (1) MY129439A (es)
NO (1) NO327161B1 (es)
NZ (1) NZ507914A (es)
OA (1) OA11567A (es)
PL (1) PL201894B1 (es)
PT (1) PT1087976E (es)
RS (1) RS49870B (es)
SA (1) SA99200321B1 (es)
SK (1) SK286340B6 (es)
TR (1) TR200003417T2 (es)
TW (1) TW562805B (es)
UA (1) UA70323C2 (es)
UY (1) UY25693A1 (es)
WO (1) WO1999065915A1 (es)
ZA (1) ZA200006386B (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792836B3 (fr) 1999-04-30 2001-07-27 Sanofi Sa Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
CA2363053C (en) * 2001-11-09 2011-01-25 Bernard Charles Sherman Clopidogrel bisulfate tablet formulation
KR100839136B1 (ko) * 2001-12-18 2008-06-20 테바 파마슈티컬 인더스트리즈 리미티드 클로피도그렐 황산수소염의 다형
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
ATE378330T1 (de) 2002-04-16 2007-11-15 Schering Corp Trizyklische thrombin rezeptor antagonisten
AR040233A1 (es) * 2002-05-31 2005-03-23 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
WO2004031143A2 (en) * 2002-10-02 2004-04-15 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
ITMI20022228A1 (it) * 2002-10-21 2004-04-22 Dinamite Dipharma S P A Sali di clopidogrel con acidi alchil-solforici.
WO2004048385A2 (en) * 2002-11-28 2004-06-10 Instytut Farmaceutyczny A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate
DE10307343B4 (de) * 2003-02-21 2005-10-06 Volkswagen Ag On-Board-Diagnosevorrichtung und On-Board-Diagnoseverfahren für Kraftfahrzeuge
US20060100231A1 (en) * 2003-03-10 2006-05-11 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
WO2004081016A1 (en) 2003-03-12 2004-09-23 Cadila Healthcare Limited Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
DE04770646T1 (de) 2003-04-25 2011-12-08 Cadila Healthcare Ltd. Salze von clopidogrel und herstellungsverfahren
EA010684B1 (ru) * 2003-07-02 2008-10-30 Эгиш Дьёдьсердьяр Рт. Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов
WO2005003138A2 (en) 2003-07-02 2005-01-13 EGIS Gyógyszergyár Rt. Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
WO2005012300A1 (en) * 2003-08-04 2005-02-10 Wockhardt Limited A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
CA2676121A1 (en) * 2003-11-03 2005-07-14 Cadila Healthcare Limited Processes for preparing different forms of (s)-(+)-clopidogrel bisulfate
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
EP1720884A1 (de) * 2004-02-24 2006-11-15 Siegfried Generics International AG Pharmakologisch akzeptierbare salze von clopidogrel
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate
BRPI0418726A (pt) * 2004-04-09 2007-09-11 Hanmi Pharm Ind Co Ltd naftalenossulfonato de clopidogrel cristalino ou hidrato do mesmo, método para sua preparação e composição farmacêutica contendo o mesmo
SI1740593T1 (sl) * 2004-04-19 2016-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfata
BRPI0510008A (pt) * 2004-04-20 2007-09-18 Sanofi Aventis sal de clopidogrel e formas polimórficas deste
EP1756116A1 (en) * 2004-04-20 2007-02-28 Sanofi-Aventis Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide
US7829720B2 (en) * 2004-05-04 2010-11-09 Bristol-Myers Squibb Company Process for preparing atazanavir bisulfate and novel forms
WO2006034451A2 (en) * 2004-09-21 2006-03-30 Teva Pharmaceutical Industries Ltd. Crystalline clopidogrel hydrobromide and processes for preparation thereof
US7446200B2 (en) * 2004-10-04 2008-11-04 Usv, Ltd. Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I
AU2005327776A1 (en) * 2005-02-15 2006-08-24 Usv Limited Rapid resolution process for clopidogrel base and a process for preparation of Clopidogrel bisulfate polymorph - Form I
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
MX2007010267A (es) * 2005-02-24 2007-09-11 Teva Pharma Base de clopidogrel adecuada para formulacion farmaceutica y preparacion de ella.
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
EA200702444A1 (ru) * 2005-05-10 2008-04-28 Элан Фарма Интернэшнл Лимитед Композиции с наночастицами клопидогреля
CN101237868A (zh) * 2005-06-13 2008-08-06 伊兰制药国际有限公司 纳米粒氯吡格雷和阿司匹林组合制剂
KR20070009851A (ko) * 2005-07-14 2007-01-19 씨제이 주식회사 클로피도그렐 황산수소염 함유 약학 조성물
US7994322B2 (en) 2005-09-05 2011-08-09 Cadila Healthcare Limited Processes for the preparation of different forms of (S)-(+)-clopidogrel besylate
AU2006292946B2 (en) * 2005-09-21 2009-12-10 Chong Kun Dang Pharmaceutical Corp. Novel resinate complex of s-clopidogrel and production method thereof
WO2007091253A2 (en) * 2006-02-06 2007-08-16 C.T.S. Ltd. Pharmaceutical compositions comprising clopidogrel and vitamins which reduce homocysteine levels
US20070225320A1 (en) * 2006-03-27 2007-09-27 Eswaraiah Sajja Process for preparing clopidogrel
JP2009532462A (ja) * 2006-04-05 2009-09-10 カディラ・ヘルスケア・リミテッド 調節放出クロピドグレル製剤
CA2650471A1 (en) * 2006-04-27 2007-11-08 Ind-Swift Laboratories Limited Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
WO2007146039A2 (en) * 2006-06-06 2007-12-21 Bristol-Myers Squibb Company Crystalline forms of n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl] thio]-2-thiazolyl]-4-piperidinecarboxamide
CA2655844A1 (en) * 2006-08-03 2008-02-14 Teva Pharmaceutical Industries Ltd. Process for preparing clopidogrel bisulphate
PT2064217E (pt) * 2006-09-04 2011-04-19 Ranbaxy Lab Ltd Processo melhorado para a preparação de clopidogrel e seus sais farmaceuticamente aceitáveis
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
KR20080055356A (ko) * 2006-12-15 2008-06-19 에스케이케미칼주식회사 보관안정성이 우수한 클로피도그렐 함유 포접 복합체
WO2008079260A2 (en) * 2006-12-22 2008-07-03 Schering Corporation Disintegration promoters in solid dose wet granulation formulations
WO2008093357A2 (en) * 2007-01-29 2008-08-07 Ipca Laboratories Limited Process for preparation of crystalline clopidogrel hydrogen sulphate form i
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
EP2152078B8 (en) 2007-04-27 2021-03-17 CyDex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
WO2009080469A1 (en) * 2007-12-24 2009-07-02 Sandoz Ag Process for the preparation of clopidogrel bisulphate form i
ATE530172T1 (de) * 2008-02-26 2011-11-15 Lesvi Laboratorios Sl Pharmazeutische formulierungen mit clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
WO2010118435A2 (en) 2009-04-10 2010-10-14 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
US8236782B2 (en) 2009-05-13 2012-08-07 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
WO2011010318A1 (en) * 2009-07-23 2011-01-27 Praveen Laboratories Private Limited Process for the preparation of clopidogrel polymorphous form 1 using seed chrystals
WO2011042804A2 (en) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
KR101130445B1 (ko) * 2009-10-29 2012-03-27 동아제약주식회사 클로피도그랠 황산수소염 ⅰ형 제조방법
WO2011051976A2 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
CN101766573B (zh) 2010-02-05 2013-02-13 上海安必生制药技术有限公司 硫酸氢氯吡格雷固体制剂的制备工艺
WO2011125069A1 (en) 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
ES2592280T3 (es) 2010-04-19 2016-11-29 Cadila Healthcare Limited Una composición farmacéutica que comprende agentes antiplaquetarios y un agente estimulante de eritropoyesis
JP2014518260A (ja) 2011-06-27 2014-07-28 アイピーシーエー ラボラトリーズ リミテッド 抗血栓症化合物
KR101324862B1 (ko) * 2011-07-12 2013-11-01 (주)에이에스텍 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型,它们的制备及应用
WO2014118802A1 (en) 2013-01-31 2014-08-07 Pharmazell Gmbh An improved process for the preparation of clopidogrel bisulfate form-i
JP5905165B2 (ja) 2013-08-02 2016-04-20 サノフイ アセチルサリチル酸およびクロピドグレルを含む医薬錠剤
CN103524528A (zh) * 2013-09-16 2014-01-22 吉林省博大伟业制药有限公司 一种改进的ⅱ型硫酸氢氯吡格雷结晶制备方法
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
BR112019015107A2 (pt) 2017-01-23 2020-03-10 Dong Wha Pharm. Co., Ltd. Formulação de complexo compreendendo inibidor de hmg-coa redutase e clopidogrel
CN107163060B (zh) * 2017-05-24 2021-03-02 常州制药厂有限公司 一种硫酸氢氯吡格雷晶型ii制备方法
CN107337683B (zh) * 2017-08-16 2019-08-16 中荣凯特(北京)生物科技有限公司 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用
CN109438467B (zh) * 2018-11-14 2021-03-26 四川青木制药有限公司 一种硫酸氢氯吡格雷ⅱ型球形结晶的制备方法
US20230059869A1 (en) 2021-08-03 2023-02-23 Liqmeds Worldwide Limited Oral pharmaceutical solution of clopidogrel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2664276B1 (fr) 1990-07-04 1992-10-23 Sanofi Sa Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

Also Published As

Publication number Publication date
HRP20000863B1 (en) 2003-04-30
DE69902536D1 (en) 2002-09-19
EA200001187A1 (ru) 2001-08-27
AR014854A1 (es) 2001-04-11
NZ507914A (en) 2002-11-26
TW562805B (en) 2003-11-21
IL139790A0 (en) 2002-02-10
MY129439A (en) 2007-04-30
WO1999065915A1 (fr) 1999-12-23
FR2779726A1 (fr) 1999-12-17
KR20010052835A (ko) 2001-06-25
HRP20000863A2 (en) 2001-10-31
ZA200006386B (en) 2001-05-07
HU225871B1 (en) 2007-11-28
IS2469B (is) 2008-12-15
IS5716A (is) 2000-11-17
TR200003417T2 (tr) 2001-03-21
DK1087976T3 (da) 2002-12-02
CA2334870C (en) 2005-03-15
CN1128805C (zh) 2003-11-26
JP2002518399A (ja) 2002-06-25
YU77700A (sh) 2003-04-30
PL201894B1 (pl) 2009-05-29
NO327161B1 (no) 2009-05-04
HUP0104343A3 (en) 2003-03-28
BG104987A (en) 2001-11-30
CZ299654B6 (cs) 2008-10-08
AU752170B2 (en) 2002-09-05
JP3641584B2 (ja) 2005-04-20
EE200000745A (et) 2002-04-15
IL139790A (en) 2006-10-05
UY25693A1 (es) 2000-03-31
BR9911219A (pt) 2001-03-06
US20020198229A1 (en) 2002-12-26
EG24015A (en) 2008-03-24
DZ2817A1 (fr) 2004-06-02
EE03972B1 (et) 2003-02-17
AP1344A (en) 2004-12-15
ME00686B (me) 2008-08-07
CA2334870A1 (en) 1999-12-23
US6429210B1 (en) 2002-08-06
KR100511238B1 (ko) 2005-08-31
OA11567A (en) 2004-05-24
EA002386B1 (ru) 2002-04-25
PL344998A1 (en) 2001-11-19
PT1087976E (pt) 2002-11-29
CZ20004637A3 (cs) 2001-04-11
BG64508B1 (bg) 2005-05-31
EP1087976B1 (fr) 2002-08-14
NO20006395D0 (no) 2000-12-14
NO20006395L (no) 2001-02-15
CN1305483A (zh) 2001-07-25
SK286340B6 (en) 2008-07-07
ID28264A (id) 2001-05-10
FR2779726B1 (fr) 2001-05-18
EP1087976A1 (fr) 2001-04-04
CO5040084A1 (es) 2001-05-29
ATE222256T1 (de) 2002-08-15
SK19092000A3 (sk) 2001-05-10
ES2181439T3 (es) 2003-02-16
SA99200321B1 (ar) 2006-10-11
RS49870B (sr) 2008-08-07
AP2000001979A0 (en) 2000-12-31
UA70323C2 (uk) 2004-10-15
US6504030B1 (en) 2003-01-07
DE69902536T2 (de) 2003-03-13
HUP0104343A2 (hu) 2002-03-28
AU4048399A (en) 2000-01-05

Similar Documents

Publication Publication Date Title
AP2000001979A0 (en) Polymorphic clopidogrel hydrogenesulphate form
PL345589A1 (en) β-CARBOLINE COMPOUNDS
DE59912932D1 (en) Arylphenylsubstituierte cyclische ketoenole
DE59912303D1 (en) Arylphenylsubstituierte cyclische ketoenole
DE59903023D1 (en) Perorale wirkstoff-suspension
DE59914151D1 (en) Arylalkanoylpyridazine
EG24143A (en) Polymorphic salt
DE59904407D1 (en) Chromanderivate
DE59900495D1 (en) Multimetalloxidmassen
DE59900471D1 (en) Inchbremseinrichtung
GB9803322D0 (en) Methods
SI1087976T1 (en) Polymorphic clopidogrel hydrogenesulphate form
DE59905941D1 (en) Methoximinophenylessigsäureamide
DE59911094D1 (en) Tryptase-inhibitoren
TW407677U (en) Form
GB9807430D0 (en) Rapid Floar
CA83750S (en) Golfing aid
GB2340966B (en) Golfing aid
CA84573S (en) Sungalsses
CA85048S (en) Bedboard
AU1538P (en) Guinevere Mandevilla sanderi
GB9822889D0 (en) Putting aid
PL107637U1 (en) Shape
GB9824501D0 (en) Methods
GB9824856D0 (en) Methods

Legal Events

Date Code Title Description
PF Patent in force
CHPA Change of a particular in the register (except of change of ownership)
PE Patent expired

Effective date: 20190609