HK1028350A1 - Leptin as an inhibitor of tumor cell proliferation. - Google Patents
Leptin as an inhibitor of tumor cell proliferation.Info
- Publication number
- HK1028350A1 HK1028350A1 HK00107866A HK00107866A HK1028350A1 HK 1028350 A1 HK1028350 A1 HK 1028350A1 HK 00107866 A HK00107866 A HK 00107866A HK 00107866 A HK00107866 A HK 00107866A HK 1028350 A1 HK1028350 A1 HK 1028350A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- leptin
- inhibitor
- cell proliferation
- tumor cell
- tumor
- Prior art date
Links
- 102000016267 Leptin Human genes 0.000 title 1
- 108010092277 Leptin Proteins 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1
- 229940039781 leptin Drugs 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12073397A IL120733A0 (en) | 1997-04-29 | 1997-04-29 | Leptin as an inhibitor of cell proliferation |
PCT/IL1998/000196 WO1998048831A1 (en) | 1997-04-29 | 1998-04-26 | Leptin as an inhibitor of tumor cell proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1028350A1 true HK1028350A1 (en) | 2001-02-16 |
Family
ID=11070075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00107866A HK1028350A1 (en) | 1997-04-29 | 2000-12-07 | Leptin as an inhibitor of tumor cell proliferation. |
Country Status (26)
Country | Link |
---|---|
US (1) | US7109159B1 (ja) |
EP (1) | EP0981365B1 (ja) |
JP (1) | JP4330662B2 (ja) |
KR (1) | KR100507731B1 (ja) |
CN (1) | CN1168497C (ja) |
AR (1) | AR012626A1 (ja) |
AT (1) | ATE283702T1 (ja) |
AU (1) | AU742927B2 (ja) |
BG (1) | BG63490B1 (ja) |
CA (1) | CA2288238A1 (ja) |
CZ (1) | CZ299872B6 (ja) |
DE (1) | DE69827942T2 (ja) |
EA (1) | EA002353B1 (ja) |
EE (1) | EE04801B1 (ja) |
ES (1) | ES2232944T3 (ja) |
HK (1) | HK1028350A1 (ja) |
HU (1) | HUP0002427A3 (ja) |
IL (2) | IL120733A0 (ja) |
NO (1) | NO322304B1 (ja) |
NZ (1) | NZ500589A (ja) |
PL (1) | PL195275B1 (ja) |
PT (1) | PT981365E (ja) |
SK (1) | SK284848B6 (ja) |
UA (1) | UA66793C2 (ja) |
WO (1) | WO1998048831A1 (ja) |
ZA (1) | ZA983608B (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7208572B2 (en) | 1998-08-21 | 2007-04-24 | Albany Medical College | Leptin-related peptides |
US6777388B1 (en) | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
IL132312A0 (en) * | 1999-09-05 | 2001-03-19 | Yeda Res & Dev | Use of leptin in inhibition of endothelial cell proliferation |
EP2422807A3 (en) | 2004-02-11 | 2012-05-30 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
US7863240B2 (en) * | 2004-10-08 | 2011-01-04 | Enzo Therapeutics, Inc. | Methods and uses of leptin in hepatocellular carcinoma |
US8969291B2 (en) | 2004-10-08 | 2015-03-03 | Enzo Therapeutics, Inc. | Methods for decreasing leptin levels or activity for treating inflammation |
US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
SG159551A1 (en) | 2005-02-11 | 2010-03-30 | Amylin Pharmaceuticals Inc | Gip analog and hybrid polypeptides with selectable properties |
AU2006279680B2 (en) | 2005-08-11 | 2012-12-06 | Amylin Pharmaceuticals, Llc | Hybrid polypeptides with selectable properties |
BRPI0614649A2 (pt) | 2005-08-11 | 2011-04-12 | Amylin Pharmaceuticals Inc | polipeptìdeos hìbridos com propriedades selecionáveis |
US8227408B2 (en) * | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
CN101939443B (zh) * | 2008-02-08 | 2014-01-29 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
EP2326339A4 (en) * | 2008-05-21 | 2012-06-20 | Neurotez Inc | METHOD FOR TREATING PROGRESSIVE COGNITIVE DISORDER IN CONNECTION WITH NEUROFIBRILLARY TANGLES |
WO2010054017A1 (en) * | 2008-11-04 | 2010-05-14 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
KR102563568B1 (ko) | 2016-11-08 | 2023-08-04 | 리제너론 파마슈티칼스 인코포레이티드 | 렙틴 수용체에 길항하는 항원-결합 단백질 |
MX2020006508A (es) | 2017-12-18 | 2020-09-17 | Regeneron Pharma | Moleculas de union a antigeno biespecificas que se unen al receptor de leptina y/o gp130, y metodos para el uso de estas. |
CA3094400A1 (en) | 2018-04-06 | 2019-10-10 | Regeneron Pharmaceuticals, Inc. | A leptin receptor agonist antibody for use in treating a metabolic dysfunction or hypoleptinemia |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU695934B2 (en) * | 1995-06-30 | 1998-08-27 | Eli Lilly And Company | Methods for treating diabetes |
JPH11512296A (ja) * | 1995-09-19 | 1999-10-26 | イーライ・リリー・アンド・カンパニー | 医療用タンパク質をコードしているdna |
CA2244693A1 (en) * | 1996-01-23 | 1997-07-31 | Progenitor, Inc. | Methods for using the obese gene and its gene product to stimulate hematopoietic development |
-
1997
- 1997-04-29 IL IL12073397A patent/IL120733A0/xx unknown
-
1998
- 1998-04-26 JP JP54678798A patent/JP4330662B2/ja not_active Expired - Fee Related
- 1998-04-26 HU HU0002427A patent/HUP0002427A3/hu unknown
- 1998-04-26 SK SK1471-99A patent/SK284848B6/sk not_active IP Right Cessation
- 1998-04-26 KR KR10-1999-7009705A patent/KR100507731B1/ko not_active IP Right Cessation
- 1998-04-26 CA CA002288238A patent/CA2288238A1/en not_active Abandoned
- 1998-04-26 ES ES98917580T patent/ES2232944T3/es not_active Expired - Lifetime
- 1998-04-26 PT PT98917580T patent/PT981365E/pt unknown
- 1998-04-26 DE DE69827942T patent/DE69827942T2/de not_active Expired - Lifetime
- 1998-04-26 AT AT98917580T patent/ATE283702T1/de active
- 1998-04-26 WO PCT/IL1998/000196 patent/WO1998048831A1/en active IP Right Grant
- 1998-04-26 EP EP98917580A patent/EP0981365B1/en not_active Expired - Lifetime
- 1998-04-26 EA EA199900981A patent/EA002353B1/ru not_active IP Right Cessation
- 1998-04-26 UA UA99116415A patent/UA66793C2/uk unknown
- 1998-04-26 EE EEP199900510A patent/EE04801B1/xx not_active IP Right Cessation
- 1998-04-26 PL PL98336582A patent/PL195275B1/pl not_active IP Right Cessation
- 1998-04-26 US US09/403,897 patent/US7109159B1/en not_active Expired - Fee Related
- 1998-04-26 CZ CZ0384899A patent/CZ299872B6/cs not_active IP Right Cessation
- 1998-04-26 CN CNB988066920A patent/CN1168497C/zh not_active Expired - Fee Related
- 1998-04-26 AU AU70762/98A patent/AU742927B2/en not_active Ceased
- 1998-04-26 NZ NZ500589A patent/NZ500589A/xx not_active IP Right Cessation
- 1998-04-29 ZA ZA983608A patent/ZA983608B/xx unknown
- 1998-04-29 AR ARP980102003A patent/AR012626A1/es unknown
-
1999
- 1999-10-25 BG BG103832A patent/BG63490B1/bg unknown
- 1999-10-28 NO NO19995267A patent/NO322304B1/no not_active IP Right Cessation
- 1999-10-28 IL IL132633A patent/IL132633A/en not_active IP Right Cessation
-
2000
- 2000-12-07 HK HK00107866A patent/HK1028350A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1028350A1 (en) | Leptin as an inhibitor of tumor cell proliferation. | |
ZA972000B (en) | Inhibition of proliferation of cells. | |
ZA973146B (en) | Prodrugs of COX-2 inhibitors. | |
EP0971723A4 (en) | COMPOSITIONS AND METHODS FOR INHIBITING CELL PROLIFERATION | |
GB2321641B (en) | Sulfamide-metalloprotease inhibitors | |
AU1536799A (en) | Bishydroxyureas as inhibitors of the 5-lipoxygenase | |
CY2483B1 (en) | Substituted bisindolylmaleimides for the inhibition of cell proliferation. | |
AU4296397A (en) | Substituted bisindolylmaleimides for the inhibition of cell proliferation | |
HK1036452A1 (en) | Substituted bisindolymaleimides for the inhibition of cell proliferation | |
PL337091A1 (en) | Cyanoguanidines as inhibitors of cell proliferation | |
AU7638498A (en) | Cyanoguanidines as cell proliferation inhibitors | |
PL337031A1 (en) | Cyanoguanidines as inhibitors of cell proliferation | |
AU3459497A (en) | Cancer cell proliferation inhibitors | |
IL132633A0 (en) | Leptin as an inhibitor of tumor cell proliferation | |
SI0981365T1 (en) | Leptin as an inhibitor of tumor cell proliferation | |
AU2001290241A1 (en) | Tumor cell proliferation inhibitors | |
AU8492598A (en) | Methods and compositions for tumor reduction | |
EP1086261A4 (en) | ANTI-CORROSION TREATMENT | |
AU2924897A (en) | Tumor suppressor gene | |
AU4089699A (en) | Tumor suppressor | |
GB9804178D0 (en) | Tumour suppressor gene | |
PL336896A1 (en) | Cyanoamidines as inhibitors of cell proliferation | |
AU2086597A (en) | Inhibition of proliferation of cells | |
AUPO851597A0 (en) | Treatment of prostate cancer | |
EP0846765A4 (en) | CELL PROLIFERATION INHIBITOR |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130426 |