HK1027040A1 - Molecular dispersion composition with enhanced bioavailability. - Google Patents

Molecular dispersion composition with enhanced bioavailability.

Info

Publication number
HK1027040A1
HK1027040A1 HK00106351A HK00106351A HK1027040A1 HK 1027040 A1 HK1027040 A1 HK 1027040A1 HK 00106351 A HK00106351 A HK 00106351A HK 00106351 A HK00106351 A HK 00106351A HK 1027040 A1 HK1027040 A1 HK 1027040A1
Authority
HK
Hong Kong
Prior art keywords
dispersion composition
molecular dispersion
enhanced bioavailability
bioavailability
enhanced
Prior art date
Application number
HK00106351A
Other languages
English (en)
Inventor
Surendra A Sangekar
Ping I Lee
Amin A Nomeir
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1027040A1 publication Critical patent/HK1027040A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
HK00106351A 1997-12-22 2000-10-09 Molecular dispersion composition with enhanced bioavailability. HK1027040A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99716897A 1997-12-22 1997-12-22
PCT/US1998/026218 WO1999032118A1 (en) 1997-12-22 1998-12-17 Molecular dispersion composition with enhanced bioavailability

Publications (1)

Publication Number Publication Date
HK1027040A1 true HK1027040A1 (en) 2001-01-05

Family

ID=25543717

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00106351A HK1027040A1 (en) 1997-12-22 2000-10-09 Molecular dispersion composition with enhanced bioavailability.

Country Status (28)

Country Link
EP (1) EP1039908B1 (cs)
JP (2) JP2001526227A (cs)
KR (1) KR100597331B1 (cs)
CN (1) CN1116039C (cs)
AR (1) AR017436A1 (cs)
AT (1) ATE260105T1 (cs)
AU (1) AU761994C (cs)
BR (1) BR9813728A (cs)
CA (1) CA2315685C (cs)
CO (1) CO4970793A1 (cs)
CZ (1) CZ295956B6 (cs)
DE (1) DE69821984T2 (cs)
DK (1) DK1039908T3 (cs)
ES (1) ES2214757T3 (cs)
HK (1) HK1027040A1 (cs)
HU (1) HU229052B1 (cs)
ID (1) ID28304A (cs)
IL (1) IL136460A0 (cs)
MY (1) MY126580A (cs)
NO (1) NO327383B1 (cs)
NZ (1) NZ504834A (cs)
PE (1) PE20000012A1 (cs)
PL (1) PL192423B1 (cs)
PT (1) PT1039908E (cs)
SK (1) SK285662B6 (cs)
TW (1) TW527196B (cs)
WO (1) WO1999032118A1 (cs)
ZA (1) ZA9811592B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
ES2333645T3 (es) 2001-06-22 2010-02-25 Bend Research, Inc. Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros.
EP1492508A4 (en) * 2002-03-04 2009-05-06 Teva Pharma DOSAGE FORMS WITH CONTROLLED RELEASE
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
WO2008136394A1 (ja) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. ラクタム化合物の製造方法及びその製造中間体
US8835635B2 (en) * 2012-06-05 2014-09-16 Symed Labs Limited Amorphous form of vilazodone hydrochloride substantially free of crystalline forms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2546577B2 (de) * 1975-10-17 1981-04-02 Sandoz-Patent-GmbH, 7850 Lörrach Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden
EP0214092A1 (en) * 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
JP3722293B2 (ja) * 1991-12-18 2005-11-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 新規な薬学的固体分散物
JPH0848632A (ja) * 1994-08-08 1996-02-20 Kanebo Ltd エトポシドを含有する固形組成物および固形製剤
NZ326035A (en) * 1995-12-22 2000-01-28 Schering Corp Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1998000113A1 (en) * 1996-06-28 1998-01-08 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability

Also Published As

Publication number Publication date
KR20010033397A (ko) 2001-04-25
JP2010059212A (ja) 2010-03-18
HUP0100850A3 (en) 2002-12-28
CA2315685C (en) 2008-02-05
KR100597331B1 (ko) 2006-07-10
CZ20002304A3 (cs) 2001-04-11
TW527196B (en) 2003-04-11
ZA9811592B (en) 1999-06-17
PL341344A1 (en) 2001-04-09
CO4970793A1 (es) 2000-11-07
IL136460A0 (en) 2001-06-14
CN1116039C (zh) 2003-07-30
ES2214757T3 (es) 2004-09-16
BR9813728A (pt) 2000-10-10
AR017436A1 (es) 2001-09-05
DE69821984T2 (de) 2004-12-30
PE20000012A1 (es) 2000-01-18
NO20003235L (no) 2000-07-27
JP2001526227A (ja) 2001-12-18
DE69821984D1 (de) 2004-04-01
NO327383B1 (no) 2009-06-22
CN1282245A (zh) 2001-01-31
SK285662B6 (sk) 2007-05-03
MY126580A (en) 2006-10-31
DK1039908T3 (da) 2004-05-03
AU1814399A (en) 1999-07-12
EP1039908A1 (en) 2000-10-04
HUP0100850A2 (hu) 2001-10-28
AU761994B2 (en) 2003-06-12
CA2315685A1 (en) 1999-07-01
ID28304A (id) 2001-05-10
EP1039908B1 (en) 2004-02-25
PL192423B1 (pl) 2006-10-31
ATE260105T1 (de) 2004-03-15
CZ295956B6 (cs) 2005-12-14
SK8962000A3 (en) 2001-07-10
WO1999032118A1 (en) 1999-07-01
AU761994C (en) 2004-01-08
HU229052B1 (en) 2013-07-29
NZ504834A (en) 2001-12-21
PT1039908E (pt) 2004-06-30
NO20003235D0 (no) 2000-06-21

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20141217