HK1025511A1 - Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors - Google Patents

Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors

Info

Publication number
HK1025511A1
HK1025511A1 HK00104779A HK00104779A HK1025511A1 HK 1025511 A1 HK1025511 A1 HK 1025511A1 HK 00104779 A HK00104779 A HK 00104779A HK 00104779 A HK00104779 A HK 00104779A HK 1025511 A1 HK1025511 A1 HK 1025511A1
Authority
HK
Hong Kong
Prior art keywords
amino
peptidyl
protease inhibitors
cysteine protease
hydroxyalkanesulfonic acid
Prior art date
Application number
HK00104779A
Other languages
English (en)
Inventor
Ron Bihovsky
Ming Tao
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of HK1025511A1 publication Critical patent/HK1025511A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK00104779A 1997-04-18 2000-07-31 Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors HK1025511A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4467697P 1997-04-18 1997-04-18
PCT/US1998/007499 WO1998047523A1 (en) 1997-04-18 1998-04-15 Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
US09/060,491 US6348448B1 (en) 1997-04-18 1998-04-15 Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors

Publications (1)

Publication Number Publication Date
HK1025511A1 true HK1025511A1 (en) 2000-11-17

Family

ID=26721855

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00104779A HK1025511A1 (en) 1997-04-18 2000-07-31 Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors

Country Status (11)

Country Link
US (2) US6348448B1 (ja)
EP (1) EP0975353B1 (ja)
JP (1) JP4144811B2 (ja)
AT (1) ATE309264T1 (ja)
AU (1) AU733420B2 (ja)
CA (1) CA2286722C (ja)
DE (1) DE69832268T2 (ja)
ES (1) ES2252831T3 (ja)
HK (1) HK1025511A1 (ja)
NZ (1) NZ500045A (ja)
WO (1) WO1998047523A1 (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
ES2221227T3 (es) * 1997-11-24 2004-12-16 MERCK & CO., INC. Derivados sustituidos de beta-alanina como inhibidores de la adhesion celular.
WO2003024923A1 (en) * 2001-09-14 2003-03-27 Axys Pharmaceuticals, Inc. Sulfonamide compounds as protease inhibitors
WO2012174552A2 (en) * 2011-06-17 2012-12-20 Virobay, Inc. Cathepsin inhibitors for treating microglia-mediated neuron loss in the central nervous system
BR112013033816A2 (pt) 2011-07-01 2017-02-14 Novozymes A / S composição de detergente líquido sem boro
EP2726592B1 (en) 2011-07-01 2015-04-01 Novozymes A/S Stabilized subtilisin composition
EP2970830B1 (en) 2013-03-14 2017-12-13 Novozymes A/S Enzyme and inhibitor contained in water-soluble films
EP3461881A1 (en) 2013-05-03 2019-04-03 Novozymes A/S Microencapsulation of detergent enzymes
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
CN107109388A (zh) 2014-12-19 2017-08-29 诺维信公司 蛋白酶变体以及对其进行编码的多核苷酸
CN107969136B (zh) 2015-07-06 2021-12-21 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
WO2018202846A1 (en) 2017-05-05 2018-11-08 Novozymes A/S Compositions comprising lipase and sulfite
US20200181542A1 (en) 2017-06-30 2020-06-11 Novozymes A/S Enzyme Slurry Composition
BR112020008737A2 (pt) 2017-11-01 2020-10-13 Novozymes A/S polipeptídeos e composições que compreendam tais polipeptídeos
CN111479919A (zh) 2017-11-01 2020-07-31 诺维信公司 多肽以及包含此类多肽的组合物
CN111770788B (zh) 2018-03-13 2023-07-25 诺维信公司 使用氨基糖低聚物进行微囊化
EP3647398B1 (en) 2018-10-31 2024-05-15 Henkel AG & Co. KGaA Cleaning compositions containing dispersins v
EP3647397A1 (en) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Cleaning compositions containing dispersins iv
CN114008068A (zh) 2019-07-01 2022-02-01 巴斯夫欧洲公司 稳定酶的肽缩醛
EP4077656A2 (en) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides having proteolytic activity and use thereof
EP4305146A1 (en) 2021-03-12 2024-01-17 Novozymes A/S Polypeptide variants
WO2024131880A2 (en) 2022-12-23 2024-06-27 Novozymes A/S Detergent composition comprising catalase and amylase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124317B1 (en) 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
JPH075634B2 (ja) * 1987-10-30 1995-01-25 日東紡績株式会社 トリペプチド類及びこれを含有する抗プラスミン剤
DE4101895C1 (ja) 1991-01-23 1991-12-05 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
US5436229A (en) 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
WO1997018190A1 (en) 1995-11-16 1997-05-22 G.D. Searle & Co. N-protected/n-substituted-beta-amino hydroxy sulfonates

Also Published As

Publication number Publication date
CA2286722A1 (en) 1998-10-29
DE69832268D1 (en) 2005-12-15
AU733420B2 (en) 2001-05-17
EP0975353A4 (en) 2001-11-28
CA2286722C (en) 2010-10-19
NZ500045A (en) 2001-02-23
US6500802B1 (en) 2002-12-31
AU6972098A (en) 1998-11-13
ES2252831T3 (es) 2006-05-16
DE69832268T2 (de) 2006-07-13
WO1998047523A1 (en) 1998-10-29
EP0975353A1 (en) 2000-02-02
JP4144811B2 (ja) 2008-09-03
EP0975353B1 (en) 2005-11-09
JP2001520674A (ja) 2001-10-30
US6348448B1 (en) 2002-02-19
ATE309264T1 (de) 2005-11-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170415