HK1023998A1 - Preparation of[1s-[1a,2b,3b,4a(s*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl] propyl]amino]-3h-imidazo [4,5-b]pyridin-3-yl]-n-ethyl-2,3-dihydroxycyclopentanecarbox amide - Google Patents

Preparation of[1s-[1a,2b,3b,4a(s*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl] propyl]amino]-3h-imidazo [4,5-b]pyridin-3-yl]-n-ethyl-2,3-dihydroxycyclopentanecarbox amide

Info

Publication number
HK1023998A1
HK1023998A1 HK00103182A HK00103182A HK1023998A1 HK 1023998 A1 HK1023998 A1 HK 1023998A1 HK 00103182 A HK00103182 A HK 00103182A HK 00103182 A HK00103182 A HK 00103182A HK 1023998 A1 HK1023998 A1 HK 1023998A1
Authority
HK
Hong Kong
Prior art keywords
dihydroxycyclopentanecarbox
imidazo
pyridin
thienyl
chloro
Prior art date
Application number
HK00103182A
Other languages
English (en)
Inventor
Michael K O'brien
Herve Garcia
Patrick Leon
Tory H Powner
Laurence W Reilly
Harshavadan C Shah
Michael D Thompson
Ching T Tsuei
Benoit J Vanasse
Francis L Walther
Original Assignee
Aventis Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceutical Inc filed Critical Aventis Pharmaceutical Inc
Publication of HK1023998A1 publication Critical patent/HK1023998A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
HK00103182A 1996-12-11 2000-05-30 Preparation of[1s-[1a,2b,3b,4a(s*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl] propyl]amino]-3h-imidazo [4,5-b]pyridin-3-yl]-n-ethyl-2,3-dihydroxycyclopentanecarbox amide HK1023998A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3276496P 1996-12-11 1996-12-11
PCT/US1997/021439 WO1998025921A1 (en) 1996-12-11 1997-11-24 PREPARATION OF [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-CHLORO-2-THIENYL) METHYL]PROPYL]AMINO]-3H-IMIDAZO[4,5-b]PYRIDIN-3-yl]-N-ETHYL-2,3-DIHYDROXYCYCLOPENTANECARBOXAMIDE

Publications (1)

Publication Number Publication Date
HK1023998A1 true HK1023998A1 (en) 2000-09-29

Family

ID=21866680

Family Applications (2)

Application Number Title Priority Date Filing Date
HK00103182A HK1023998A1 (en) 1996-12-11 2000-05-30 Preparation of[1s-[1a,2b,3b,4a(s*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl] propyl]amino]-3h-imidazo [4,5-b]pyridin-3-yl]-n-ethyl-2,3-dihydroxycyclopentanecarbox amide
HK03104142A HK1051862A1 (en) 1996-12-11 2003-06-11 Preparation of Ä1S-Ä1A,2B,3B,4A(S*)ÜÜ-4-Ä7-ÄÄ1-(3-chloro-2-thienyl)methylÜpropylÜaminoÜ-3H-imidazoÄ4,5-BÜpyridin-3-ylÜ-N-ethyl-2,3-dihydroxycyclopentanecarboxamide.

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK03104142A HK1051862A1 (en) 1996-12-11 2003-06-11 Preparation of Ä1S-Ä1A,2B,3B,4A(S*)ÜÜ-4-Ä7-ÄÄ1-(3-chloro-2-thienyl)methylÜpropylÜaminoÜ-3H-imidazoÄ4,5-BÜpyridin-3-ylÜ-N-ethyl-2,3-dihydroxycyclopentanecarboxamide.

Country Status (27)

Country Link
US (2) US6143894A (es)
EP (2) EP1609791A1 (es)
JP (1) JP2001506626A (es)
KR (4) KR100510389B1 (es)
CN (3) CN1191251C (es)
AP (1) AP1063A (es)
AT (1) ATE301120T1 (es)
AU (1) AU738581B2 (es)
BG (1) BG63805B1 (es)
BR (1) BR9713705A (es)
CA (1) CA2274630C (es)
DE (1) DE69733897T2 (es)
DK (1) DK0946550T3 (es)
EA (1) EA001989B1 (es)
ES (1) ES2242984T3 (es)
HK (2) HK1023998A1 (es)
HU (1) HUP0000342A3 (es)
IL (1) IL130397A (es)
MX (1) MXPA03006730A (es)
NO (2) NO319722B1 (es)
OA (1) OA11061A (es)
PT (1) PT946550E (es)
SI (1) SI0946550T1 (es)
SK (1) SK71199A3 (es)
UA (1) UA54479C2 (es)
WO (1) WO1998025921A1 (es)
ZA (1) ZA9711035B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1140933T1 (en) 1998-12-31 2005-02-28 Aventis Pharmaceuticals Inc. Process for preparing n6-substituted deaza-adenosine derivatives
US7291603B2 (en) * 2002-07-24 2007-11-06 Ptc Therapeutics, Inc. Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
FR2846656B1 (fr) * 2002-11-05 2004-12-24 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2505085B2 (ja) * 1990-09-25 1996-06-05 ローヌ−プーラン ローラー インターナショナル （ホウルディングス） インコーポレイテッド 抗昇圧および抗虚血特性を有する化合物
AU746706B2 (en) * 1997-07-03 2002-05-02 Du Pont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
EA003645B1 (ru) * 1998-12-21 2003-08-28 Авентис Фармасьютикалз Инк. Способ получения n6-замещенных производных деаза-аденозина

Also Published As

Publication number Publication date
NO20052327L (no) 1999-08-10
CN1090630C (zh) 2002-09-11
AP1063A (en) 2002-04-26
PT946550E (pt) 2005-09-30
DK0946550T3 (da) 2005-08-29
MXPA03006730A (es) 2003-10-24
US6143894A (en) 2000-11-07
KR20050046793A (ko) 2005-05-18
UA54479C2 (uk) 2003-03-17
WO1998025921A1 (en) 1998-06-18
IL130397A (en) 2005-11-20
BR9713705A (pt) 2000-05-09
NO319722B1 (no) 2005-09-05
BG63805B1 (bg) 2003-01-31
EP0946550A4 (en) 2003-05-14
DE69733897T2 (de) 2006-06-01
AU5360798A (en) 1998-07-03
KR20060002030A (ko) 2006-01-06
EP0946550A1 (en) 1999-10-06
OA11061A (en) 2002-02-27
BG103484A (en) 2000-06-30
NO992795L (no) 1999-08-10
KR20000057505A (ko) 2000-09-15
IL130397A0 (en) 2000-06-01
CN1394859A (zh) 2003-02-05
NO992795D0 (no) 1999-06-09
EA001989B1 (ru) 2001-10-22
CA2274630C (en) 2000-10-03
CN1240445A (zh) 2000-01-05
SK71199A3 (en) 2000-07-11
SI0946550T1 (en) 2005-10-31
EA199900527A1 (ru) 2000-02-28
CN1191251C (zh) 2005-03-02
HUP0000342A3 (en) 2001-01-29
ATE301120T1 (de) 2005-08-15
AP9901550A0 (en) 1999-06-30
KR100571690B1 (ko) 2006-04-18
AU738581B2 (en) 2001-09-20
NO20052327D0 (no) 2005-05-12
KR100510389B1 (ko) 2005-08-31
KR20060002029A (ko) 2006-01-06
ES2242984T3 (es) 2005-11-16
JP2001506626A (ja) 2001-05-22
US6235909B1 (en) 2001-05-22
ZA9711035B (en) 1998-06-15
CN1660842A (zh) 2005-08-31
DE69733897D1 (de) 2005-09-08
EP0946550B1 (en) 2005-08-03
HUP0000342A2 (hu) 2000-10-28
EP1609791A1 (en) 2005-12-28
HK1051862A1 (en) 2003-08-22

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20061124