HK1020058A1 - Bicyclic pyrimidine derivatives and their use as anti-coagulants - Google Patents

Bicyclic pyrimidine derivatives and their use as anti-coagulants

Info

Publication number
HK1020058A1
HK1020058A1 HK99105314A HK99105314A HK1020058A1 HK 1020058 A1 HK1020058 A1 HK 1020058A1 HK 99105314 A HK99105314 A HK 99105314A HK 99105314 A HK99105314 A HK 99105314A HK 1020058 A1 HK1020058 A1 HK 1020058A1
Authority
HK
Hong Kong
Prior art keywords
coagulants
pyrimidine derivatives
bicyclic pyrimidine
compounds
directed
Prior art date
Application number
HK99105314A
Other languages
English (en)
Inventor
Michael M Morrissey
Brad Buckham
Raju Mohan
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of HK1020058A1 publication Critical patent/HK1020058A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK99105314A 1996-08-16 1999-11-18 Bicyclic pyrimidine derivatives and their use as anti-coagulants HK1020058A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/699,372 US5693641A (en) 1996-08-16 1996-08-16 Bicyclic pyrimidine derivatives and their use as anti-coagulants
PCT/EP1997/004444 WO1998007723A1 (en) 1996-08-16 1997-08-14 Bicyclic pyrimidine derivatives and their use as anti-coagulants

Publications (1)

Publication Number Publication Date
HK1020058A1 true HK1020058A1 (en) 2000-03-10

Family

ID=24809035

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99105314A HK1020058A1 (en) 1996-08-16 1999-11-18 Bicyclic pyrimidine derivatives and their use as anti-coagulants

Country Status (22)

Country Link
US (3) US5693641A (da)
EP (1) EP0922045B1 (da)
JP (1) JP2000516241A (da)
KR (1) KR20000068173A (da)
CN (1) CN1112363C (da)
AT (1) ATE237617T1 (da)
AU (1) AU724413B2 (da)
CA (1) CA2261908A1 (da)
CZ (1) CZ297323B6 (da)
DE (1) DE69721008T2 (da)
DK (1) DK0922045T3 (da)
ES (1) ES2195163T3 (da)
HK (1) HK1020058A1 (da)
IL (1) IL128062A0 (da)
NO (1) NO990708L (da)
NZ (1) NZ333774A (da)
PL (1) PL331634A1 (da)
PT (1) PT922045E (da)
RU (1) RU2198884C2 (da)
SK (1) SK19199A3 (da)
UA (1) UA59370C2 (da)
WO (1) WO1998007723A1 (da)

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US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
CZ86199A3 (cs) 1996-09-12 1999-08-11 Schering Aktiengesellschaft Benzamidinové deriváty substituované cyklickou aminokyselinou a cyklické hydrokyselinové deriváty, farmaceutický prostředek obsahující tyto látky a jejich použití jako protisrážecích činidel
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
CA2315070A1 (en) 1997-12-17 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
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US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DE10239821A1 (de) * 2002-08-29 2004-03-11 Roche Diagnostics Gmbh Verbesserung der Spezifität bei der Bestimmung von Antithrombin
DK1569912T3 (da) 2002-12-03 2015-06-29 Pharmacyclics Inc 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazol-5-carboxamidin derivater som factor VIIa inhibitorer.
RU2478635C2 (ru) 2006-10-19 2013-04-10 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Гетероарильные соединения, содержащие их композиции и способы лечения с применением этих соединений
WO2010057118A2 (en) * 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
EA021377B9 (ru) 2008-12-09 2015-09-30 Джилид Сайэнс, Инк. Модуляторы толл-подобных рецепторов
ES2661850T3 (es) * 2009-09-14 2018-04-04 Gilead Sciences, Inc. Moduladores de receptores del tipo toll
CA2799381A1 (en) 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Male contraceptive compositions and methods of use
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
EP3733060B1 (en) 2013-05-07 2021-06-16 St. Jude Medical, Atrial Fibrillation Division, Inc. Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
RU2016134947A (ru) 2014-01-31 2018-03-01 Дана-Фарбер Кансер Институт, Инк. Производные диаминопиримидин бензолсульфона и их применение
MX2016009976A (es) 2014-01-31 2016-11-15 Dana Farber Cancer Inst Inc Derivados de diazepam y sus usos.
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
WO2015131113A1 (en) 2014-02-28 2015-09-03 Tensha Therapeutics, Inc. Treatment of conditions associated with hyperinsulinaemia
TWI806081B (zh) 2014-07-11 2023-06-21 美商基利科學股份有限公司 用於治療HIV之toll樣受體調節劑
JP2017525759A (ja) * 2014-08-08 2017-09-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジヒドロプテリジノン誘導体およびその使用
JP2017526741A (ja) 2014-08-08 2017-09-14 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体およびその使用
UY36298A (es) 2014-09-16 2016-04-29 Gilead Science Inc Formas sólidas de un modulador del receptor tipo toll
PT3194402T (pt) 2014-09-16 2019-02-11 Gilead Sciences Inc Métodos de preparação de moduladores dos recetores tipo toll
WO2016069578A1 (en) 2014-10-27 2016-05-06 Tensha Therapeutics, Inc. Bromodomain inhibitors
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RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
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CN116963750A (zh) 2021-01-06 2023-10-27 通尼克斯制药有限公司 用经修饰的抗-cd154抗体诱导免疫耐受的方法

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CA1297100C (en) * 1986-08-28 1992-03-10 Ryuji Niwa Medicament for curing arteriosclerosis, comprising pyrimido [2,1-b]-benxothiazole derivative
PT100631B (pt) * 1991-06-28 1999-06-30 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
DE69321344D1 (de) * 1992-02-14 1998-11-05 Corvas Int Inc Inhibitoren der thrombose
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
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IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives

Also Published As

Publication number Publication date
CZ297323B6 (cs) 2006-11-15
ATE237617T1 (de) 2003-05-15
EP0922045A1 (en) 1999-06-16
DE69721008T2 (de) 2003-12-24
PT922045E (pt) 2003-07-31
NZ333774A (en) 2000-08-25
CN1112363C (zh) 2003-06-25
AU4015697A (en) 1998-03-06
CZ50199A3 (cs) 1999-06-16
ES2195163T3 (es) 2003-12-01
US5846972A (en) 1998-12-08
US5846970A (en) 1998-12-08
SK19199A3 (en) 1999-07-12
NO990708D0 (no) 1999-02-15
CN1227553A (zh) 1999-09-01
DE69721008D1 (de) 2003-05-22
JP2000516241A (ja) 2000-12-05
IL128062A0 (en) 1999-11-30
RU2198884C2 (ru) 2003-02-20
KR20000068173A (ko) 2000-11-25
US5693641A (en) 1997-12-02
NO990708L (no) 1999-04-15
DK0922045T3 (da) 2003-06-30
WO1998007723A1 (en) 1998-02-26
EP0922045B1 (en) 2003-04-16
CA2261908A1 (en) 1998-02-26
UA59370C2 (uk) 2003-09-15
AU724413B2 (en) 2000-09-21
PL331634A1 (en) 1999-08-02

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070814