ES2195163T3 - Derivados de pirimidina biciclicos y su uso como anticoagulantes. - Google Patents
Derivados de pirimidina biciclicos y su uso como anticoagulantes.Info
- Publication number
- ES2195163T3 ES2195163T3 ES97937584T ES97937584T ES2195163T3 ES 2195163 T3 ES2195163 T3 ES 2195163T3 ES 97937584 T ES97937584 T ES 97937584T ES 97937584 T ES97937584 T ES 97937584T ES 2195163 T3 ES2195163 T3 ES 2195163T3
- Authority
- ES
- Spain
- Prior art keywords
- anticoagulants
- bicycle
- pirimidine derivatives
- derivatives
- pirimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
LA INVENCION SE REFIERE A DERIVADOS DE PIRIMIDINA BICICLICOS QUE SON UTILES COMO ANTICOAGULANTES, DE FORMULAS (I) Y (II), DONDE A ES - O -, - N(R 5 ) - O - S(O) N - (DONDE N ES 0, 1 O 2); Z 1 Y Z 2 SON INDEPENDIENTEMENTE - O -, - N(4 5 ) - O - OCH 2 -. LA INVENCION SE REFIERE ASIMISMO A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS COMPUESTOS DE LA INVENCION Y A PROCEDIMIENTOS DE UTILIZACION DE DICHOS COMPUESTOS PARA TRATAR ESTADOS DE ENFERMEDAD, CARACTERIZADOS POR UNA ACTIVIDAD TROMBOTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/699,372 US5693641A (en) | 1996-08-16 | 1996-08-16 | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195163T3 true ES2195163T3 (es) | 2003-12-01 |
Family
ID=24809035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97937584T Expired - Lifetime ES2195163T3 (es) | 1996-08-16 | 1997-08-14 | Derivados de pirimidina biciclicos y su uso como anticoagulantes. |
Country Status (22)
Country | Link |
---|---|
US (3) | US5693641A (es) |
EP (1) | EP0922045B1 (es) |
JP (1) | JP2000516241A (es) |
KR (1) | KR20000068173A (es) |
CN (1) | CN1112363C (es) |
AT (1) | ATE237617T1 (es) |
AU (1) | AU724413B2 (es) |
CA (1) | CA2261908A1 (es) |
CZ (1) | CZ297323B6 (es) |
DE (1) | DE69721008T2 (es) |
DK (1) | DK0922045T3 (es) |
ES (1) | ES2195163T3 (es) |
HK (1) | HK1020058A1 (es) |
IL (1) | IL128062A0 (es) |
NO (1) | NO990708L (es) |
NZ (1) | NZ333774A (es) |
PL (1) | PL331634A1 (es) |
PT (1) | PT922045E (es) |
RU (1) | RU2198884C2 (es) |
SK (1) | SK19199A3 (es) |
UA (1) | UA59370C2 (es) |
WO (1) | WO1998007723A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2214685C (en) | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
KR20000036017A (ko) | 1996-09-12 | 2000-06-26 | 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 | 시클릭 아미노산 및 시클릭 히드록시산 유도체로 치환된 벤즈아 |
US6004985A (en) | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
IL135536A0 (en) | 1997-12-19 | 2001-05-20 | Schering Ag | Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same |
US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
US6127376A (en) | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
CA2320730A1 (en) | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
CA2469435A1 (en) | 2001-12-21 | 2003-07-24 | X-Ceptor Therapeutics, Inc. | Modulators of lxr |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
DE10239821A1 (de) * | 2002-08-29 | 2004-03-11 | Roche Diagnostics Gmbh | Verbesserung der Spezifität bei der Bestimmung von Antithrombin |
DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
ZA200902382B (en) | 2006-10-19 | 2010-08-25 | Signal Pharm Llc | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors |
US8383654B2 (en) * | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
EP2364314B1 (en) | 2008-12-09 | 2014-03-12 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
NO2477987T3 (es) * | 2009-09-14 | 2018-06-09 | ||
CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
WO2014159392A1 (en) | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
EP3733060B1 (en) | 2013-05-07 | 2021-06-16 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions |
WO2015013635A2 (en) | 2013-07-25 | 2015-01-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
JP2017504650A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体およびその使用 |
EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
CN106456653A (zh) | 2014-02-28 | 2017-02-22 | 腾沙治疗公司 | 高胰岛素血症相关病症的治疗 |
NZ728072A (en) | 2014-07-11 | 2018-06-29 | Gilead Sciences Inc | Modulators of toll-like receptors for the treatment of hiv |
BR112017002369A2 (pt) | 2014-08-08 | 2017-12-05 | Dana Farber Cancer Inst Inc | derivados de diazepana e usos dos mesmos |
CA2955077A1 (en) * | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体モジュレーターの固体形態 |
CN107074860B (zh) | 2014-09-16 | 2022-07-15 | 吉利德科学公司 | 制备toll样受体调节剂的方法 |
EA033325B1 (ru) | 2014-10-27 | 2019-09-30 | Тэнша Терапеутикс, Инк. | Ингибиторы бромодомена |
WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
WO2017044792A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazoldiazepines and uses thereof |
BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
BR112021026410A2 (pt) | 2019-07-01 | 2022-02-08 | Tonix Pharma Ltd | Anticorpos anti-cd154 e usos dos mesmos |
US20240059781A1 (en) | 2021-01-06 | 2024-02-22 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1297100C (en) * | 1986-08-28 | 1992-03-10 | Ryuji Niwa | Medicament for curing arteriosclerosis, comprising pyrimido [2,1-b]-benxothiazole derivative |
AU666318B2 (en) * | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
WO1993015756A1 (en) * | 1992-02-14 | 1993-08-19 | Corvas International, Inc. | Inhibitors of thrombosis |
DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
WO1994013693A1 (en) * | 1992-12-15 | 1994-06-23 | Corvas International, Inc. | NOVEL INHIBITORS OF FACTOR Xa |
US5332822A (en) * | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
JP3466614B2 (ja) * | 1993-02-12 | 2003-11-17 | コルバス・インターナショナル、インコーポレイテッド | 血栓症のインヒビター |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
-
1996
- 1996-08-16 US US08/699,372 patent/US5693641A/en not_active Expired - Fee Related
-
1997
- 1997-06-17 US US08/877,318 patent/US5846970A/en not_active Expired - Fee Related
- 1997-06-17 US US08/877,231 patent/US5846972A/en not_active Expired - Fee Related
- 1997-08-14 RU RU99105117/04A patent/RU2198884C2/ru not_active IP Right Cessation
- 1997-08-14 NZ NZ333774A patent/NZ333774A/xx unknown
- 1997-08-14 DE DE69721008T patent/DE69721008T2/de not_active Expired - Fee Related
- 1997-08-14 AU AU40156/97A patent/AU724413B2/en not_active Ceased
- 1997-08-14 SK SK191-99A patent/SK19199A3/sk unknown
- 1997-08-14 PL PL97331634A patent/PL331634A1/xx unknown
- 1997-08-14 CN CN97197218A patent/CN1112363C/zh not_active Expired - Fee Related
- 1997-08-14 UA UA99031392A patent/UA59370C2/uk unknown
- 1997-08-14 DK DK97937584T patent/DK0922045T3/da active
- 1997-08-14 KR KR1019997001281A patent/KR20000068173A/ko not_active Application Discontinuation
- 1997-08-14 EP EP97937584A patent/EP0922045B1/en not_active Expired - Lifetime
- 1997-08-14 ES ES97937584T patent/ES2195163T3/es not_active Expired - Lifetime
- 1997-08-14 IL IL12806297A patent/IL128062A0/xx unknown
- 1997-08-14 WO PCT/EP1997/004444 patent/WO1998007723A1/en active IP Right Grant
- 1997-08-14 JP JP10510376A patent/JP2000516241A/ja not_active Ceased
- 1997-08-14 AT AT97937584T patent/ATE237617T1/de not_active IP Right Cessation
- 1997-08-14 CZ CZ0050199A patent/CZ297323B6/cs not_active IP Right Cessation
- 1997-08-14 CA CA002261908A patent/CA2261908A1/en not_active Abandoned
- 1997-08-14 PT PT97937584T patent/PT922045E/pt unknown
-
1999
- 1999-02-15 NO NO990708A patent/NO990708L/no not_active Application Discontinuation
- 1999-11-18 HK HK99105314A patent/HK1020058A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL331634A1 (en) | 1999-08-02 |
EP0922045B1 (en) | 2003-04-16 |
ATE237617T1 (de) | 2003-05-15 |
RU2198884C2 (ru) | 2003-02-20 |
NO990708D0 (no) | 1999-02-15 |
WO1998007723A1 (en) | 1998-02-26 |
PT922045E (pt) | 2003-07-31 |
NO990708L (no) | 1999-04-15 |
CN1112363C (zh) | 2003-06-25 |
US5693641A (en) | 1997-12-02 |
CA2261908A1 (en) | 1998-02-26 |
SK19199A3 (en) | 1999-07-12 |
EP0922045A1 (en) | 1999-06-16 |
US5846972A (en) | 1998-12-08 |
IL128062A0 (en) | 1999-11-30 |
UA59370C2 (uk) | 2003-09-15 |
AU724413B2 (en) | 2000-09-21 |
DK0922045T3 (da) | 2003-06-30 |
CN1227553A (zh) | 1999-09-01 |
JP2000516241A (ja) | 2000-12-05 |
NZ333774A (en) | 2000-08-25 |
DE69721008T2 (de) | 2003-12-24 |
CZ50199A3 (cs) | 1999-06-16 |
HK1020058A1 (en) | 2000-03-10 |
KR20000068173A (ko) | 2000-11-25 |
DE69721008D1 (de) | 2003-05-22 |
US5846970A (en) | 1998-12-08 |
CZ297323B6 (cs) | 2006-11-15 |
AU4015697A (en) | 1998-03-06 |
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