HK1018008A1 - Thiol derivatives with metallopeptidase inhibitory activity - Google Patents

Thiol derivatives with metallopeptidase inhibitory activity

Info

Publication number
HK1018008A1
HK1018008A1 HK99103110A HK99103110A HK1018008A1 HK 1018008 A1 HK1018008 A1 HK 1018008A1 HK 99103110 A HK99103110 A HK 99103110A HK 99103110 A HK99103110 A HK 99103110A HK 1018008 A1 HK1018008 A1 HK 1018008A1
Authority
HK
Hong Kong
Prior art keywords
inhibitory activity
thiol derivatives
metallopeptidase inhibitory
metallopeptidase
thiol
Prior art date
Application number
HK99103110A
Other languages
English (en)
Inventor
Franco Pellacini
Mario Fantucci
Gabriele Norcini
Stefano Romagnano
Francesco Santangelo
Claudio Semeraro
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of HK1018008A1 publication Critical patent/HK1018008A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Treatment Of Fiber Materials (AREA)
  • Preliminary Treatment Of Fibers (AREA)
  • Medicines Containing Plant Substances (AREA)
HK99103110A 1995-12-28 1999-07-20 Thiol derivatives with metallopeptidase inhibitory activity HK1018008A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002773A IT1277737B1 (it) 1995-12-28 1995-12-28 Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
PCT/EP1996/005663 WO1997024342A1 (en) 1995-12-28 1996-12-17 Thiol derivatives with metallopeptidase inhibitory activity

Publications (1)

Publication Number Publication Date
HK1018008A1 true HK1018008A1 (en) 1999-12-10

Family

ID=11372827

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99103110A HK1018008A1 (en) 1995-12-28 1999-07-20 Thiol derivatives with metallopeptidase inhibitory activity

Country Status (31)

Country Link
EP (1) EP0877740B1 (xx)
JP (1) JP2000502687A (xx)
KR (1) KR19990076809A (xx)
CN (1) CN1071325C (xx)
AP (1) AP1186A (xx)
AR (1) AR004413A1 (xx)
AT (1) ATE292123T1 (xx)
AU (1) AU713156B2 (xx)
BG (1) BG63942B1 (xx)
BR (1) BR9612373A (xx)
CA (1) CA2241414A1 (xx)
CZ (1) CZ204698A3 (xx)
DE (1) DE69634543D1 (xx)
EA (1) EA000991B1 (xx)
EE (1) EE03766B1 (xx)
GE (1) GEP19991871B (xx)
HK (1) HK1018008A1 (xx)
IL (1) IL124915A (xx)
IS (1) IS1885B (xx)
IT (1) IT1277737B1 (xx)
NO (1) NO310914B1 (xx)
NZ (1) NZ325785A (xx)
OA (1) OA10704A (xx)
PL (1) PL188151B1 (xx)
RO (1) RO119882B1 (xx)
SK (1) SK282977B6 (xx)
TR (1) TR199801229T2 (xx)
UA (1) UA62923C2 (xx)
UY (1) UY24425A1 (xx)
WO (1) WO1997024342A1 (xx)
ZA (1) ZA9610891B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289522B1 (it) 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di eteroaril-fenilalanine
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
GB0203665D0 (en) * 2002-02-15 2002-04-03 Glaxo Group Ltd Process
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
DE60336986D1 (de) 2002-03-05 2011-06-16 Sumitomo Chemical Co Verfahren zur herstellung von biarylverbindungen
WO2003104200A1 (en) * 2002-06-07 2003-12-18 Glaxo Group Limited N-mercaptoacyl phenyalanine derivatives, process for their preparation, and pharmaceutical compositions containing them
GB0213122D0 (en) * 2002-06-07 2002-07-17 Glaxo Group Ltd Compounds
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
BRPI0508880A (pt) 2004-03-17 2007-09-04 Novartis Ag uso de compostos orgánicos
CA2757650C (en) 2009-04-03 2016-06-07 Statoil Asa Equipment and method for reinforcing a borehole of a well while drilling
CN102811989A (zh) * 2010-02-03 2012-12-05 Meh联合公司 作为具有选择性和生物活性的等排物的多取代氟甲烷
WO2011116115A1 (en) 2010-03-16 2011-09-22 Novartis Ag Aliskiren composition comprising a medium chain fatty acid, their process of manufacturing

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
FR2682952B1 (fr) * 1991-10-25 1993-12-03 Institut Nal Sante Recherc Medic Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi

Also Published As

Publication number Publication date
OA10704A (en) 2002-11-28
TR199801229T2 (xx) 1998-09-21
ITMI952773A1 (it) 1997-06-28
GEP19991871B (en) 1999-12-06
EE03766B1 (et) 2002-06-17
EA199800544A1 (ru) 1999-02-25
NZ325785A (en) 1999-09-29
EP0877740A1 (en) 1998-11-18
EE9800192A (et) 1998-12-15
CN1206411A (zh) 1999-01-27
AR004413A1 (es) 1998-11-04
IL124915A0 (en) 1999-01-26
NO982977D0 (no) 1998-06-26
IT1277737B1 (it) 1997-11-12
SK282977B6 (sk) 2003-01-09
BG63942B1 (bg) 2003-07-31
JP2000502687A (ja) 2000-03-07
ZA9610891B (en) 1997-06-27
ITMI952773A0 (xx) 1995-12-28
NO982977L (no) 1998-08-27
PL188151B1 (pl) 2004-12-31
CZ204698A3 (cs) 1998-11-11
SK88998A3 (en) 1998-12-02
CN1071325C (zh) 2001-09-19
IS4780A (is) 1998-06-22
EA000991B1 (ru) 2000-08-28
BG102553A (en) 1999-04-30
BR9612373A (pt) 1999-07-13
RO119882B1 (ro) 2005-05-30
AU713156B2 (en) 1999-11-25
KR19990076809A (ko) 1999-10-15
AP1186A (en) 2003-07-07
NO310914B1 (no) 2001-09-17
AU1301897A (en) 1997-07-28
UA62923C2 (en) 2004-01-15
CA2241414A1 (en) 1997-07-10
ATE292123T1 (de) 2005-04-15
UY24425A1 (es) 1997-01-09
PL327580A1 (en) 1998-12-21
EP0877740B1 (en) 2005-03-30
DE69634543D1 (de) 2005-05-04
WO1997024342A1 (en) 1997-07-10
AP9801264A0 (en) 1998-06-30
IL124915A (en) 2001-10-31
IS1885B (is) 2003-08-15

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20051217