HK1016580A1 - Purine derivatives and processes for their preparation - Google Patents

Purine derivatives and processes for their preparation

Info

Publication number
HK1016580A1
HK1016580A1 HK99101415A HK99101415A HK1016580A1 HK 1016580 A1 HK1016580 A1 HK 1016580A1 HK 99101415 A HK99101415 A HK 99101415A HK 99101415 A HK99101415 A HK 99101415A HK 1016580 A1 HK1016580 A1 HK 1016580A1
Authority
HK
Hong Kong
Prior art keywords
processes
preparation
purine derivatives
purine
derivatives
Prior art date
Application number
HK99101415A
Other languages
English (en)
Inventor
Jurg Zimmermann
Hans-Georg Capraro
Patricia Imbach
Pascal Furet
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1016580A1 publication Critical patent/HK1016580A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK99101415A 1995-11-01 1999-04-08 Purine derivatives and processes for their preparation HK1016580A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH309495 1995-11-01
CH221396 1996-09-10
PCT/EP1996/004573 WO1997016452A1 (en) 1995-11-01 1996-10-22 Purine derivatives and processes for their preparation

Publications (1)

Publication Number Publication Date
HK1016580A1 true HK1016580A1 (en) 1999-11-05

Family

ID=25689809

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99101415A HK1016580A1 (en) 1995-11-01 1999-04-08 Purine derivatives and processes for their preparation

Country Status (14)

Country Link
US (1) US7091346B1 (es)
EP (1) EP0874846B1 (es)
JP (2) JP4004066B2 (es)
CN (1) CN1066147C (es)
AR (1) AR004134A1 (es)
AT (1) ATE236161T1 (es)
AU (1) AU7296896A (es)
BR (1) BR9611157A (es)
CA (1) CA2234609C (es)
DE (1) DE69627195T2 (es)
ES (1) ES2196181T3 (es)
HK (1) HK1016580A1 (es)
PT (1) PT874846E (es)
WO (1) WO1997016452A1 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US6794390B2 (en) * 1996-08-02 2004-09-21 Cv Therapeutics, Inc. Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US6790958B2 (en) * 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
AU4920397A (en) * 1996-10-11 1998-05-11 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
US6432947B1 (en) * 1997-02-19 2002-08-13 Berlex Laboratories, Inc. N-heterocyclic derivatives as NOS inhibitors
US6573044B1 (en) 1997-08-07 2003-06-03 The Regents Of The University Of California Methods of using chemical libraries to search for new kinase inhibitors
US6255485B1 (en) 1997-08-07 2001-07-03 The Regents Of The University Of California Purine inhibitors of protein kinases, G proteins and polymerases
CN1158269C (zh) 1997-10-27 2004-07-21 阿古龙制药公司 作为cdk抑制剂的取代的4-氨基-噻唑-2-基化合物
AU1631699A (en) * 1997-12-18 1999-07-05 E.I. Du Pont De Nemours And Company Cyclohexylamine arthropodicides and fungicides
US6479487B1 (en) 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
RU2200162C2 (ru) * 1998-02-26 2003-03-10 Авентис Фармасьютикалз Инк. 6,9-дизамещенные 2-[транс(4-аминоциклогексил)амино] пурины
PL344021A1 (en) * 1998-02-26 2001-09-24 Aventis Pharma Inc 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6642231B2 (en) * 1998-02-26 2003-11-04 Aventis Pharmaceuticals Inc. 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
GB9903762D0 (en) 1999-02-18 1999-04-14 Novartis Ag Organic compounds
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
GB9918035D0 (en) * 1999-07-30 1999-09-29 Novartis Ag Organic compounds
AU3540101A (en) * 2000-01-07 2001-07-16 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
AU2001252562A1 (en) * 2000-04-28 2001-11-12 Toshiharu Suzuki Medicinal compositions for suppressing beta-amyloid production
US6861524B2 (en) 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
GB2378180B8 (en) 2001-06-27 2009-10-21 Cyclacel Ltd New purine derivatives
EP2258371A1 (en) 2001-08-10 2010-12-08 Novartis AG Use of c-Src inhibitors alone or in combination with STI571 for the treatment of leukaemia
EP1578722A4 (en) * 2001-10-12 2006-09-06 Irm Llc KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF
GB0219054D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New purine derivatives
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
MY136840A (en) 2002-09-19 2008-11-28 Schering Corp Pyrazolopyridines as cyclin dependent kinase inhibitors
CA2501999A1 (en) * 2002-10-15 2004-04-29 Irm Llc Compositions and methods for inducing osteogenesis
JP2006521398A (ja) 2003-03-28 2006-09-21 サイオス・インコーポレーテツド ＴＧＦβの二−環式ピリミジン阻害剤
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
ES2562428T3 (es) 2005-12-15 2016-03-04 Rigel Pharmaceuticals, Inc. Inhibidores de cinasa y sus usos
AU2007333394C1 (en) * 2006-12-08 2011-08-18 Novartis Ag Compounds and compositions as protein kinase inhibitors
ES2559528T3 (es) 2006-12-08 2016-02-12 Novartis Ag Compuestos y composiciones como inhibidores de proteína cinasa
WO2008116911A1 (en) * 2007-03-28 2008-10-02 Neurosearch A/S Purinyl derivatives and their use as potassium channel modulators
NZ579248A (en) * 2007-03-28 2011-08-26 Neurosearch As Purinyl derivatives and their use as potassium channel modulators
CZ302225B6 (cs) * 2007-07-04 2010-12-29 Univerzita Palackého v Olomouci Substituované 6-anilinopurinové deriváty jako inhibitory cytokinin oxidasy a prípravky obsahující tyto slouceniny
MX2010010968A (es) * 2008-04-07 2010-10-26 Irm Llc Compuestos y composiciones como inhibidores de cinasa de proteina.
US20110237607A1 (en) * 2008-09-26 2011-09-29 Neurosearch A/S Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators
WO2010034707A1 (en) 2008-09-26 2010-04-01 Neurosearch A/S Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators
MX2013010330A (es) 2011-03-09 2014-11-26 Richard G Pestell Líneas de célula cancerosa de próstata, signaturas de gen, y usos de las mismas.
AU2012340200B2 (en) 2011-11-17 2017-10-12 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-Terminal Kinase (JNK)
CN104853806A (zh) 2012-05-14 2015-08-19 理查德·G·佩斯泰尔 使用ccr5调节剂治疗癌症
IN2014DN11027A (es) 2012-06-26 2015-09-25 Aniona Aps
CN105283206B (zh) * 2013-03-27 2019-11-08 财团法人峨山社会福祉财团 包含p34的表达抑制剂或活性抑制剂作为有效成分的用于治疗或转移抑制癌的组合物
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
JP6854762B2 (ja) 2014-12-23 2021-04-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
EP3273966B1 (en) * 2015-03-27 2023-05-03 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JP7028766B2 (ja) 2015-09-09 2022-03-02 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼの阻害剤
US10722515B2 (en) 2016-09-30 2020-07-28 Sri International Dual CLK/CDK1 inhibitors for cancer treatment
WO2020152686A1 (en) 2019-01-23 2020-07-30 Yeda Research And Development Co. Ltd. Culture media for pluripotent stem cells

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529497A1 (de) 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
WO1990009178A1 (en) 1989-01-31 1990-08-23 Whitby Research, Inc. N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
DK0625158T3 (da) * 1992-01-06 1999-10-11 Wellcome Found Terapeutiske nucleosider af 2',3'-dideoxy-3'-fluorpurinrækken
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US6107300A (en) 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
AU4920397A (en) 1996-10-11 1998-05-11 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
EP1578722A4 (en) * 2001-10-12 2006-09-06 Irm Llc KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF
CA2501999A1 (en) * 2002-10-15 2004-04-29 Irm Llc Compositions and methods for inducing osteogenesis

Also Published As

Publication number Publication date
CA2234609C (en) 2006-11-28
CN1066147C (zh) 2001-05-23
JP4004066B2 (ja) 2007-11-07
CN1202896A (zh) 1998-12-23
PT874846E (pt) 2003-08-29
JPH11514336A (ja) 1999-12-07
AU7296896A (en) 1997-05-22
ATE236161T1 (de) 2003-04-15
DE69627195D1 (de) 2003-05-08
EP0874846A1 (en) 1998-11-04
BR9611157A (pt) 1999-03-30
JP2007231023A (ja) 2007-09-13
DE69627195T2 (de) 2004-01-29
ES2196181T3 (es) 2003-12-16
EP0874846B1 (en) 2003-04-02
US7091346B1 (en) 2006-08-15
CA2234609A1 (en) 1997-05-09
WO1997016452A1 (en) 1997-05-09
AR004134A1 (es) 1998-09-30

Similar Documents

Publication Publication Date Title
HK1016580A1 (en) Purine derivatives and processes for their preparation
IL116851A0 (en) 3-arylidene-2-oxindole derivatives their preparation and use
IL116831A0 (en) Guanine derivatives its preparation and use
IL118825A (en) Substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane derivatives their preparation and use
GB2306473A8 (en) Glucoxide derivatives
ZA964138B (en) Substituted camptothecin derivatives and process for their preparation
ZA969220B (en) Nucleoside derivatives and process for preparing the same
HUP9603527A3 (en) 3-amino-2-mercaptobenzoic acid derivatives and processes for their and the intermediers preparation and the intermediers
IL126839A0 (en) Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
AU6629496A (en) Antiviral agent and process for preparing the same
IL118443A0 (en) Cycloalkane-benzylidene derivatives their preparation and use
IL123092A0 (en) Pyrazol-4-ylbenzoyl derivatives their preparation and use
AU6015096A (en) Antiviral method and antiviral agent
EP0754668A3 (de) Fluorbenzylether-Derivate
GB9516349D0 (en) Aza-anthracyclinone derivatives
HU9603105D0 (en) Adenosine derivatives
ZA969168B (en) Purine derivatives and processes for their preparation
HRP970649B1 (en) Dibenzosuberone derivatives and processes for their preparation
AU3710395A (en) Nucleoside derivatives and process for preparing thereof
GB2302691B (en) Oxaindene derivatives and process for the preparation thereof
AU7140696A (en) Purine and guanine derivatives
GB9608199D0 (en) Pyrimide nucleoside derivatives
EP0804205A4 (en) 4-AZA-19-NORANDROSTANDERIVATE
GB9201224D0 (en) Difluoromethylenandrostenone derivatives and process for their preparation
GB2308593A (en) Imidazopyridedine derivatives

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20081022