HK1011974A1 - Oxime derivatives their preparation and their therapeutic use - Google Patents
Oxime derivatives their preparation and their therapeutic useInfo
- Publication number
- HK1011974A1 HK1011974A1 HK98113077A HK98113077A HK1011974A1 HK 1011974 A1 HK1011974 A1 HK 1011974A1 HK 98113077 A HK98113077 A HK 98113077A HK 98113077 A HK98113077 A HK 98113077A HK 1011974 A1 HK1011974 A1 HK 1011974A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- chem
- alkyl
- hydrogen
- formula
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24387694 | 1994-10-07 | ||
JP13678895 | 1995-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1011974A1 true HK1011974A1 (en) | 1999-07-23 |
Family
ID=26470291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98113077A HK1011974A1 (en) | 1994-10-07 | 1998-12-10 | Oxime derivatives their preparation and their therapeutic use |
Country Status (21)
Country | Link |
---|---|
US (3) | US5703096A (ko) |
EP (1) | EP0708098B1 (ko) |
KR (1) | KR100250175B1 (ko) |
CN (1) | CN1056840C (ko) |
AT (1) | ATE177088T1 (ko) |
AU (1) | AU688573B2 (ko) |
CA (1) | CA2159938A1 (ko) |
CZ (1) | CZ261095A3 (ko) |
DE (1) | DE69508029T2 (ko) |
DK (1) | DK0708098T3 (ko) |
ES (1) | ES2132536T3 (ko) |
FI (1) | FI954763A (ko) |
GR (1) | GR3030207T3 (ko) |
HK (1) | HK1011974A1 (ko) |
HU (1) | HUT72642A (ko) |
IL (1) | IL115536A (ko) |
MX (1) | MX9504261A (ko) |
NO (1) | NO305954B1 (ko) |
NZ (1) | NZ280181A (ko) |
RU (1) | RU2122998C1 (ko) |
TW (1) | TW400329B (ko) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996038427A1 (fr) * | 1995-06-02 | 1996-12-05 | Sankyo Company, Limited | Derives d'oxyimino aromatiques |
RU2158607C2 (ru) * | 1995-07-03 | 2000-11-10 | Санкио Компани Лимитед | Лечение артериосклероза и ксантомы |
EP0783888A1 (en) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
DK0916651T3 (da) * | 1996-04-04 | 2003-12-01 | Sankyo Co | Phenylalkylcarboxylsyrederivater |
US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
AU744518B2 (en) | 1996-07-01 | 2002-02-28 | Dr. Reddy's Laboratories Limited | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6114526A (en) | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
WO1998020871A1 (fr) * | 1996-11-08 | 1998-05-22 | Nippon Chemiphar Co., Ltd. | Agent diminuant la graisse viscerale |
HUP9902721A2 (hu) * | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
US6019229A (en) * | 1997-12-18 | 2000-02-01 | Fleetguard, Inc. | Self-centering, floating retainer for spin-on filter |
SK16412000A3 (sk) | 1998-05-11 | 2001-08-06 | Takeda Chemical Industries, Ltd. | Deriváty kyseliny oxyiminoalkánovej |
US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
TW550264B (en) * | 1999-04-07 | 2003-09-01 | Sankyo Co | Amine derivated compounds and the pharmaceutical compositions thereof |
WO2001034579A1 (fr) * | 1999-11-10 | 2001-05-17 | Takeda Chemical Industries, Ltd. | Derives d'acide alcoxyiminoalcanoique |
US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
WO2006010546A2 (en) * | 2004-07-28 | 2006-02-02 | F. Hoffman-La Roche Ag | Aryl-pyridine derivatives as 11-beta-hsd1 inhibitors |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
EP0295828A1 (en) * | 1987-06-13 | 1988-12-21 | Beecham Group Plc | Novel compounds |
US4728739A (en) * | 1987-06-15 | 1988-03-01 | American Home Products Corporation | Hypoglycemic thiazolidinediones |
ES2137915T3 (es) * | 1987-09-04 | 2000-01-01 | Beecham Group Plc | Derivados de tiazolidindiona sustituida. |
GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
KR930701420A (ko) * | 1990-08-23 | 1993-06-11 | 알렌 제이. 스피겔 | 혈당저하제로서의 하이드록시우레아 유도체 |
GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5420146A (en) * | 1994-05-10 | 1995-05-30 | American Home Products Corporation | Di-oxadiazolidine derivatives as antihyperglycemic agents |
JPH08143556A (ja) * | 1994-11-15 | 1996-06-04 | Terumo Corp | ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物 |
JPH08143568A (ja) * | 1994-11-22 | 1996-06-04 | Terumo Corp | ピリドピリミジン誘導体及びそれを含有する医薬組成物 |
JPH08143566A (ja) * | 1994-11-25 | 1996-06-04 | Terumo Corp | キナゾリン誘導体及びそれを含有する医薬組成物 |
JP3929512B2 (ja) * | 1995-06-02 | 2007-06-13 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
-
1995
- 1995-10-05 CA CA002159938A patent/CA2159938A1/en not_active Abandoned
- 1995-10-05 US US08/539,541 patent/US5703096A/en not_active Expired - Fee Related
- 1995-10-05 CZ CZ952610A patent/CZ261095A3/cs unknown
- 1995-10-06 NZ NZ280181A patent/NZ280181A/en unknown
- 1995-10-06 KR KR1019950034189A patent/KR100250175B1/ko not_active IP Right Cessation
- 1995-10-06 FI FI954763A patent/FI954763A/fi unknown
- 1995-10-06 RU RU95117054A patent/RU2122998C1/ru active
- 1995-10-06 CN CN95119194A patent/CN1056840C/zh not_active Expired - Fee Related
- 1995-10-06 AU AU33076/95A patent/AU688573B2/en not_active Ceased
- 1995-10-06 TW TW084110541A patent/TW400329B/zh not_active IP Right Cessation
- 1995-10-06 IL IL11553695A patent/IL115536A/xx not_active IP Right Cessation
- 1995-10-06 HU HU9502925A patent/HUT72642A/hu unknown
- 1995-10-06 MX MX9504261A patent/MX9504261A/es unknown
- 1995-10-06 NO NO953990A patent/NO305954B1/no not_active IP Right Cessation
- 1995-10-09 ES ES95307131T patent/ES2132536T3/es not_active Expired - Lifetime
- 1995-10-09 AT AT95307131T patent/ATE177088T1/de active
- 1995-10-09 DE DE69508029T patent/DE69508029T2/de not_active Expired - Fee Related
- 1995-10-09 DK DK95307131T patent/DK0708098T3/da active
- 1995-10-09 EP EP95307131A patent/EP0708098B1/en not_active Expired - Lifetime
-
1997
- 1997-06-18 US US08/878,219 patent/US5780490A/en not_active Expired - Fee Related
-
1998
- 1998-04-21 US US09/063,609 patent/US5972959A/en not_active Expired - Fee Related
- 1998-12-10 HK HK98113077A patent/HK1011974A1/xx not_active IP Right Cessation
-
1999
- 1999-05-13 GR GR990401292T patent/GR3030207T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69508029D1 (de) | 1999-04-08 |
NO953990D0 (no) | 1995-10-06 |
CN1143639A (zh) | 1997-02-26 |
NO305954B1 (no) | 1999-08-23 |
FI954763A0 (fi) | 1995-10-06 |
US5703096A (en) | 1997-12-30 |
IL115536A (en) | 1999-07-14 |
CA2159938A1 (en) | 1996-04-08 |
GR3030207T3 (en) | 1999-08-31 |
ATE177088T1 (de) | 1999-03-15 |
CZ261095A3 (en) | 1996-04-17 |
KR100250175B1 (ko) | 2000-05-01 |
MX9504261A (es) | 1997-01-31 |
US5780490A (en) | 1998-07-14 |
US5972959A (en) | 1999-10-26 |
DE69508029T2 (de) | 1999-10-21 |
KR960014124A (ko) | 1996-05-22 |
NZ280181A (en) | 1996-11-26 |
HUT72642A (en) | 1996-05-28 |
IL115536A0 (en) | 1996-01-19 |
RU2122998C1 (ru) | 1998-12-10 |
FI954763A (fi) | 1996-04-08 |
TW400329B (en) | 2000-08-01 |
ES2132536T3 (es) | 1999-08-16 |
EP0708098A1 (en) | 1996-04-24 |
HU9502925D0 (en) | 1995-11-28 |
CN1056840C (zh) | 2000-09-27 |
DK0708098T3 (da) | 1999-10-04 |
EP0708098B1 (en) | 1999-03-03 |
NO953990L (no) | 1996-04-09 |
AU688573B2 (en) | 1998-03-12 |
AU3307695A (en) | 1996-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUT72642A (en) | Oxime derivatives, their preparation and their therapeutic use | |
DK0745600T3 (da) | Benzimidazolderivater, deres fremstilling og deres terapeutiske anvendelse | |
DE69213892D1 (de) | Aromatische Aminoalkoholderivate mit antidiabetischer und Antiobesitäts-Wirkung, ihre Herstellung und therapeutische Verwendung | |
NO970892L (no) | Isoksazolderivater | |
DE69935718D1 (de) | Antidiabetische medikamente | |
DE69016866D1 (de) | Verwendung von Bis(4-hydroxyphenylthio)methan-Derivaten zur Behandlung von Diabetes mellitus. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |