HK1011693A1 - Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives - Google Patents

Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives

Info

Publication number
HK1011693A1
HK1011693A1 HK98112739A HK98112739A HK1011693A1 HK 1011693 A1 HK1011693 A1 HK 1011693A1 HK 98112739 A HK98112739 A HK 98112739A HK 98112739 A HK98112739 A HK 98112739A HK 1011693 A1 HK1011693 A1 HK 1011693A1
Authority
HK
Hong Kong
Prior art keywords
hydrogen
fluorine
alkyl
andostran
3one
Prior art date
Application number
HK98112739A
Other languages
English (en)
Inventor
Achille Panzeri
Marcella Nesi
Enrico Di Salle
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of HK1011693A1 publication Critical patent/HK1011693A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Lubricants (AREA)
HK98112739A 1992-07-31 1998-12-03 Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives HK1011693A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216284A GB9216284D0 (en) 1992-07-31 1992-07-31 Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
PCT/EP1993/002037 WO1994003475A1 (en) 1992-07-31 1993-07-29 FLUORINATED 17β-SUBSTITUTED 4-AZA-5α-ANDROSTAN-3-ONE DERIVATIVES

Publications (1)

Publication Number Publication Date
HK1011693A1 true HK1011693A1 (en) 1999-07-16

Family

ID=10719598

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98112739A HK1011693A1 (en) 1992-07-31 1998-12-03 Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives

Country Status (29)

Country Link
US (1) US5407939A (ja)
EP (1) EP0607400B1 (ja)
JP (1) JP3325025B2 (ja)
KR (1) KR100311547B1 (ja)
CN (1) CN1041096C (ja)
AT (1) ATE159951T1 (ja)
AU (1) AU660562B2 (ja)
CA (1) CA2120343A1 (ja)
CZ (1) CZ286240B6 (ja)
DE (1) DE69315050T2 (ja)
DK (1) DK0607400T3 (ja)
ES (1) ES2110620T3 (ja)
FI (1) FI113778B (ja)
GB (1) GB9216284D0 (ja)
GR (1) GR3025546T3 (ja)
HK (1) HK1011693A1 (ja)
HU (2) HUT67043A (ja)
IL (1) IL106520A (ja)
MX (1) MX9304579A (ja)
MY (1) MY109633A (ja)
NO (1) NO305401B1 (ja)
NZ (1) NZ254787A (ja)
PH (1) PH29938A (ja)
PL (1) PL178591B1 (ja)
RU (1) RU2125061C1 (ja)
TW (1) TW286319B (ja)
UA (1) UA41291C2 (ja)
WO (1) WO1994003475A1 (ja)
ZA (1) ZA935481B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE203162T1 (de) * 1992-12-18 2001-08-15 Merck & Co Inc Verfahren zur behandlung von chronischer prostatitis mit 17-beta-n-tertbutylcarbamoyl-4- aza-5 alpha-androst-1-en-3-one
ES2173889T3 (es) * 1993-06-24 2002-11-01 Richter Gedeon Vegyeszet Nuevo procedimiento para preparar derivados de 4-azaandrostano 17 beta-sustituidos.
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
EP0724592B1 (en) * 1993-10-21 1999-01-07 Merck & Co. Inc. 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
IT1275594B1 (it) * 1995-07-21 1997-08-06 Pharmacia S P A Ora Pharmacia Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
GB9518858D0 (en) * 1995-09-14 1995-11-15 Pharmacia Spa Phenylsubstituted 4-azasteroid fluoroderivatives
GB9727522D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Process for preparing carboxamido-4-azasteroids
US6645974B2 (en) * 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
CN1652786A (zh) * 2002-03-13 2005-08-10 麦克公司 作为雄激素受体调节剂的氟代4－氮杂甾体衍生物
US7329750B2 (en) * 2003-06-30 2008-02-12 Merck & Co., Inc. 17-Acetamido-4-azasteroid derivatives as androgen receptor modulators
US7696217B2 (en) * 2003-06-30 2010-04-13 Merck Sharp & Dohme Corp. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
JP2007521297A (ja) * 2003-06-30 2007-08-02 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
WO2005005606A2 (en) 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
WO2005025572A1 (en) * 2003-09-10 2005-03-24 Merck & Co., Inc. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators
EP1670483A4 (en) 2003-09-10 2010-02-17 Merck & Co Inc 17-heterocyclic 4-azasteroid derivatives as androgen receptor modules
EP1734964A4 (en) * 2004-04-08 2009-06-17 Merck & Co Inc 17-BETA-ACETAMIDE-4-AZASTEROIDS AS ANDROGEN RECEPTOR MODULATORS
CA2739251A1 (en) * 2008-10-28 2010-06-03 Biomarin Pharmaceutical Inc. Decahydro-1h-indenoquinolinone and decahydro-3h-cyclopentaphenanthridinone cyp17 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74365A (en) * 1984-02-27 1990-07-26 Merck & Co Inc 17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
AUPP930799A0 (en) * 1999-03-18 1999-04-15 University Of Sydney, The Optical planar waveguide device and method of its fabrication

Also Published As

Publication number Publication date
CN1085224A (zh) 1994-04-13
PH29938A (en) 1996-09-16
NZ254787A (en) 1995-11-27
CZ286240B6 (cs) 2000-02-16
AU660562B2 (en) 1995-06-29
FI941424A (fi) 1994-05-27
CZ153893A3 (en) 1994-02-16
US5407939A (en) 1995-04-18
UA41291C2 (uk) 2001-09-17
DE69315050D1 (de) 1997-12-11
AU4704893A (en) 1994-03-03
CA2120343A1 (en) 1994-02-17
TW286319B (ja) 1996-09-21
WO1994003475A1 (en) 1994-02-17
DE69315050T2 (de) 1998-03-05
ZA935481B (en) 1994-05-16
NO305401B1 (no) 1999-05-25
DK0607400T3 (da) 1998-01-26
KR100311547B1 (ko) 2002-06-20
FI113778B (fi) 2004-06-15
EP0607400B1 (en) 1997-11-05
HU211238A9 (en) 1995-11-28
FI941424A0 (fi) 1994-03-28
JPH06511497A (ja) 1994-12-22
RU2125061C1 (ru) 1999-01-20
NO941080L (no) 1994-05-18
MX9304579A (es) 1994-02-28
CN1041096C (zh) 1998-12-09
IL106520A0 (en) 1993-11-15
GR3025546T3 (en) 1998-03-31
PL178591B1 (pl) 2000-05-31
ATE159951T1 (de) 1997-11-15
HU9400914D0 (en) 1994-06-28
GB9216284D0 (en) 1992-09-16
NO941080D0 (no) 1994-03-24
HUT67043A (en) 1995-01-30
JP3325025B2 (ja) 2002-09-17
ES2110620T3 (es) 1998-02-16
MY109633A (en) 1997-03-31
EP0607400A1 (en) 1994-07-27
IL106520A (en) 1997-11-20

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060729