ES2173889T3 - Nuevo procedimiento para preparar derivados de 4-azaandrostano 17 beta-sustituidos. - Google Patents

Nuevo procedimiento para preparar derivados de 4-azaandrostano 17 beta-sustituidos.

Info

Publication number
ES2173889T3
ES2173889T3 ES93913459T ES93913459T ES2173889T3 ES 2173889 T3 ES2173889 T3 ES 2173889T3 ES 93913459 T ES93913459 T ES 93913459T ES 93913459 T ES93913459 T ES 93913459T ES 2173889 T3 ES2173889 T3 ES 2173889T3
Authority
ES
Spain
Prior art keywords
cir
general formula
group
beta
palladium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913459T
Other languages
English (en)
Inventor
Zoltan Tuba
Judit Horvath
Janos Szeles
Laszlu Kollar
Gabor Balogh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of ES2173889T3 publication Critical patent/ES2173889T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO NOVEDOSO DE DERIVADOS DE 4-AZAANDROSTANO 17{BE}-SUSTITUIDOS DE LA FORMULA GENERAL (I), DONDE R REPRESENTA HIDROGENO O UN GRUPO ALQUIL C{SUB,1-3}; R{SUP,1} REPRESENTA UN GRUPO CARBOXAMIDO MONO O DESUSTITUIDO POR UN GRUPO O GRUPOS DE ALQUIL C{SUB,1-8}; O UN GRUPO DE CARBOXIL LIBRE; O UN GRUPO DE CARBOXIL ESTERIFICADO CONUN ALCOHOL C{SUB,15} Y LINEA DE UNION ----- REPRESENTA UNA UNION SENCILLA O DOBLE; ADEMAS DE SUS SALES. EL PROCESO COMPRENDE REACCIONAR UN DERIVADO DE 17-HALOGENO-4-AZAANDROSTENO DE LA FORMULA GENERAL (II), DONDE R Y LA LINEA DE UNION ----- SON COMO DEFINIDAS ARRIBA, Y X ES CLORO, BROMINA O IONDINA, CON UN ALQUILAMINO PRIMARIO O SECUNDARIO O UN ALCOHOL C{SUB,1-5}, EN UN MEDIO DIMETILFORMAMIDA O DIMETILSULFOXIDO EN LA PRESENCIA DE UNA SAL DE PALADIO(II) Y FOSFINAS O UN COMPLEJO DE PALADIO(II) Y UNA BASE DE AMINA TERCIARIA EN UNA ATMOSFERA DE MONOXIDO DE CARBONO A UNA TEMPERATURA ENTRE 35 Y 80 GRADOS C; ENTONCES, SI SE DESEA, SE TRANSFORMA ELCOMPUESTO OBTENIDO DE LA FORMULA GENERAL (I) A OTRO COMPUESTO DE LA FORMULA GENERAL (I) MEDIANTE LA HIDROGENACION, HIDROLISIS O REACCION FORMADORA DE SAL.
ES93913459T 1993-06-24 1993-06-24 Nuevo procedimiento para preparar derivados de 4-azaandrostano 17 beta-sustituidos. Expired - Lifetime ES2173889T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/HU1993/000039 WO1995000531A1 (en) 1993-06-24 1993-06-24 NOVEL PROCESS FOR PREPARING 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES

Publications (1)

Publication Number Publication Date
ES2173889T3 true ES2173889T3 (es) 2002-11-01

Family

ID=10982846

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913459T Expired - Lifetime ES2173889T3 (es) 1993-06-24 1993-06-24 Nuevo procedimiento para preparar derivados de 4-azaandrostano 17 beta-sustituidos.

Country Status (14)

Country Link
EP (1) EP0705272B1 (es)
JP (1) JP3253088B2 (es)
KR (1) KR100279567B1 (es)
AT (1) ATE215092T1 (es)
AU (1) AU681585B2 (es)
CA (1) CA2166090C (es)
DE (1) DE69331763T2 (es)
DK (1) DK0705272T3 (es)
ES (1) ES2173889T3 (es)
FI (1) FI956236A (es)
PT (1) PT705272E (es)
RU (1) RU2109746C1 (es)
UA (1) UA41933C2 (es)
WO (1) WO1995000531A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
ES2153789B1 (es) * 1999-07-05 2001-10-16 Raga Consultores S L Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
WO2004100874A2 (en) 2003-05-07 2004-11-25 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Also Published As

Publication number Publication date
FI956236A0 (fi) 1995-12-22
PT705272E (pt) 2002-07-31
ATE215092T1 (de) 2002-04-15
DE69331763D1 (de) 2002-05-02
UA41933C2 (uk) 2001-10-15
RU2109746C1 (ru) 1998-04-27
CA2166090A1 (en) 1995-01-05
DK0705272T3 (da) 2002-05-27
CA2166090C (en) 2006-01-24
AU681585B2 (en) 1997-09-04
JP3253088B2 (ja) 2002-02-04
AU4352693A (en) 1995-01-17
KR100279567B1 (ko) 2001-03-02
WO1995000531A1 (en) 1995-01-05
FI956236A (fi) 1995-12-22
DE69331763T2 (de) 2002-10-02
EP0705272A1 (en) 1996-04-10
EP0705272B1 (en) 2002-03-27
JPH08511796A (ja) 1996-12-10
KR960703133A (ko) 1996-06-19

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