HK1010108A1 - Process for the preparation of polypeptides with prourokinase activity - Google Patents

Process for the preparation of polypeptides with prourokinase activity

Info

Publication number
HK1010108A1
HK1010108A1 HK98110955A HK98110955A HK1010108A1 HK 1010108 A1 HK1010108 A1 HK 1010108A1 HK 98110955 A HK98110955 A HK 98110955A HK 98110955 A HK98110955 A HK 98110955A HK 1010108 A1 HK1010108 A1 HK 1010108A1
Authority
HK
Hong Kong
Prior art keywords
polypeptides
rscupa
amino acids
preparation
compounds
Prior art date
Application number
HK98110955A
Other languages
English (en)
Inventor
Gerd Josef Steffens
Wolfgang A Gunzler
Leopold Flohe
Bernhard Wolf
Regina E Brigelius-Flohe
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of HK1010108A1 publication Critical patent/HK1010108A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK98110955A 1991-01-22 1998-09-25 Process for the preparation of polypeptides with prourokinase activity HK1010108A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4101736A DE4101736A1 (de) 1991-01-22 1991-01-22 Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
HK1010108A1 true HK1010108A1 (en) 1999-06-11

Family

ID=6423453

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98110955A HK1010108A1 (en) 1991-01-22 1998-09-25 Process for the preparation of polypeptides with prourokinase activity

Country Status (15)

Country Link
EP (1) EP0496327B1 (pt)
JP (1) JPH06169770A (pt)
AT (1) ATE204326T1 (pt)
DE (2) DE4101736A1 (pt)
DK (1) DK0496327T3 (pt)
ES (1) ES2164048T3 (pt)
FI (1) FI920263A (pt)
HK (1) HK1010108A1 (pt)
HU (1) HU212510B (pt)
IE (1) IE914040A1 (pt)
IL (1) IL100163A0 (pt)
LT (1) LT3948B (pt)
LV (1) LV10974A (pt)
PT (1) PT496327E (pt)
RU (1) RU2108387C1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
KR100225511B1 (ko) * 1994-12-30 1999-10-15 성재갑 소 성장호르몬의 대량 생산 방법
WO1999045105A2 (en) * 1998-03-06 1999-09-10 Abbott Laboratories Highly crystalline urokinase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI88932C (fi) * 1982-04-15 1993-07-26 Genentech Inc Framstaellning av funktionellt maenskligt urokinasprotein
NL8601240A (nl) 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法
DE3735917A1 (de) * 1987-10-23 1989-05-03 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3810474A1 (de) * 1988-03-26 1989-10-05 Boehringer Ingelheim Int Expressionsvektoren
GB8809093D0 (en) * 1988-04-18 1988-05-18 Erba Carlo Spa Low molecular weight derivatives of prourokinase
AU5515790A (en) * 1989-05-18 1990-11-22 Green Cross Corporation, The Human prourokinase variants, methods of producing same, dna sequences, plasmids and hosts therefor
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator

Also Published As

Publication number Publication date
ATE204326T1 (de) 2001-09-15
LT3948B (en) 1996-05-27
FI920263A0 (fi) 1992-01-21
IL100163A0 (en) 1992-08-18
HU9200127D0 (en) 1992-04-28
EP0496327A1 (de) 1992-07-29
DE4101736A1 (de) 1992-07-23
LV10974A (lv) 1995-12-20
EP0496327B1 (de) 2001-08-16
PT496327E (pt) 2002-02-28
DK0496327T3 (da) 2001-12-03
HUT63877A (en) 1993-10-28
FI920263A (fi) 1992-07-23
RU2108387C1 (ru) 1998-04-10
ES2164048T3 (es) 2002-02-16
LTIP1532A (en) 1995-06-26
JPH06169770A (ja) 1994-06-21
DE59209915D1 (de) 2001-09-20
HU212510B (en) 1996-07-29
IE914040A1 (en) 1992-07-29

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060120