HK1006173A1 - Biologically active peptides containing d-2-alkyltryptophan - Google Patents
Biologically active peptides containing d-2-alkyltryptophanInfo
- Publication number
- HK1006173A1 HK1006173A1 HK98105280A HK98105280A HK1006173A1 HK 1006173 A1 HK1006173 A1 HK 1006173A1 HK 98105280 A HK98105280 A HK 98105280A HK 98105280 A HK98105280 A HK 98105280A HK 1006173 A1 HK1006173 A1 HK 1006173A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyltryptophan
- peptides
- peptides containing
- biologically active
- active peptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 125000003941 D-tryptophan group Chemical group [H]C1=C([H])C([H])=C2C(C([C@@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000010525 oxidative degradation reaction Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20273A IT1240643B (it) | 1990-05-11 | 1990-05-11 | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
| PCT/EP1991/000727 WO1991018016A1 (en) | 1990-05-11 | 1991-04-17 | Biologically active peptides containing d-2-alkyltryptophan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1006173A1 true HK1006173A1 (en) | 1999-02-12 |
Family
ID=11165335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98105280A HK1006173A1 (en) | 1990-05-11 | 1998-06-15 | Biologically active peptides containing d-2-alkyltryptophan |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0531461B1 (es) |
| JP (1) | JP3319595B2 (es) |
| KR (1) | KR100216386B1 (es) |
| AT (1) | ATE114321T1 (es) |
| AU (1) | AU657475B2 (es) |
| CA (1) | CA2081450C (es) |
| DE (1) | DE69105270T2 (es) |
| DK (1) | DK0531461T3 (es) |
| ES (1) | ES2067256T3 (es) |
| GR (1) | GR3015146T3 (es) |
| HK (1) | HK1006173A1 (es) |
| IT (1) | IT1240643B (es) |
| WO (1) | WO1991018016A1 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872100A (en) * | 1990-05-11 | 1999-02-16 | Deghenghi; Romano | Peptides containing D-2-Alkyl-Tryptophan |
| DE69231395T3 (de) | 1991-09-20 | 2005-07-21 | Glaxo Group Ltd., Greenford | Neue medizinische Indikation für Tachykinin-Antagonisten |
| WO1994019368A1 (en) * | 1993-02-23 | 1994-09-01 | Banyu Pharmaceutical Co., Ltd. | Novel endothelin antagonist |
| WO1996010040A1 (en) * | 1994-09-27 | 1996-04-04 | Romano Deghenghi | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| IT1277391B1 (it) * | 1995-07-28 | 1997-11-10 | Romano Deghenghi | Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita |
| CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| IT1277113B1 (it) * | 1995-12-20 | 1997-11-04 | Romano Deghenghi | Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita |
| US6759509B1 (en) | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
| CA2264610A1 (en) * | 1996-11-05 | 1998-05-14 | Bristol-Myers Squibb Company | Branched peptide linkers |
| US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
| EP0981364B1 (en) | 1997-05-13 | 2006-03-01 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Method and compositions for treating hyperlipidemia |
| ES2202864T3 (es) | 1997-05-13 | 2004-04-01 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Agonistas de la somatostatina para disminuir el peso corporal. |
| US6051558A (en) * | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| AU7906998A (en) | 1997-06-20 | 1999-01-04 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| ATE281467T1 (de) | 1998-01-16 | 2004-11-15 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| US5968903A (en) * | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
| US6124263A (en) * | 1998-11-16 | 2000-09-26 | Asta Medica Ag | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
| US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| ES2325880T3 (es) | 2001-06-08 | 2009-09-23 | Ipsen Pharma | Analogos quimericos de somatostatina-dopamina. |
| WO2003006043A1 (en) | 2001-07-10 | 2003-01-23 | Massachusetts Institute Of Technology | Surfactant peptide nanostructures, and uses thereof |
| CA2466659A1 (en) | 2001-11-13 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Anticancer agents |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| AU2003299659A1 (en) | 2002-12-13 | 2004-07-09 | Durect Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
| AU2004232314B2 (en) | 2003-04-22 | 2007-11-22 | Ipsen Pharma S.A.S. | Peptide vectors |
| JP5285275B2 (ja) | 2004-09-17 | 2013-09-11 | デュレクト コーポレーション | 制御されたデリバリーシステム |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| GB0603295D0 (en) | 2006-02-18 | 2006-03-29 | Ardana Bioscience Ltd | Methods and kits |
| AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| CN101641099A (zh) | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物 |
| JP2011506318A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 経口医薬製剤 |
| JP5799397B2 (ja) | 2008-06-12 | 2015-10-28 | イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ | 癌の抑制 |
| US20110171191A1 (en) | 2008-06-12 | 2011-07-14 | Syntaxin Limited | Suppression of neuroendocrine diseases |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| CA2905131A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1080470A (en) * | 1963-12-31 | 1967-08-23 | Merck & Co Inc | Indole derivatives |
| JPS58501861A (ja) * | 1981-12-28 | 1983-11-04 | ベツクマン・インストルメンツ・インコ−ポレ−テツド | 下垂体成長ホルモン放出活性を有する合成ペプチド |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
-
1990
- 1990-05-11 IT IT20273A patent/IT1240643B/it active IP Right Grant
-
1991
- 1991-04-17 ES ES91920995T patent/ES2067256T3/es not_active Expired - Lifetime
- 1991-04-17 AU AU76997/91A patent/AU657475B2/en not_active Ceased
- 1991-04-17 EP EP91920995A patent/EP0531461B1/en not_active Expired - Lifetime
- 1991-04-17 KR KR1019920702659A patent/KR100216386B1/ko not_active IP Right Cessation
- 1991-04-17 WO PCT/EP1991/000727 patent/WO1991018016A1/en active IP Right Grant
- 1991-04-17 DE DE69105270T patent/DE69105270T2/de not_active Expired - Fee Related
- 1991-04-17 DK DK91920995.7T patent/DK0531461T3/da active
- 1991-04-17 AT AT91920995T patent/ATE114321T1/de not_active IP Right Cessation
- 1991-04-17 CA CA002081450A patent/CA2081450C/en not_active Expired - Lifetime
- 1991-04-17 JP JP50792291A patent/JP3319595B2/ja not_active Expired - Fee Related
-
1995
- 1995-02-22 GR GR950400366T patent/GR3015146T3/el unknown
-
1998
- 1998-06-15 HK HK98105280A patent/HK1006173A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT9020273A1 (it) | 1991-11-11 |
| CA2081450A1 (en) | 1991-11-12 |
| GR3015146T3 (en) | 1995-05-31 |
| AU7699791A (en) | 1991-12-10 |
| DK0531461T3 (da) | 1995-05-15 |
| KR100216386B1 (ko) | 1999-08-16 |
| EP0531461B1 (en) | 1994-11-23 |
| DE69105270D1 (de) | 1995-01-05 |
| AU657475B2 (en) | 1995-03-16 |
| JPH05507066A (ja) | 1993-10-14 |
| JP3319595B2 (ja) | 2002-09-03 |
| IT1240643B (it) | 1993-12-17 |
| IT9020273A0 (it) | 1990-05-11 |
| DE69105270T2 (de) | 1995-04-13 |
| CA2081450C (en) | 2001-03-27 |
| ATE114321T1 (de) | 1994-12-15 |
| WO1991018016A1 (en) | 1991-11-28 |
| ES2067256T3 (es) | 1995-03-16 |
| EP0531461A1 (en) | 1993-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| AS | Change of ownership |
Owner name: MEDIOLANUM PHARMACEUTICALS LIMITED Free format text: FORMER OWNER(S): ARDANA BIOSCIENCE LIMITED Owner name: ARDANA BIOSCIENCE LIMITED Free format text: FORMER OWNER(S): ARDANA BIOSCIENCE LIMITED Owner name: ARDANA BIOSCIENCE LIMITED Free format text: FORMER OWNER(S): ROMANO DEGHENGHI |
|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20100417 |