DK0531461T3 - Biologisk aktive peptider indeholdende D-2-alkyltryptophan - Google Patents
Biologisk aktive peptider indeholdende D-2-alkyltryptophanInfo
- Publication number
- DK0531461T3 DK0531461T3 DK91920995.7T DK91920995T DK0531461T3 DK 0531461 T3 DK0531461 T3 DK 0531461T3 DK 91920995 T DK91920995 T DK 91920995T DK 0531461 T3 DK0531461 T3 DK 0531461T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyltryptophan
- peptides
- peptides containing
- biologically active
- active peptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 125000003941 D-tryptophan group Chemical group [H]C1=C([H])C([H])=C2C(C([C@@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000010525 oxidative degradation reaction Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20273A IT1240643B (it) | 1990-05-11 | 1990-05-11 | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0531461T3 true DK0531461T3 (da) | 1995-05-15 |
Family
ID=11165335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91920995.7T DK0531461T3 (da) | 1990-05-11 | 1991-04-17 | Biologisk aktive peptider indeholdende D-2-alkyltryptophan |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0531461B1 (da) |
| JP (1) | JP3319595B2 (da) |
| KR (1) | KR100216386B1 (da) |
| AT (1) | ATE114321T1 (da) |
| AU (1) | AU657475B2 (da) |
| CA (1) | CA2081450C (da) |
| DE (1) | DE69105270T2 (da) |
| DK (1) | DK0531461T3 (da) |
| ES (1) | ES2067256T3 (da) |
| GR (1) | GR3015146T3 (da) |
| HK (1) | HK1006173A1 (da) |
| IT (1) | IT1240643B (da) |
| WO (1) | WO1991018016A1 (da) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872100A (en) * | 1990-05-11 | 1999-02-16 | Deghenghi; Romano | Peptides containing D-2-Alkyl-Tryptophan |
| EP0919245A3 (en) | 1991-09-20 | 2000-11-15 | Glaxo Group Limited | NK-1 receptor antagonist and a systemic antiinflammatory corticosteroid for the treatment of emesis |
| WO1994019368A1 (en) * | 1993-02-23 | 1994-09-01 | Banyu Pharmaceutical Co., Ltd. | Novel endothelin antagonist |
| DE69528531T2 (de) * | 1994-09-27 | 2003-06-05 | Ardana Bioscience Ltd., Edinburgh | D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| IT1277391B1 (it) * | 1995-07-28 | 1997-11-10 | Romano Deghenghi | Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita |
| CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| IT1277113B1 (it) * | 1995-12-20 | 1997-11-04 | Romano Deghenghi | Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita |
| JP2001505194A (ja) * | 1996-11-05 | 2001-04-17 | ブリストル―マイヤーズ・スクイブ・カンパニー | 分枝ペプチド・リンカー |
| US6759509B1 (en) | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
| US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
| AU8019798A (en) | 1997-05-13 | 1998-12-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Method and compositions for treating hyperlipidemia and other conditions |
| WO1998051331A1 (en) | 1997-05-13 | 1998-11-19 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) | Somatostatin and somatostatin agonists for decreasing body weight |
| US6051558A (en) * | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| WO1998058950A1 (en) | 1997-06-20 | 1998-12-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1999036431A1 (en) | 1998-01-16 | 1999-07-22 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US5968903A (en) * | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
| US6124263A (en) * | 1998-11-16 | 2000-09-26 | Asta Medica Ag | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
| US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| BR0210915A (pt) | 2001-06-08 | 2004-06-08 | Sod Conseils Rech Applic | Análogos quiméricos de somatostatina-dopamina |
| WO2003006043A1 (en) | 2001-07-10 | 2003-01-23 | Massachusetts Institute Of Technology | Surfactant peptide nanostructures, and uses thereof |
| CA2466659A1 (en) | 2001-11-13 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Anticancer agents |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| SI2218448T1 (sl) | 2002-12-13 | 2016-01-29 | Durect Corporation | Sistem za oralno dajanje zdravila, ki obsega tekoči nosilec materialov z visoko viskoznostjo |
| WO2004093807A2 (en) | 2003-04-22 | 2004-11-04 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Somatostatin vectors |
| EA201001885A1 (ru) | 2004-09-17 | 2011-12-30 | Дьюрект Корпорейшн | Система контролируемой доставки |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| GB0603295D0 (en) | 2006-02-18 | 2006-03-29 | Ardana Bioscience Ltd | Methods and kits |
| PT2117521E (pt) | 2006-11-03 | 2012-09-10 | Durect Corp | Sistemas de administração transdérmica que compreendem bupivacaína |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| AU2008335809A1 (en) | 2007-12-06 | 2009-06-18 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
| ES2732205T3 (es) | 2008-06-12 | 2019-11-21 | Ipsen Bioinnovation Ltd | Proteínas de fusión para uso en el tratamiento del cáncer |
| EP2719392B1 (en) | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| CN105120659A (zh) | 2013-03-15 | 2015-12-02 | 度瑞公司 | 用于降低溶解可变性的具有流变改性剂的组合物 |
| EP4090353A4 (en) | 2020-01-13 | 2023-08-09 | Durect Corporation | REDUCED IMPURITY EXTENDED-RELEASE DRUG DELIVERY SYSTEMS AND METHODS |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1080470A (en) * | 1963-12-31 | 1967-08-23 | Merck & Co Inc | Indole derivatives |
| BR8208035A (pt) * | 1981-12-28 | 1983-11-22 | Beckman Instruments Inc | Peptideos sinteticos tendo atividade liberadora de hormonio do crescimento da pituitaria |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
-
1990
- 1990-05-11 IT IT20273A patent/IT1240643B/it active IP Right Grant
-
1991
- 1991-04-17 AT AT91920995T patent/ATE114321T1/de not_active IP Right Cessation
- 1991-04-17 WO PCT/EP1991/000727 patent/WO1991018016A1/en active IP Right Grant
- 1991-04-17 DK DK91920995.7T patent/DK0531461T3/da active
- 1991-04-17 CA CA002081450A patent/CA2081450C/en not_active Expired - Lifetime
- 1991-04-17 ES ES91920995T patent/ES2067256T3/es not_active Expired - Lifetime
- 1991-04-17 JP JP50792291A patent/JP3319595B2/ja not_active Expired - Fee Related
- 1991-04-17 AU AU76997/91A patent/AU657475B2/en not_active Ceased
- 1991-04-17 EP EP91920995A patent/EP0531461B1/en not_active Expired - Lifetime
- 1991-04-17 DE DE69105270T patent/DE69105270T2/de not_active Expired - Fee Related
- 1991-04-17 KR KR1019920702659A patent/KR100216386B1/ko not_active IP Right Cessation
-
1995
- 1995-02-22 GR GR950400366T patent/GR3015146T3/el unknown
-
1998
- 1998-06-15 HK HK98105280A patent/HK1006173A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2067256T3 (es) | 1995-03-16 |
| EP0531461A1 (en) | 1993-03-17 |
| DE69105270D1 (de) | 1995-01-05 |
| KR100216386B1 (ko) | 1999-08-16 |
| AU7699791A (en) | 1991-12-10 |
| EP0531461B1 (en) | 1994-11-23 |
| IT9020273A0 (it) | 1990-05-11 |
| IT1240643B (it) | 1993-12-17 |
| AU657475B2 (en) | 1995-03-16 |
| GR3015146T3 (en) | 1995-05-31 |
| ATE114321T1 (de) | 1994-12-15 |
| IT9020273A1 (it) | 1991-11-11 |
| CA2081450A1 (en) | 1991-11-12 |
| JPH05507066A (ja) | 1993-10-14 |
| DE69105270T2 (de) | 1995-04-13 |
| CA2081450C (en) | 2001-03-27 |
| HK1006173A1 (en) | 1999-02-12 |
| JP3319595B2 (ja) | 2002-09-03 |
| WO1991018016A1 (en) | 1991-11-28 |
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