HK1005886A1 - Expression signal-peptide-free staphylokinases - Google Patents

Expression signal-peptide-free staphylokinases

Info

Publication number
HK1005886A1
HK1005886A1 HK98104968A HK98104968A HK1005886A1 HK 1005886 A1 HK1005886 A1 HK 1005886A1 HK 98104968 A HK98104968 A HK 98104968A HK 98104968 A HK98104968 A HK 98104968A HK 1005886 A1 HK1005886 A1 HK 1005886A1
Authority
HK
Hong Kong
Prior art keywords
pct
peptide
free
staphylokinases
expression signal
Prior art date
Application number
HK98104968A
Other languages
English (en)
Inventor
Detlev Behnke
Bernhard Schlott
Sybille Albrecht
Karl-Heinz Guehrs
Manfred Hartmann
Original Assignee
Thromb X N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4143279A external-priority patent/DE4143279A1/de
Priority claimed from DE4240801A external-priority patent/DE4240801A1/de
Application filed by Thromb X N V filed Critical Thromb X N V
Publication of HK1005886A1 publication Critical patent/HK1005886A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
HK98104968A 1991-12-30 1998-06-05 Expression signal-peptide-free staphylokinases HK1005886A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4143279A DE4143279A1 (de) 1991-12-30 1991-12-30 Neue plasminogenaktivatoren, die sie kodierenden dna-sequenzen, zugehoerige expressionsplasmide und rekombinante escherichia coli-staemme, verfahren zur produktion dieser proteine und ihre verwendung
DE4220516 1992-06-22
DE4240801A DE4240801A1 (de) 1992-12-01 1992-12-01 Reife methioninfreie Staphylokinasen, die sie kodierenden DNA-Sequenzen, zugehörige Expressionsplasmide und rekombinante Escherichia coli-Stämme, Verfahren zur Herstellung dieser Proteine und ihre Verwendung

Publications (1)

Publication Number Publication Date
HK1005886A1 true HK1005886A1 (en) 1999-01-29

Family

ID=27203268

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104968A HK1005886A1 (en) 1991-12-30 1998-06-05 Expression signal-peptide-free staphylokinases

Country Status (14)

Country Link
US (2) US5801037A (es)
EP (1) EP0621899B1 (es)
JP (1) JP3310672B2 (es)
KR (1) KR100221150B1 (es)
AT (1) ATE139570T1 (es)
AU (1) AU669149B2 (es)
DE (1) DE59206628D1 (es)
DK (1) DK0621899T3 (es)
ES (1) ES2089784T3 (es)
FI (1) FI943146A (es)
GR (1) GR3020529T3 (es)
HK (1) HK1005886A1 (es)
HU (1) HU218043B (es)
WO (1) WO1993013209A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0621899B1 (de) * 1991-12-30 1996-06-19 Medac Gesellschaft für klinische Spezialpräparate mbH Expression signalpeptid-freier staphylokinasen
CN1035192C (zh) * 1994-04-04 1997-06-18 上海医科大学 一种重组葡激酶的制备方法
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
EP0721982A1 (en) * 1995-01-06 1996-07-17 Leuven Research & Development V.Z.W. New staphylokinase derivatives
EP0721013B1 (en) * 1995-01-06 2005-03-09 Leuven Research & Development VZW New staphylokinase derivatives
US5846943A (en) * 1996-11-08 1998-12-08 Synsorb Biotech, Inc. Solid support matricles containing a toxin binding oligosaccharide
CN1059926C (zh) * 1997-07-19 2000-12-27 张其玖 葡激酶基因及其高表达工程菌株
CN1322126C (zh) * 1998-02-04 2007-06-20 思罗姆-X股份有限公司 免疫原性降低和/或清除率降低的葡激酶衍生物的鉴定、生产和应用
US7781209B2 (en) * 2005-09-25 2010-08-24 Multispan, Inc. GPCR-expressing cell lines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5867181A (ja) * 1981-10-16 1983-04-21 Yakult Honsha Co Ltd スタフイロキナーゼ産生遺伝情報を担うｄｎａ断片組み換え体ｄｎａおよびそれを導入した大腸菌
WO1987002732A1 (en) * 1985-11-01 1987-05-07 Vaughan Thomas L Hanger assembly
EP0563385B1 (en) * 1990-12-17 1997-09-24 Kabushiki Kaisha Yakult Honsha Thrombolytic peptide, production thereof and thrombolytic agent
DK0525252T3 (da) * 1991-06-28 1997-07-28 Leuven Res & Dev Vzw Anvendelse af stafylokinase til fremstilling af en farmaceutisk sammensætning til behandling af arteriel thrombose.
EP0621899B1 (de) * 1991-12-30 1996-06-19 Medac Gesellschaft für klinische Spezialpräparate mbH Expression signalpeptid-freier staphylokinasen

Also Published As

Publication number Publication date
HU218043B (hu) 2000-05-28
JP3310672B2 (ja) 2002-08-05
EP0621899B1 (de) 1996-06-19
HU9401949D0 (en) 1994-11-28
US5801037A (en) 1998-09-01
DE59206628D1 (en) 1996-07-25
ES2089784T3 (es) 1996-10-01
FI943146A0 (fi) 1994-06-30
ATE139570T1 (de) 1996-07-15
AU3347293A (en) 1993-07-28
AU669149B2 (en) 1996-05-30
DK0621899T3 (da) 1996-10-28
KR940703920A (ko) 1994-12-12
GR3020529T3 (en) 1996-10-31
WO1993013209A1 (de) 1993-07-08
HUT68067A (en) 1995-05-29
KR100221150B1 (ko) 1999-10-01
US6010897A (en) 2000-01-04
EP0621899A1 (de) 1994-11-02
JPH07502652A (ja) 1995-03-23
FI943146A (fi) 1994-06-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)