HK1005725A1 - Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses - Google Patents

Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses

Info

Publication number
HK1005725A1
HK1005725A1 HK98104822A HK98104822A HK1005725A1 HK 1005725 A1 HK1005725 A1 HK 1005725A1 HK 98104822 A HK98104822 A HK 98104822A HK 98104822 A HK98104822 A HK 98104822A HK 1005725 A1 HK1005725 A1 HK 1005725A1
Authority
HK
Hong Kong
Prior art keywords
opt
substd
halo
cycloalkyl
roco
Prior art date
Application number
HK98104822A
Other languages
English (en)
Inventor
Yasuhiro Morisawa
Akio Saito
Toshimitsu Toyama
Susumu Kaneko
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of HK1005725A1 publication Critical patent/HK1005725A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HK98104822A 1990-03-01 1998-06-03 Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses HK1005725A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5076090 1990-03-01

Publications (1)

Publication Number Publication Date
HK1005725A1 true HK1005725A1 (en) 1999-01-22

Family

ID=12867790

Family Applications (3)

Application Number Title Priority Date Filing Date
HK98104822A HK1005725A1 (en) 1990-03-01 1998-06-03 Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses
HK98104832A HK1005731A1 (en) 1990-03-01 1998-06-03 Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses
HK98111030A HK1010456A1 (en) 1990-03-01 1998-09-28 Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK98104832A HK1005731A1 (en) 1990-03-01 1998-06-03 Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses
HK98111030A HK1010456A1 (en) 1990-03-01 1998-09-28 Milbemycin ether derivatives their preparation and their therapeutic and agrochemical uses

Country Status (14)

Country Link
US (2) US5346918A (xx)
EP (3) EP0552817B1 (xx)
JP (1) JP2622197B2 (xx)
KR (1) KR0168848B1 (xx)
AT (3) ATE133174T1 (xx)
AU (1) AU634864B2 (xx)
CA (1) CA2037414A1 (xx)
DE (3) DE69126534T2 (xx)
DK (3) DK0552817T3 (xx)
ES (3) ES2084767T3 (xx)
GR (2) GR3019205T3 (xx)
HK (3) HK1005725A1 (xx)
NZ (1) NZ237276A (xx)
ZA (1) ZA911533B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202452B (xx) * 1989-12-01 1993-03-21 Ciba Geigy Ag
JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
KR0171426B1 (ko) * 1991-12-18 1999-02-01 가와무라 요시부미 13-(치환 티오) 아세톡시밀베마이신 유도체, 그의 제조방법 및 농화학적 용도
CA2105251C (en) * 1992-09-01 2004-12-07 Mitsugi Shibano Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
US5614470A (en) * 1994-04-01 1997-03-25 Sankyo Company, Limited 13-substituted milbemycin derivatives, their preparation and their use
AU3935495A (en) * 1994-11-24 1996-06-17 Sankyo Company Limited 13-etherified milbemycin derivative with insecticidal activity
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
JP2021501198A (ja) * 2017-10-27 2021-01-14 トランスフュージョン ヘルス，リミティド ライアビリティ カンパニー フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法
CN111217828B (zh) * 2018-11-26 2022-11-25 浙江海正药业股份有限公司 一种乐平霉素的制备方法及其中间体

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4315023A (en) * 1979-09-06 1982-02-09 Westwood Pharmaceuticals, Inc. 1-Phenethylimidazole derivatives
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
JPS57120589A (en) * 1981-01-20 1982-07-27 Sankyo Co Ltd 5-methoxy and 5-lower alkanoyloxy derivative, its preparation and acaricide and parasiticide
JPS57190589A (en) * 1981-05-19 1982-11-24 Brother Ind Ltd Sound displayable sewing machine
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS5916894A (ja) * 1982-07-21 1984-01-28 Sankyo Co Ltd ミルベマイシンｄの５−アシルオキシ誘導体
JPS5920285A (ja) * 1982-07-23 1984-02-01 Sankyo Co Ltd ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
EP0170006B1 (en) * 1984-06-05 1992-07-08 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
US4547491A (en) * 1984-07-18 1985-10-15 Merck & Co., Inc. C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
EP0180539A1 (de) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- und 13-Hydroximilbemycine
US4646541A (en) * 1984-11-13 1987-03-03 Columbia Gas System Service Corporation Absorption refrigeration and heat pump system
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
ES8802229A1 (es) * 1985-04-30 1988-04-16 Glaxo Group Ltd Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
CH669382A5 (en) * 1986-05-21 1989-03-15 Ciba Geigy Ag 13-0-substd. milbemycin derivs. - with insecticidal, acaricidal, nematocidal and anthelmintic activity, prepd. by etherification of 13-0 unsubstituted cpds
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
KR0171426B1 (ko) * 1991-12-18 1999-02-01 가와무라 요시부미 13-(치환 티오) 아세톡시밀베마이신 유도체, 그의 제조방법 및 농화학적 용도

Also Published As

Publication number Publication date
ZA911533B (en) 1991-12-24
US5604182A (en) 1997-02-18
DE69129498T2 (de) 1999-03-04
GR3019205T3 (en) 1996-06-30
ES2117678T3 (es) 1998-08-16
ATE154357T1 (de) 1997-06-15
DE69126534T2 (de) 1998-02-05
EP0552818B1 (en) 1997-06-11
JPH04211087A (ja) 1992-08-03
NZ237276A (en) 1993-04-28
AU7202691A (en) 1991-09-05
EP0448243B1 (en) 1996-01-17
CA2037414A1 (en) 1991-09-02
ES2084767T3 (es) 1996-05-16
JP2622197B2 (ja) 1997-06-18
ES2104987T3 (es) 1997-10-16
DE69116403D1 (de) 1996-02-29
DE69129498D1 (de) 1998-07-02
HK1010456A1 (en) 1999-06-17
EP0552818A3 (en) 1993-10-06
ATE166651T1 (de) 1998-06-15
HK1005731A1 (en) 1999-01-22
EP0448243A1 (en) 1991-09-25
GR3024542T3 (en) 1997-12-31
EP0552817A2 (en) 1993-07-28
US5346918A (en) 1994-09-13
KR0168848B1 (ko) 1999-01-15
DK0552817T3 (da) 1999-01-25
EP0552817B1 (en) 1998-05-27
ATE133174T1 (de) 1996-02-15
AU634864B2 (en) 1993-03-04
DE69116403T2 (de) 1996-09-19
DE69126534D1 (de) 1997-07-17
DK0552818T3 (da) 1998-01-19
EP0552817A3 (en) 1993-10-06
KR910016757A (ko) 1991-11-05
EP0552818A2 (en) 1993-07-28
DK0448243T3 (da) 1996-05-20

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)