GB1210520A - Glycine derivatives and a process for the preparation thereof - Google Patents
Glycine derivatives and a process for the preparation thereofInfo
- Publication number
- GB1210520A GB1210520A GB58905/67A GB5890567A GB1210520A GB 1210520 A GB1210520 A GB 1210520A GB 58905/67 A GB58905/67 A GB 58905/67A GB 5890567 A GB5890567 A GB 5890567A GB 1210520 A GB1210520 A GB 1210520A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- trihaloethyl
- bromo
- chloro
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,210,520. 2,2,2-Trihaloethyl glycinates. BRISTOL-MYERS CO. 28 Dec., 1967 [28 Dec., 1966], No. 58905/67. Heading C2C. Novel 2,2,2-trihaloethyl glycinates of the general formula X 3 C-CH 2 -O 2 C-CH 2 -NH 2 , wherein X is chloro or bromo, and pharmaceutically acceptable, non-toxic acid addition salts thereof are prepared by acylation of a 2,2,2-trihaloethanol of the general formula with an acetic acid derivative of the general formula HOOC-CH 2 -Z, wherein Z is amino, chloro, bromo or iodo, or with a reactive functional derivative thereof and, when Z is chloro, bromo or iodo, subsequent treatment with liquid ammonia or concentrated ammonium hydroxide solution, followed by optional conversion of the product to a pharmaceutically acceptable, non- toxic acid addition salt thereof. Pharmaceutical compositions having sedative, hypnotic and anaesthetic activity comprise, as active ingredient, a 2,2,2-trihaloethyl glycinate of the first general formula above or a pharmaceutically acceptable, non-toxic acid addition salt thereof, together with a diluent or carrier, and may be administered orally, parenterally or rectally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60515666A | 1966-12-28 | 1966-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1210520A true GB1210520A (en) | 1970-10-28 |
Family
ID=24422490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB58905/67A Expired GB1210520A (en) | 1966-12-28 | 1967-12-28 | Glycine derivatives and a process for the preparation thereof |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT277186B (en) |
| BE (1) | BE708555A (en) |
| CH (1) | CH495333A (en) |
| DE (1) | DE1643267B2 (en) |
| FR (2) | FR1571342A (en) |
| GB (1) | GB1210520A (en) |
| GR (1) | GR34948B (en) |
| IL (1) | IL29190A (en) |
| NL (1) | NL6717739A (en) |
| NO (1) | NO122702B (en) |
| SE (1) | SE347254B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374765A (en) * | 1990-09-03 | 1994-12-20 | Mitsui Toatsu Chemicals, Incorporated | Method for extracting an amino acid ester from a hydrous solution of a mineral acid salt thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2923009B2 (en) * | 1990-09-03 | 1999-07-26 | 三井化学株式会社 | Extraction method of amino acid ester |
-
1967
- 1967-12-21 IL IL2919067A patent/IL29190A/en unknown
- 1967-12-22 GR GR670134948A patent/GR34948B/en unknown
- 1967-12-26 CH CH1826767A patent/CH495333A/en not_active IP Right Cessation
- 1967-12-27 BE BE708555D patent/BE708555A/xx unknown
- 1967-12-27 SE SE1778267A patent/SE347254B/xx unknown
- 1967-12-27 NO NO17116367A patent/NO122702B/no unknown
- 1967-12-27 DE DE19671643267 patent/DE1643267B2/en active Granted
- 1967-12-28 NL NL6717739A patent/NL6717739A/xx unknown
- 1967-12-28 FR FR1571342D patent/FR1571342A/fr not_active Expired
- 1967-12-28 AT AT1175267A patent/AT277186B/en active
- 1967-12-28 GB GB58905/67A patent/GB1210520A/en not_active Expired
-
1968
- 1968-03-27 FR FR145696A patent/FR7556M/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374765A (en) * | 1990-09-03 | 1994-12-20 | Mitsui Toatsu Chemicals, Incorporated | Method for extracting an amino acid ester from a hydrous solution of a mineral acid salt thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1643267C3 (en) | 1975-02-13 |
| GR34948B (en) | 1968-07-24 |
| AT277186B (en) | 1969-12-10 |
| BE708555A (en) | 1968-06-27 |
| NL6717739A (en) | 1968-07-01 |
| FR7556M (en) | 1969-12-29 |
| NO122702B (en) | 1971-08-02 |
| DE1643267B2 (en) | 1974-06-20 |
| CH495333A (en) | 1970-08-31 |
| FR1571342A (en) | 1969-06-20 |
| IL29190A (en) | 1972-03-28 |
| SE347254B (en) | 1972-07-31 |
| DE1643267A1 (en) | 1972-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1210520A (en) | Glycine derivatives and a process for the preparation thereof | |
| GB1322112A (en) | 3,4,5-trimethoxybenzoic acid derivatives and their uses | |
| GB1247711A (en) | Antibacterial agents and a process for the preparation thereof | |
| GB1137530A (en) | A thiazolyl-acetamide derivative | |
| GB1256723A (en) | ||
| GB1349138A (en) | Quinazoline derivative | |
| GB1359560A (en) | Preparation of pyrrylsalicylic acid | |
| GB1297035A (en) | ||
| GB1054906A (en) | ||
| GB1276719A (en) | Benzomorphan derivatives and their salts | |
| GB1364366A (en) | Derivatives of 4-chloro-5-sulphamoyl-anthranilic acid their preparation and pahamaceutical compositions comprising them | |
| GB1154454A (en) | New Anthranilic Acid Derivatives | |
| GB1494299A (en) | Propionic acid derivative salts having hiperlipemic activity | |
| GB1421089A (en) | Arginine pyroglutamate and a procedure for its preparation | |
| GB1261660A (en) | alpha-HYDRAZINO ACIDS | |
| GB1437149A (en) | Spiro-compounds and a process for their preparation | |
| GB1425911A (en) | Phenylacetic acid derivatives, process for their preparation and therapeutic composition containing same | |
| GB1154494A (en) | Novel N-Cycloalkyl-Azabicyclooctanes and Nonanes and Novel Intermediates and process for preparation | |
| GB1380265A (en) | Thiazole derivatives | |
| GB1132424A (en) | New n'-substituted n-arylsulphonyl urea preparations and compositions containing same | |
| GB1180250A (en) | Improvements in or relating to New But-2-Yne Derivative and Process for Preparing same | |
| GB1313838A (en) | 3,4,5-trialkoxybenzoic acid derivatives and their uses | |
| IE33581B1 (en) | Method of treatment and pharmaceutical preparation | |
| GB1171827A (en) | Improvements in or relating to Substituted Propanols and the Manufacture thereof | |
| GB1211387A (en) | 0-benzylpiperidine derivative and a process for the preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |