GB1349138A - Quinazoline derivative - Google Patents

Quinazoline derivative

Info

Publication number
GB1349138A
GB1349138A GB2616373A GB1349138DA GB1349138A GB 1349138 A GB1349138 A GB 1349138A GB 2616373 A GB2616373 A GB 2616373A GB 1349138D A GB1349138D A GB 1349138DA GB 1349138 A GB1349138 A GB 1349138A
Authority
GB
United Kingdom
Prior art keywords
dihydroxypropylamine
trimethoxyquinazoline
novel compound
dihydroxypropyl
dec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2616373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1349138A publication Critical patent/GB1349138A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1349138 Quinazoline derivative SANDOZ Ltd 2 Dec 1970 [5 Dec 1969 26 Aug 1970] 26163/73 Divided out of 1349136 Heading C2C The novel compound, 4 - (2,3 - dihydroxypropyl)amino - 6,7,8 - trimethoxyquinazoline is prepared by reacting a 4-halo-6,7,8-trimethoxyquinazoline with 2,3 - dihydroxypropylamine dinitrate ester or 2,3-dihydroxypropylamine, followed, when using the latter compound, by nitrating the resulting 4-(2,3-dihydroxypropyl)- amino - 6,7,8 - trimethoxyquinazoline. The novel compound forms acid addition salts in the usual manner. 2,3 - Dihydroxypropylamine dinitrate ester is prepared by 2,3-dihydroxypropylamine with a mixture of nitric acid and acetic anhydride. Pharmaceutical compositions having antianginal activity, for oral administration, comprise the above novel compound, or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical diluent or carrier.
GB2616373A 1969-12-05 1970-12-02 Quinazoline derivative Expired GB1349138A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87043969A 1969-12-05 1969-12-05
SE1157870 1970-08-26

Publications (1)

Publication Number Publication Date
GB1349138A true GB1349138A (en) 1974-03-27

Family

ID=26655842

Family Applications (5)

Application Number Title Priority Date Filing Date
GB5722170A Expired GB1349136A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB2616273A Expired GB1349137A (en) 1969-12-05 1970-12-02 Quinazoline derivative
GB3491073A Expired GB1349140A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB3059973A Expired GB1349139A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB2616373A Expired GB1349138A (en) 1969-12-05 1970-12-02 Quinazoline derivative

Family Applications Before (4)

Application Number Title Priority Date Filing Date
GB5722170A Expired GB1349136A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB2616273A Expired GB1349137A (en) 1969-12-05 1970-12-02 Quinazoline derivative
GB3491073A Expired GB1349140A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB3059973A Expired GB1349139A (en) 1969-12-05 1970-12-02 Quinazoline derivatives

Country Status (17)

Country Link
JP (1) JPS4837035B1 (en)
AU (1) AU5918873A (en)
BE (1) BE759842R (en)
BG (2) BG17598A3 (en)
CH (2) CH549581A (en)
DE (1) DE2059164A1 (en)
ES (1) ES386121A1 (en)
FR (1) FR2081329B2 (en)
GB (5) GB1349136A (en)
HU (2) HU162866B (en)
IE (1) IE34780B1 (en)
IL (1) IL35779A (en)
NL (1) NL7017669A (en)
OA (1) OA03536A (en)
PL (1) PL81227B1 (en)
RO (2) RO62627A (en)
SU (2) SU449487A3 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793371A (en) * 1971-12-27 1973-06-27 Sandoz Sa NEW DERIVATIVES OF 4-AMINO-QUINAZOLINE, THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE
JPS5416626U (en) * 1977-07-05 1979-02-02
IE51802B1 (en) 1979-12-03 1987-04-01 Fujisawa Pharmaceutical Co Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
US4510307A (en) * 1980-08-20 1985-04-09 Asahi Kasei Kogyo Kabushiki Kaisha 6-Quinazolinesulfonyl derivatives and process for preparation thereof
CA2148260A1 (en) * 1993-09-10 1995-03-16 Yasutaka Takase Quinazoline cpompounds
GB0307333D0 (en) * 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1199768A (en) * 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines

Also Published As

Publication number Publication date
HU162867B (en) 1973-04-28
CH552601A (en) 1974-08-15
PL81227B1 (en) 1975-08-30
NL7017669A (en) 1971-06-08
FR2081329B2 (en) 1975-06-06
IE34780L (en) 1971-06-05
RO62626A (en) 1978-05-15
BG17599A3 (en) 1973-11-10
DE2059164A1 (en) 1971-06-09
CH549581A (en) 1974-05-31
GB1349140A (en) 1974-03-27
IE34780B1 (en) 1975-08-20
JPS4837035B1 (en) 1973-11-08
GB1349139A (en) 1974-03-27
SU449487A3 (en) 1974-11-05
IL35779A (en) 1974-06-30
SU439091A3 (en) 1974-08-05
BE759842R (en) 1971-06-03
BG17598A3 (en) 1973-11-10
HU162866B (en) 1973-04-28
OA03536A (en) 1971-03-30
GB1349136A (en) 1974-03-27
ES386121A1 (en) 1973-12-16
GB1349137A (en) 1974-03-27
RO62627A (en) 1978-05-15
FR2081329A2 (en) 1971-12-03
AU5918873A (en) 1974-02-14

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees