ES386121A1 - Procedure for the obtaining of 4-amino-quinazoline derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of 4-amino-quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES386121A1 ES386121A1 ES0386121A ES386121A ES386121A1 ES 386121 A1 ES386121 A1 ES 386121A1 ES 0386121 A ES0386121 A ES 0386121A ES 386121 A ES386121 A ES 386121A ES 386121 A1 ES386121 A1 ES 386121A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- group
- formula
- see formula
- ono2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining 4-amino-quinazoline derivatives of formula I, **(See formula)** Wherein each of Y, Y1 and Y2, which may be the same or different, means an alkoxy radical of 1 to 3 carbon atoms, and each of R and R1 means a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a radical selected from the group consisting of a) -CH2 - (- CH2) n-0N02, b) (see formula), and c) -CH2 (-CH2) zN = [-CH2 (-CH2) z-ONO2] 2, where R2 means a hydrogen atom or a radical - (CH2) m-CH3 or - (CH2) y-ONO2, n means 1 to 6, m means 0 to 4, and means 1 to 4, and z means 1 to 4, provided that (i) at least one nitrate group is present and no more of two nitrate groups; (ii) one of the symbols R and R1 means a hydrogen atom or an alkyl radical when the other symbol means a radical defined in section b) above; (iii) in any radical defined in section b) above that is present, only one substituent R2 has a meaning other than hydrogen; (iv) the sum of n and m does not exceed 6, and (v) the sum of n and y does not exceed 7, or R and R1, together with the nitrogen atom to which they are bound, signify a radical **(See formula)** wherein z has the meaning indicated above, characterized in that a corresponding hydroxy compound of formula II is nitrated, **(See formula)** where Y, Y1 and Y2 have the meanings indicated above, and R3 and R4 have the same meanings as R and R1, respectively, defined above, except that each -ONO2 group in R and R1 is replaced by a hydroxy group, preferably with nitric acid in the presence of a carboxylic acid anhydrous and preferably at a temperature of -10º to + 50ºC, more preferably of + 5º to + 20ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87043969A | 1969-12-05 | 1969-12-05 | |
| SE1157870 | 1970-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES386121A1 true ES386121A1 (en) | 1973-12-16 |
Family
ID=26655842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0386121A Expired ES386121A1 (en) | 1969-12-05 | 1970-12-03 | Procedure for the obtaining of 4-amino-quinazoline derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS4837035B1 (en) |
| AU (1) | AU5918873A (en) |
| BE (1) | BE759842R (en) |
| BG (2) | BG17598A3 (en) |
| CH (2) | CH549581A (en) |
| DE (1) | DE2059164A1 (en) |
| ES (1) | ES386121A1 (en) |
| FR (1) | FR2081329B2 (en) |
| GB (5) | GB1349137A (en) |
| HU (2) | HU162866B (en) |
| IE (1) | IE34780B1 (en) |
| IL (1) | IL35779A (en) |
| NL (1) | NL7017669A (en) |
| OA (1) | OA03536A (en) |
| PL (1) | PL81227B1 (en) |
| RO (2) | RO62626A (en) |
| SU (2) | SU439091A3 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793371A (en) * | 1971-12-27 | 1973-06-27 | Sandoz Sa | NEW DERIVATIVES OF 4-AMINO-QUINAZOLINE, THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE |
| JPS5416626U (en) * | 1977-07-05 | 1979-02-02 | ||
| IE51802B1 (en) * | 1979-12-03 | 1987-04-01 | Fujisawa Pharmaceutical Co | Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them |
| US4510307A (en) * | 1980-08-20 | 1985-04-09 | Asahi Kasei Kogyo Kabushiki Kaisha | 6-Quinazolinesulfonyl derivatives and process for preparation thereof |
| EP0669324A4 (en) * | 1993-09-10 | 1996-04-03 | Eisai Co Ltd | Quinazoline compound. |
| GB0307333D0 (en) * | 2003-03-29 | 2003-05-07 | Astrazeneca Ab | Therapeutic agent |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1199768A (en) * | 1966-10-31 | 1970-07-22 | Pfizer & Co C | Nitrogen Heterocycles and process for their preparation |
| US3470182A (en) * | 1967-02-09 | 1969-09-30 | Sandoz Ag | 4-amino-substituted quinazolines |
-
0
- BE BE759842D patent/BE759842R/en active
-
1970
- 1970-11-23 CH CH1735770A patent/CH549581A/en unknown
- 1970-11-23 CH CH1519173A patent/CH552601A/en not_active IP Right Cessation
- 1970-12-02 IE IE1541/70A patent/IE34780B1/en unknown
- 1970-12-02 GB GB2616273A patent/GB1349137A/en not_active Expired
- 1970-12-02 GB GB3059973A patent/GB1349139A/en not_active Expired
- 1970-12-02 DE DE19702059164 patent/DE2059164A1/en active Pending
- 1970-12-02 GB GB2616373A patent/GB1349138A/en not_active Expired
- 1970-12-02 GB GB3491073A patent/GB1349140A/en not_active Expired
- 1970-12-02 GB GB5722170A patent/GB1349136A/en not_active Expired
- 1970-12-03 HU HUSA2280A patent/HU162866B/hu unknown
- 1970-12-03 RO RO7000074396A patent/RO62626A/en unknown
- 1970-12-03 IL IL35779A patent/IL35779A/en unknown
- 1970-12-03 RO RO7000074397A patent/RO62627A/en unknown
- 1970-12-03 BG BG16189A patent/BG17598A3/xx unknown
- 1970-12-03 HU HUSA2281A patent/HU162867B/hu unknown
- 1970-12-03 ES ES0386121A patent/ES386121A1/en not_active Expired
- 1970-12-03 PL PL1970144794A patent/PL81227B1/en unknown
- 1970-12-03 NL NL7017669A patent/NL7017669A/xx unknown
- 1970-12-04 SU SU1785910A patent/SU439091A3/en active
- 1970-12-04 FR FR7043720A patent/FR2081329B2/fr not_active Expired
- 1970-12-04 SU SU1785908A patent/SU449487A3/en active
- 1970-12-04 OA OA54108A patent/OA03536A/en unknown
- 1970-12-13 BG BG17324A patent/BG17599A3/xx unknown
-
1972
- 1972-04-14 JP JP47037000A patent/JPS4837035B1/ja active Pending
-
1973
- 1973-08-13 AU AU59188/73A patent/AU5918873A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1349139A (en) | 1974-03-27 |
| OA03536A (en) | 1971-03-30 |
| GB1349137A (en) | 1974-03-27 |
| RO62627A (en) | 1978-05-15 |
| BG17598A3 (en) | 1973-11-10 |
| CH549581A (en) | 1974-05-31 |
| AU5918873A (en) | 1974-02-14 |
| HU162867B (en) | 1973-04-28 |
| SU439091A3 (en) | 1974-08-05 |
| DE2059164A1 (en) | 1971-06-09 |
| GB1349136A (en) | 1974-03-27 |
| IE34780B1 (en) | 1975-08-20 |
| SU449487A3 (en) | 1974-11-05 |
| BE759842R (en) | 1971-06-03 |
| IE34780L (en) | 1971-06-05 |
| JPS4837035B1 (en) | 1973-11-08 |
| IL35779A (en) | 1974-06-30 |
| NL7017669A (en) | 1971-06-08 |
| RO62626A (en) | 1978-05-15 |
| BG17599A3 (en) | 1973-11-10 |
| CH552601A (en) | 1974-08-15 |
| GB1349140A (en) | 1974-03-27 |
| HU162866B (en) | 1973-04-28 |
| FR2081329A2 (en) | 1971-12-03 |
| PL81227B1 (en) | 1975-08-30 |
| FR2081329B2 (en) | 1975-06-06 |
| GB1349138A (en) | 1974-03-27 |
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