GB1349137A - Quinazoline derivative - Google Patents

Quinazoline derivative

Info

Publication number
GB1349137A
GB1349137A GB2616273A GB2616270A GB1349137A GB 1349137 A GB1349137 A GB 1349137A GB 2616273 A GB2616273 A GB 2616273A GB 2616270 A GB2616270 A GB 2616270A GB 1349137 A GB1349137 A GB 1349137A
Authority
GB
United Kingdom
Prior art keywords
hydroxyhexylamine
reacting
nitrate ester
hydroxyhexyl
dec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2616273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1349137A publication Critical patent/GB1349137A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1349137 Quinazoline derivative SANDOZ Ltd 2 Dec 1970 [5 Dec 1969 26 Aug 1970] 26162/73 Divided out of 1349136 Heading C2C The novel compound, 4-(6-hydroxyhexyl)- amino - 6,7,8 - trimethoxy quinazoline nitrate ester, and its acid addition salts, are prepared by reacting a 4-halo-6,7,8-trimethoxyquinazoline with 6-hydroxyhexylamine nitrate ester, or 6-hydroxyhexylamine, followed when using the latter compound, by reacting the resulting 4 - (6 - hydroxyhexyl)amino - 6,7,8 - trimethoryquinazoline with nitric acid. 6 - Hydroxyhexylamine nitrate ester is prepared by reacting 6-hydroxyhexylamine with a mixture of nitric acid and acetic anhydride. Pharmaceutical compositions having antianginal and anti-arrhythmic activity, for oral administration, comprise the above novel compound, or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical diluent or carrier.
GB2616273A 1969-12-05 1970-12-02 Quinazoline derivative Expired GB1349137A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87043969A 1969-12-05 1969-12-05
SE1157870 1970-08-26

Publications (1)

Publication Number Publication Date
GB1349137A true GB1349137A (en) 1974-03-27

Family

ID=26655842

Family Applications (5)

Application Number Title Priority Date Filing Date
GB3059973A Expired GB1349139A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB2616373A Expired GB1349138A (en) 1969-12-05 1970-12-02 Quinazoline derivative
GB3491073A Expired GB1349140A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB2616273A Expired GB1349137A (en) 1969-12-05 1970-12-02 Quinazoline derivative
GB5722170A Expired GB1349136A (en) 1969-12-05 1970-12-02 Quinazoline derivatives

Family Applications Before (3)

Application Number Title Priority Date Filing Date
GB3059973A Expired GB1349139A (en) 1969-12-05 1970-12-02 Quinazoline derivatives
GB2616373A Expired GB1349138A (en) 1969-12-05 1970-12-02 Quinazoline derivative
GB3491073A Expired GB1349140A (en) 1969-12-05 1970-12-02 Quinazoline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB5722170A Expired GB1349136A (en) 1969-12-05 1970-12-02 Quinazoline derivatives

Country Status (17)

Country Link
JP (1) JPS4837035B1 (en)
AU (1) AU5918873A (en)
BE (1) BE759842R (en)
BG (2) BG17598A3 (en)
CH (2) CH552601A (en)
DE (1) DE2059164A1 (en)
ES (1) ES386121A1 (en)
FR (1) FR2081329B2 (en)
GB (5) GB1349139A (en)
HU (2) HU162866B (en)
IE (1) IE34780B1 (en)
IL (1) IL35779A (en)
NL (1) NL7017669A (en)
OA (1) OA03536A (en)
PL (1) PL81227B1 (en)
RO (2) RO62627A (en)
SU (2) SU439091A3 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793371A (en) * 1971-12-27 1973-06-27 Sandoz Sa NEW DERIVATIVES OF 4-AMINO-QUINAZOLINE, THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE
JPS5416626U (en) * 1977-07-05 1979-02-02
IE51802B1 (en) 1979-12-03 1987-04-01 Fujisawa Pharmaceutical Co Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
US4510307A (en) * 1980-08-20 1985-04-09 Asahi Kasei Kogyo Kabushiki Kaisha 6-Quinazolinesulfonyl derivatives and process for preparation thereof
WO1995007267A1 (en) * 1993-09-10 1995-03-16 Eisai Co., Ltd. Quinazoline compound
GB0307333D0 (en) * 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1199768A (en) * 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines

Also Published As

Publication number Publication date
SU449487A3 (en) 1974-11-05
NL7017669A (en) 1971-06-08
GB1349140A (en) 1974-03-27
DE2059164A1 (en) 1971-06-09
IL35779A (en) 1974-06-30
RO62626A (en) 1978-05-15
AU5918873A (en) 1974-02-14
BE759842R (en) 1971-06-03
GB1349138A (en) 1974-03-27
JPS4837035B1 (en) 1973-11-08
BG17599A3 (en) 1973-11-10
IE34780B1 (en) 1975-08-20
FR2081329A2 (en) 1971-12-03
HU162867B (en) 1973-04-28
OA03536A (en) 1971-03-30
HU162866B (en) 1973-04-28
ES386121A1 (en) 1973-12-16
GB1349139A (en) 1974-03-27
GB1349136A (en) 1974-03-27
IE34780L (en) 1971-06-05
BG17598A3 (en) 1973-11-10
CH549581A (en) 1974-05-31
PL81227B1 (en) 1975-08-30
CH552601A (en) 1974-08-15
SU439091A3 (en) 1974-08-05
FR2081329B2 (en) 1975-06-06
RO62627A (en) 1978-05-15

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees