GB1223062A - Improvements in or relating to new aminoacid derivatives - Google Patents
Improvements in or relating to new aminoacid derivativesInfo
- Publication number
- GB1223062A GB1223062A GB21700/69A GB2170069A GB1223062A GB 1223062 A GB1223062 A GB 1223062A GB 21700/69 A GB21700/69 A GB 21700/69A GB 2170069 A GB2170069 A GB 2170069A GB 1223062 A GB1223062 A GB 1223062A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aspartic
- phenoxyacetyl
- general formula
- prepared
- halogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title 1
- 239000004220 glutamic acid Substances 0.000 abstract 4
- 235000013922 glutamic acid Nutrition 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- SODPIMGUZLOIPE-UHFFFAOYSA-N (4-chlorophenoxy)acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1 SODPIMGUZLOIPE-UHFFFAOYSA-N 0.000 abstract 1
- VRBVHQUSAOKVDH-UHFFFAOYSA-N 2-(4-chlorophenoxy)acetyl chloride Chemical compound ClC(=O)COC1=CC=C(Cl)C=C1 VRBVHQUSAOKVDH-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N Aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- -1 phenoxyacetyl halide Chemical class 0.000 abstract 1
- 239000003368 psychostimulant agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,223,062. N - Phenoxyacetyl - aspartic and - glutamic acids. SERDEX-SOC. D'ETUDES DE RECHERCHES DE DIFFUSION ET D'EXPLOITATION. 29 April, 1969 [8 May, 1968], No. 21700/69. Heading C2C. Novel N-phenoxyacetyl-aspartic and -glutamic acids of the general formula wherein X is a halogen atom or an alkoxy radical and n is 1 or 2, and salts thereof are prepared by condensation of a phenoxyacetyl halide of the general formula wherein Y is a halogen atom, with aspartic or glutamic acid, followed optionally by salification. p-Chlorophenoxyacetyl chloride is prepared by treatment of p-chlorophenoxyacetic acid with thionyl chloride. Pharmaceutical compositions having psychostimulant activity comprise, as active ingredient, an N-phenoxy-acetyl-aspartic or -glutamic acid of the first general formula above or a non-toxic salt thereof, in admixture with a pharmaceutically acceptable vehicle or excipient, and may be administered orally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR150939A FR7434M (en) | 1969-05-08 | 1969-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1223062A true GB1223062A (en) | 1971-02-17 |
Family
ID=8649944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21700/69A Expired GB1223062A (en) | 1968-05-08 | 1969-04-29 | Improvements in or relating to new aminoacid derivatives |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE732384A (en) |
| FR (1) | FR7434M (en) |
| GB (1) | GB1223062A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0205327A1 (en) * | 1985-06-08 | 1986-12-17 | Suntory Limited | Phenoxyacetylamide derivative and process for production and use thereof |
| EP0207690A1 (en) * | 1985-06-18 | 1987-01-07 | Suntory Limited | N-Substituted glutamic acid derivative and process for production and use thereof |
| FR2826549A1 (en) * | 2001-06-28 | 2003-01-03 | Roquette Freres | PROCESS FOR THE PREPARATION OF A COMPRESSED EDULCORANT TABLET AND A COMPRESSED EDULCORANT THUS OBTAINED |
-
1969
- 1969-04-29 GB GB21700/69A patent/GB1223062A/en not_active Expired
- 1969-04-30 BE BE732384D patent/BE732384A/xx unknown
- 1969-05-08 FR FR150939A patent/FR7434M/fr not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0205327A1 (en) * | 1985-06-08 | 1986-12-17 | Suntory Limited | Phenoxyacetylamide derivative and process for production and use thereof |
| EP0207690A1 (en) * | 1985-06-18 | 1987-01-07 | Suntory Limited | N-Substituted glutamic acid derivative and process for production and use thereof |
| US4701210A (en) * | 1985-06-18 | 1987-10-20 | Suntory Limited | N-substituted glutamic acid derivative and process for production and use thereof |
| FR2826549A1 (en) * | 2001-06-28 | 2003-01-03 | Roquette Freres | PROCESS FOR THE PREPARATION OF A COMPRESSED EDULCORANT TABLET AND A COMPRESSED EDULCORANT THUS OBTAINED |
| WO2003001925A2 (en) * | 2001-06-28 | 2003-01-09 | Roquette Freres | Method for preparing a sweetening tablet and resulting sweetening tablet |
| WO2003001925A3 (en) * | 2001-06-28 | 2003-04-17 | Roquette Freres | Method for preparing a sweetening tablet and resulting sweetening tablet |
Also Published As
| Publication number | Publication date |
|---|---|
| FR7434M (en) | 1969-11-17 |
| BE732384A (en) | 1969-10-01 |
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