DE69129498D1 - Milbemycinetherderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch - Google Patents

Milbemycinetherderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch

Info

Publication number
DE69129498D1
DE69129498D1 DE69129498T DE69129498T DE69129498D1 DE 69129498 D1 DE69129498 D1 DE 69129498D1 DE 69129498 T DE69129498 T DE 69129498T DE 69129498 T DE69129498 T DE 69129498T DE 69129498 D1 DE69129498 D1 DE 69129498D1
Authority
DE
Germany
Prior art keywords
opt
substd
halo
cycloalkyl
roco
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69129498T
Other languages
English (en)
Other versions
DE69129498T2 (de
Inventor
Yasuhiro Morisawa
Akio Saito
Toshimitsu Toyama
Susumu Kaneko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE69129498D1 publication Critical patent/DE69129498D1/de
Publication of DE69129498T2 publication Critical patent/DE69129498T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69129498T 1990-03-01 1991-03-01 Milbemycinetherderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch Expired - Fee Related DE69129498T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5076090 1990-03-01

Publications (2)

Publication Number Publication Date
DE69129498D1 true DE69129498D1 (de) 1998-07-02
DE69129498T2 DE69129498T2 (de) 1999-03-04

Family

ID=12867790

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69129498T Expired - Fee Related DE69129498T2 (de) 1990-03-01 1991-03-01 Milbemycinetherderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch
DE69126534T Expired - Fee Related DE69126534T2 (de) 1990-03-01 1991-03-01 Milbemycinetherderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch
DE69116403T Expired - Fee Related DE69116403T2 (de) 1990-03-01 1991-03-01 Milbemycinderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69126534T Expired - Fee Related DE69126534T2 (de) 1990-03-01 1991-03-01 Milbemycinetherderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch
DE69116403T Expired - Fee Related DE69116403T2 (de) 1990-03-01 1991-03-01 Milbemycinderivate, ihre Herstellung und ihr therapeutischer und agrochemischer Gebrauch

Country Status (14)

Country Link
US (2) US5346918A (de)
EP (3) EP0552818B1 (de)
JP (1) JP2622197B2 (de)
KR (1) KR0168848B1 (de)
AT (3) ATE154357T1 (de)
AU (1) AU634864B2 (de)
CA (1) CA2037414A1 (de)
DE (3) DE69129498T2 (de)
DK (3) DK0552818T3 (de)
ES (3) ES2117678T3 (de)
GR (2) GR3019205T3 (de)
HK (3) HK1005731A1 (de)
NZ (1) NZ237276A (de)
ZA (1) ZA911533B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202452B (de) * 1989-12-01 1993-03-21 Ciba Geigy Ag
JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
US5276033A (en) * 1991-12-18 1994-01-04 Sankyo Company, Limited 13-(substituted thio)acetoxymilbemycin derivatives, their preparation and their agrochemical uses
CA2105251C (en) * 1992-09-01 2004-12-07 Mitsugi Shibano Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
US5614470A (en) * 1994-04-01 1997-03-25 Sankyo Company, Limited 13-substituted milbemycin derivatives, their preparation and their use
AU3935495A (en) * 1994-11-24 1996-06-17 Sankyo Company Limited 13-etherified milbemycin derivative with insecticidal activity
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
EP1849363A1 (de) * 2006-03-09 2007-10-31 Cheminova A/S Synergistische Kombinationen aus Glutaminsäure- und GABA-aktivierten Chloridkanälen agonistischen Pestiziden und mindestens eins von Vitamin E und Niacin
CA3079959A1 (en) * 2017-10-27 2018-10-26 Transfusion Health, Llc Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene
CN111217828B (zh) * 2018-11-26 2022-11-25 浙江海正药业股份有限公司 一种乐平霉素的制备方法及其中间体

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4315023A (en) * 1979-09-06 1982-02-09 Westwood Pharmaceuticals, Inc. 1-Phenethylimidazole derivatives
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
JPS57120589A (en) * 1981-01-20 1982-07-27 Sankyo Co Ltd 5-methoxy and 5-lower alkanoyloxy derivative, its preparation and acaricide and parasiticide
JPS57190589A (en) * 1981-05-19 1982-11-24 Brother Ind Ltd Sound displayable sewing machine
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS5916894A (ja) * 1982-07-21 1984-01-28 Sankyo Co Ltd ミルベマイシンｄの５−アシルオキシ誘導体
JPS5920285A (ja) * 1982-07-23 1984-02-01 Sankyo Co Ltd ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
US4547491A (en) * 1984-07-18 1985-10-15 Merck & Co., Inc. C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
EP0180539A1 (de) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- und 13-Hydroximilbemycine
US4646541A (en) * 1984-11-13 1987-03-03 Columbia Gas System Service Corporation Absorption refrigeration and heat pump system
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
CH669382A5 (en) * 1986-05-21 1989-03-15 Ciba Geigy Ag 13-0-substd. milbemycin derivs. - with insecticidal, acaricidal, nematocidal and anthelmintic activity, prepd. by etherification of 13-0 unsubstituted cpds
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US5276033A (en) * 1991-12-18 1994-01-04 Sankyo Company, Limited 13-(substituted thio)acetoxymilbemycin derivatives, their preparation and their agrochemical uses

Also Published As

Publication number Publication date
EP0552818B1 (de) 1997-06-11
EP0448243A1 (de) 1991-09-25
US5604182A (en) 1997-02-18
EP0552818A3 (en) 1993-10-06
DE69129498T2 (de) 1999-03-04
DE69126534D1 (de) 1997-07-17
DK0552818T3 (da) 1998-01-19
ES2104987T3 (es) 1997-10-16
ATE133174T1 (de) 1996-02-15
DE69116403D1 (de) 1996-02-29
HK1005731A1 (en) 1999-01-22
ATE154357T1 (de) 1997-06-15
ATE166651T1 (de) 1998-06-15
GR3019205T3 (en) 1996-06-30
DK0552817T3 (da) 1999-01-25
EP0552817B1 (de) 1998-05-27
EP0552817A2 (de) 1993-07-28
KR910016757A (ko) 1991-11-05
ES2117678T3 (es) 1998-08-16
HK1010456A1 (en) 1999-06-17
DE69116403T2 (de) 1996-09-19
HK1005725A1 (en) 1999-01-22
GR3024542T3 (en) 1997-12-31
AU634864B2 (en) 1993-03-04
DE69126534T2 (de) 1998-02-05
US5346918A (en) 1994-09-13
JPH04211087A (ja) 1992-08-03
NZ237276A (en) 1993-04-28
KR0168848B1 (ko) 1999-01-15
DK0448243T3 (da) 1996-05-20
JP2622197B2 (ja) 1997-06-18
CA2037414A1 (en) 1991-09-02
EP0448243B1 (de) 1996-01-17
EP0552818A2 (de) 1993-07-28
ES2084767T3 (es) 1996-05-16
ZA911533B (en) 1991-12-24
AU7202691A (en) 1991-09-05
EP0552817A3 (en) 1993-10-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee