HK1002032A1 - Sulfated glycosaminoglycanoid derivatives - Google Patents

Sulfated glycosaminoglycanoid derivatives Download PDF

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Publication number
HK1002032A1
HK1002032A1 HK98101027A HK98101027A HK1002032A1 HK 1002032 A1 HK1002032 A1 HK 1002032A1 HK 98101027 A HK98101027 A HK 98101027A HK 98101027 A HK98101027 A HK 98101027A HK 1002032 A1 HK1002032 A1 HK 1002032A1
Authority
HK
Hong Kong
Prior art keywords
group
sulfate
alkyl
aryl
groups
Prior art date
Application number
HK98101027A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1002032B (en
Inventor
Petitou Maurice
Adriaan Anton Van Boeckel Constant
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HK1002032B publication Critical patent/HK1002032B/en
Publication of HK1002032A1 publication Critical patent/HK1002032A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
HK98101027A 1991-08-23 1998-02-11 Sulfated glycosaminoglycanoid derivatives HK1002032A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91402299 1991-08-23
EP91402299 1991-08-23

Publications (2)

Publication Number Publication Date
HK1002032B HK1002032B (en) 1998-07-24
HK1002032A1 true HK1002032A1 (en) 1998-07-24

Family

ID=8208605

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101027A HK1002032A1 (en) 1991-08-23 1998-02-11 Sulfated glycosaminoglycanoid derivatives

Country Status (19)

Country Link
EP (1) EP0529715B1 (cs)
JP (1) JP3048198B2 (cs)
KR (1) KR100274115B1 (cs)
AT (1) ATE149504T1 (cs)
AU (1) AU656610B2 (cs)
BR (1) BR1100632A (cs)
CA (1) CA2076063C (cs)
DE (1) DE69217774T2 (cs)
DK (1) DK0529715T3 (cs)
ES (1) ES2101026T3 (cs)
FI (1) FI111726B (cs)
GR (1) GR3023580T3 (cs)
HK (1) HK1002032A1 (cs)
HU (2) HUT62594A (cs)
IL (1) IL102758A (cs)
NO (1) NO179452C (cs)
NZ (1) NZ244057A (cs)
TW (1) TW213470B (cs)
ZA (1) ZA926029B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2157388C (en) * 1993-03-01 1998-12-15 Daniel P. Witt Analogs for specific oligosaccharide-protein interactions and uses thereof
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
US6083933A (en) * 1999-04-19 2000-07-04 Stellar International Inc. Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
CA2435637A1 (en) 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
CA2507707C (en) 2002-12-03 2011-06-21 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US20040161476A1 (en) 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
RU2413734C2 (ru) 2004-08-05 2011-03-10 Ивакс Драг Рисерч Инститьют Лтд Полисульфатированные гликозиды и их соли
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
BRPI0912277A2 (pt) 2008-05-30 2015-12-22 Momenta Pharmaceuticals Inc estruturas sacarídicas e métodos de preparação e utilização dessas estruturas
FR2938541B1 (fr) * 2008-11-20 2011-08-26 Sanofi Aventis Pentasaccharide cristallise,son procede d'obtention et son utilisation pour la preparation d'idraparinux
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
EP2614089A1 (fr) 2010-09-10 2013-07-17 Sanofi-Aventis Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
EP2578594A1 (en) 2011-10-04 2013-04-10 Sanofi Process of preparation of L-iduronic acid comprising a decarboxylation/intramolecular cyclisation tandem reaction
US20250228878A1 (en) * 2021-10-14 2025-07-17 Owlstone Medical Limited Method for the synthesis of evoc probes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3017407A (en) * 1958-08-18 1962-01-16 Riker Laboratories Inc Process for producing polysulfuric acid esters of polysaccharides
GB1110939A (en) * 1965-10-06 1968-04-24 Meito Sangyo Kk Sulphuric acid esters of disaccharides and hexitols,and their use as antipeptic ulcer agents
HU172937B (hu) * 1975-12-18 1979-01-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh khondroitin-sernoj kisloty s mestno anestezirujuhhim ehffektom
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2543145B1 (fr) * 1983-03-24 1986-10-17 Sanofi Sa Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante
AU607690B2 (en) * 1985-12-24 1991-03-14 Marion Laboratories, Inc. Use of synthetic sulfated saccharides to enhance wound healing
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
IE64378B1 (en) * 1990-04-23 1995-07-26 Akzo Nv Carbohydrate derivatives comprising a trisaccharide unit
EP2301618B1 (en) * 2009-09-23 2011-12-07 Covidien AG A dilation device for dilating an opening

Also Published As

Publication number Publication date
KR930004324A (ko) 1993-03-22
KR100274115B1 (ko) 2000-12-15
DK0529715T3 (da) 1997-09-08
FI923726A0 (fi) 1992-08-19
ZA926029B (en) 1993-03-10
AU2121892A (en) 1993-02-25
NO179452B (no) 1996-07-01
IL102758A (en) 1997-03-18
CA2076063A1 (en) 1993-02-24
ES2101026T3 (es) 1997-07-01
ATE149504T1 (de) 1997-03-15
GR3023580T3 (en) 1997-08-29
HUT62594A (en) 1993-05-28
IL102758A0 (en) 1993-01-31
FI111726B (fi) 2003-09-15
NO923297D0 (no) 1992-08-21
NO923297L (no) 1993-02-24
EP0529715B1 (en) 1997-03-05
BR1100632A (pt) 2000-06-13
TW213470B (cs) 1993-09-21
NO179452C (no) 1996-10-09
AU656610B2 (en) 1995-02-09
JPH05194602A (ja) 1993-08-03
DE69217774D1 (de) 1997-04-10
CA2076063C (en) 2003-12-30
NZ244057A (en) 1995-05-26
DE69217774T2 (de) 1997-06-26
EP0529715A1 (en) 1993-03-03
JP3048198B2 (ja) 2000-06-05
FI923726L (fi) 1993-02-24
HU211738A9 (en) 1995-12-28

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Legal Events

Date Code Title Description
AS Change of ownership

Owner name: SANOFI-SYNTHELABO

Free format text: FORMER OWNER(S): SANOFI-SYNTHELABO, AKZO NOBEL N.V

PF Patent in force
CHPA Change of a particular in the register (except of change of ownership)
PE Patent expired

Effective date: 20120816