HK1000098A1 - Acridinium esters and method for detection of an analyte using acridinium esters and liposomes - Google Patents
Acridinium esters and method for detection of an analyte using acridinium esters and liposomesInfo
- Publication number
- HK1000098A1 HK1000098A1 HK97101553A HK97101553A HK1000098A1 HK 1000098 A1 HK1000098 A1 HK 1000098A1 HK 97101553 A HK97101553 A HK 97101553A HK 97101553 A HK97101553 A HK 97101553A HK 1000098 A1 HK1000098 A1 HK 1000098A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- acridinium esters
- analyte
- liposomes
- detection
- acridinium
- Prior art date
Links
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 2
- 239000012491 analyte Substances 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 239000002502 liposome Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22663988A | 1988-08-01 | 1988-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1000098A1 true HK1000098A1 (en) | 1997-11-21 |
Family
ID=22849773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK97101553A HK1000098A1 (en) | 1988-08-01 | 1997-07-11 | Acridinium esters and method for detection of an analyte using acridinium esters and liposomes |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0353971B1 (fr) |
JP (2) | JP2601347B2 (fr) |
AU (2) | AU634716B2 (fr) |
CA (1) | CA1339490C (fr) |
DE (1) | DE68925603T2 (fr) |
HK (1) | HK1000098A1 (fr) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656426A (en) * | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
CA1339491C (fr) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Derives de polysubstitution d'ester d'acridinium arylique, nucleophiles;leurs utilisations |
US5155022A (en) * | 1991-02-08 | 1992-10-13 | Becton, Dickinson And Company | Assay for lyme disease |
US5436155A (en) * | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
EP0761652A1 (fr) * | 1995-08-01 | 1997-03-12 | Mochida Pharmaceutical Co., Ltd. | Dérivés d'acridinium à plusieurs groupes luminescents et groupes liants et leur conjugués |
ES2320055T3 (es) * | 1998-08-11 | 2009-05-18 | Siemens Healthcare Diagnostics Inc. | Compuestos de uso acridino quiminolumicentes en el infrarrojo cercano y sus usos. |
US6723851B2 (en) * | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
US9829494B2 (en) | 2005-12-01 | 2017-11-28 | Adrenomed Ag | Methods of treatment using ADM antibodies |
US8119422B2 (en) * | 2006-10-13 | 2012-02-21 | Siemens Healthcare Diagnostics Inc. | Stable acridinium esters with fast light emission |
SG11201402358RA (en) | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy of an acute disease or acute condition of a patient for stabilizing the circulation |
MY174877A (en) | 2011-11-16 | 2020-05-20 | Adrenomed Ag | Anti-adrenomedullin (adm) antibpdy or anti-adm antibody fragment of anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic of acute disease or acute condition |
SG10202006318TA (en) | 2011-11-16 | 2020-08-28 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
PL2780371T3 (pl) | 2011-11-16 | 2019-06-28 | Adrenomed Ag | Przeciwciało przeciwko adrenomedulinie (ADM) lub fragment przeciwciała przeciwko ADM lub rusztowanie nie-Ig przeciwko ADM do regulowania równowagi płynów u pacjenta z chorobą przewlekłą lub ostrą |
PL2594587T3 (pl) | 2011-11-16 | 2014-11-28 | Adrenomed Ag | Przeciwciało przeciwko adrenomedulinie (ADM) lub fragment przeciwciała anty-ADM lub szkielet białkowy niestanowiący Ig anty-ADM do zmniejszenia ryzyka śmierci u pacjenta cierpiącego na chorobę przewlekłą lub ostrą lub stan ostry |
KR102176469B1 (ko) | 2011-11-16 | 2020-11-10 | 아드레노메드 아게 | 요법에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드 |
CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
PL2904403T3 (pl) | 2012-10-02 | 2018-08-31 | Sphingotec Gmbh | Sposób rozpoznawania lub monitorowania funkcji nerki lub rozpoznawania dysfunkcji nerki |
RU2671578C2 (ru) | 2012-10-02 | 2018-11-02 | Сфинготек Гмбх | Способ прогнозирования риска возникновения рака или диагностирования рака у женщины |
JP6317763B2 (ja) | 2013-01-08 | 2018-04-25 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 対象における癌となる危険性を予測し又は癌と診断する方法 |
EP2943795B1 (fr) | 2013-01-08 | 2021-02-24 | sphingotec GmbH | Taux à jeûn d'hormone de croissance comme marqueur de prédiction d'un risque cardiovasculaire |
JP2017502973A (ja) | 2013-12-30 | 2017-01-26 | オンコプレフェント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌を予防する方法において使用するためのニューロキニン−1受容体アンタゴニスト |
US20160097781A1 (en) | 2014-10-01 | 2016-04-07 | Sphingotec Gmbh | Method for stratifying a female subject for hormone replacement therapy |
EP3262421B1 (fr) | 2015-02-27 | 2020-02-26 | SphingoTec GmbH | Méthode de prédiction du risque d'obésité chez un sujet |
DE112017002105T5 (de) | 2016-04-21 | 2019-04-25 | Sphingotec Therapeutics Gmbh | Verfahren zur Bestimmung von DPP3 und therapeutische Verfahren |
SG11201900133WA (en) | 2016-07-08 | 2019-02-27 | Sphingotec Gmbh | Adrenomedullin for assessing congestion in a subject with acute heart failure |
EP3309550A1 (fr) | 2016-10-12 | 2018-04-18 | sphingotec GmbH | Procédé pour la détection de l'apolipoprotéine e4 |
BR112019011713A2 (pt) | 2016-12-16 | 2019-10-15 | Adrenomed Ag | anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou arcabouço anti-adm não ig para uso na intervenção e terapia da congestão em um paciente com necessidade da mesma |
EP3339324A1 (fr) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anticorps anti-adrénomedulline (adm) ou fragment d'anticorps anti-adm ou échafaudage anti-adm non-ig destiné à être utilisé dans l'intervention et la thérapie de congestion chez un patient ayantbesoin |
MX2019014441A (es) | 2017-05-30 | 2020-02-10 | Sphingotec Gmbh | Un metodo in vitro para diagnosticar o monitorear la funcion renal o diagnosticar disfuncion renal. |
JP7424972B2 (ja) | 2017-10-25 | 2024-01-30 | 4ティーン4 ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特定のdpp3エピトープに指向され、そしてそれに結合するdpp3バインダー、ならびに酸化ストレスに関連する疾患/急性病態の予防または治療におけるその使用 |
MX2020008345A (es) | 2018-02-08 | 2020-09-25 | Sphingotec Gmbh | Adrenomedulina (adm) para el diagnostico y/o prediccion de demencia y un aglutinante de anti-adrenomedulina para usarse en la terapia o prevencion de demencia. |
JP2022516438A (ja) | 2018-12-21 | 2022-02-28 | 4ティーン4 ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | アンジオテンシン受容体アゴニストおよび/またはその前駆体による治療のための治療ガイドおよび/または治療モニタリング |
EP4014049A1 (fr) | 2019-08-15 | 2022-06-22 | sphingotec GmbH | Procédé de diagnostic ou de surveillance de la fonction rénale ou de diagnostic d'une dysfonction rénale chez des patients pédiatriques |
BR112022002856A2 (pt) | 2019-08-30 | 2022-08-09 | 4TEEN4 Pharmaceuticals GmbH | Orientação de terapia e/ou monitoramento de terapia para o tratamento de choque |
EP3871689A1 (fr) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anticorps anti-adm se liant à l'extrémité n-terminale libre pour accélérer la transition de l'adm-gly vers la bio-adm chez les patients dont le rapport adm-gly/bio-adm est supérieur à un seuil et combinaison avec la vitamine c |
JP2023515042A (ja) | 2020-02-27 | 2023-04-12 | アドレノメト アクチェンゲゼルシャフト | ショックの治療若しくは予防において使用するための抗アドレノメデュリン(ADM)抗体若しくは抗ADM抗体フラグメント又は抗ADM非Ig足場 |
EP4111204A1 (fr) | 2020-02-27 | 2023-01-04 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 pour le guidage, la surveillance et la stratification thérapeutique d'anticorps nt-adm chez des patients présentant un choc |
WO2021178988A1 (fr) * | 2020-03-04 | 2021-09-10 | Siemens Healthcare Diagnostics Inc. | Méthodes d'amplification de signaux d'immunoessai |
WO2021178987A1 (fr) * | 2020-03-04 | 2021-09-10 | Siemens Healthcare Diagnostics Inc. | Compositions et procédés d'utilisation de liposomes modifiés |
EP3922993A1 (fr) | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 chez des patients infectés par le coronavirus |
CN115917325A (zh) | 2020-03-16 | 2023-04-04 | 艾德里诺医药公司 | 感染冠状病毒的患者中的肾上腺髓质素原或其片段以及用针对肾上腺髓质素的结合剂进行的治疗 |
CA3171332A1 (fr) | 2020-03-16 | 2021-09-23 | Andreas Bergmann | Dpp3 chez des patients infectes par un coronavirus |
EP4023218A1 (fr) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Thérapie combinée pour les patients souffrant d'une dyspnée aiguë et/ou persistante |
WO2022234111A1 (fr) | 2021-05-07 | 2022-11-10 | Sphingotec Gmbh | Adrénomédulline mature permettant une stratification thérapeutique de corticostéroïdes chez des patients gravement malades |
WO2024023368A1 (fr) | 2022-07-29 | 2024-02-01 | 4TEEN4 Pharmaceuticals GmbH | Prédiction d'augmentation de dpp3 chez un patient souffrant d'un choc septique |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
DE3628573C2 (de) * | 1986-08-22 | 1994-10-13 | Hoechst Ag | Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays |
US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
CA1339491C (fr) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Derives de polysubstitution d'ester d'acridinium arylique, nucleophiles;leurs utilisations |
-
1989
- 1989-07-27 AU AU39033/89A patent/AU634716B2/en not_active Ceased
- 1989-07-31 DE DE68925603T patent/DE68925603T2/de not_active Expired - Fee Related
- 1989-07-31 CA CA000607098A patent/CA1339490C/fr not_active Expired - Fee Related
- 1989-07-31 JP JP1199178A patent/JP2601347B2/ja not_active Expired - Lifetime
- 1989-07-31 EP EP89307752A patent/EP0353971B1/fr not_active Expired - Lifetime
-
1993
- 1993-01-27 AU AU32034/93A patent/AU654754B2/en not_active Ceased
-
1996
- 1996-07-09 JP JP8179488A patent/JP2822320B2/ja not_active Expired - Lifetime
-
1997
- 1997-07-11 HK HK97101553A patent/HK1000098A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0353971A3 (en) | 1990-10-10 |
JP2822320B2 (ja) | 1998-11-11 |
AU654754B2 (en) | 1994-11-17 |
JPH0925422A (ja) | 1997-01-28 |
AU634716B2 (en) | 1993-03-04 |
AU3203493A (en) | 1993-04-01 |
EP0353971B1 (fr) | 1996-02-07 |
DE68925603D1 (de) | 1996-03-21 |
EP0353971A2 (fr) | 1990-02-07 |
AU3903389A (en) | 1990-02-08 |
DE68925603T2 (de) | 1996-09-26 |
JP2601347B2 (ja) | 1997-04-16 |
JPH0296567A (ja) | 1990-04-09 |
CA1339490C (fr) | 1997-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |