DE68925603D1 - Akridiniumester und Verfahren zum Nachweis von Analyt mit Akridiniumestern und Liposomen - Google Patents
Akridiniumester und Verfahren zum Nachweis von Analyt mit Akridiniumestern und LiposomenInfo
- Publication number
- DE68925603D1 DE68925603D1 DE68925603T DE68925603T DE68925603D1 DE 68925603 D1 DE68925603 D1 DE 68925603D1 DE 68925603 T DE68925603 T DE 68925603T DE 68925603 T DE68925603 T DE 68925603T DE 68925603 D1 DE68925603 D1 DE 68925603D1
- Authority
- DE
- Germany
- Prior art keywords
- acridinium esters
- analyte
- liposomes
- detection
- acridinium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 2
- 239000012491 analyte Substances 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 239000002502 liposome Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22663988A | 1988-08-01 | 1988-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68925603D1 true DE68925603D1 (de) | 1996-03-21 |
| DE68925603T2 DE68925603T2 (de) | 1996-09-26 |
Family
ID=22849773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68925603T Expired - Fee Related DE68925603T2 (de) | 1988-08-01 | 1989-07-31 | Akridiniumester und Verfahren zum Nachweis von Analyt mit Akridiniumestern und Liposomen |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0353971B1 (de) |
| JP (2) | JP2601347B2 (de) |
| AU (2) | AU634716B2 (de) |
| CA (1) | CA1339490C (de) |
| DE (1) | DE68925603T2 (de) |
| HK (1) | HK1000098A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656426A (en) * | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
| CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
| US5155022A (en) * | 1991-02-08 | 1992-10-13 | Becton, Dickinson And Company | Assay for lyme disease |
| US5436155A (en) * | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
| US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| EP0761652A1 (de) * | 1995-08-01 | 1997-03-12 | Mochida Pharmaceutical Co., Ltd. | Acridiniumverbindung mit mehreren lumineszierenden Gruppen und Bindungsgruppen und Konjugate derselben |
| WO2000009487A1 (en) * | 1998-08-11 | 2000-02-24 | Bayer Corporation | Near infrared chemiluminescent acridinium compounds and uses thereof |
| US6723851B2 (en) * | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
| WO2007062676A1 (en) | 2005-12-01 | 2007-06-07 | B.R.A.H.M.S. Aktiengesellschaft | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| EP2074101B1 (de) * | 2006-10-13 | 2012-08-08 | Siemens Healthcare Diagnostics Inc. | Stabile acridiniumester mit schneller lichtemission |
| NZ624873A (en) | 2011-11-16 | 2016-07-29 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
| CN104144948B (zh) | 2011-11-16 | 2021-10-15 | 艾德里诺医药公司 | 用于治疗的抗肾上腺髓质素(ADM)抗体或抗ADM抗体片段或抗ADM非Ig骨架 |
| SG11201402358RA (en) | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy of an acute disease or acute condition of a patient for stabilizing the circulation |
| PT2594587E (pt) | 2011-11-16 | 2014-08-27 | Adrenomed Ag | Anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou andaime proteico não ig anti-adm para diminuir o risco de mortalidade num paciente com uma doença aguda ou crónica ou num estado agudo |
| PT2780717T (pt) | 2011-11-16 | 2017-02-16 | Sphingotec Gmbh | Ensaios de adrenomedulina e processos para a determinação de adrenomedulina madura |
| SG11201402354YA (en) | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
| CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
| CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
| CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
| CN110221071A (zh) | 2012-10-02 | 2019-09-10 | 斯弗因高泰克有限公司 | 预测女性对象患癌症风险或诊断其癌症的方法 |
| WO2014053501A1 (en) | 2012-10-02 | 2014-04-10 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction |
| ES2710974T3 (es) | 2013-01-08 | 2019-04-29 | Sphingotec Gmbh | Método para predecir el riesgo de contraer cáncer de mama o diagnosticar cáncer en un sujeto femenino |
| SG11201505222RA (en) | 2013-01-08 | 2015-08-28 | Sphingotec Gmbh | Fasting levels of growth hormone as a predictive marker of cardiovascular risk |
| US20160324881A1 (en) | 2013-12-30 | 2016-11-10 | Oncoprevent Gmbh | Neurokinin-1 Receptor Antagonists For Use In A Method Of Prevention Of Cancer |
| US20160097781A1 (en) | 2014-10-01 | 2016-04-07 | Sphingotec Gmbh | Method for stratifying a female subject for hormone replacement therapy |
| WO2016066862A2 (en) | 2015-02-27 | 2016-05-06 | Sphingotec Gmbh | A method for predicting the risk of obesity in a subject |
| SG11201809252YA (en) | 2016-04-21 | 2018-11-29 | Sphingotec Therapeutics Gmbh | Methods for determining dpp3 and therapeutic methods |
| WO2018007588A1 (en) | 2016-07-08 | 2018-01-11 | Sphingotec Gmbh | Adrenomedullin for assessing congestion in a subject with acute heart failure |
| EP3309550A1 (de) | 2016-10-12 | 2018-04-18 | sphingotec GmbH | Verfahren zum nachweis von apolipoprotein e4 |
| EP3339324A1 (de) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm)-antikörper oder anti-adm antikörperfragment oder anti-adm-nicht-ig-gerüst zur verwendung in einer intervention und therapie von verstopfung bei einem darauf angewiesenen patienten |
| CN110167962B (zh) | 2016-12-16 | 2024-06-07 | 艾德里诺医药公司 | 用于干预和治疗需要的患者的充血的抗肾上腺髓质素(ADM)抗体或抗ADM抗体片段或抗ADM非Ig支架 |
| US20200182885A1 (en) | 2017-05-30 | 2020-06-11 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfuntion |
| WO2019081595A2 (en) | 2017-10-25 | 2019-05-02 | Sphingotec Therapeutics Gmbh | DPP3 BINDER DIRECTED TO AND BINDING SPECIFIC DPP3 EPITOPES AND USE THEREOF IN THE PREVENTION OR TREATMENT OF OXIDATIVE STRESS ASSOCIATED DISEASES / CONDITIONS |
| MX2020008345A (es) | 2018-02-08 | 2020-09-25 | Sphingotec Gmbh | Adrenomedulina (adm) para el diagnostico y/o prediccion de demencia y un aglutinante de anti-adrenomedulina para usarse en la terapia o prevencion de demencia. |
| EP3897686A2 (de) | 2018-12-21 | 2021-10-27 | 4TEEN4 Pharmaceuticals GmbH | Therapieführung und/oder therapieüberwachung für eine behandlung mit angiotensin-rezeptor-agonist und/oder einem vorläufer davon |
| JP2022544942A (ja) | 2019-08-15 | 2022-10-24 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 小児患者における腎機能を診断若しくはモニタリングする、又は腎機能障害を診断する方法 |
| CN114556100A (zh) | 2019-08-30 | 2022-05-27 | 4Teen4制药有限公司 | 用于治疗休克的疗法指引和/或疗法监测 |
| EP3871689A1 (de) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anti-adm-antikörper, die an den freien n-terminus binden, für einen beschleunigten übergang von adm-gly zu bio-adm bei patienten mit einem adm-gly/bio-adm-verhältnis über einem schwellenwert und kombination mit vitamin c |
| EP4111204A1 (de) | 2020-02-27 | 2023-01-04 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 zur therapieführung, überwachung und stratifizierung von nt-adm-antikörpern bei patienten mit schock |
| IL295728A (en) | 2020-02-27 | 2022-10-01 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm backbone without ig for use in the treatment of cure or prevention of shock |
| JP2023516379A (ja) * | 2020-03-04 | 2023-04-19 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 修飾リポソームを使用する組成物および方法 |
| JP7513734B2 (ja) * | 2020-03-04 | 2024-07-09 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | イムノアッセイシグナルを増幅するための方法 |
| EP3922993A1 (de) | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 bei patienten, die mit coronavirus infiziert sind |
| MX2022011577A (es) | 2020-03-16 | 2022-10-18 | Sphingotec Gmbh | Proadrenomedulina o fragmento de la misma en pacientes infectados con coronavirus y tratamientos con aglutinante contra la adrenomedulina. |
| CN115769076A (zh) | 2020-03-16 | 2023-03-07 | 4Teen4制药有限公司 | 感染冠状病毒的患者中的dpp3 |
| EP4023218A1 (de) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Kombinationstherapie für patienten mit akuter und/oder anhaltender dyspnoe |
| US20240255531A1 (en) | 2021-05-07 | 2024-08-01 | Sphingotec Gmbh | Mature adrenomedullin for therapy stratification of corticosteroids in critically ill patients |
| WO2024023368A1 (en) | 2022-07-29 | 2024-02-01 | 4TEEN4 Pharmaceuticals GmbH | Prediction of an increase of dpp3 in a patient with septic shock |
| WO2024126793A1 (en) | 2022-12-15 | 2024-06-20 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 inhibitor for improvement of pulmonary function in critically ill patients |
| WO2024200862A1 (en) | 2023-03-29 | 2024-10-03 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 inhibitor for myocardial protection and prevention of myocardial injury in critically ill patients with blood pressure decline |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| DE3645292C2 (de) * | 1986-08-22 | 1997-12-11 | Hoechst Ag | Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
-
1989
- 1989-07-27 AU AU39033/89A patent/AU634716B2/en not_active Ceased
- 1989-07-31 DE DE68925603T patent/DE68925603T2/de not_active Expired - Fee Related
- 1989-07-31 JP JP1199178A patent/JP2601347B2/ja not_active Expired - Lifetime
- 1989-07-31 EP EP89307752A patent/EP0353971B1/de not_active Expired - Lifetime
- 1989-07-31 CA CA000607098A patent/CA1339490C/en not_active Expired - Fee Related
-
1993
- 1993-01-27 AU AU32034/93A patent/AU654754B2/en not_active Ceased
-
1996
- 1996-07-09 JP JP8179488A patent/JP2822320B2/ja not_active Expired - Lifetime
-
1997
- 1997-07-11 HK HK97101553A patent/HK1000098A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU634716B2 (en) | 1993-03-04 |
| JPH0296567A (ja) | 1990-04-09 |
| JP2822320B2 (ja) | 1998-11-11 |
| CA1339490C (en) | 1997-10-07 |
| EP0353971A3 (en) | 1990-10-10 |
| EP0353971B1 (de) | 1996-02-07 |
| JPH0925422A (ja) | 1997-01-28 |
| EP0353971A2 (de) | 1990-02-07 |
| AU3203493A (en) | 1993-04-01 |
| DE68925603T2 (de) | 1996-09-26 |
| HK1000098A1 (en) | 1997-11-21 |
| AU3903389A (en) | 1990-02-08 |
| AU654754B2 (en) | 1994-11-17 |
| JP2601347B2 (ja) | 1997-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |